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  2. Rhinophyma: Our experience based on a series of 12 cases. Eur Ann Otorhinolaryngol Head Neck Dis. 2017 Sep 21;: Authors: Clarós P, Sarr MC, Nyada FB, Clarós A Abstract INTRODUCTION: Rhinophyma is a rare, benign and unsightly disease of the skin of the nose that was first described a very long time ago, as illustrated by portrait of an old man with a bulbous nose holding his grandson, by Ghirlandaio in 1490. It was described for the first time by Ferdinando Hebra Von (1816-1880), as the third stage of rosacea. The objective of this study is to report the author's experience and propose a new treatment option in the management of rhinophyma. MATERIAL AND METHODS: We describe our experience of rhinophyma based on a retrospective case study. RESULTS: We identified 12 cases over a 12-year period, with a marked male predominance. The therapeutic approach was the same in all patients, consisting of a combination of dermabrasion, decortication and application of fibrin glue, with a favourable outcome in every case with complete epithelialisation. CONCLUSION: Rhinophyma is a rare condition of uncertain pathophysiology. Management is surgical and, in view of the many techniques and procedures proposed, we advocate the slogan "to each his own technique", until a consensus has been reached. Our technique combining dermabrasion, decortication and application of fibrin glue has given very good results. PMID: 28943211 [PubMed - as supplied by publisher] {url} = URL to article
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  5. The Rosacea Treatment Clinic offers retinaldehyde capsules for rosacea.
  6. IowaDavid's Soothing Rain Red Light LED Therapy

    IowaDavid, RF poster, has a web site where he is selling the Soothing Rain Light Unit.
  7. Romeo Milea has been appointed to the RRDi Board of Directors. The board of directors looks forward to Romeo's volunteer spirit and the energy he brings to our non profit organization. You may read his first post
  8. Rosacea affects about 16 million Americans, and most of them don’t know they have it. According to a Gallup survey, almost eight in 10 Americans do not know that rosacea exists. GUEST COLUMN: Rosacea affects about 16 million Americans By Fred Cicetti, International Falls Journal
  9. A Danish population -based cohort study identified a significant association between patients who have rosacea and their risk of having certain other gastrointestinal diseases – specifically celiac disease, Crohn's disease, ulcerative colitis, and irritable bowel syndrome. “While a co-occurrence of rosacea and gastrointestinal disorders has previously been evaluated, the topic remains controversial,” wrote the authors, led by the department of dermatology and allergy, Herlev and Gentofte Hospital, Hellerup, Denmark. Study identifies link between rosacea and GI diseases YOUR DOSE OF MEDICINE By Charles C. Chante, MD (The Philippine Star) |
  10. My dear friends in need, My drama story started in 1989 as a result of seborrheic acne and between 1989 and 1997 my face was chemically peeled of thousand of layers and after that treated with a corticoid like Flocinolon N cream. As a resullt of that my face was red all the time(actually the colour of my face was the one of a sour-cherry), the skin was very sensitive and I was dehydrating very fast. Between 1997 and 2012 I had no ideea that what was happening to be could be rosacea. At that time I was still able to go to the beach during summer days(I live close to the Black Sea) but I was not able to shave very often as my skin was immediately irritated and I was not putting any cream on my face or taking any pills other than aspirin. In September 2009 a new problem started at the level of the head - the cronic fatigue of the brain. Till October 2010 I had no neurological or psyhiatrical treatment for that. Somewhere in 2012 my face started to burn and flush at a specific hour 6.30 pm for hours. No dermatological or psychiarical treatment worked for me. No rosacea cream was working for more than 2-3 days and no pill was having a positive result. During the last 7 years I had 2 MRIs, tests for hystamine, bacteria, fungi, malabsorbtion, H. Pylori, food alergies, gluten, vitamin D3, heavy metals and so on. Nothing wrong was found. In November 2015 clonidine was prescribed to me by a dermatologist(Mirvaso was also prescribed by the same dermatologist with no positive result) and the flushing and burning became more rare from daily one to 2-3 per month but very severe. The following antidepresants were prescribed to me in the last years: Anafranil, Esprital, Cymbalta, Zoloft, Cipralex, Alprazolam, Abylifi, Fobiless, Mirtazapine, Trittico and the last one I have tried - Seroxat - I was almost ready to die a couple of times in August 2017. I was on the edge of collaps and I was thinking that the best way out for me from this story it will be to commit suicide(my mind was imagining all kind of scenarios from taking all the pills in the house to throwing in Danube with my car or in a deep vally in the mountains). Despair and disappointment were my only daily so called friends. In these circumstancies I wish I was dead as there was no life in my life anymore. Beyond flushing and burning I was having a permanet acid sensations in the skin that I was not even bearing to sweat on my face(Niacineamide was the second medicine that helped me for a while because I was not sweating any more). In the last four years I have send numberless petitions to the Prime Minister and the President of Romania to determine the Ministry of Health to let me consult a doctor abroad( I wanted to see dr. Chu in London). But after years of waiting they finally analyzed my case from June to July 2017 and decided to not help me as only surgical treatments are a priority to be treated abroad according with Romanian law. So you can imagine my psyhological status every day. Two weeks ago I have chaged the psychiatrist after 3 years of variable results at the same doctor and the month of August in which a new psychiatrist tried on my brain Seroxat(while taking Seroxat I was lethargic and not able to wake up from my bed) with very bad concequencies. What is my new treatment? - Coaxil(3 per day), Bromazepam(1), Sanval(1) and Romparkin(half). What is happening to me now is almost unbelievable: no more acid sensations in the skin from the very first hour of the day, no more sweating, I am able to stay in the sun without exageration, I can shave being able to leave from the house in the same day, I sleep very well, I started to enjoy hearing music again and I am almost ready to dance in every second. God what is this? Am I in remision or am I cured? I have 4 different psyhiatrical diagnostics (In Romania a dermatologist will never prescribe an antidepresant) and the opinion of psychiatrists is that I have a persistent somatic delirium disorder and that I, by my fear of a heavy / incurable disease, set off all my splendor. I can hardly believe it as the medicine for that disorder - Olanzapin is the only medicine known today for persistent somatic delirium disorder - taken for two years changed nothing in the picture. Dear friends keep the fingers crossed for me. I'll keep you up to date with what's happening to me. A great weekend to all of you. Hugs and kisses. God help us all.
  11. Rod102988 reports, "A year ago this time I was diagnosed with Rosacea due to heavy drinking and long bouts in the sun. I was devastated, depressed and embarrassed. I quit several jobs, tried makeup, turmeric, eating healthy, water etc. You know name it. I spent hundreds on products for up to a year. I even tried Finacea which while it helped the bumps not so much with the redness plus my insurance didn't cover it and it cost $330 a tube. Finally, I did tons of research online and found two products which I use in combination and they only cost a combined $80 on Amazon. 1) La roche Posay Rosaliac AR Intense. It's a visible redness reducing serum made by scientists in France. It's light and has no smell. You apply twice a day after washing. 2) GIGI Bioplasma Azaleic Acid 15 percent cream. This stuff is better than Finacea IMO and much much cheaper. It tackles all the same things as Finacea; redness, blemishes, acne and hyperpigmenation. Now what I do is usually is place both on at the same time but always one significantly less than the other....only on the problems spots. For example, a full dot full of one and miniscule dot full of the other. But, some may get irritated by that I wouldn't suggest starting off like that. In would initially alternate with one each day and then maybe alternate throughout the day. With that said, this cream and serum has worked wonders and its only costing me $80 bucks a month but I could really stretch both to a month and a half of I want to. After using these for 3 months I am amazed and these combination have been a complete and utter life saver."
  12. Baby Shampoo and Tea Tree Oil Regimen

    Found this post at healthboard.com: "My husband and I both have rosacea. We have used Metrogel daily for years and sometimes it would keep the rosacea under control and other times it would not. I researched home remedies and this is what has worked for both of us. We no longer have to go to the dermatologist for an Rx for Metrogel. Please note that this is NOT a cure. We do this daily and then we have no recurrence of the rosacea. When I stopped using it, the rosacea would return after a few weeks. I purchased a 12 ounce bottle of baby shampoo. It doesn't matter what brand as long as it is not too runny like water. Then I bought a 1 ounce bottle of 100% tea tree oil at Trader Joes. It doesn't matter where you buy your bottle of 100% tea tree oil. I poured about 1/3 of the 1 ounce bottle of tea tree oil into the 12 ounce bottle of baby shampoo. I then closed the cap of the baby shampoo and shook it really well. In the beginning when my rosacea was prevalent, every morning I would put some of the tea tree oil infused baby shampoo on those areas. I would leave it on while I brushed my teeth. I tried to keep it on for at least 5 minutes. Then I would rinse it off. That evening I would do it again and keep it on for at least 5 minutes. Then rinse off. After a few days I saw my rosacea disappear. When I stopped this treatment, the rosacea would ultimately return. So now to keep my rosacea from returning I put on the tea tree oil infused baby shampoo every morning while I brush my teeth. I no longer need to put it on at night as the once daily application has kept my rosacea from returning. It is has been well over a year since the rosacea has resurfaced. My husband still continues to put his application of tea tree oil infused baby shampoo on twice a day because he gets good results and he doesn't want to chance it returning as his rosacea was far worse than mine. This daily regime has worked for both my husband and I. If you choose to try this, I hope it works for you as well." This probably would help improve demodectic rosacea.
  13. Related Articles An empirically generated responder definition for rosacea treatment. Clin Cosmet Investig Dermatol. 2017;10:347-352 Authors: Staedtler G, Shakery K, Endrikat J, Nkulikiyinka R, Gerlinger C Abstract OBJECTIVE: The aim of this study was to empirically generate a responder definition for the treatment of papulopustular rosacea. METHODS: A total of 8 multicenter clinical studies on patients with papulopustular facial rosacea were analyzed. All patients were treated with azelaic acid and/or comparator treatments. The severity of rosacea was described by the Investigator Global Assessment (IGA) and the number of lesions. Patients with the IGA score of "clear/minimal" were considered as responders, and those staying in the range of IGA "mild to severe" as nonresponders. The respective number of lesions was determined. RESULTS: A total of 2,748 patients providing 12,410 measurements were included. After treatment, responders showed 2.23±2.48 lesions (median 2 lesions [0-3]), and nonresponders showed 13.74±10.40 lesions (median 12 lesions [6-18]). The optimal cutoff point between both groups was 5.69 lesions. CONCLUSION: The calculated cutoff point of 5.69 lesions allows discrimination of responders (5 or less remaining lesions) and nonresponders (6 or more remaining lesions) of therapeutic interventions in rosacea. PMID: 28932125 [PubMed] {url} = URL to article
  14. Private Contractors Used by the NRS

    These two corporations receive on average 60% of the donated funds to the NRS. You can do your own Illinois corporate lookup to get the same results. For more information.
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  16. The relationship between migraine and rosacea: Systematic review and meta-analysis. Cephalalgia. 2017 Jan 01;:333102417731777 Authors: Christensen CE, Andersen FS, Wienholtz N, Egeberg A, Thyssen JP, Ashina M Abstract Objective To systematically review the association between migraine and rosacea. Background Migraine is a complex disorder with episodes of headache, nausea, photo- and phonophobia. Rosacea is an inflammatory skin condition with flushing, erythema, telangiectasia, papules, and pustules. Both are chronic disorders with exacerbations of symptoms almost exclusively in areas innervated by the trigeminal nerve. Previous studies found an association between these disorders. We review these findings, provide a meta-analysis, and discuss possible pathophysiological commonalities. Methods A search through PubMed and EMBASE was undertaken for studies investigating the association between all forms of migraine and rosacea published until November 2016, and meta-analysis of eligible studies. Results Nine studies on eight populations were identified. Studies differed in methodology and diagnostic process, but all investigated co-occurrence of migraine and rosacea. Four studies were eligible for meta-analysis, resulting in a pooled odds ratio of 1.96 (95% confidence interval 1.41-2.72) for migraine in a rosacea population compared to a non-rosacea population. Conclusion Our meta-analysis confirmed an association in occurrence of migraine and rosacea. Future studies should specifically investigate possible shared pathophysiological mechanisms between the two disorders. PMID: 28920449 [PubMed - as supplied by publisher] {url} = URL to article
  17. Increased Retinoid Therapy for Acne

    A recently published paper concluded, "Expert groups and evidence-based guidelines agree that topical retinoids should be considered the foundation of acne therapy." So this article explains the increased use of retinoids by physicians over antibiotics since there is concern over antibiotic resistance. This article states, "The use of retinoids plus BPO targets multiple pathways and can often eliminate the need for antibiotics, reducing the likelihood of antibiotic resistance."Isotretinoin is just one of the several retinoids used to treat acne. The retinoids mentioned in the article are, "adapalene 0.1% and 0.3%; tazarotene 0.1%; tretinoin 0.01%, 0.025%, 0.038%, 0.04%, 0.05%, 0.08%, and 0.1% in the USA; isotretinoin 0.05% and 0.1% in other regions of the world" and reviews "the evidence supporting why retinoids should be considered the foundation of acne therapy (with a focus on topical retinoids)." The article states, "Both dermatologists and other physicians were less likely to prescribe a retinoid for patients aged 19 or older compared to those aged 10–19." The topical retinoids mentioned in this article are a "fixed combination adapalene 0.3%-benzoyl peroxide (BPO) 2.5% (0.3 A/BPO; Epiduo Forte®, Galderma Laboratories) and topical retinoids (adapalene, tazarotene, or tretinoin) and Retinoids are also available in fixed-combination formulations with BPO [adapalene-BPO 0.1%/2.5% and 0.3%/2.5% (Epiduo® and Epiduo Forte®, Galderma Laboratories)] and clindamycin [tretinoin 0.025%/clindamycin phosphate 1.2% (Veltin, Aqua Pharmaceuticals; Ziana®, Valeant Pharmaceuticals)]."The article does address the concern of "retinoid irritation" and offers "Strategies to minimize tolerability issues" in Table 1 but does not mention anything about long term risks of 'accutane induced rosacea' which many in RF and other anecdotal reports have confirmed happens to some. Dermatol Ther (Heidelb). 2017 Sep; 7(3): 293–304. Published online 2017 Jun 5. doi: 10.1007/s13555-017-0185-2 PMCID: PMC5574737 Why Topical Retinoids Are Mainstay of Therapy for Acne James Leyden, Linda Stein-Gold, and Jonathan Weiss
  18. Chili Powder for Rosacea?

    sepi takes "half teaspoon fine chili powder and I mix it with about 15g face cream" and reports it works for rosacea. Read her report.
  19. Galderma - Almost is Not Clear

    "...the results of a pooled analysis of four Galderma-sponsored studies evaluating the use of topical therapies for the treatment of inflammatory papules and pustules of rosacea were presented at the 26th European Academy of Dermatology and Venereology Congress in Geneva, Switzerland. The success of rosacea treatment is usually defined as a score of 1 ('almost clear') or 0 ('clear') on the 5-point Investigator Global Assessment (IGA) scale. The new analysis reports that rosacea patients who achieve 'clear' (IGA 0), not only experience a more complete reduction in inflammatory lesions compared with patients who achieve 'almost clear' (IGA 1), but also an extended time to relapse that is associated with improved quality of life." ‘CLEAR’ (IGA 0) ROSACEA PATIENTS EXPERIENCE A DELAYED TIME TO RELAPSE, Lausanne, Switzerland – September 16, 2017 Galderma: 'Clear' (IGA 0) Rosacea Patients Experience a Delayed Time to Relapse PR Newswire Sep. 16, 2017
  20. Is Sugar Addictive?

    Is Sugar Addictive? There are reputable sources who say it is and those who say it is is not. I have collected the sources who say it is along with the those who say sugar is not addictive (scroll down). You be the judge. Sources Who Say Sugar is Addictive "Our findings clearly demonstrate that intense sweetness can surpass cocaine reward, even in drug-sensitized and -addicted individuals. We speculate that the addictive potential of intense sweetness results from an inborn hypersensitivity to sweet tastants. In most mammals, including rats and humans, sweet receptors evolved in ancestral environments poor in sugars and are thus not adapted to high concentrations of sweet tastants. The supranormal stimulation of these receptors by sugar-rich diets, such as those now widely available in modern societies, would generate a supranormal reward signal in the brain, with the potential to override self-control mechanisms and thus to lead to addiction." Intense Sweetness Surpasses Cocaine Reward Magalie Lenoi , Fuschia Serre, Lauriane Cantin, Serge H. Ahmed Plos One "Sugar is addictive. And we don’t mean addictive in that way that people talk about delicious foods. We mean addictive, literally, in the same way as drugs. And the food industry is doing everything it can to keep us hooked." Sugar Season. It’s Everywhere, and Addictive. By JAMES J. DiNICOLANTONIO and SEAN C. LUCANDEC. 22, 2014, New York Times "Withdrawal from a “sugar-rich” diet is associated with behavior suggestive of “withdrawal” symptoms." Diabetes 2016 Jul; 65(7): 1797-1799. Is Sugar Addictive? George A. Bray "Sugar addiction happens due to intense cravings for sweet food. It is triggered by the brain by sending signals to the receptors in our tongue that were not able to develop from the low-sugar diets of our ancestors" The Truth About Sugar Addiction By Dr. Mercola, "The biological robustness in the neural substrates of sugar and sweet reward may be sufficient to explain why many people can have difficultly to control the consumption of foods high in sugar when continuously exposed to them." Curr Opin Clin Nutr Metab Care. 2013 Jul;16(4):434-9. doi: 10.1097/MCO.0b013e328361c8b8. Sugar addiction: pushing the drug-sugar analogy to the limit. Ahmed SH, Guillem K, Vandaele Y. "In animals, it’s a “no-brainer.” Dr. Nicole Avena of Columbia University exposes rats to sugar water in an excess-deprivation paradigm for three weeks, and they demonstrate all the criteria needed to diagnose addiction: binging, withdrawal, craving, and addiction transfer (when you’re addicted to one substance, you’re addicted to others as well)." The Sugar-Addiction Taboo When can you call a food addictive? ROBERT H. LUSTIG, The Atlantic "In animal studies, sugar has been found to produce more symptoms than is required to be considered an addictive substance. Animal data has shown significant overlap between the consumption of added sugars and drug-like effects, including bingeing, craving, tolerance, withdrawal, cross-sensitisation, cross-tolerance, cross-dependence, reward and opioid effects. Sugar addiction seems to be dependence to the natural endogenous opioids that get released upon sugar intake. In both animals and humans, the evidence in the literature shows substantial parallels and overlap between drugs of abuse and sugar, from the standpoint of brain neurochemistry as well as behaviour." Sugar addiction: is it real? A narrative review James J DiNicolantonio, James H O'Keefe, William L Wilson British Journal of Sports Medicine "In an interview with Lisa Mullins from Here & Now, Dr. DiNicolantonio further stated that some studies on rats show that sugar is potentially more addictive that cocaine because even after being hooked on cocaine, they invariably switch to sugar when it is introduced to them." Sugar Addiction: Facts And Figures AddictionResource "Your brain also sees sugar as a reward, which makes you keep wanting more of it. If you often eat a lot of sugar, you're reinforcing that reward, which can make it tough to break the habit." Slideshow: The Truth About Sugar Addiction WebMD "So drugs and sugar both activate the same reward system in the brain, causing the release of dopamine." Fact or fiction – is sugar addictive? TheConversation "The link between sugar and addictive behavior is tied to the fact that, when we eat sugar, opioids and dopamine are released." Experts Agree: Sugar Might Be as Addictive as Cocaine Written by Anna Schaefer and Kareem Yasin, healthline "Scientists have found that sugar is addictive and stimulates the same pleasure centers of the brain as cocaine or heroin. Just like those hard-core drugs, getting off sugar leads to withdrawal and cravings, requiring an actual detox process to wean off." Are You Addicted to Sugar? Here’s How to Break the Cycle, by Sarah Elizabeth Richards, Daily Burn, Life "While it is true that sugary foods can stimulate the same part of the brain responsible for pleasure and reward, as do many illicit substances, there are reasons other than addiction that eating could be linked with the reward area of the brain." Is sugar addictive? CSU External Relations Staff "Despite the anecdotal reports of people who claim to be addicted to sugar, and seemingly endless Web sites devoted to sugar addiction," says Cynthia Bartok, associate director for the Center for Childhood Obesity Research in Penn State's College of Health and Human Development, "modern science has not yet validated that idea." "However, 'yet' may be the key word," Bartok adds. "It was once thought of as pseudoscience, but a whole field of research has sprung out of the idea that food components such as sugar or fat may have some similarities to addictive drugs." Probing Question: Is sugar addictive? Lisa Duchene, Penn State "But the study inadvertently highlights an important truth: Anything that provides pleasure (or relieves stress) can be the focus of an addiction, the strength of which depends not on the inherent power of the stimulus but on the individual's relationship with it, which in turn depends on various factors, including his personality, circumstances, values, tastes, and preferences. As Peele and other critics of neurological reductionism have been pointing out for many years, the reality of addiction lies not in patterns of brain activity but in the lived experience of the addict." Research Shows Cocaine And Heroin Are Less Addictive Than Oreos, Jacob Sullum, Forbes "The evidence supports the hypothesis that under certain circumstances rats can become sugar dependent. This may translate to some human conditions as suggested by the literature on eating disorders and obesity." Neuroscience & Biobehavioral Reviews Volume 32, Issue 1, 2008, Pages 20-39 Evidence for sugar addiction: Behavioral and neurochemical effects of intermittent, excessive sugar intake Nicole M. Avena, Pedro Rada, Bartley G. Hoebel "For many years, studies have demonstrated that sugar triggers the brain’s pleasure and reward centers—areas in the emotional centers of the brain responsible for the release of “feel good” neurotransmitters called dopamine. These are the same brain areas stimulated by cocaine, nicotine, opiates (such as heroin and morphine), and alcohol. This addiction is not an imaginary thing in the minds of millions of sugar junkies—it’s associated with real physiological changes in the brain. And, perhaps because the brain’s pleasure areas are also very close to the pain centers, withdrawal from sugar has been described by many patients as being painful—like romantic pain or eliminating nicotine or caffeine." Sugar Addiction: Is It Real? By Dr. Phil Maffetone April 9, 2015, Fat-Burning Journal, Nutrition, MAF "According to Avena, when we eat sugar a signal is sent from the tongue to the cerebral cortex that activates a “rewards system.” This in turn encourages us to eat more. A huge part of the rewards system is the release of dopamine in our brain, which, when put into overdrive, can be pretty addictive." This Is Why You’re ‘Addicted’ To Sugar There’s a reason it feels so darn good. By Cate Matthews, Healthy Living, Huffpost "Speaking to the Guardian, DiNicolantonio said that the consumption of sugar was a grave concern. “In animals, it is actually more addictive than even cocaine, so sugar is pretty much probably the most consumed addictive substance around the world and it is wreaking havoc on our health.” Is sugar really as addictive as cocaine? Scientists row over effect on body and brain, by Nicola Davis, theguardian "Studies show that sugar lights up the same exact area of our brain that is stimulated by drugs. For some people, the highs, lows and withdrawal from sugar can be just as powerful and dramatic as what a drug addict experiences." Sugar and Your Brain: Why Sugar Is So Very Addictive, By: Rachel Gargano MS, RD, LDN, CSSD, Reboot with Joe "Sugar addiction should be treated like drug abuse, new research has revealed." Sugar addiction like drug abuse, study reveals, by Nicola Harley, Telegraph "It is widely thought to affect the brain in a similar way to cocaine, and now a new study has suggested people addicted to sugar should be treated in the same way as other drug abusers." Sugar addiction 'should be treated as a form of drug abuse' by Matt Payton, Independent "Taubes surveys the admittedly sparse research on sugar's psychoactive effects. For example, researchers have found that eating sugar stimulates the release of dopamine, a neurotransmitter that is also released when consuming nicotine, cocaine, heroin, or alcohol. Researchers are still debating the question of whether or not sugar is, in some sense, addictive." Is Sugar an Addictive Poison? Hypothesis: More sugar causes both more diabetes and more obesity Ronald Bailey | January 6, 2017, reason.com "Research published in the Public Library of Science highlights a strange lab rat experiment involving sugar and cocaine. The rats were given cocaine until they became dependent on it. Then, researchers provided them a choice – the rats could continue to have the cocaine or they could switch to sugar. Guess which one the rodents chose? Yup, the sugar. 94% chose to make the switch. Even when they had to work hard to access the sugar, the rats were more interested in it than they were in the cocaine." Study Shows Sugar is More Addictive Than Cocaine!, David Wolfe Sources Who Say Sugar is Not Addictive "That is definitely a problem, but is not necessarily an addiction." Is Sugar Addiction? by Susan J. SMith, Ph.D, CDE, Visalia Medical Clinic "Most of the research they found on sugar addiction was done using mice or rats, and it’s not clear that these findings will translate perfectly to people." Everyone Calm Down for a Minute About ‘Sugar Addiction,’ Neuroscientists Plead By Melissa Dahl, Science of Us, NYMag "Given the lack of evidence supporting it, we argue against a premature incorporation of sugar addiction into the scientific literature and public policy recommendations." European Journal of Nutrition November 2016, Volume 55, Supplement 2, pp 55–69 Sugar addiction: the state of the science Margaret L. WestwaterPaul C. FletcherHisham Ziauddeen "Prof Suzanne Dickson, of Gothenburg University and co-ordinator of the NeuroFAST project, said: "There has been a major debate over whether sugar is addictive. "There is currently very little evidence to support the idea that any ingredient, food item, additive or combination of ingredients has addictive properties." Sugar 'not addictive' says Edinburgh University study, 9 September 2014 From the section Edinburgh, Fife & East Scotland, BBC "Sugary and high-fat food have both been shown to increase the expression of ΔFosB, an addiction biomarker, in the D1-type medium spiny neurons of the nucleus accumbens; however, there is very little research on the synaptic plasticity from compulsive food consumption, a phenomenon which is known to be caused by ΔFosB overexpression." Food Addiction, Wikipedia
  21. new volunteer

    asmaa, Thanks for posting, which is the best thing you can do. Public relations is a great place to post. What is your background? PR? Tell us about your rosacea?
  22. new volunteer

    hi all, hi brady barrows as you know i am already member in the rosacea forum, and i would like to be an active member in this forum (RRDi) too, i received your e-mail and i am happy to participate. i need more details to know how can i help thanks to all
  23. Treatment of Rosacea With Concomitant Use of Topical Ivermectin 1% Cream and Brimonidine 0.33% Gel: A Randomized, Vehicle-controlled Study. J Drugs Dermatol. 2017 Sep 01;16(9):909-916 Authors: Gold LS, Papp K, Lynde C, Lain E, Gooderham M, Johnson S, Kerrouche N Abstract BACKGROUND: There is currently a lack of data on the simultaneous treatment of different features of rosacea. Individually, ivermectin 1% (IVM) cream and brimonidine 0.33% (BR) gel have demonstrated efficacy on inflammatory lesions and persistent erythema, respectively. OBJECTIVE: To evaluate the efficacy, safety, patient satisfaction, and optimal timing of administration of IVM associated with BR (IVM+BR) versus their vehicles in rosacea (investigator global assessment [IGA] ≥3). METHODS: Multicenter, randomized, double-blind study including subjects with rosacea characterized by moderate to severe persistent erythema and inflammatory lesions. The active treatment group included the IVM+BR/12 weeks subgroup (once-daily BR and once-daily IVM for 12 weeks), and the IVM+BR/8 weeks subgroup (once-daily BR vehicle for 4 weeks followed by once-daily BR for the remaining 8 weeks and once-daily IVM for 12 weeks). The vehicle group received once-daily BR vehicle and once-daily IVM vehicle for 12 weeks. RESULTS: The association showed superior efficacy (IGA success [clear/almost clear]) for erythema and inflammatory lesions in the total active group (combined active subgroups) compared to vehicle (55.8% vs. 36.8%, P=0.007) at week 12. The success rate increased from 32.7% to 61.2% at hour 0 and hour 3, respectively, in the IVM+BR/12 weeks subgroup, and from 28.3% to 50% in the IVM+BR/8 weeks subgroup. Reductions in erythema and inflammatory lesion counts confirmed the additive effect of BR to IVM treatment. Subjects reported greater improvement in the active subgroups than in the vehicle group, and similar rates for facial appearance satisfaction after the first 4 weeks of treatment in both active subgroups. All groups showed similar tolerability profiles. CONCLUSION: Concomitant administration of IVM cream with BR gel demonstrated good efficacy and safety, endorsing the comprehensive approach to this complex disease. Early introduction of BR, along with a complete daily skin care regimen may accelerate treatment success without impairing tolerability. <p><em>J Drugs Dermatol. 2017;16(9):909-916.</em></p>. PMID: 28915286 [PubMed - in process] {url} = URL to article
  24. Related Articles Painful subcutaneous nodules in a patch of livedo reticularis. Int J Dermatol. 2017 Mar;56(3):e44-e46 Authors: Barnes P, Chapman C, Fett N PMID: 27496315 [PubMed - indexed for MEDLINE] {url} = URL to article
  25. Treatment of Rosacea With Concomitant Use of Topical Ivermectin 1% Cream and Brimonidine 0.33% Gel: A Randomized, Vehicle-controlled Study. J Drugs Dermatol. 2017 Sep 01;16(9):909-916 Authors: Gold LS, Papp K, Lynde C, Lain E, Gooderham M, Johnson S, Kerrouche N Abstract BACKGROUND: There is currently a lack of data on the simultaneous treatment of different features of rosacea. Individually, ivermectin 1% (IVM) cream and brimonidine 0.33% (BR) gel have demonstrated efficacy on inflammatory lesions and persistent erythema, respectively. OBJECTIVE: To evaluate the efficacy, safety, patient satisfaction, and optimal timing of administration of IVM associated with BR (IVM+BR) versus their vehicles in rosacea (investigator global assessment [IGA] ≥3). METHODS: Multicenter, randomized, double-blind study including subjects with rosacea characterized by moderate to severe persistent erythema and inflammatory lesions. The active treatment group included the IVM+BR/12 weeks subgroup (once-daily BR and once-daily IVM for 12 weeks), and the IVM+BR/8 weeks subgroup (once-daily BR vehicle for 4 weeks followed by once-daily BR for the remaining 8 weeks and once-daily IVM for 12 weeks). The vehicle group received once-daily BR vehicle and once-daily IVM vehicle for 12 weeks. RESULTS: The association showed superior efficacy (IGA success [clear/almost clear]) for erythema and inflammatory lesions in the total active group (combined active subgroups) compared to vehicle (55.8% vs. 36.8%, P=0.007) at week 12. The success rate increased from 32.7% to 61.2% at hour 0 and hour 3, respectively, in the IVM+BR/12 weeks subgroup, and from 28.3% to 50% in the IVM+BR/8 weeks subgroup. Reductions in erythema and inflammatory lesion counts confirmed the additive effect of BR to IVM treatment. Subjects reported greater improvement in the active subgroups than in the vehicle group, and similar rates for facial appearance satisfaction after the first 4 weeks of treatment in both active subgroups. All groups showed similar tolerability profiles. CONCLUSION: Concomitant administration of IVM cream with BR gel demonstrated good efficacy and safety, endorsing the comprehensive approach to this complex disease. Early introduction of BR, along with a complete daily skin care regimen may accelerate treatment success without impairing tolerability. <p><em>J Drugs Dermatol. 2017;16(9):909-916.</em></p>. PMID: 28915286 [PubMed - in process] {url} = URL to article
  26. Related Articles Painful subcutaneous nodules in a patch of livedo reticularis. Int J Dermatol. 2017 Mar;56(3):e44-e46 Authors: Barnes P, Chapman C, Fett N PMID: 27496315 [PubMed - indexed for MEDLINE] {url} = URL to article
  27. Sugar And Rosacea

    Is Sugar Addictive? This post has moved
  28. The Association Between Low Grade Systemic Inflammation and Skin Diseases: A Cross-sectional Survey in the Northern Finland Birth Cohort 1966. Acta Derm Venereol. 2017 Sep 13;: Authors: Sinikumpu SP, Huilaja L, Auvinen J, Jokelainen J, Puukka K, Ruokonen A, Timonen M, Tasanen K Abstract Low grade inflammation is associated with many noncommunicable diseases. The association between skin diseases in general and systemic inflammation has not previously been studied at the population level. A whole-body investigation on 1,930 adults belonging to Northern Finland Birth Cohort 1966 was performed and high sensitive C-reactive protein (CRP) level was measured as a marker of low grade inflammation in order to determine the association between low grade inflammation and skin diseases in an unselected adult population. After adjustment for confounding factors the following skin disorders were associated with low grade inflammation in multinomial logistic regression analysis: atopic eczema (OR 2.2, 95% CI 1.2-3.9), onychomycosis (OR 2.0, 1.2-3.2) and rosacea (OR 1.7, 1.1-2.5). After additionally adjusting for body mass index and systemic diseases, the risks for atopic eczema (OR 2.4, 1.3-4.6) and onychomycosis (OR 1.9, 1.1-3.1) remained statistically significant. In conclusion, low grade inflammation is present in several skin diseases. PMID: 28902946 [PubMed - as supplied by publisher] {url} = URL to article
  29. Chemical Peels: Indications and Special Considerations for the Male Patient. Dermatol Surg. 2017 Sep 04;: Authors: Reserva J, Champlain A, Soon SL, Tung R Abstract BACKGROUND: Chemical peels are a mainstay of aesthetic medicine and an increasingly popular cosmetic procedure performed in men. OBJECTIVE: To review the indications for chemical peels with an emphasis on performing this procedure in male patients. MATERIALS AND METHODS: Review of the English PubMed/MEDLINE literature and specialty texts in cosmetic dermatology, oculoplastic, and facial aesthetic surgery regarding sex-specific use of chemical peels in men. RESULTS: Conditions treated successfully with chemical peels in men include acne vulgaris, acne scarring, rosacea, keratosis pilaris, melasma, actinic keratosis, photodamage, resurfacing of surgical reconstruction scars, and periorbital rejuvenation. Chemical peels are commonly combined with other nonsurgical cosmetic procedures to optimize results. Male patients may require a greater number of treatments or higher concentration of peeling agent due to increased sebaceous quality of skin and hair follicle density. CONCLUSION: Chemical peels are a cost-effective and reliable treatment for a variety of aesthetic and medical skin conditions. Given the increasing demand for noninvasive cosmetic procedures among men, dermatologists should have an understanding of chemical peel applications and techniques to address the concerns of male patients. PMID: 28902026 [PubMed - as supplied by publisher] {url} = URL to article
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