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  1. Today
  2. A rare condition involving SD is eyebrow hairloss. Sickening started an interesting thread on this subject if you are suffering from this disorder. A similar thread was started by angelstar. Sometimes it can be confused with Frontal Fibrosis Alopecia.
  3. StatPearls Book. 2020 01 Authors: Abstract Lupus miliaris disseminatus faciei (LMDF) is an idiopathic granulomatous disease affecting facial skin primarily. Nosologically, it is on a spectrum of facial granulomatous dermatoses and shares overlapping features with rosacea and sarcoidosis. In most cases, this disorder resolves spontaneously within several years but can leave potentially disfiguring scarring. The name derives from a historic putative association with tuberculosis, as discussed below. More recent authors have proposed adopting the term facial idiopathic granulomas with regressive evolution (FIGURE) instead of the entrenched LMDF. However, it does not appear that a name change has been widely accepted.[1] Older terms for a similar facial granulomatous dermatosis include micropapular tuberculid, Lewandowsky’s eruption, and lupoid rosacea.[2] Acne agminata has been used to refer to similar lesions in the axilla. PMID: 32644491 {url} = URL to article
  4. Yesterday
  5. Admin

    Brady's Blog

    Just wanted to update what I have been using for about three weeks. I purchased Sesderma Sebovalis Facial Gel (key ingredients 8% lithium gluconate - 0.5% Piroctone olamine - 4.5% glycolic acid - Calendula extract) from the company website since it is not available at Amazon. I learned about it from Yatzil at RF [post no 1] and have heard about Piroctone Olamine which is the ingredient in this gel that I think may improve SD. I have been having what I think is SD on the back of my scalp near my neck going up the scalp to near the top of my head. I have tried over the last eight to ten months, Sulfur Butter, Equate Coal Tar Shampoo, Yesto Tree Tea Scalp Treatment, Nizoral none of which worked. I tried borax and epsom salt baths. Then I went to a nurse practitioner who prescribed Fluocinolone Acetonide Topical Oil which did stop the itch but didn't do anything to relieve the fungal issue. At the same time I received Tom Busby's AquaVive which I have been using for a month as well. What I have noticed is that whatever the issue is, my guess it is a fungus, is beginning to dry up whatever it is but it still lingers. I have stopped the Fluocinolone and am continuing the borax/epsom salt baths and AquaVive. I just received my second tube of Sesderma Sebovalis Facial Gel. I also still use the ZZ cream on red spots and try to follow my Rosacea Diet by reducing sugar/carbohydrate as much as possible but I confess, I cheat on occasion. I will post photos soon.
  6. (1) Diet First, keep in mind this recommendation is only for thirty days. After the thirty days, go back to eating whatever you want. What you are probably eating is mostly carbohydrate since the typical American diet is high carbohydrate. Carbohydrate is simply different forms of sugar. There are absolutely no nutrients in carbohydrate, none. Carbohydrate is simply carbon, hydrogen and oxygen (absolutely no vitamins, minerals, or any nutrients). Sugar is the fire that inflames rosacea. For example, oats, brown rice, fruit, sweet potato have significant carbohydrate. It is extremely difficult to cut out all carbohydrate. But if you can reduce your carbohydrate to no more than 30 grams a day for 30 days to see if this improves your rosacea, then you will know. What will you lerarn? Sugar/carbohydrate is a rosacea trigger. If you do see improvement within the thirty days, at the end of the thirty days go back to your oats, brown rice, fruit, sweet potato or whatever you are eating and see what happens. This simple diet just for thirty days will either work or it won't in improving your rosacea. Please read a list of anecdotal reports that this actually works. To help you understand how to figure out how many grams of carbohydrate you may be eating, just take a bowl of oats which contains 27 grams of carbohydrate in a half a cup. So if you decide to eat that half a cup of oats, you now only have 3 grams of carbohydrate to your 30 gram limit for the day. The only way you can do this is stick to broccoli since one cup (91 grams) of raw broccoli contains 6 grams of carbs. Kale is ok too, since one cup (67 grams) of raw kale contains 7 grams of carbs. You can have a lot of broccoli and kale in your day and still keep within the 30 gram limit. So anything that goes into your mouth that you digest, simply watch how many grams of carbohydrate and limit it to 30 grams a day. And watch how many carbohydrate is in anything you drink! Liquid or any food, 30 gram carbohydrate limit. Only for 30 days. 30 grams/30 days. So what do you eat? Protein and Fat, as much as you want, no limit. And remember, when someone or some authority says eating high protein/fat is bad, the reply is, 'this is just for thirty days.' Thirty days on a high protein/diet is not bad. No one can cite any clinical paper that eating high protein/fat for just thirty days is any health risk. Remember, just thirty days. No risk. And if you like meat, fish, and chicken it will be easier. If you are a vegan, it will be more difficult to find the protein/fat to eat but it can be done. The Rosacea Diet has a vegan 30 day diet. Remember, this is only for thirty days. At the end of the thirty days you can then eat whatever you want. Eat whatever sugar and carbohydrate you want and as much as you want and see what happens. Does your rosacea return when you eat high sugar/carbohydate? If so, you have learned something. Then you decide what to do about this. Not everyone chooses this course because it is so difficult. Why? Because sugar is addictive. Your choice. (2) Topical As for a topical, recommend the ZZ cream. Before you use, be sure to apply a dab of the ZZ cream on your inner wrist and see if your skin turns red? If so, you are allergic to the ZZ cream. Remember that if you use the ZZ cream it gets worse before it gets better. It takes at least a month to see any improvement with the ZZ cream and three to four months for clearance. 'Getting worse before it gets better' is a common occurrence in medicine, not just in using the ZZ cream. Conclusion Have you noticed I repeat myself? Indulge me since I have been doing this for years. These two simple treatments may work to control your rosacea if you reduce your sugar/carbohydrate to 30 grams a day for 30 days and use the ZZ cream as a topical.
  7. Hi Kara, Welcome to the RRDi. It would be good to know if your partner did get a diagnosis of rosacea (or what exactly) and what particular antibiotic and how much, whether low dose or high dose, I.e., how many milligrams per day? Is your partner applying any topical(s)? The laser mentioned in the article in this thread, pulsed dye, has been around for years. Coherent model 899 ring dye laser, with rhodamine 6G dye, pumped with a 514 nm argon laser. The laser is tuned somewhere around 580 nm. Photo taken by Han-Kwang at the AMOLF Institute in Amsterdam, Netherlands. P - image courtesy of Wikipedia Commons By the way, the article is an abstract made available through an RSS feed from PubMed published in Dermatologic Therapy. So this pulsed dye laser is usually in either a dermatology or cosmetic surgeon clinic and as you can imagine expensive. One treatment with an experienced practitioner as you can imagine is expensive, between $350 to $600 US Dollars and usually three or more treatments are required. Most insurance companies in the USA will cover such treatment if they are designated a medical diagnosis but usually such treatments are considered cosmetic and are not covered. I imagine the same conditions exist in the UK regarding whether insurance covers such laser treatments or not. You would have to ask. Most Rosaceans who rave about Laser treatment have to spend the money out of pocket. There are others who have negative experience with laser. By the way, some Rosaceans have now purchased their own light device, sometimes laser, others purchase LED or IPL devices since they are now available to the pubic. There is a learning curve using these devices and you can easily damage your skin so if you decide to go that route take care. Our store has some listed in broad band light. Using laser is just one of the many light devices under the treatment called photo dynamic therapy. The article in this thread used the pulsed dye laser along with intradermal botulinum toxin type-A, a particular botulinum used in cosmetics. This treatment is also expensive and the practitioner should have experience using it since you can imagine if you were his first patient you might feel uneasy. The article concludes this combination of treatment “demonstrated high efficacy and satisfaction rate with this combined approach and a low side-effect profile.” If it cost several thousand dollars, you would expect such results. Just remember that you sign off on a lot of waivers and notices that you are warned of the risks and side effects of laser and botulinum treatment. Dr. Braun performs Botox Injections on a client at Vancouver Laser & Skin Care Skin. Botox Injections temporarily reduces or eliminates frown lines, forehead creases, crow’s feet near the eyes and thick bands in the neck. By temporarily blocking the nerve impulses, the muscles that cause wrinkles relax, giving the skin a smoother, more refreshed appearance. - image courtesy of Wikimedia Commons There are clinical papers showing improvement in rosacea using Botox, I.e., Botox for Rosacea. Depending on what your partner is suffering with, recommend your partner read our welcome page or our newbies page. Some have found that simply reducing sugar/carbohydrate in the diet improves rosacea or whatever skin issue along with the topical ZZ cream.
  8. Hi i read your article and find it very interesting. My partner has a very aggressive form of rosacea that sometimes spreads up to the eye. Most of the time he is on antibiotics but as soon as he stops the flushing starts again. Is this treatment that you mentioned available in London???? If not where can it be done.
  9. Last week
  10. To give you an idea of the prescription rosacea market you can view the number of prescriptions for the four leading rosacea prescription treatments shown below in two graphs the first one in surrogates, and the second one in market size as revealed in a Menlo Therapeutics investor presentation dated March 2020.
  11. Before/after photos released by an investor presentation dated March 2020 .
  12. Related ArticlesPulsed dye laser followed by intradermal botulinum toxin type-A in the treatment of rosacea-associated erythema and flushing. Dermatol Ther. 2020 Jul 07;: Authors: Al-Niaimi F, Glagoleva E, Araviiskaia E Abstract Rosacea is a common inflammatory skin disease characterized by erythema, episodes of flushing and inflammatory lesions. It typically affects the face and is more prevalent among fair skin individuals affecting women more than men. Various treatments are available for rosacea with light-based therapies commonly used in the management of erythema. The use of intradermal botulinum toxin type-A has been reported to be beneficial in the treatment of rosacea-associated erythema and flushing with good results and a low side-effect profile. In this article we present our experience on the successful combination of both pulsed dye laser and intradermal botulinum toxin type-A in erythema and flushing in 20 rosacea patients. In addition to subjective improvement we measured the degree of erythema using a 3D Antera™ camera in order to quantify our results. We demonstrated high efficacy and satisfaction rate with this combined approach and a low side-effect profile. To our knowledge the combination of laser and intradermal botulinum toxin in the management of rosacea has not been previously reported. This article is protected by copyright. All rights reserved. PMID: 32633449 [PubMed - as supplied by publisher] {url} = URL to article
  13. Admin

    IPL for DED

    "Dry Eye Disease (DED) is a common ocular condition that needs prompt diagnosis and careful treatment interventions....In this review, we demonstrated the mechanism of action of IPL, including its benefits on DED. The emerging evidence shows that the role of IPL in DED is novel and therapeutic. These results direct us to conclude that IPL is a potentially beneficial tool and essential future therapy for dry eye disease." Int J Med Sci. 2020; 17(10): 1385–1392.Published online 2020 Jun 1. doi: 10.7150/ijms.44288 Use of Intense Pulsed Light to Mitigate Meibomian Gland Dysfunction for Dry Eye Disease Abhishek Suwal, Ji-long Hao, Dan-dan Zhou, Xiu-fen Liu, Raja Suwal, and Cheng-wei Lu Image [Diffuse lissamine green staining in a person with severe keratoconjunctivitis sicca.] Courtesy of Wikimedia Commons
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    Bio‑Oil researches and develops specialist skincare products, using oil to achieve superior product performance. The brand is known as Bio‑Oil® in all countries other than Austria, Czech Republic, France, Germany, Slovakia and Switzerland where the name Bi-Oil® is used and in Japan where the name Bioil® is used. In 1987 Bio‑Oil pioneered using oil to help improve the appearance of scars and stretch marks. At the time almost every product on the shelf was either a cream or a lotion, and the product was met with much scepticism. Today the product is the world’s leading scar and stretch mark product. In 2010 Bio‑Oil set up a specialist laboratory dedicated to researching how oil could be used to treat other skin concerns. In 2018 it launched an oil-based formulation for the treatment of dry skin. In Q3 2020 a natural version of Bio‑Oil's original scar and stretch mark product will be launched. Most of the laboratory’s development work over the past decade will come on stream in 2021. Bio‑Oil focuses exclusively on research and development, with the selling and distribution of its products licensed to leading skincare companies around the world. Oil has the remarkable ability to improve the skin. How and why, is not completely understood as the benefits of oil are mostly known only through folklore. Bio‑Oil® Skincare Oil was one of the first products to submit an oil to clinical trials and prove that it could improve the appearance of scars and stretch marks. It was the success of these trials that prompted doctors and pharmacists around the world to begin recommending the product. Today Bio‑Oil® Skincare Oil is the world’s leading scar and stretch mark product with over 400 skincare awards to its name. Bio‑Oil is currently working on a natural version of Bio‑Oil® Skincare Oil. The product is in clinical trials and is expected to launch in Q3 2020.

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  15. Just received the TEA Form 990 for 2019, which this non profit is not required to file for 2019 since donations were less than $50K (only received $21,578.00 in donations in 2019). TEA spent $18K on 'printing, publications, postage, shipping and other expenses.' So no research grants were sponsored in 2019. No money spent on staff or 'conventions' for members. Considering TEA has at least 3000 members who donated $21K, this non profit gets high marks for what is being accomplished according to the mission statement and still has over $125K in the bank in net assets. Read the Form 990 yourself. We could only wish that RRDi members would donate half as much as TEA members do. TEA 990 . 2019.pdf
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  17. 6554b6be8c0d829a8bf63ae0c82cf121_purchas
    Purchase. BeauKON Tea Tree Relaxing Facial Sheet Mask with Centella Asiatica, Korean Daily Face Mask, Hydrating and Relaxing (4 Pack)
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  18. I continue to take the Puritan Pride Lutein/Zeazanthin because I do think it helps dry my oily skin and as you point out, for the 'antioxidant effects' and I think it is similar to taking an oral retinoid since Lutein/Zeazanthin is actually a xanthophylls (carotenoid) that 'is a virulence factor with an antioxidant action that helps the microbe evade death by reactive oxygen species used by the host immune system." It may improve the eyes as well. We haven't had other anecdotal reports that it clears rosacea as Marcel the attorney raves about in his initial report. Keep us posted on your results. It has not cured my rosacea, but I still think it is worth taking daily. I take one a day.
  19. I’m wondering if anyone has continued this treatment and would share results. I took my first oil today and plan to continue to just for the antioxidant effects. I wake up with a few to many p&ps daily and am experimenting with the results.
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  21. A rare case of lupoid leishmaniasis defying diagnosis for a decade. J Cutan Pathol. 2020 Jul 04;: Authors: Gehlhausen J, Sibindi C, Ko CJ, Grant M, Zubek A Abstract Cutaneous leishmaniasis is a common disease affecting millions in endemic areas worldwide. We present a case of lupoid leishmaniasis, a rare variant of cutaneous leishmaniasis, which clinically mimicked sarcoidosis and/or granulomatous rosacea for ten years until ultimate diagnosis. An 82-year-old U.S. citizen with an extensive travel history presented with a ten-year history of facial plaques on the cheeks and was previously diagnosed and treated as sarcoidosis. Multiple biopsies (previously and at presentation) revealed tuberculoid granulomas with negative special stains for microrganisms and negative sterile tissue cultures for AFB, bacteria, and fungal organisms. A diagnosis of granulomatous rosacea was rendered and multiple medical therapies were attempted, none with sustained improvement. Repeat biopsy of a new lesion revealed intracellular organisms consistent with leishmaniasis, which was confirmed by PCR. Lupoid leishmaniasis is a rare presentation of cutaneous leishmaniasis including facial plaques that can mimic granulomatous diseases affecting the face including sarcoidosis and granulomatous rosacea. Cutaneous leishmaniasis can sometimes be challenging to diagnose through standard histopathologic examination; IHC for CD1a can be used to augment tissue-based examination and PCR should be sent early in cases with sufficient concern. This article is protected by copyright. All rights reserved. PMID: 32623733 [PubMed - as supplied by publisher] {url} = URL to article
  22. Efficacy and Safety Results of Micellar Water, Cream and Serum for Rosacea in comparison to a control group. J Cosmet Dermatol. 2020 Jul 05;: Authors: Guertler A, Jøntvedt NM, Clanner-Engelshofen BM, Cappello C, Sager A, Reinholz M Abstract BACKGROUND: Rosacea is a common inflammatory skin disorder with centrofacial erythema, flushing, telangiectasia, papules/pustules and possible ocular or phymatous manifestation. Patients' skin is particularly sensitive to chemical and physical stimuli leading to burning, stinging, dryness and skin tightness. OBJECTIVE: Dermatological evaluation of the efficacy and safety of skin care products designed for centrofacial erythema in rosacea patients, in comparison to a control group using objective measurements. Rosacea symptoms (itching, tension, warmth, burning, dryness) and quality of life were examined. METHODS: Sixty Caucasians with centrofacial erythema were enrolled in an eight-week prospective study, fifty of them exclusively using the study products (micellar water, cream and serum) with ten participants randomly assigned to a control group. Patients were evaluated at baseline (V0), at four weeks (V1) and at eight weeks (V2). Three-dimensional objective measurements (VECTRA® ) as well as standardized questionnaires were used. RESULTS: Results were compared with the control group. A significant reduction of 16% in skin redness as indicated by VECTRA® analysis was seen in the intervention group comparing V0 to V2. Furthermore, rosacea associated symptoms diminished by 57.1%, while life quality of affected patients within the intervention group improved by 54.5% comparing V0 to V2 respectively. CONCLUSIONS: A skin care regime suitable for sensitive and redness prone skin led to an enhanced clinical appearance, to a decrease of associated symptoms in rosacea patients and to an improved life quality. PMID: 32623833 [PubMed - as supplied by publisher] {url} = URL to article
  23. Related ArticlesRosacea and the cardiovascular system. J Cosmet Dermatol. 2020 Jul 03;: Authors: Searle T, Al-Niaimi F, Ali FR Abstract Rosacea and the cardiometabolic syndrome are both associated with chronic inflammation and a pro-inflammatory phenotype. Emerging clinical evidence supports the relationship between rosacea and cardiometabolic syndrome hypertension and obesity. This article reviews our current findings and understanding in the skin and cardiovascular relationship in rosacea. Rosacea appears to be associated with hypertension, dyslipidaemia and obesity. The role of smoking in rosacea is currently less clear. It remains uncertain whether treatment of these risk factors will aid improvement of rosacea. Greater understanding of rosacea and its association with the cardiovascular system and underlying risk factors could allow for a greater understanding of the body's inflammatory response as well as the formulation of new guidelines for attending clinicians. Dermatologists treating rosacea patients might need to consider enquiring and evaluate their patients' underlying cardiovascular risk factors. PMID: 32621366 [PubMed - as supplied by publisher] {url} = URL to article
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  25. Related ArticlesRosacea induced by selexipag in a patient with pulmonary arterial hypertension. Dermatol Ther. 2020 Jul 02;:e13947 Authors: Dominguez-Santas M, Diaz-Guimaraens B, Burgos-Blasco P, Ortega-Quijano D, Suarez-Valle A, Saceda-Corralo D PMID: 32618056 [PubMed - as supplied by publisher] {url} = URL to article
  26. UPDATE "The study concluded that treatment with hydroxychloroquine significantly reduces the death rate of COVID-19 patients, Zervos said. Of those treated with hydroxychloroquine alone, 13% of them died, compared to the 26.4% who died and were were not treated with the drug. There was an overall 18.1% in-hospital mortality rate and patients were over the age of 18, with a median age of 64." Hydroxychloroquine is effective in treating COVID-19, says Henry Ford Health System study, Andrew Mullin, MLive
  27. Earlier
  28. Diagram depicting the major determinants of gastric acid secretion, with inclusion of drug targets for peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD). Image courtesy of Wikimedia Commons. Proton Pump Inhibitors Theory One of the systemic cormorbidities in rosacea is the use of Proton Pump Inhibitors (PPIs). What are PPIs? "Proton-pump inhibitors (PPIs) are members of a class of medications whose main action is a profound and prolonged reduction of stomach acid production." [1] Why are they called proton pump inhibitor? "They are called 'proton pump inhibitors' because they work by blocking (inhibiting) a chemical system called the hydrogen-potassium adenosine triphosphatase enzyme system (otherwise known as the 'proton pump'). This chemical system is found in the cells in the stomach lining that make stomach acid." [2] What do PPIs do that is related to causing rosacea? One of the related rosacea theories is the Low Gastric Acid and Rosacea which has been around for sometime now, back to a paper in 1931 by Epstein and Susnow. [3] PPIs inhibit gastric acid production. What happens in the stomach without a doubt is related to what happens in the gut. There are a number of rosacea theories related to the gut, i.e, IBD and Rosacea, IBS and Rosacea, SIBO and Rosacea, and Rosacea and the Gut. GUT Rosacea is listed as a variant of rosacea. H Pylori (Helicobacter Pylori) in the gut has been a subject of investigation with rosacea for sometime now and continues to be investigated in clinical papers. Antibiotics have been the mainstay of medical treatment for rosacea, particularly those medicines derived from tetracycline, i.e., doxycycline, which work in the gut and has an effect on the stomach and bowel microbiota. The vast majority of rosacea patients have taken antibiotics, usually high dose for a significant period of time or low dose for even much longer periods. There is evidence that PPIs may even contribute to antibiotic resistance. [4] PPIs Systemic Cormorbidity in Rosacea Related to Gastric Acid Reduction One paper concluded, "In conclusion, prolonged PPI use was associated with an increased risk of rosacea, particularly in women and patients with peptic ulcers." [5] Theory Therefore, the theory that the use of PPIs may have a relationship in causing rosacea. Obviously not all rosacea sufferers have used PPIs so this is just one theory among the long list. For example, one theory is that rosacea is caused by demodex mites, but not all rosacea sufferers have any increase in demodex mites and treatment for demodex doesn't improve the rosacea, nevertheless, the theory is still listed since some rosacea sufferers respond well to treatment for demodectic rosacea. Ergo, the PPI and rosacea theory stands. A theory. End Notes [1] Proton-pump inhibitors, Wikipedia [2] Proton Pump Inhibitors, Dr Laurence Knott, Patient [3] Cal West Med. 1931 Aug;35(2):118-20.ACNE ROSACEA: WITH PARTICULAR REFERENCE TO GASTRIC SECRETION.Epstein N, Susnow D.ACNE_ROSACEA_GASTRIC_SECRETION_Hypochlorhydria_Acid_Epstein_1931.pdf [4] JAMA Intern Med 2020 Feb 24 Does Gastric Acid Suppression Encourage Antibiotic Resistance? Abigail Zuger, MD reviewing Willems RPJ et al. JAMA Intern Med 2020 Feb 24 Lee TC and McDonald EG. J Clin Microbiol. 2005 Jul; 43(7): 3059–3065.doi: 10.1128/JCM.43.7.3059-3065.2005 Effect of pH and Antibiotics on Microbial Overgrowth in the Stomachs and Duodena of Patients Undergoing Percutaneous Endoscopic Gastrostomy Feeding Graeme A. O'May, Nigel Reynolds, Aileen R. Smith, Aileen Kennedy, and George T. Macfarlane [5] J Dermatol. 2020 Jul 01;: Use of proton pump inhibitors and risk of rosacea: A nationwide population-based study. Dai YX, Tai YH, Chen CC, Chang YT, Chen TJ, Chen MH
  29. Related ArticlesUse of proton pump inhibitors and risk of rosacea: A nationwide population-based study. J Dermatol. 2020 Jul 01;: Authors: Dai YX, Tai YH, Chen CC, Chang YT, Chen TJ, Chen MH Abstract Proton pump inhibitors (PPI) are commonly used drugs. However, little is known about the association between PPI use and rosacea. This study aimed to investigate the association between PPI use and rosacea risk. Patients with prior PPI therapy, including 1067 rosacea cases and 4268 matched controls, were identified from the National Health Insurance Research Database in Taiwan. The cumulative defined daily dose (cDDD) was used to quantify the PPI use. Logistic regression was used for the analyses. After adjustment for potential confounders, PPI use with cDDD of more than 365 was significantly associated with an increased risk of rosacea (odds ratio [OR], 1.54; 95% confidence interval [CI], 1.10-2.15). Rosacea risk was significantly associated with PPI use of cDDD of more than 365 in women (OR, 1.62; 95% CI, 1.08-2.46) but not in men. Stratified by PPI indications, risk of rosacea was significantly associated with PPI use of cDDD of more than 365 for peptic ulcer (OR, 1.58; 95% CI, 1.12-2.21). In conclusion, prolonged PPI use was associated with an increased risk of rosacea, particularly in women and patients with peptic ulcers. PMID: 32613686 [PubMed - as supplied by publisher] {url} = URL to article
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