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  1. Today
  2. Hydroxychloroquine (brand name Plaquenil) [and the related drug, chloroquine (brand name Arelene)] has been in the news for its alleged ability to treat coronavirus, mostly due to President Trump’s advocacy on its use during the pandemic. This subject has ‘divided the medical community’ according to The New York Times. The American Society for Biochemisty and Molecular Biology reports that there are few published papers on this subject, acknowledging that one small study in France was 'encouraging,' however, other reports indicate that hydroxychloroguine are 'not effective for treating coronavirus.' [1] According to Forbes, the FDA "The Food and Drug Administration on Sunday issued an emergency authorization for experimental coronavirus treatments using chloroquine and hydroxychloroquine, anti-malaria drugs touted by President Donald Trump despite inconclusive clinical proof of their efficacy." Hydroxychloroquine has been shown to be effective in treating rosacea. [2] Duffman reported in April 2017, "The only thing that finally worked for me with long lasting, real remission, is plaquenil." [3] Dan Charles, on April 3, 2020, NPR reports, "Dr. Anthony Fauci of the National Institutes of Health was asked March 24 whether the drug was considered a treatment for the novel coronavirus."The answer is no," he said, "and the evidence that you're talking about ... is anecdotal evidence." " James Hamblin, MD, staff writer for The Atlantic, wrote an article on the history of this subject on April 6, 2020 explaining in detail how the president has been advocating the use of this drug for the coronavirus epidemic, and concludes, "It is unclear how hydroxychloroquine would work to treat COVID-19, but the drug is one of many now being urgently studied for the treatment of the disease." [4] One other anti-parasitic drug being studied is ivermectin, another treatment for rosacea. [5] The American Academy of Ophthalmology states on its website concerning hydroxychloroquine and chloroquine that, "These drugs may stop the immune system from going overboard in its attack on the virus." [6] If you are interested in a clinical trial with hydroxychloroquine you may want to contact Elizabeth Oelsner, Columbia University. Of course, you won't be able to know whether you actually receive hydrochloroquine or the placebo. The CDC lists on it's Information for Clinicians on Therapeutic Options for COVID-19 Patients that "Hydroxychloroquine is currently under investigation in clinical trials for pre-exposure or post-exposure prophylaxis of SARS-CoV-2 infection, and treatment of patients with mild, moderate, and severe COVID-19." A Chinese clinical study published in Cell Discovery concluded, "In conclusion, our results show that HCQ can efficiently inhibit SARS-CoV-2 infection in vitro. In combination with its anti-inflammatory function, we predict that the drug has a good potential to combat the disease. This possibility awaits confirmation by clinical trials." [7] Another Chinese study states, "In this study, hydroxychloroquine exhibited better in vitro anti-SARS-CoV-2 activity than chloroquine." [8] The French study that may have started all this states, "In conclusion, we confirm the efficacy of hydroxychloroquine associated with azithromycin in the treatment of COVID-19 and its potential effectiveness in the early impairment of contagiousness. Given the urgent therapeutic need to manage this disease with effective and safe drugs and given the negligible cost of both hydroxychloroquine and azithromycin, we believe that other teams should urgently evaluate this therapeutic strategy both to avoid the spread of the disease and to treat patients before severe irreversible respiratory complications take hold." [9] End notes [1] A small trial finds that hydroxychloroquine is not effective for treating coronavirus, Katherine Seley-Radtke, April 05, 2020, ASBMBTODAY [2] Int Immunopharmacol. 2020 Jan 06;79:106178 Hydroxychloroquine is a novel therapeutic approach for rosacea. Li J, Yuan X, Tang Y, Wang B, Deng Z, Huang Y, Liu F, Zhao Z, Zhang Y [3] Plaquenil (Hydroxychloroquine) [4] Why Does the President Keep Pushing a Malaria Drug?, The Atlantic The Guardian also has its version of the history of this subject. [5] Ivermectin Treats Coronavirus [6] Treating Coronavirus With Plaquenil and Aralen, Reena Mukamal, AAO [7] Cell Discov 6, 16 (2020). Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro Jia Liu, Ruiyuan Cao, Mingyue Xu, Xi Wang, Huanyu Zhang, Hengrui Hu, Yufeng Li, Zhihong Hu, Wu Zhong & Manli Wang [8] ciaa237.pdf [9] COVID-IHU-2-1.pdf
  3. Two is better than one: The combined effects of glycolic acid and salicylic acid on acne-related disorders. J Cosmet Dermatol. 2020 Apr 06;: Authors: Wiegmann D, Haddad L Abstract BACKGROUND: Many companies capitalized on treatable skin conditions by providing expensive prescription medications or high-end over-the-counter cosmetics. However, patients have become more apprehensive toward these medications in lieu of their often-detrimental side effect profile and reactivity with sensitive skin. AIMS: We developed a serum was created to counteract this budding problem. Our goal was to bring an alternative prescription acne medication that was superior in controlling acne when compared to several OTC and prescription-strength medications. We created a new formulary comprising primarily of all natural glycolic acid and salicylic acid. PATIENTS/METHODS: We designed a prospective study to assess the efficacy of our serum composed of glycolic and salicylic acid for patients suffering from mild to moderate inflammatory and cystic acne, rosacea, folliculitis, and keratosis pilaris. Sixty-six patients were selected ranging in age from 17 to 46. They were asked to apply the wake-up serum at night for 2 weeks. At the follow-up appointment, the patients were asked to fill out a questionnaire regarding the changes they have noticed with their skin. RESULTS: Over 90% of the patients reported they had significant overall improvement in acne with decrease in comedonal and cystic acne. 70%-80% of the patients stated decrease in oiliness, even texture, and smoother looking skin. Physical examination findings were consistent with patient-reported assessment. CONCLUSION: A glycolic and salicylic acid combination serum may be considered an alternative treatment method for patients who wish to opt out of the typical prescription medication treatment. PMID: 32250551 [PubMed - as supplied by publisher] {url} = URL to article
  4. Anxiety, Depression, and Suicidal Ideation amongst Patients with Facial Dermatoses (Acne, Rosacea, Perioral Dermatitis, and Folliculitis) in Lithuania. Dermatology. 2020 Apr 06;:1-9 Authors: Lukaviciute L, Ganceviciene R, Navickas P, Navickas A, Grigaitiene J, Zouboulis CC Abstract BACKGROUND/OBJECTIVE: Skin diseases, especially those with visible manifestation, are considered to cause a major influence on global mental health. Therefore, we determined the prevalence and severity of anxiety, depression, and suicidal ideation in a large sample of patients with facial dermatoses, namely acne, rosacea, folliculitis, and perioral dermatitis. METHODS: The mental health of patients with facial dermatoses and respective controls was assessed using the Hospital Anxiety and Depression Scale and questions concerning suicidal ideation. RESULTS: The study included 543 patients with facial dermatoses and 497 healthy individuals. Anxiety was present in 37.6% of the patients (14.9% of controls), depression in 21.7% (6.8%), and suicidal thoughts in 9.8% (3.2%) (p < 0.001). Acne patients demonstrated the highest anxiety and depression subscale scores (mean ± standard deviation: 7.1 ± 0.25, 95% confidence interval (CI): 6.58-7.56; controls: 5 ± 0.23, 95% CI: 4.57-5.49). In rosacea 30% of the patients had depression symptoms (adjusted odds ratio (OR): 7.216, 95% CI: 4.122-12.632, p < 0.001), while in folliculitis patients 15.4% (OR: 3.138, 95% CI: 1.241-7.936, p = 0.016) had suicidal thoughts. Patients with anxiety symptoms and suicidal thoughts were on average younger than those without (28.3 ± 0.76 vs. 31.2 ± 0.66 years, p = 0.001 and 25.3 ± 0.98 vs. 30.5 ± 0.55 years, p = 0.007, respectively). CONCLUSION: Acne and rosacea are associated with anxiety, depression, and suicidal ideation in Lithuanian patients. Younger patients are more prone to report such symptoms than older ones. PMID: 32252051 [PubMed - as supplied by publisher] {url} = URL to article
  5. Yesterday
  6. In a related news item, Ivermectin, another anti-parasitic drug, has been purported to treat coronavirus.
  7. In a related news item, Plaquenil (Hydroxychloroquine), another anti-parasitic drug, has been purported to treat coronavirus. Read the third post in this thread.
  8. "It’s still not clear exactly how Ivermectin works. But it appears to stop the processes that allow proteins to move within the virus. These proteins would normally dampen the body’s antiviral response, allowing the virus to replicate and enhance the infection." Head lice drug Ivermectin is being tested as a possible coronavirus treatment, but that’s no reason to buy it, April 6, 2020, Andrew McLachlan, The Conversation "Wagstaff cautions that these are very early test results and much more will need to be done, including clinical trials and human testing and will be necessary before any action can be taken. But, he says, it’s a sign of hope." Researchers discover anti-parasite drug kills coronavirus in lab, Chris Patrick, Sunday, April 5, 2020, Trib
  9. Last week
  10. There are multiple news reports that ivermectin, a common drug used to treat rosacea orally and topically, has been found effective in treating the coronavirus (scoll down for more reports). Virus and rosacea has never, ever been ruled out. A collaborative study led by the Monash Biomedicine Discovery Institute and the Doherty Institute found the drug Ivermectin stops coronavirus growing in cell culture." Warning issued as researchers reveal another potential treatment for coronavirus, ABC News Australia "Researchers at Monash University in Melbourne, Australia have discovered that the antiparasitic drug Ivermectin can inhibit replication of SARS-CoV-2, the virus the causes COVID-19, according to a study published Friday in the journal Antiviral Research....Ivermectin has been widely used since the 1980s to treat head lice, scabies and several other infections caused by parasites. The drug is also used to treat the skin condition rosacea." [bold added] ANTI-PARASITE DRUG USED SINCE 1980S MAY HELP STOP CORONAVIRUS, NEW STUDY SAYS BY AILA SLISCO ON 4/3/20 AT 10:46 PM EDT, 3 April 2020, Newsweek The report by Caly et al is published in Antiviral Research, funded by a National Breast Cancer Foundation Fellowship, is cited below: Antiviral Research Available online 3 April 2020 The FDA-approved Drug Ivermectin inhibits the replication of SARS-CoV-2 in vitro Leon Caly, Julian D.Druce, Mike G.Catton, David A.Jans, Kylie M.Wagstaff Science Daily • Drugs.com • Nature World News • EurekaAlert! • Futureism/Neoscope • Pharmaceutical Technology • SciTechDaily • PHARMAfield • The US Sun • Archyde • Metro News • MoneyControl • The Tecake •
  11. There appears to be a shortage of Hydroxychloroquine (HCQ) according to several news sources. So if you somehow receive Hydroxychloroquine (HCQ) treatment for covid19 and your rosacea improves, please find the green reply button in this thead to post your results. Furthermore, virus has never, ever been ruled out in rosacea. End notes Physicians Seek to Reassure Amid Hydroxychloroquine Shortage, Jeff Evans, March 27, 2020, Medscape FDA SAYS THERE'S A SHORTAGE OF HYDROXYCHLOROQUINE AND CHLOROQUINE 'DUE TO A SIGNIFICANT SURGE IN DEMAND, BY KASHMIRA GANDER ON 4/1/20 AT 11:58 AM EDT, Newsweek As Trump touts an unproven coronavirus treatment, supplies evaporate for patients who need those drugs, By Christopher Rowland , March 23, 2020 at 1:02 p.m. CDT, The Washington Post
  12. Related Articles [Recurrent chalazions in children]. Rev Prat. 2019 Oct;69(8):881-883 Authors: Doan S Abstract Recurrent chalazions in children. Chalazia are caused by an acute inflammation of sebaceous palpebral glands and lead to emergency consultation. Their treatment is most often medical, surgery is reserved for persistant forms. In case of multiple recurrent chalazia in a child, ametropia and ocular rosacea should be ruled out. The latter is a rare but potentially severe disease that can have blinding corneal complications. PMID: 32237654 [PubMed - in process] {url} = URL to article
  13. Related Articles The role of hypothalamus-pituitary-adrenal (HPA)-like axis in inflammatory pilosebaceous disorders. Dermatol Online J. 2020 Feb 15;26(2): Authors: Saric-Bosanac S, Clark AK, Sivamani RK, Shi VY Abstract Skin is the largest peripheral endocrine organ and functions as a hormone target and endocrine gland. A cutaneous hypothalamus-pituitary-adrenal (HPA)-like axis enables the skin to respond to stress and regulates its steroidogenic activity. The pilosebaceous unit is a site for production and metabolism of a number of steroid hormones, including stress and sex hormones. This is an overview of the important role that the cutaneous HPA-like-axis plays in the pathogenesis and treatment of inflammatory pilosebaceous disorders, including acne, rosacea, seborrheic dermatitis, and hidradenitis suppurativa. PMID: 32239884 [PubMed - as supplied by publisher] {url} = URL to article
  14. Try Oshea Herbals Papaya Face Pack enriched with the goodness of pure papaya, aloe vera and licorice extracts which helps to control the production of melanin and enhance the skin complexion. It works as a bleaching agent and removes blemishes and pigmentation.
  15. Frequently some are concerned that if they have a red nose that they will end up like WC Fields, the rosacea poster boy. This is due to a misunderstanding that rosacea progresses in stages which has been debunked. While it is possible if you don't treat your rosacea (or your red nose) it may get worse, it certainly does not mean that it will necessarily get worse or progress into 'stages'. Obviously WC Fields didn't care about whether his nose got redder or turned into rhinophyma, so it is good you are concerned about your red nose. The good thing about rhinophyma or what is more recently classified as Phenotype 5 is that this is the most successfully treated rosacea phenotype (scroll to the subheading TREATMENT in this post for the list).
  16. Coffee Extracts Protect Cells Against Oxidative Stress One of the many theories on the cause of rosacea is the Antioxidant System Defect Hypothesis which is related to Oxidative Stress, Ferritin and Rosacea. One paper concluded the following; "Further experiments using LPS-induced murine macrophages revealed that coffee extracts protect cells against oxidative stress by enhancing the content of the antioxidant GSH and stimulating expressions of the genes related with the cellular antioxidation system. Also, coffee extracts decreased the expression of proinflammatory cytokines and inflammatory mediators in LPS-stimulated RAW 264.7 cells. However, different roasting levels may dilute those effects by decreasing the concentrations of key compounds during the roasting procedures." Journal of Medicinal Food Cellular Antioxidant and Anti-Inflammatory Effects of Coffee Extracts with Different Roasting Levels Jung Soohan, Kim Min Hyung, Park Jae Hee, Jeong Yoonhwa, and Ko Kwang Suk. Journal of Medicinal Food. June 2017, 20(6): 626-635. https://doi.org/10.1089/jmf.2017.3935 Online Ahead of Print: June 5, 2017 Published in Volume: 20 Issue 6: June 1, 2017
  17. Related Articles Serum bilirubin and uric acid antioxidant levels in rosacea patients. J Cosmet Dermatol. 2020 Mar 31;: Authors: Turkmen D Abstract BACKGROUND: Rosacea is a common chronic inflammatory skin disease that the pathogenesis is not fully understood. Although the significant role of oxidative stress in rosacea pathophysiology has been shown in recent studies, there is no study addressing the potential roles of bilirubin and uric acid (UA) in rosacea. AIM: The purpose of this study was to assign serum bilirubin and UA antioxidant levels in rosacea patients. METHODS: Eighty-seven rosacea patients and 81 healthy controls (HCs) similar age and gender were included in the study. From all study participants, blood samples were taken and the values of total bilirubin (Tbil), direct bilirubin (Dbil), indirect bilirubin (Ibil), and UA were analyzed in the laboratory of biochemistry. RESULTS: The type of rosacea was erythematotelangiectatic in 51.7% of the patients, papulopustular in 43.7%, and phymatous in 4.6%. In rosacea group serum, Tbil, Dbil, Ibil, and UA values were found to be significantly lower than in the HCs. Male rosacea patients were found to have lower Tbil, Dbil, Ibil, and UA levels when compared with the males in the HCs. There was also the same significant difference in female patients. CONCLUSION: Main finding of our study was that when compared with the control group, serum bilirubin and UA levels were significantly lower in rosacea patients. These levels sustain the hypothesis that antioxidant status and oxidative stress are important in the pathogenesis of rosacea. PMID: 32233016 [PubMed - as supplied by publisher] {url} = URL to article Antioxidant System Defect Hypothesis
  18. Is rosacea a condition or a disease? Technically, it depends on how you are referring to rosacea in a statement. Condition "A medical condition is a broad term that includes all diseases, lesions, disorders, or nonpathologic condition that normally receives medical treatment, such as pregnancy or childbirth." [1] One report says, “rosacea is not actually a disease, but rather a chronic dermatologic condition that predominantly affects the convexities of the central aspect of the face.” [2] “Francis Wilkin of the FDA, whose serious studies have given us impressive insights into the nature and mechanisms of flushing, has proposed some concepts, which are inexplicable to most of us. He avers that rosacea is not a disease but a “condition”. He labels rosacea an ideotype, a cluster of signs and symptoms, apparently not a pathologic entity warranting a specific nosologic status. To be sure, rosacea is a multifactional disorder with many different clinical expressions. Nonetheless, it meets all the classical requirements of a pathologic process, most obviously the presence of chronic inflammation, both clinically and histologically. Calling rosacea a ‘condition’ downgrades the seriousness of the disorder, perhaps implying that it is only a cosmetic nuisance.” [3] Disease "A disease is a particular abnormal condition that negatively affects the structure or function of all or part of an organism, and that is not due to any immediate external injury....The term disease broadly refers to any condition that impairs the normal functioning of the body." [1] “Rosacea is a common and chronic disorder characterized by flushing, erythema, papules, pustules, and telangiectasia on the central part of the face. Because the facial skin of individuals with rosacea is particularly sensitive, irritants can trigger a worsening of the signs and symptoms of the disease.” [4] “Once considered a variant of acne, this common skin disorder seems fairly well entrenched as a disease sui generis.” [5] Terms Condition/Disease Used Interchangeably “Most words of this type in medicine rooted in Latin from thousands of years ago do not have precise definitions!” [6] “The terms disease & condition are often used interchangeably in the literature.” [7] “…this is semantics: disease, affliction or condition all refer to the same meaning.” [8] Conclusion While both Dr. Millikan and Dr. Wilkin refer to rosacea as a 'condition' and not a 'disease, there is no need to feel that somehow makes rosacea less important since the two words are used in most medical literature interchangeably. End Notes [1] Disease, Wikipedia [2] Skinmed 2003;2(1) The Proposed Inflammatory Pathophysiology of Rosacea: Implications for Treatment Larry Millikan, MD [3] A Personal Critique on the State of Knowledge of Rosacea Albert M. Kligman , M.D., Ph.D. Department of Dermatology, University of Pennsylvania, Philadelphia, PA, U.S.A. The William J. Cunliffe Lectureship 2003—Manuscript publikation_kligman.pdf [4] J Dermatolog Treat. 2007;18(3):158-62. Beneficial use of Cetaphil(R) Moisturizing Cream as part of a daily skin care regimen for individuals with rosacea Laquieze S, Czernielewski J, Baltas E. [5] Postgrad Med. 2002 Dec;112(6):51-8, 82; quiz 9. Unraveling the mystery of rosacea, Keys to getting the red out Ken Landow, MD [6] Robert T. Brodell, MD, RRDi MAC, post no 2 [7] Sandra Cremers, M.D., RRDi MAC, post no 3 [8] Marianne Boes, PhD, RRDi MAC (former member), post no 3
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    LOWER DOWN high skin temperature by patented Soothing Cooler
    Long lasting moisture with jelly type mist
    The blue capsules provide high moisture to skin
    Immediately reduces skin temperature from external stresses
    RECOMMENDED TO THOSE
    Various usage on skin types
    For dry and sensitive skin : use as a mist to moisturize and soothe the skin frequently.
    For combination type skin : use as a 'high moisturizing toner' instead of general toner.
    For oily skin : use as a light soothing gel to balance the oil & hydration level of the skin.
    If skin temperature increase 1℃, then sebum increases by 10%. It takes away moisture when the skin temperature increases. In addition to excessive sebum, causes redness and troubles in the skin, and reduces elasticity, resulting in wrinkles and aging easily. Natural ingredients such as yam, aloe vera, and kombu cooling down the skin temperature to prevent moisture evaporation and reduces stimulation - Matricaria Flower Extract - Matricaria Flower Extract

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    Purchase - Hellocell Tea Tree Spot Patch - Premium, Salicylic Acid, Invisible, Spot Cover, Acne, Pimple, Blemish, Face, Korean, 30 Round Patches  
    Thin, transparent patches_intensive care for skin trouble
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    With excellent anti-inflammatory effects. Removing dead skins to care the acne effectively
    Troubles pre-care by sebum control, hydrating_Witch Hazel & Propolis
    Adjusting sebum and supplying moisture to the area where it tickles or pimples have just started.

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  28. There are several acne treatments used to treat rosacea, i.e., Dapsone, Sarecycline, Azithromycin, Minocycline, and the list continues, not to mention the plethora of over the counter acne treatments to consider. A typical example of an acne treatment, Benzaclin, that is also used to treat rosacea is discussed in the following paper: “Based on the theory that rosacea shares the same inflammatory features of acne, a recent study showed that, just as the combination of benzoyl peroxide 1 percent and clindamycin 5 percent gel is a powerful treatment modality for reducing Propionibacterium acnes levels, it also significantly reduces the papules and pustules of rosacea, according to Debra L. Breneman, M.D..… ‘Benzaclin, once daily, was found to be well tolerated and effective in the reduction of papules and pustules in patients with rosacea,’ said Dr. Breneman. ‘This lends credence to the theory that P. acnes is a potential aggravating factor in rosacea. This gives dermatologists a very effective treatment for rosacea.’ ” [1] Herbal Extracts for Acne One report on the 'clinical efficacy of herbal extracts in treatment of mild to moderate acne vulgaris' concludes, "This herbal extracts can be a new therapeutic option for patients with mild to moderate acne vulgaris who are reluctant to use drugs." [2] The herbal extracts include: Mangosteen extract Lithospermum officinale extract Tribulus terrestris L. extract Houttuynia cordata Thunb extract End Notes [1] Dermatology Times Publish date: Apr 1, 2003 P. Acnes Possible Factor in Rosacea BenzaClin a significant Tx in lesion reduction Beth Kapes Another example similar to above paper discussing topical benzoyl peroxide 5%/clindamycin 1% (BP/C) gel (BenzaClin) concluded, "These results showed that BP/C was significantly more effective than vehicle in improving papules and pustules associated with rosacea.' Cutis. 2004 Jun;73(6 Suppl):11-7. Photographic review of results from a clinical study comparing benzoyl peroxide 5%/clindamycin 1% topical gel with vehicle in the treatment of rosacea. Leyden JJ, Thiboutot D, Shalita A. [2] J Dermatolog Treat. 2019 Oct 16:1-5. doi: 10.1080/09546634.2019.1657792. [Epub ahead of print] Clinical efficacy of herbal extracts in treatment of mild to moderate acne vulgaris: an 8-week, double-blinded, randomized, controlled trial. Yang JH, Hwang EJ, Moon J, Yoon JY, Kim JW, Choi S, Cho SI, Suh DH.
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