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  2. Related Articles ADAMDEC1 promotes skin inflammation in rosacea via modulating the polarization of M1 macrophages. Biochem Biophys Res Commun. 2019 Oct 15;: Authors: Liu T, Deng Z, Xie H, Chen M, Xu S, Peng Q, Sha K, Xiao W, Zhao Z, Li J Abstract Rosacea is a chronic inflammatory cutaneous disease which mainly affects central face, leading to cosmetic disfigurement and compromised social psychology in billions of rosacea patients. Though the exact etiology of rosacea remains elusive, accumulating evidence has highlighted the dysfunction of innate immunity and inflammation in rosacea pathogenesis. Disintegrin Metalloprotease ADAM-like Decysin-1 (ADAMDEC1) is an orphan ADAM-like metalloprotease which is believed to be closely related to inflammation. Here for the first time, we reported that Adamdec1 expression was significantly increased in the skin lesions of rosacea patients and LL37-induced rosacea-like mouse models. Immunofluorescence analysis revealed co-localization of ADAMDEC1 and macrophages in patient and mouse biopsies. In cellular experiment, the expression of ADAMDEC1 was prominently elevated in M1 but not M2 macrophages. Knocking down of ADAMDEC1 significantly blunted M1 polarization in macrophages induced from human monocytes and THP-1 cell lines. Furthermore, silencing of Adamdec1 in LL-37-induced mouse model also suppressed the expression of M1 signature genes such as IL-6, iNOS and TNF-α, resulting in attenuated rosacea-like phenotype and inflammation. Taken together, our results demonstrate that ADAMDEC1 plays a pro-inflammatory role in rosacea via modulating the M1 polarization of macrophages. PMID: 31627897 [PubMed - as supplied by publisher] {url} = URL to article
  3. Related Articles An Open-Label, Intra-Individual Study to Evaluate a Regimen of Three Cosmetic Products Combined with Medical Treatment of Rosacea: Cutaneous Tolerability and Effect on Hydration. Dermatol Ther (Heidelb). 2019 Oct 17;: Authors: Santoro F, Lachmann N Abstract INTRODUCTION: Although rosacea management includes general skincare, previous studies have not evaluated comprehensive skincare regimens as adjuvants to other treatments. METHODS: The primary objective of this open-label, intra-individual study of subjects with rosacea was to evaluate the cutaneous tolerability of a regimen consisting of Cetaphil PRO Redness Control Day Moisturizing Cream (once daily in the morning), Cetaphil PRO Redness Control Night Repair Cream (once daily in the evening) and Cetaphil PRO Redness Control Facial Wash (foam once in the morning and once in the evening). Secondary objectives were to evaluate the effect on transepidermal water loss (TEWL) and cutaneous hydration and to determine the subjects' evaluation of efficacy, tolerability and future use. A dermatologist examined subjects and measured TEWL and cutaneous hydration on day (D) 0, D7 and D21, when subjects ranked symptoms. Subjects completed a questionnaire on D21. RESULTS: The per-protocol population consisted of 42 subjects receiving treatment for rosacea. Eleven subjects developed adverse events, none of which were considered to be related to the skincare products. Five subjects showed signs or symptoms that were potentially associated with the skincare products that might suggest poor cutaneous tolerability; these were generally mild. TEWL decreased significantly by a mean of 17% on D7 and a mean of 28% on D21 compared with baseline (both P < 0.001). Skin hydration increased significantly by a mean of 5% on D7 (P = 0.008) and a mean of 10% on D21 (P < 0.001) compared with baseline. Subjects reported that the regimen was pleasant (98%) and effective (95%) and that it offered various benefits; 90% of subjects reported that they would like to continue to use the regimen and would buy the products. CONCLUSION: The skincare regimen improved skin hydration and skin barrier function in subjects receiving medical treatment for rosacea and was well tolerated. FUNDING: Galderma S.A. PMID: 31625112 [PubMed - as supplied by publisher] {url} = URL to article
  4. Related Articles Dermoscopy in the differential diagnosis between malar rash of systemic lupus erythematosus and erythematotelangiectatic rosacea: an observational study. Lupus. 2019 Oct 16;:961203319882493 Authors: Errichetti E, Lallas A, De Marchi G, Apalla Z, Zabotti A, De Vita S, Stinco G Abstract BACKGROUND: Malar rash is one of the three cutaneous diagnostic criteria of systemic lupus erythematosus (SLE). Although its clinical recognition is often straightforward, the differential diagnosis with erythematotelangiectatic rosacea may sometimes be challenging. OBJECTIVE: To describe dermoscopic features of SLE malar rash and investigate the accuracy of dermoscopy for the differential diagnosis with erythematotelangiectatic rosacea. METHODS: A representative dermoscopic image of target areas was evaluated for the presence of specific features. Fisher's test was used to compare their prevalence between the two cohorts, and accuracy parameters (specificity, sensitivity, and positive and negative predictive values) were evaluated. RESULTS: Twenty-eight patients were included in the analysis, of which 13 had SLE malar rash and 15 erythematotelangiectatic rosacea. The main dermoscopic features of malar rash were reddish/salmon-coloured follicular dots surrounded by white halos ('inverse strawberry' pattern), being present in 53.9% of the cases, while network-like vessels (vascular polygons) turned out to be the main feature of erythematotelangiectatic rosacea, with a prevalence of 93.3%. The comparative analysis showed that the 'inverse strawberry' pattern was significantly more common in SLE malar rash, with a specificity of 86.7%, while vascular polygons were significantly more frequent in rosacea, with a specificity of 92.3%. CONCLUSION: Dermoscopy may be a useful support to distinguish SLE malar rash and erythematotelangiectatic rosacea by showing peculiar features. PMID: 31619142 [PubMed - as supplied by publisher] {url} = URL to article
  5. Related Articles Immunohistochemical Evaluation of Matrix Metalloproteinases-1, -9, Transient Receptor Potential Vanilloid Type 1, and CD117 in Granulomatous Rosacea Compared with Non-granulomatous Rosacea. Acta Derm Venereol. 2019 Oct 17;: Authors: Park JB, Suh KS, Jang JY, Seong SH, Yang MH, Kang JS, Jang MS PMID: 31620803 [PubMed - as supplied by publisher] {url} = URL to article
  6. Coffee and Skin - Considerations Beyond the Caffeine Perspective. J Am Acad Dermatol. 2019 Oct 14;: Authors: Bray ER, Kirsner RS, Issa NT PMID: 31622642 [PubMed - as supplied by publisher] {url} = URL to article
  7. Clinical diagnosis through paintworks observation Rev Med Inst Mex Seguro Soc. 2019 Jul 31;57(2):113-117 Authors: Zamudio-Martínez G, Zamudio-Martínez A Abstract Despite of the important technological advances which today allow a precise diagnosis through genetic or imaging studies, one of the fundamental pillars of medical diagnosis is, and always will be, patient examination. The visual identification of the signs that distinguish a disease is still important to make a clinical diagnosis. These very same examination skills and the knowledge on the disorders’ appearance, as well as the technical abilities of the artists that once painted pictures, allow us to diagnose a rosacea among Rembrandt’s self-portraits, or Marfan’s syndrome amidst Egon Schiele’s elongated figures. It is possible to find diseases represented in paintworks from long before someone ever described them in a book, longer even before someone considered them illnesses. PMID: 31618566 [PubMed - as supplied by publisher] {url} = URL to article
  8. Aclaris has now sold Rhofade to EPI Health, LLC.
  9. "Aclaris Therapeutics, Inc. (Nasdaq: ACRS), a physician-led biopharmaceutical company focused on immuno-inflammatory diseases, today announced it has divested RHOFADE® (oxymetazoline hydrochloride) cream, 1% (RHOFADE) and related intellectual property assets to EPI Health, LLC (EPI Health). The divestiture of RHOFADE is a key component of Aclaris’ recently announced strategic plan to refocus resources on the development of its immuno-inflammatory development programs." GlobalNewswire, Inc, October 10, 2019 "Allergan developed and brought RHOFADE to market in 2017 after acquiring the drug as part of its 2011 acquisition of Vicept Therapeutics, Inc., a company established by certain members of the current senior management team of Aclaris." Business Insider, October 15. 2018 Aclaris owned Rhofade and sold it to Allergan and bought it back on October 2018. The new owner, EPI Health, states on its website, "EPI Health is continually expanding our prescription product line to offer healthcare professionals and patients new and better options to treat skin conditions." EPI Health's president, John A. Donofrio, joined EPI Health in March of 2019. image courtesy of EPI Health, LLC
  10. Related Articles Skin changes in the obese patient. J Am Acad Dermatol. 2019 Nov;81(5):1037-1057 Authors: Hirt PA, Castillo DE, Yosipovitch G, Keri JE Abstract Obesity is a worldwide major public health problem with an alarmingly increasing prevalence over the past 2 decades. The consequences of obesity in the skin are underestimated. In this paper, we review the effect of obesity on the skin, including how increased body mass index affects skin physiology, skin barrier, collagen structure, and wound healing. Obesity also affects sebaceous and sweat glands and causes circulatory and lymphatic changes. Common skin manifestations related to obesity include acanthosis nigricans, acrochordons, keratosis pilaris, striae distensae, cellulite, and plantar hyperkeratosis. Obesity has metabolic effects, such as causing hyperandrogenism and gout, which in turn are associated with cutaneous manifestations. Furthermore, obesity is associated with an increased incidence of bacterial and Candida skin infections, as well as onychomycosis, inflammatory skin diseases, and chronic dermatoses like hidradenitis suppurativa, psoriasis, and rosacea. The association between atopic dermatitis and obesity and the increased risk of skin cancer among obese patients is debatable. Obesity is also related to rare skin conditions and to premature hair graying. As physicians, understanding these clinical signs and the underlying systemic disorders will facilitate earlier diagnoses for better treatment and avoidance of sequelae. PMID: 31610857 [PubMed - in process] {url} = URL to article
  11. The efficacy and safety of permethrin 2.5% with tea tree oil gel on rosacea treatment: A double-blind, controlled clinical trial. J Cosmet Dermatol. 2019 Oct 15;: Authors: Ebneyamin E, Mansouri P, Rajabi M, Qomi M, Asgharian R, Azizian Z Abstract BACKGROUND: Rosacea is a chronic skin condition that typically affects the face and it results in redness and inflammation. The main risk factors of this disease are Demodex folliculorum, living in the pilosebaceous units. AIMS: To evaluate the efficacy and safty of permethrin 2.5% in combination with tea tree oil (TTO) topical gel versus placebo on Demodex density (Dd) and clinical manifestation using standard skin surface biopsy (SSSB) in rosacea patients. PATIENT/METHODS: In this double-blind, randomized clinical trial, 47 papulopustular rosacea patients were enrolled, with 35 patients finishing the 12 weeks of treatment. Each patient used permethrin 2.5% with TTO on one side of the face and a placebo on the other, twice daily for 12 weeks. SSSB, photography and clinical rosacea scores according to National Rosacea Society, as well as adverse drug reaction (ADRs) were reported at the baseline, 2nd, 5th, 8th, and 12th weeks. RESULTS: A total of 47 patients were enrolled with papulopustular rosacea, and 35 patients finished the study. The effects of permethrin 2.5% with TTO gel on mite density were significant at week 5, 8, 12 (P value = .001). Clinical features and global assessments showed papules, pustules and nontransient erythema had improvement in drug group after 12 weeks (P values <.05). The improvement of burning and stinging and dry appearance was greater than the placebo gel (P value <.05). Itching in placebo group was significantly more than other group (P value = .002). CONCLUSION: Administration of permethrin 2.5% with TTO gel demonstrated good efficacy and safety in rosacea. This topical gel inhibited the inflammatory effects of rosacea and reduced Demodex mite. PMID: 31613050 [PubMed - as supplied by publisher] {url} = URL to article
  12. I have with my care controlled or you can say remitted the condition of rosacea. It is less exacerbating and only bothers in fall and winter and I have control over it at many times but how stress and less sleep can relapse the condition of rosacea when it is already in control, I have experienced. The dilation of blood capillaries start showing and the erythematic condition characterized by flushing is more prevalent when there were less signs. So the things you can do are take more antioxidants since stress means if you go beyond it is cellular stress which changes the skin resident proteins and immune cells and do the things which help alleviate stress so that you can have good sound sleep because again less sleep means increasing the oxidative stress. Antioxidants and good sleep are the main things you can count on.
  13. Earlier
  14. 0_purchase.png.90e351976c60ab1694dd926e4
    Purchase. Nurture My Body All-Natural Regenerating Facial Cream | Soothes Rosacea, Fragrance Free | 2 fl oz. - Certified Organic Ingredients
    21 CERTIFIED ORGANIC INGREDIENTS and nutrient-rich emollients that help smooth skin and calm dry, red patches. Great for rosacea. Ideal for extra nourishment at night or for rich hydration in the day. For dry and mature skin
    FRAGRANCE FREE AND ANTIOXIDANT RICH - Infuses your skin with antioxidant rich botanicals - Also aids in healing scars and sun damage
    MADE FOR ROSACEA AND SENSITIVE SKIN - Our special formulation is especially effective for those with sensitive skin or common skin issues.
    GOOD FOR ALL - Made with Certified Organic ingredients and bottled in glass for your health and well-being. Sulfate Free, Certified Vegan, Oat and Nut Free, Not Animal Tested - Cruelty Free - EWG Rating: 1
    LOVE IT, OR YOUR MONEY BACK - 100% Organic and Natural. 100% Money Back Guarantee!
    Nurture My Body products are all plant-derived and extensively researched to ensure they’re safe for you and the environment.
    Parabens, sulfates, artificial fragrances and phthalates have no place in our products. Instead, they're filled with nourishing ingredients that are wildcrafted and all natural.
    Read our labels — we like ingredients that we can pronounce, not ones that are synthetically created in a lab.
    Each organic or wildcrafted, plant-based ingredient in our products is hand chosen for a reason, to give your body the best of what nature has to offer. Our products are made in small batches from fresh ingredients to ensure your skin gets the freshest and most valuable qualities from each botanical.

    $37.95 NOTE: Our shopping cart is disabled. We are using it to display affiliate items which if you click on PURCHASE in the PRODUCT INFORMATION by scrolling below or click on the Amazon banner the RRDi receives a small affiliate fee upon completion of your purchase. Mahalo.

  15. 0_purchase.png.90e351976c60ab1694dd926e4
    Purchase. 8.82 oz (250gm) - 100% Natural honey, Raw honey – Ultra Premium
    SMOOTH, CREAMY & DELICIOUS – The Highest Quality Pure Manuka Honey from New Zealand with unmatched Taste and Texture. Just Sweet enough, with a Smooth, Creamy Texture. Enjoy daily by the spoonful or combine with your favorite food or drink
    THE WORLDS FINEST MANUKA HONEY – Three Peaks Honey is from a UNESCO Heritage Site, The Tongariro National Park. Our Beekeepers Work in Harmony with Nature so that only the Highest Quality Makes the Three Peaks Manuka Honey Grade
    NATURAL REMEDY & SUPER FOOD – Customers use Raw Manuka Honey to Support Respiratory & Digestive Health, Relieve Coughs & Sore Throats, Accelerate Healing, and Promote Wellbeing
    CERTIFIED UMF 10+ / MGO 263+ - 100% PURE & AUTHENTIC – Sourced, and Packaged in New Zealand, this Premium Manuka honey is Independently Certified by Stringent NZ UMF Honey Association for Purity & Quality Standards, Ensuring the Authenticity of our New Zealand Manuka Honey
    SATISFACTION GUARANTEED: We offer a 100% Satisfaction Guarantee... love them or your money back...Add to Cart Risk-Free and Taste the difference

    $19.99 NOTE: Our shopping cart is disabled. We are using it to display affiliate items which if you click on PURCHASE in the PRODUCT INFORMATION by scrolling below or click on the Amazon banner the RRDi receives a small affiliate fee upon completion of your purchase. Mahalo.

  16. 0_purchase.png.90e351976c60ab1694dd926e4
    Purchase. 7.05 oz (200gm) - 100% Natural honey, Raw honey – Ultra Premium
    CRAFTED BY NATURE – Three Peaks home is the volcanic central plateau of New Zealand’s North Island. Careful harvesting preserves the natural properties, health benefits & superb Manuka honey flavor.
    CERTIFIED 100% PURE & AUTHENTIC RAW MANUKA HONEY UMF 20+ – Sourced, and packaged in New Zealand, this ultra-premium Manuka honey is independently certified by stringent NZ UMF Honey Association purity & quality standards ensuring the authenticity of our New Zealand Manuka honey.
    STUNNING PRESENTATION – Beautiful gold-foiled packaging & a glass 7oz container showing the natural, rich amber color of Three Peaks high UMF Raw Manuka honey. Perfect for your own use or as a gift
    ULTRA-PREMIUM – Three Peaks Manuka honey is the finest quality Manuka honey from New Zealand. Smooth, creamy & delicious, this Manuka honey has rich flavor. Enjoy daily by the spoonful or combine with your favorite food or drink.
    NATURAL REMEDY AND SUPER FOOD – Customers use bio active Manuka honey to support respiratory & digestive health, relieve coughs & sore throats, accelerate healing, and promote wellbeing.

    $159.99 NOTE: Our shopping cart is disabled. We are using it to display affiliate items which if you click on PURCHASE in the PRODUCT INFORMATION by scrolling below or click on the Amazon banner the RRDi receives a small affiliate fee upon completion of your purchase. Mahalo.

  17.  0_purchase.png.90e351976c60ab1694dd926e4
    Purchase. 7.6 oz (500gm) - 100% Natural honey, Raw honey – Ultra Premium
    SMOOTH, CREAMY & DELICIOUS – The Highest Quality Pure Manuka Honey from New Zealand with unmatched Taste and Texture. Just Sweet enough, with a Smooth, Creamy Texture. Enjoy daily by the spoonful or combine with your favorite food or drink
    THE WORLDS FINEST MANUKA HONEY – Three Peaks Honey is from a UNESCO Heritage Site, The Tongariro National Park. Our Beekeepers Work in Harmony with Nature so that only the Highest Quality Makes the Three Peaks Manuka Honey Grade
    NATURAL REMEDY & SUPER FOOD – Customers use Raw Manuka Honey to Support Respiratory & Digestive Health, Relieve Coughs & Sore Throats, Accelerate Healing, and Promote Wellbeing
    CERTIFIED UMF 10+ / MGO 263+ - 100% PURE & AUTHENTIC – Sourced, and Packaged in New Zealand, this Premium Manuka honey is Independently Certified by Stringent NZ UMF Honey Association for Purity & Quality Standards, Ensuring the Authenticity of our New Zealand Manuka Honey.
    SATISFACTION GUARANTEED: We offer a 100% Satisfaction Guarantee... love them or your money back...Add to Cart Risk-Free and Taste the difference

    $46.99 NOTE: Our shopping cart is disabled. We are using it to display affiliate items which if you click on PURCHASE in the PRODUCT INFORMATION by scrolling below or click on the Amazon banner the RRDi receives a small affiliate fee upon completion of your purchase. Mahalo.

  18. 0_purchase.png.90e351976c60ab1694dd926e4
    Purchase. (MGO 514) 17.6 Ounce jar | Pure Raw Unpasteurized Honey From New Zealand NZ | Traceability Code on Each Label
    HONEY THE WAY NATURE INTENDED: 100% raw, cold-pressed, unpasteurized & untouched Manuka honey
    BUZZING WITH BENEFITS: Supports digestive & respiratory health, accelerates healing of wounds & more
    SUPER FOOD & HEALTH: Our filtering system retains Bee Bread- a food rich in B vitamins & amino acids
    HOME TO HIVE TRACEABILITY: Follow the code on your label & discover where your honey was collected!
    CUSTOMERS SAY: This honey gives me energy, makes me feel full of life & lowers illness time greatly!
     

    Steens Honey is New Zealand's leading producer of high grade UMF Manuka honey. The company was started by Paul and Sheryl Steens because they wanted to bring a better quality Manuka to market; one that is raw, unpasteurised and minimally processed - just as nature intended.

    We've been beekeeping for over 34 years so we know a thing or two about honey. Subjecting our Manuka to high temperatures just isn't in our thinking. You won't find us cranking up the heat to 70C (118F) and creaming our honey. Studies have shown that the flavonoids and enzymes which give Manuka it's unique qualities are damaged through these heating processes. Most commercial honeys are creamed which means the honey is processed twice and the natural crystals are melted out to give it a smooth consistency. Steens Manuka is different. Our honey is raw & unpasteurised which means the natural crystals are retained.

    Its like dipping your finger straight into the honeycomb!

    RAW COLD PRESSED MANUKA: Steens Manuka honey is unique to other Manuka honeys as it is not heated to high temperatures unlike creamed honeys. We cold press our Manuka honey using a proprietary process, meaning our Manuka honey is processed at hive temperatures (36C / 96F ) ensuring that the nutritional properties, plant phenols, flavanoids and enzymes are retained in our honey. We have been using science to continually refine this process for over 30 years.

    UMF CERTIFIED: Steens Manuka honey is graded using the Unique Manuka Factor (UMF) grading system which is extremely important to ensure that the Manuka honey you are buying is authentic. The UMF grading system appraises natural markers found in manuka honey and assures purity and quality. Each Steens UMF manuka honey jar states its UMF grade. The UMF grade is well recognised as the mark of real Manuka honey, as it identifies one of the main organic compounds responsible for the stable Non Peroxide Activity (NPA) for which manuka honey has become globally renowned. Products claiming to be manuka honey but not showing a UMF rating are unlikley to be genuine. Buying UMF rated Manuka honeys protects you from honey with little or no beneficial health value (often labeled 'active' or 'bio-active')

    Steens UMF Licence number is #2204.

    BEEBREAD: Steens honey is unique to other Manuka honeys because it contains the highest levels of a substance called bee bread. You may have already heard about bee (plant) pollen and how nutritious it is. Bee bread is plant pollen that is taken into the hive by the bees. The bees add extra enzymes, microbial secretions and honey to pollen stored within the honeycomb. It then undergoes a lactic acid fermentation process which breaks down the hard outer shell of plant pollen, making it easier for humans to digest. Bee bread is the food the worker bees use to make royal jelly. It is widely recognised as a nourishing and complete, natural food.

    Steens have a unique extraction and filtering process to retain high levels of this precious substance within their honey.

    TRACE & TRACE - FROM HOME TO HIVE: Here at Steens we believe every consumer has the right to know where their food has come from, and our traceability program intends to deliver on this belief. We are one of the only vertically integrated Manuka producers in the world, which means our Manuka is completely traceable back to source. We have developed a unique integrated software system called 'Hive Tracker' which allows us to collect data on over 60,000 hive components.

    Every pot of Steens honey has a trace code which can be used to trace your honey back to the region it is harvested from. Consumers can enter the trace code on the label and track their honey pot back to source. Every batch of Manuka we produce is tested for specific qualities including the UMF grade (which includes the MGO level) to ensure that the Manuka Honey you buy from Steens is absolutely authentic and true to label.

    $102.99 NOTE: Our shopping cart is disabled. We are using it to display affiliate items which if you click on PURCHASE in the PRODUCT INFORMATION by scrolling below or click on the Amazon banner the RRDi receives a small affiliate fee upon completion of your purchase. Mahalo.

  19. 0_purchase.png.90e351976c60ab1694dd926e4
    Purchase. (MGO 829) 8.8 Ounce jar | Pure Raw Unpasteurized Honey From New Zealand NZ | Traceability Code on Each Label

    Steens Honey is New Zealand's leading producer of high grade UMF Manuka honey. The company was started by Paul and Sheryl Steens because they wanted to bring a better quality Manuka to market; one that is raw, unpasteurised and minimally processed - just as nature intended.

    We've been beekeeping for over 34 years so we know a thing or two about honey. Subjecting our Manuka to high temperatures just isn't in our thinking. You won't find us cranking up the heat to 70C (118F) and creaming our honey. Studies have shown that the flavonoids and enzymes which give Manuka it's unique qualities are damaged through these heating processes. Most commercial honeys are creamed which means the honey is processed twice and the natural crystals are melted out to give it a smooth consistency. Steens Manuka is different. Our honey is raw & unpasteurised which means the natural crystals are retained.

    Its like dipping your finger straight into the honeycomb!

    RAW COLD PRESSED MANUKA: Steens Manuka honey is unique to other Manuka honeys as it is not heated to high temperatures unlike creamed honeys. We cold press our Manuka honey using a proprietary process, meaning our Manuka honey is processed at hive temperatures (36C / 96F ) ensuring that the nutritional properties, plant phenols, flavanoids and enzymes are retained in our honey. We have been using science to continually refine this process for over 30 years.

    UMF CERTIFIED: Steens Manuka honey is graded using the Unique Manuka Factor (UMF) grading system which is extremely important to ensure that the Manuka honey you are buying is authentic. The UMF grading system appraises natural markers found in manuka honey and assures purity and quality. Each Steens UMF manuka honey jar states its UMF grade. The UMF grade is well recognised as the mark of real Manuka honey, as it identifies one of the main organic compounds responsible for the stable Non Peroxide Activity (NPA) for which manuka honey has become globally renowned. Products claiming to be manuka honey but not showing a UMF rating are unlikley to be genuine. Buying UMF rated Manuka honeys protects you from honey with little or no beneficial health value (often labeled 'active' or 'bio-active')

    Steens UMF Licence number is #2204.

    BEEBREAD: Steens honey is unique to other Manuka honeys because it contains the highest levels of a substance called bee bread. You may have already heard about bee (plant) pollen and how nutritious it is. Bee bread is plant pollen that is taken into the hive by the bees. The bees add extra enzymes, microbial secretions and honey to pollen stored within the honeycomb. It then undergoes a lactic acid fermentation process which breaks down the hard outer shell of plant pollen, making it easier for humans to digest. Bee bread is the food the worker bees use to make royal jelly. It is widely recognised as a nourishing and complete, natural food.

    Steens have a unique extraction and filtering process to retain high levels of this precious substance within their honey.

    TRACE & TRACE - FROM HOME TO HIVE: Here at Steens we believe every consumer has the right to know where their food has come from, and our traceability program intends to deliver on this belief. We are one of the only vertically integrated Manuka producers in the world, which means our Manuka is completely traceable back to source. We have developed a unique integrated software system called 'Hive Tracker' which allows us to collect data on over 60,000 hive components.

    Every pot of Steens honey has a trace code which can be used to trace your honey back to the region it is harvested from. Consumers can enter the trace code on the label and track their honey pot back to source. Every batch of Manuka we produce is tested for specific qualities including the UMF grade (which includes the MGO level) to ensure that the Manuka Honey you buy from Steens is absolutely authentic and true to label.

    $119.95 NOTE: Our shopping cart is disabled. We are using it to display affiliate items which if you click on PURCHASE in the PRODUCT INFORMATION by scrolling below or click on the Amazon banner the RRDi receives a small affiliate fee upon completion of your purchase. Mahalo.

  20. 0_purchase.png.90e351976c60ab1694dd926e4
    Purchase. Manuka Honey Healing Eczema Cream : Aloe Vera + Shea Butter + Coconut Oil + Hemp Seed Oil Anti Itch Natural Moisturizer Face and Body Lotion for Dry Skin Dermatitis Psoriasis Rosacea Sunburn Relief
    MANUKA HONEY (UMF 12+) - A powerful moisturizer packed with a unique blend of vitamins, minerals and amino acids that only nature can provide. Honey naturally seals in moisture to heal and protect dry, damaged skin. Manuka Honey has unmatched healing properties, and is the most antibacterial honey on earth - found only in New Zealand, made from bees that pollinate the manuka tree.
    CHEMICAL FREE - Made with natural ingredients - mostly food-grade nutrients - with no cheap fillers. Great for SENSITIVE SKIN. Won't clog pores. Non-greasy and absorbs quickly - perfectly pH balanced at 5.5 (just like your skin) - that means it goes in your skin, not on it. Hypoallergenic. No animal or petroleum ingredients. No fragrance. No parabens. No alcohols. No dyes. Cruelty free and no animal testing.
    IMMEDIATE & LONG-LASTING RELIEF - Cehami extract is included for natural pain & itch relief. You'll notice our first ingredient is Organic Aloe Vera, not water like most skin care products. Aloe penetrates deep into skin and delivers all the quality ingredients down to the cellular level - like soothing shea butter, hydrating coconut oil, nourishing hemp seed oil, and more.
    NOURISH - MOISTURIZE - REPAIR - Non-greasy and absorbs quickly. Great for sunburns, rosacea, dermatitis, eczema, psoriasis, and dry, cracked, red, inflamed, itchy, or irritated skin.
    LOVE IT OR YOUR MONEY BACK! - We are all about customer satisfaction - if for any reason you aren't satisfied, we offer a FULL MONEY-BACK GUARANTEE. We love our products and know you will too. Proudly made in the USA.
    Made with a healing honey found only in New Zealand called manuka honey. Its healing properties have been known for centuries. Honey naturally attracts and retains moisture, and is an anti-irritant. But this honey is unlike any other honey – because of its unprecedented antibacterial and skin regeneration qualities, it’s now used in burn wards across America. There’s just nothing like it on earth.
     

    $24.95 NOTE: Our shopping cart is disabled. We are using it to display affiliate items which if you click on PURCHASE in the PRODUCT INFORMATION by scrolling below or click on the Amazon banner the RRDi receives a small affiliate fee upon completion of your purchase. Mahalo.

  21. 0_purchase.png.90e351976c60ab1694dd926e4
    Purchase. Quickly Heal Rosacea, Eczema, Dry, Cracked Skin! Prescription Strength Healing Cream! W EGF, Shea Butter, Aloe, Cucumber, Vitamins. Soothe, Nourish & Heal Cream! Dab to Nourish (1oz)
    ❤️ NEVER SUFFER FROM ROSACEA, ECZEMA, ATOPIC DERMATITIS OR SEVERELY DRY SKIN AGAIN - This cream quickly soothes the irritation, accelerates healing, and provides nourishment to affected skin cells.
    ❤️ OTHER CREAMS DON'T HEAL DAMAGED SKIN - Dab to Nourish contains highly potent proteins and various peptides that other cheap brands don't have. 1 - EGF is a peptide that accelerates the growth of epidermal cells, reduces wrinkles and assists in wound healing. 2 - Caprooyl Tetrapeptide-3 boosts collagen production, activates skin repair, and also reduces appearance of fine lines and wrinkles. Together these two compounds leave your skin feeling more taut and repaired.
    ❤️ SOOTHE IRRITATED SKIN - This amazing miracle cream contains the natural soothing ingredients shea butter, aloe, cucumber and calendula extracts, and vitamins A, E, & B to calm skin irritations.
    ❤️ ANTI AGING PROPERTIES & ADDITIONAL BENEFITS - Dab to Nourish is also a powerful anti-aging moisturizer that accelerates tissue repair and builds skin immunity. Designed specially for aging, dry, and sun-exposed skin, EGF Cream contains growth factors and powerful antioxidants to supplement your skin’s health, protect it from free radicals, accelerate cell turnover, and gently retexturize.
    ❤️ ALL DERMAL DAB PRODUCTS ARE CRUELTY FREE - Our products are never tested on animals and are free of parabens, sulfates, GMO’s, artificial fragrance, and silicones. We also make all of our products in the USA and use American manufactured packaging. We also make all of our products in the USA and use American manufactured packaging.

    Dab to Nourish is a gentle, non-greasy, daily moisturizer that is clinically proven to heal eczema and rosacea and repair dry, itchy skin. We have combined powerful ingredients that address a variety of the causes severely dry skin and dry skin disorders into a triple action healing formula:

         Action 1: Proprietary ingredients nourish, hydrate, and soothe the skin to eliminate redness and irritation immediately.

         Action 2: Strengthen the skin & reinvigorate the elasticity with active peptides.

         Action 3: EGF stimulates the healing and regrowth of more youthful skin.

    As a result, this premium cream is a highly-concentrated triple threat to rejuvenates the driest, most damaged, irritated skin.

    $33.00 NOTE: Our shopping cart is disabled. We are using it to display affiliate items which if you click on PURCHASE in the PRODUCT INFORMATION by scrolling below or click on the Amazon banner the RRDi receives a small affiliate fee upon completion of your purchase. Mahalo.

  22. 0_purchase.png.90e351976c60ab1694dd926e4
    Purchase. For Scalp Rosacea, Adult Acne, Hair Loss. Works well with Mama Nature of London ProSkin Rosacea Natural Skin Cream
    Money back guarantee. TREAT YOURSELF TODAY! BUY ANY 3 MAMA NATURE PRODUCTS AND RECEIVE A FREE MOTHER OF SKIN CLEANSING CREAM.
    Effective & proven rosacea treatment
    Finest quality natural & organic ingredients.
    Vegan & Eco-friendly
    Freshly prepared
    Product description
    WE GIVE A HASSLE FREE FULL REFUND IF, FOR ANY REASON, YOU ARE NOT SATISFIED WITH THE PRODUCT. SIMPLY SEND IT BACK (UNUSED OR PARTIALLY USED) TO US WITHIN 60 DAYS.ADDRESS IS ON THE PACKAGING. We know that natural is best and our unique range of skin care recipes have been especially formulated to harness the magic that Mother Nature’s larder has to offer. This product is Vegan and has not been tested on animals. ProSkin Rosacea is lovingly hand prepared to order by our experienced team of natural skin care specialists JUST FOR YOU! ProSkin Rosacea Natural Hair Treatment is a very effective treatment for scalp rosacea that contains jojoba oil and a unique blend of essential oils that treats the root cause of this medical condition as well as the symptoms. These oils have been used used for centuries to effectively treat rosacea and have been clinically proven to heal this skin condition and relieve inflammation, pain and itching. They can reduce the appearance of blood vessels, pimples, bumps and other scalp rosacea symptoms and can reverse hair loss caused by scalp rosacea. We care passionately about our natural environment. All orders will be sent in recycled padded envelopes/cardboard boxes (depending on the size of the order) and the external packaging and inserts are made from recycled cardboard/paper. We have used plastic containers since they are more eco-friendly than glass ones and all of the packaging can be recycled

    $52.95 NOTE: Our shopping cart is disabled. We are using it to display affiliate items which if you click on PURCHASE in the PRODUCT INFORMATION by scrolling below or click on the Amazon banner the RRDi receives a small affiliate fee upon completion of your purchase. Mahalo.

  23. 0_purchase.png.90e351976c60ab1694dd926e4
    Purchase. Product description
    If you don't find ProSkin Rosacea to be the most effective rosacea treatment you have ever used we will give you your money back. Simply send us the unused portion within the original container together with proof of purchase within 60days of purchase and we will give you a full refund. We know that natural is best and our unique range of skin care recipes have been especially formulated to harness the magic that Mother Nature’s larder has to offer. This product is Vegan and has not been tested on animals. ProSkin Rosacea is lovingly hand prepared to order by our experienced team of natural skin care specialists JUST FOR YOU! It is a very effective natural skin care cream that contains calendula extract and a unique blend of essential oils. These oils have been used for centuries to effectively treat rosacea and have been clinically proven to be able to heal this skin condition and relieve inflammation, pain and itching. Our cream can reduce redness, the appearance of blood vessels, spider veins, pimples/acne and bumps. Many people with rosacea have been cured using our cream and it is also an excellent moisturizer.
    Money back guarantee. TREAT YOURSELF TODAY! BUY ANY 3 MAMA NATURE PRODUCTS AND RECEIVE A FREE MOTHER OF SKIN CLEANSING CREAM.
    Effective & proven rosacea treatment
    Finest quality natural & organic ingredients.
    Vegan & Eco-friendly
    Freshly prepared - great value, one pot lasts on average 3 months

    Seb91 at RF reports, "Funny enough, I actually do use this. I started using this literally when I first got rosacea 7 years ago. I haven't stopped since. This is the only topical I can put on my face that won't aggrevate it. Whether this is because I started using it so long ago when my rosacea was just mild flushing, I don't know. I don't know whether it makes my skin better but I use it as a security blanket, just in case. I just apply it as night."

    $52.94 NOTE: Our shopping cart is disabled. We are using it to display affiliate items which if you click on PURCHASE in the PRODUCT INFORMATION by scrolling below or click on the Amazon banner the RRDi receives a small affiliate fee upon completion of your purchase. Mahalo.

  24. Related Articles Gnathophyma. Skinmed. 2018;16(1):45 Authors: Kumar P, Das A PMID: 29551113 [PubMed - indexed for MEDLINE] {url} = URL to article
  25. Related Articles Well-Circumscribed Localized-Rhinophyma as a Very Rare Presentation of Rhinophyma. Iran J Otorhinolaryngol. 2019 Sep;31(106):323-326 Authors: Kavoussi H, Ramezani M, Ahmadaghaei F, Ghorbani I, Eftekhari Pirouz H, Kavoussi R Abstract Introduction: Rhinophyma is an uncommon subtype of rosacea, the clinical diagnosis of which is straightforward. However, localized, especially well-circumscribed, rhinophyma is a very rare condition, which requires a paraclinical assessment to be accurately diagnosed. Case Report: We report a 48-year-old male patient who presented with a well-circumscribed and dark red tumoral mass of 28 mm in diameter and smooth consistency in the right nasal ala. The patient had no former and concomitant characteristic skin lesions on the other part of his face. Histopathology and immunohistochemistry assessments documented the diagnosis of rhinophyma. Conclusion: To the best of our knowledge, this is the first case report of well-circumscribed localized rhinophyma. This lesion can be treated by CO2 laser in a fast and efficient manner with esthetically satisfactory outcome and no significant complications. PMID: 31598502 [PubMed] {url} = URL to article
  26. "All the cases, spreading rose petals on their face, at the end of the treatment show a decrease of the redness as well, and their “facies” exhibit a dark pinkish colour, that correspond to a real flesh-coloured appearance, that reveals a complete status of good health and remission of the syndrome." Our Dermatology Online, Letter to the Editor Rosacea treated with rose petals: a calembour that affffords intriguing results Piotr Brzezinski, Lorenzo Martini Since obtaining rose petals is without a doubt an easy task for most rosaceans worldwide, we should be able to easily confirm if this treatment works. Please post your results in this thread.
  27. There is a new cosmetic version of the ZZ cream now available on Amazon which is priced at $39 with free shipping until November 16, 2019. After this date the price goes up to $49. To learn more about this and what the difference is between the cosmetic ZZ cream and the original ZZ click here. I haven't used the ZZ cream for probably around nine months. I tried the horse paste because there were so many who raved about the success they were having with it and I must say, it is just as good or better than Soolantra. I just received a new shipment of the Cosmetic ZZ cream and must say this is an improved version and works much better and I have always preferred using the original ZZ cream over any other topical treatment for rosacea. Within a week my red spots have cleared up. I highly recommend you try a three month supply of the Cosmetic ZZ cream or at the very least one jar to see if your rosacea improves. If it does, you have demodectic rosacea.
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