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  1. Related Articles TRPV4 Moves toward Center-Fold in Rosacea Pathogenesis. J Invest Dermatol. 2017 Apr;137(4):801-804 Authors: Chen Y, Moore CD, Zhang JY, Hall RP, MacLeod AS, Liedtke W Abstract Mascarenhas et al. report that TRPV4 expression is upregulated in mast cells in response to the proteolytic cathelicidin fragment LL37 in a murine rosacea model and that TRPV4 loss of function attenuates mast cell degranulation. These findings render TRPV4 a translational-medical target in rosacea. However, signaling mechanisms causing increased expression of TRPV4 await elucidation. Moreover, we ask whether TRPV4-mediated Ca(++)-influx evokes mast cell degranulation. PMID: 28340683 [PubMed - in process] {url} = URL to article
  2. Related Articles Giant Rhinophyma: A Rare Case of Total Nasal Obstruction and Restitutio Ad Integrum. Aesthetic Plast Surg. 2017 Mar 24;: Authors: Wolter A, Scholz T, Liebau J Abstract Rhinophyma is considered the end stage in the development of rosacea, accompanied by hypertrophy of the sebaceous glands, which causes an enlargement of the nose. It is an uncommon condition that often results in both functional and cosmetic impairment. A large variety of surgical and nonsurgical treatments have been published to treat it. Closure is usually obtained by wound granulating in by secondary intention, skin grafting or local flaps. Rarely these lesions can attain a giant size and pose a challenge in surgical treatment. We present a 63-year-old male with the necessity for tracheostomy at the ICU due to total nasal obstruction and recurrent episodes of pneumonia caused by a huge giant rhinophyma, which had undergone extreme growth in the last five years. The tumor was removed under general anesthesia by decortication with an electrosurgical wire loop to recreate the aesthetic units of the nose preserving the alar cartilage as well as the pilosebaceous appendages. The wounds healed in by secondary intention with a very pleasant cosmetic and improved functional result. The relevant literature is discussed. Level of Evidence V This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 . PMID: 28341953 [PubMed - as supplied by publisher] {url} = URL to article
  3. Related Articles Skin disorders in Parkinson's disease: potential biomarkers and risk factors. Clin Cosmet Investig Dermatol. 2017;10:87-92 Authors: Ravn AH, Thyssen JP, Egeberg A Abstract Parkinson's disease (PD) is one of the most common neurodegenerative disorders, characterized by a symptom triad comprising resting tremor, rigidity, and akinesia. In addition, non-motor symptoms of PD are well recognized and often precede the overt motor manifestations. Cutaneous manifestations as markers of PD have long been discussed, and cumulative evidence shows an increased prevalence of certain dermatological disorders in PD. Seborrheic dermatitis is considered to occur as a premotor feature of PD referable to dysregulation of the autonomic nervous system. Also, an increased risk of melanoma has been observed in PD. Light hair color is a known risk factor for melanoma, and interestingly the risk of PD is found to be significantly higher in individuals with light hair color and particularly with red hair. Furthermore, several studies have reported a high prevalence of PD in patients with bullous pemphigoid. Moreover, a 2-fold increase in risk of new-onset PD has been observed in patients with rosacea. Besides the association between PD and various dermatological disorders, the skin may be useful in the diagnosis of PD. Early PD pathology is found not only in the brain but also in extra-neuronal tissues. Thus, the protein α-synuclein, which is genetically associated with PD, is present not only in the CNS but also in the skin. Hence, higher values of α-synuclein have been observed in the skin of patients with PD. Furthermore, an increased risk of PD has been found in the Cys/Cys genotype, which is associated with red hair color. In this review, we summarize the current evidence of the association between PD and dermatological disorders, the cutaneous adverse effects of neurological medications, and describe the potential of skin protein expression and biomarkers in identification of risk and diagnosis of PD. PMID: 28331352 [PubMed - in process] {url} = URL to article
  4. Related Articles Selection of experimental strawberry (Fragaria x ananassa) hybrids based on selection indices. Genet Mol Res. 2017 Mar 08;16(1): Authors: Vieira SD, de Souza DC, Martins IA, Ribeiro GH, Resende LV, Ferraz AK, Galvão AG, de Resende JT Abstract The strawberry (Fragaria x ananassa Dutch.), is the only vegetable belonging to the rosacea family. All strawberry species have now emerged from wild species and belong to the genus Fragaria, being that this genus presents more than 45 described species, and only 11 are considered natural species. Due to the octoploid nature of strawberry and its variability after hybridization, selecting one or more characters may result in unfavorable genotypes and even the exclusion of promising ones, because negative genetic correlations have been observed among them that cause inefficient selection. Therefore, the objective of this study was to verify the efficiency of selection indices in selecting experimental strawberry hybrids for in natura consumption and processing. Seven commercial cultivars and 103 hybrids were used, which were obtained from populations derived from their crossings. The experiment was conducted in augmented blocks, in which four agronomical traits (total mass, amount of commercial fruit, amount of noncommercial fruit, and average fruit mass) and seven physical-chemical traits (soluble solids, soluble solids:titratable acidity ratio, total sugars, total pectin, vigor, and internal and external coloration) were evaluated. For hybrid selection, the following indices were used: Mulamba and Mock (1978), Smith (1936), Hazel (1943), and genotype-ideotype, which selected 20% of the genotypes evaluated. The three indices selected about 9% of the hybrids. The selection of two experimental hybrids (89 and 495) and the use of selection indices resulted in larger estimates of selection gains. The Mulamba and Mock (1978), Smith (1936), and Hazel (1943) indices had the highest percentage of gains on selection, and are therefore recommended for the selection of strawberry clones. PMID: 28290613 [PubMed - in process] {url} = URL to article
  5. Related Articles Rosacea fulminans: unusual clinical presentation of rosacea. An Bras Dermatol. 2016 Sep-Oct;91(5 suppl 1):151-153 Authors: Coutinho JC, Westphal DC, Lobato LC, Schettini AP, Santos M Abstract Rosacea fulminans or pyoderma faciale is a rare cutaneous disorder that usually affects women usually between the ages of 15-46. The disease is characterized by sudden onset of papules, pustules, cysts, and painful coalescing nodules with red-cyanotic centrofacial erythema. Although its etiology remains unknown, hormonal, immunological, and vascular factors have been reported. Early diagnosis and prompt treatment should minimize unsightly scars. We report a case of a 33-year-old female patient treated with traditional doses of doxycycline, with improvement of the lesions and regression of the condition in two months. PMID: 28300926 [PubMed - in process] {url} = URL to article
  6. Related Articles Morbihan syndrome: a case report and literature review. An Bras Dermatol. 2016 Sep-Oct;91(5 suppl 1):157-159 Authors: Vasconcelos RC, Eid NT, Eid RT, Moriya FS, Braga BB, Michalany AO Abstract Morbihan syndrome is a rare entity that more commonly affects women in the third or fourth decade of life. It is considered a special form of rosacea and its pathogenesis is not fully known. It is clinically characterized by the slow appearance of erythema and solid edemas on the upper portion of the face, with accentuation in the periorbital region, forehead, glabella, nose, and cheeks. We report the case of a patient presented with edema on the upper eyelid for a year. These findings suggested the diagnosis of Morbihan syndrome. We aim to report a rare, particularly refractory and chronic form of rosacea, which has received little attention in the literature. PMID: 28300928 [PubMed - in process] {url} = URL to article
  7. Related Articles Oral Ivermectin to Treat Papulopustular Rosacea in a immunocompetent patient. Actas Dermosifiliogr. 2017 Mar 16;: Authors: Hernández-Martín Á PMID: 28318523 [PubMed - as supplied by publisher] {url} = URL to article
  8. Related Articles Cost of diagnosing psoriasis and rosacea for dermatologists versus primary care physicians. Cutis. 2017 Feb;99(2):134-136 Authors: Hill D, Feldman SR Abstract Growing incentives to control health care costs may cause accountable care organizations (ACOs) to reconsider how skin disease is best managed. Limited data have suggested that disease management by a primary care physician (PCP) may be less costly than seeing a specialist, though it is not clear if the same is true for the management of skin disease. This study assessed the cost of seeing a dermatologist versus a PCP for diagnosis of psoriasis and rosacea. PMID: 28319619 [PubMed - in process] {url} = URL to article
  9. Related Articles The changing faces of acne, rosacea, and hidradenitis suppurativa. Clin Dermatol. 2017 Mar - Apr;35(2):115-117 Authors: Katsambas A, Dessinioti C PMID: 28274347 [PubMed - in process] {url} = URL to article
  10. Related Articles Demodex and rosacea revisited. Clin Dermatol. 2017 Mar - Apr;35(2):195-200 Authors: Moran EM, Foley R, Powell FC Abstract Demodex mites are part of the vast microbiome living on and within human skin. The interaction of the various microorganisms with the skin plays a key role in the maintenance of homeostasis. The precise role and function of Demodex mites within normal and diseased human skin remains elusive. The emergence of ivermectin as a key therapy for rosacea has refocused interest in the role of Demodex mites in the pathogenesis of this skin disease and the ability of Demodex to modulate the host immune system. PMID: 28274359 [PubMed - in process] {url} = URL to article
  11. Related Articles The "red face": Not always rosacea. Clin Dermatol. 2017 Mar - Apr;35(2):201-206 Authors: Dessinioti C, Antoniou C Abstract Facial erythema (the "red face") is a straightforward clinical finding, and it is evident even to the untrained eye; however, a red face does not represent a single cutaneous entity. It may be due to a plethora of distinct underlying conditions of varying severity, including rosacea, demodicosis, dermatomyositis, lupus erythematosus, allergic contact dermatitis, drug-induced erythema, and emotional blushing. In clinical practice, dermatologists do not encounter only one type of facial erythema but rather a number of different shades of red. This review presents the clinical spectrum of facial erythemas and addresses the question of what lies beneath a red face by discussing the key clinical and histopathologic characteristics. PMID: 28274360 [PubMed - in process] {url} = URL to article
  12. Related Articles Pharmacologic treatments for rosacea. Clin Dermatol. 2017 Mar - Apr;35(2):207-212 Authors: Layton AM Abstract Rosacea represents a common and chronic inflammatory skin disorder. Clinical features include transient and permanent erythema, inflammatory papules and pustules, phymatous changes, and ocular signs and symptoms. Rosacea is generally classified into four subtypes and one variant. Subtype 1, erythematotelangiectatic rosacea, includes clinical features of flushing and persistent central facial erythema with or without telangiectasia. Subtype 2, papulopustular rosacea, is characterized by persistent central facial erythema with transient papules or pustules or both on the central face. Subtype 3, phymatous rosacea, includes thickening of the skin with irregular surface nodularities and enlargement. Subtype 4, ocular rosacea, includes inflammation of different parts of the eye and eyelid. A variant, granulomatous rosacea, is noninflammatory and is characterized by hard, brown, yellow, or red cutaneous papules or nodules of uniform size. Patients may present with more than one subtype, and each individual characteristic may fluctuate. There is debate whether rosacea progresses from one subtype over time or subtypes represent discreet entities. Defining clinical presentation and improved understanding of pathophysiology has resulted in identification of novel treatment approaches. This contribution outlines a rationale for treatment, highlights an evidence-based approach with approved treatments, and considers novel developments and off-license therapy available. PMID: 28274361 [PubMed - in process] {url} = URL to article
  13. Related Articles Cosmeceuticals for rosacea. Clin Dermatol. 2017 Mar - Apr;35(2):213-217 Authors: Draelos ZD Abstract Patients with rosacea present a challenge to the dermatologist, as they typically possess sensitive skin, need facial Demodex and bacterial colonization control, exhibit vasomotor instability, require camouflaging of telangiectatic mats, and desire prescription treatment. Currently available pharmaceuticals are aimed at inflammation reduction, primarily with the use of topical and oral antibiotics. Recently, vasoconstrictor formulations have emerged, but these drugs have only a temporary effect and improve appearance without addressing the underlying cause, which remains largely unknown. Cosmeceuticals, including cleansers, moisturizers, cosmetics, sunscreens, and anti-inflammatory botanicals, can be used as adjuvant therapies in combination with traditional therapies. This review explores the effective use of cosmeceuticals in the treatment of rosacea to enhance pharmaceutical outcomes and meet patient expectations in a more satisfactory manner. PMID: 28274362 [PubMed - in process] {url} = URL to article
  14. Related Articles [RISK-FSCTORS OF CARDIOVASCULAR DISEASE IN PATIENTS WITH ROSACEA]. Georgian Med News. 2017 Jan;(262):49-52 Authors: Tsiskarishvili T, Katsitadze A, Tsiskarishvili NI, Chigladze V Abstract The purpose of the research was to study the lipid profile, some indices of hemostasis and cytokine status of rosacea patients with severe climacteric syndrome. Serum lipid profile was studied by means of the following parameters: total cholesterol, high density lipoproteins (HDL), low density lipoproteins (LDL), triglycerides (the study of lipid profile was performed by the device "INTEGRAM +400" (Company "ROSH»). Haemostatic system was evaluated in terms of prothrombin, thrombin time. Content of fibrinogen, fibrinolytic activity, and prothrombin index were determined. The concentration of free VEGF (vascular endothelial growth factor) and IL-8 were measured by ELISA. The results of these studies suggest that the phenomenon of hyper coagulation and disorders in lipid profile of blood serum in patients with rosacea with climacteric syndrome can be considered as risk factors of cardiovascular disease. From the other side, as a powerful provocateur of increased permeability, atony and fragility of vessel walls, VEGF, IL-2, IL-8 may be directly related to the mechanism of the development of cardiovascular disease in rosacea patients. PMID: 28252428 [PubMed - in process] {url} = URL to article
  15. Related Articles Usefulness of dermoscopy in the diagnosis and monitoring treatment of demodicidosis. Dermatol Pract Concept. 2017 Jan;7(1):35-38 Authors: Friedman P, Sabban EC, Cabo H Abstract Demodicidosis is a common infestation and should be considered in the differential diagnosis of recurrent or recalcitrant perioral dermatitis or rosacea-like eruptions of the face. We report on a 34-year-old male, who presented with facial erythema and desquamation accompanied by a pruritic sensation. Dermoscopic examination revealed Demodex tails and Demodex follicular openings, both specific features of this entity. Microscopically, standardized skin surface biopsy test was pathogenic and the patient had positive response to anti-demodectic drugs. To our knowledge, a few reports of the dermatoscopic features of demodicidosis have been published in the literature. Dermoscopy offers a potential new option for a real-time validation of Demodex infestation and a useful tool for monitoring treatment. PMID: 28243492 [PubMed - in process] {url} = URL to article