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  2. "And if the machine shows rosacea what would you recommend for that? I heard there is a new cream on the market that works well." Kristin Auble "Yes, it’s called Rhofade and it just received FDA approval. So that’s exciting. We also have a laser called the Vbeam that helps with vascular issue such as rosacea. So I would recommend a combo of the cream and laser treatment." Dr. David Shafer, New York City Tech Alert: 3D Imaging May Be The Secret to Perfect Skin, by Kristin Auble, W Magazine
  3. Dermata Therapeutics, a San Diego development-stage biotech advancing new treatments for rosacea, eczema, and related dermatological diseases, said it has secured $5 million in additional funding from private investors and entered into a $5 million credit facility with Silicon Valley Bank. Dermata has developed DMT210 which is for rosacea. Dermata Secures $10M in Combined Financing for Skin Treatments, by Bruce V Bigelow, Xconomy, San Diego
  4. The Dermatologist Forms Collaboration with The National Rosacea Society, PRWeb, Benzinga
  5. "A recent study in the British Journal of Dermatology makes a case for treating and managing rosacea based on the clinical presentation, or phenotype." Global Consensus on Rosacea Treatments by Phenotype, by Jennifer Newton, Medical News Bulletin
  6. You've probably heard of common skin conditions like psoriasis and eczema, but do you also know about rosacea? If not, you've got to listen up. "Rosacea is abnormal blood vessel growth in all layers of the skin, caused by internal problems and inflammation within the body and skin," says Julia T. Hunter, MD, a dermatologist and founder of Wholistic Dermatology. This abnormal blood vessel growth is the result of low thyroid, fungal overgrowth internally, gut inflammation, and chronic sun overexposure, she says. 10 Things You Need to Know About Rosacea—Whether You Have It or Not, by AUBREY ALMANZA, Reader's Digest
  7. Related Articles Ivermectin therapy for papulopustular rosacea and periorificial dermatitis in children: A series of 15 cases. J Am Acad Dermatol. 2017 Mar;76(3):567-570 Authors: Noguera-Morel L, Gerlero P, Torrelo A, Hernández-Martín Á PMID: 28212765 [PubMed - in process] {url} = URL to article
  8. The topical use of oxymetazoline 0.05% solution in the management of rosacea has been primarily limited to data from case series involving fewer than 10 patients and demonstrating sustained improvements in both erythema and flushing. Alhough oxymetazoline is not recognized in national guidelines, an international consensus statement recognizes the possible therapeutic role of oxymetazoline in the management of rosacea, despite the limited evidence. Hosp Pharm. 2013 Jul-Aug; 48(7): 558–559. Published online 2013 Jul 9. doi: 10.1310/hpj4807-558 PMCID: PMC3839519 Oxymetazoline (Topical): Rosacea Joyce A. Generali, RPh, MS, FASHP, (Editor) and Dennis J. Cada, PharmD, FASHP, FASCP
  9. I haven't used the Soolantra since February 13, 2017 so for more than 72 hours my skin has been healing and I don't have the burning feeling I had, so I thought I would take three more photos to show my skin condition after using Soolantra for 105 days, just three days later.
  10. Maria, Actually I am cheap, since it costs me around $40/jar for the ZZ cream which I actually prefer. But since I have insurance in my old age now, I would prefer to pay a nominal fee for a sulphur treatment if it works reasonably well. I was using the sulphur butter due to a post made by Joanne Whitehead, PhD, (Assistant Director of the RRDi) since it was cheap and it works sort of ok, but I don't like the oily part of the formula since my skin is already oily. The ZZ cream is so different and it dries up my skin which is wonderful, and it feels cool when you put it on due to the menthol in it. I just love it and have one jar left as an emergency jar. So if the Americans can make a cheaper sulphur topical I am willing to give it a try and apparently there are a number of them. My insurance wouldn't approve the one my dermatologist prescribed yesterday (not sure of the exact Rx that was denied) and it takes days to do the documents to get it approved and my doctor doesn't like having his staff write up these letters (such are the woes of the American Medical System), so I heard he can write a Rx for a generic sulphur drug that my insurance will accept. Time will tell what Rx I get. As to the demodex population, I think I nuked all those little buggers with the ivermectin. My face is healing nicely each day now and I plan on doing nothing but washing with water for the next few days and then I will take photos of my face to show you the difference. I read a post in RF from Toen (post #684) how he only uses Soolantra occasionally which seems like a good idea to me, like if I get a pustule, since I noticed the Soolantra seems to work rather nicely on them and reduces them quickly, within a couple of days. I think I just over did the Soolantra. You would think that someone would mention this, that Soolantra is powerful, that more is not good sometimes. I can still get more tubes of Soolantra if I want. But I think the one I have which is half gone will last me months.
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  12. It could be the case that your demodex is resistant to ivermectin and after all these years of sulpur usage it's also resistant to sulfur, so I wouldn't expect much of this generic sulfur cream. I know you have the feeling that sulfur controls it, but obviously it's not a cure, otherwise you wouldn't search for other options, Brady. Maybe you could try the permethrin cream. I just read an article about permethrin being effective in ivermectin-resistant cases of scabies infection, the same should apply for demodex.
  13. Well done Brady. I think you have given Soolantra a fair go. You should have seen something really good by now so I don't blame you for ditching it. I have a similar problem with it and at the moment I need to use Tacrolimus to keep the inflammation at bay. I don't think I'm going to last much longer. Anyway I'm curious. Your Derm doesn't seem to be having huge success with his patients on Soolantra. 25% is quite a low success rate, especially when compared to the 70% success rate in the one year study. Of course I accept that a certain percentage could have ditched it too early in their treatments, but 1 in 4 is still quite low. You told your Derm that you have good results with sulfur so obviously he prescribed what you wanted. But I'd love to know what your Derm is having most success with treating the 3 out of 4 who failed on Soolantra.
  14. Maria, You are so kind. My face has been burning where I have been applying the Soolantra everynight, even when I wash it off in the am, the burning continues. I explained all this the dermatologist who said to stop using it. I really did give it a go. There must be something in the Soolantra that irritates my skin. It has been over 24 hours since I applied the Soolantra and my face has already started to calm down and cool off. The burning has almost completely gone. I am going to let my skin rest for a few days to recover from this and then apply the sulphur generic prescription my dermatologist prescribed since I have experienced good results from the sublimed sulphur in the ZZ cream. However, the ZZ cream costs more than my generic prescription since I have insurance. I am now convinced that Soolantra just isn't for me. My dermatologist says one out of four of his rosacea patients gets excellent results with Soolantra. I may in the future use a dab of Soolantra on a zit to see what happens, but no more night applications for me.
  15. Brady, what if you have such a heavy infestation with demodex, that it makes it hard for your skin to deal with the die off by itself? I think you should try taking oral antibiotics along with Soolantra and push through this phase for another month. You have put such an effort to this, it would be a pity if you quit earlier.
  16. Went to the dermatologist today and he advised me to stop Soolantra since I am not a candidate for this treatment. After 105 days, I was hoping Soolantra would work for me, but alas, as you can see below, my rosacea seems to inflamed too much from using Soolantra. My dermatologist prescribed a generic sulphur based cream for me to try since I have responded well in the past to similar treatment using the ZZ cream. I have to pick up the prescription and will start another review later. Here are my photos for today:
  17. I conveniently forgot to mention that earlier. For me and my family to buy only on coupon prescription drugs
  18. Phymatous rosacea presenting with leonine facies and clinical response to isotretinoin. Australas J Dermatol. 2017 Feb;58(1):72-73 Authors: Wee JS, Tan KB PMID: 28195321 [PubMed - in process] {url} = URL to article
  19. I will share my experience. Before I started taking the drug I went online and looked at people's opinions. I noticed that there were several people who had reported problems with rebound flushing. I also noticed that in the clinical trial, the actual success rate compared to placebo was shockingly low. I am not a medical expert so I decided to shrug it off and take use the cream anyway. My skin looked somewhat unnatural, kind of yellow, since there was no red in it.
  20. Conclusions Combined therapy was superior in decreasing the D. folliculorum count in all groups and in reducing the mite count to the normal level in rosacea and in anterior blepharitis. On the other hand, the two regimens were comparable in reducing the mite count to the normal level in acne and peri-oral dermatitis lesions. International Journal of Infectious Diseases Volume 17, Issue 5, May 2013, Pages e343–e347 Evaluation of the efficacy of oral ivermectin in comparison with ivermectin–metronidazole combined therapy in the treatment of ocular and skin lesions of Demodex folliculorum Doaa Abdel-Badie Salema, Atef El-shazlya, Nairmen Nabiha, Youssef El-Bayoumyb, Sameh Salehc
  21. Related Articles Friends or Foes? Host defense (antimicrobial) peptides and proteins in human skin diseases. Exp Dermatol. 2017 Feb 13;: Authors: Niyonsaba F, Kiatsurayanon C, Chieosilapatham P, Ogawa H Abstract Host defense peptides/proteins (HDPs), also known as antimicrobial peptides/proteins (AMPs), are key molecules in the cutaneous innate immune system. AMPs/HDPs historically exhibit broad-spectrum killing activity against bacteria, enveloped viruses, fungi and several parasites. Recently, AMPs/HDPs were shown to have important biological functions, including inducing cell proliferation, migration and differentiation; regulating inflammatory responses; controlling the production of various cytokines/chemokines; promoting wound healing; and improving skin barrier function. Despite the fact that AMPs/HDPs protect our body, several studies have hypothesized that these molecules actively contribute to the pathogenesis of various skin diseases. For example, AMPs/HDPs play crucial roles in the pathological processes of psoriasis, atopic dermatitis, rosacea, acne vulgaris, systemic lupus erythematosus and systemic sclerosis. Thus, AMPs/HDPs may be a double-edged sword, promoting cutaneous immunity while simultaneously initiating the pathogenesis of some skin disorders. This review will describe the most common skin-derived AMPs/HDPs (defensins, cathelicidins, S100 proteins, ribonucleases and dermcidin) and discuss the biology and both the positive and negative aspects of these AMPs/HDPs in skin inflammatory/infectious diseases. Understanding the regulation, functions and mechanisms of AMPs/HDPs may offer new therapeutic opportunities in the treatment of various skin disorders. This article is protected by copyright. All rights reserved. PMID: 28191680 [PubMed - as supplied by publisher] {url} = URL to article
  22. "There are many effective treatments for rosacea. Some common topical medications include metronidazole, azalaic acid, ivermectin, or sulfur-based products. Oral antibiotics are commonly used, such as doxycycline, especially when papules and pustules are present. Redness and broken blood vessels are much more difficult to treat with medications. A topical medication that was originally designed to treat glaucoma can be used, providing temporary relief by blanching the superficial blood vessels. This medication, called Mirvaso, is very effective for some people but, unfortunately, not all patients are responsive." Reviewing Rosacea, By Darrel Arthurs, ARNP, DCNP , Dermatology Education & Practice from NADNP, Healthcare POV, Advance Web
  23. There are a number of papers indicating niacinamide improves rosacea. You may want to ask your dermatologist about niacinamide. You can purchase niacinamide over the counter (non prescription). Niacinamide eases rosacea inflammation June 01, 2010 By Lisa Samalonis, Dermatology Times Niacinamide-containing facial moisturizer improves skin barrier and benefits subjects with rosacea. Cutis. 2005 Aug;76(2):135-41 Authors: Draelos ZD, Ertel K, Berge C A review of nicotinamide: treatment of skin diseases and potential side effects. J Cosmet Dermatol. 2014 Dec;13(4):324-8 Authors: Rolfe HM
  24. There are papers indicating that Niacinamide improves rosacea. For example, Helen M. Torok, M.D. reports in an article in Dermatology Times, "Niacinamide can be an effective treatment for the inflammation related to rosacea" Several non prescription topicals containing Niacinamide are Acnessential, InstaNatural Niacinamide Serum, Paula's Choice RESIST 10% Niacinamide Booster, The Posh Company B3 Nicinamide Serum, and Luminositie Niacinamide B3 Cream.
  25. I guess some could be sceptical about Soolantra's ability to kill demodex. Especially since there are no studies to prove it. Sometimes oral meds don't work as well, or even not at all, when transformed into a topical device. But I believe there is some proof that Soolantra is as effective as oral ivermectin. You may have read this study http://www.sciencedirect.com/science/article/pii/S120197121201315X It compares oral ivermectin to oral ivermectin and metronidazole in the reduction of demodex and improvement of symptoms in 4 different skin conditions. The author of this study did make one observartion which is very much identical to so many testimonials we read about from users of Soolantra. Here is a paragraph from the study: "In the cases who received ivermectin alone, there was a gradual reduction in the mean follicle mite count at the first week visit . However, rebound elevation in the mite count was evident in the third week in some patients with rosacea and those with anterior blepharitis lesions." This was only a 4 week study so obviously there was no report of a 6th week rebound.
  26. Ivermectin is supposed to kill mites. I am simply not having the success that many have reported happens to them using Soolantra. I was hoping the fourth month would really be more of an improvement but so far I am not impressed. I am seeing the dermatologist on Feb 15 and get a professional evaluation on my progress. I can tell you that using the ZZ cream works way better for me than Soolantra. I guess I am one of those who responds better to sulphur treatment than Ivermectin.
  27. Brady, from your last 2 posts would I be correct in saying you're not convinced that Soolantra kills demodex?
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