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  2. We have some instructions provided by IPS on how to use our forum. For example, watch this video on how to change your display name: Editing your profile Sending/Receiving messages General Posting Control Previewing post content Managing followed content How to Use CLUBS Two Factor Authentication Viewing Attachments Reputation & Reactions Custom Profile Fields User Ranks Post color highlighting Profile Completion Other Profile Settings
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  4. "The mechanism of action (MOA) of Soolantra® (ivermectin) Cream, 1% in treating rosacea lesions is unknown." However, we are concentrating on an investigation into the 'basis for the vehicle' statement by Galderma regarding Soolantra. In the Soolantra News post if you scroll down to Cetaphil Base, Galderma, on its Mechanism of Action page, posts : "Soolantra Cream combats inflammatory lesions of rosacea with a formulation designed for tolerability, utilizing Cetaphil® Moisturizing Cream as the basis for the vehicle." However, now this page is no longer available, but we have a screen shot of the Way Back Machine on August 21, 2018 which shows you the statement below: Soolantra mechanism of action (MOA) (Way Back Machine url) Actually after a careful search, Galderma has moved the statement that Cetaphil is the 'basis for the vehicle' statement to this page: https://www.soolantra.com/hcp/about-soolantra-cream SOOLANTRA (ivermectin) cream, 1% is a white to pale yellow hydrophilic cream. Each gram of SOOLANTRA cream contains 10 mg of ivermectin. It is intended for topical use. While the claim by Galderma that utilizing Cetaphil is 'basis for the vehicle' we have investigated and notice the differences with the inactive ingredients in Soolantra with the ingredients in Cetaphil below. SOOLANTRA cream contains the following inactive ingredients: carbomer copolymer type B, cetyl alcohol, citric acid monohydrate, dimethicone, edetate disodium, glycerin, isopropyl palmitate, methylparaben, oleyl alcohol, phenoxyethanol, polyoxyl 20 cetostearyl ether, propylene glycol, propylparaben, purified water, sodium hydroxide, sorbitan monostearate, and stearyl alcohol. Source Cetaphil Moisturizing Cream Ingredients: Water, Glycerin, Petrolatum, Dicaprylyl Ether, Dimethicone, Glyceryl Stearate, Cetyl Alcohol, Prunus Amygdalus Dulcis (Sweet Almond) Oil, PEG-30 Stearate, Tocopheryl Acetate, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Dimethiconol, Benzyl Alcohol, Phenoxyethanol, Glyceryl Acrylate/Acrylic Acid Copolymer, Propylene Glycol, Disodium EDTA, Sodium Hydroxide Source Compare Soolantra inactive ingredients to Cetaphil Moisturizing Cream Ingredients Google Sheet
  5. What is interesting is that Galderma claims Soolantra's base is Cetaphil. However, we did an investigation and compared Cetaphil's ingredients with the list shown in Soolantra and discovered there is a difference. For more information: Soolantra mechanism of action (MOA) SOOLANTRA (ivermectin) cream, 1% is a white to pale yellow hydrophilic cream. Each gram of SOOLANTRA cream contains 10 mg of ivermectin. It is intended for topical use. SOOLANTRA cream contains the following inactive ingredients: carbomer copolymer type B, cetyl alcohol, citric acid monohydrate, dimethicone, edetate disodium, glycerin, isopropyl palmitate, methylparaben, oleyl alcohol, phenoxyethanol, polyoxyl 20 cetostearyl ether, propylene glycol, propylparaben, purified water, sodium hydroxide, sorbitan monostearate, and stearyl alcohol. Source Cetaphil Moisturizing Cream Ingredients: Water, Glycerin, Petrolatum, Dicaprylyl Ether, Dimethicone, Glyceryl Stearate, Cetyl Alcohol, Prunus Amygdalus Dulcis (Sweet Almond) Oil, PEG-30 Stearate, Tocopheryl Acetate, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Dimethiconol, Benzyl Alcohol, Phenoxyethanol, Glyceryl Acrylate/Acrylic Acid Copolymer, Propylene Glycol, Disodium EDTA, Sodium Hydroxide Source Compare Soolantra inactive ingredients to Cetaphil Moisturizing Cream Ingredients Google Sheet
  6. With regard to flushing, it would be good to read this post. There are a number of drugs used to avoid flushing. There are also a number of other non prescription treatments to avoid flushing which are found here.
  7. There are so many alcohols in Soolantra's inactive ingredients which cause dryness and flakiness of skin which in turn cause itching and irritation and redness. Parabens and propylene glycol are also there which tend to penetrate the skin to help allow other ingredients to enter and this may be the reason your skin reacted and couldn't handle because everyone's skin reacts differently to chemicals.
  8. Yes admin I had learned about the difference when I got rosacea sometimes It was sudden intense redness and bump and sometimes it was episodic redness so I researched about it because it happens with me with the onset of autumn. When the autumn starts I get sudden intense flare with redness and bumps and then the redness and bumps last longer and take time to go and during full autumn and winter after that flare-up, I get short episodic flushing very frequently which looks like it is blushing. but it is all unexpected and unanticipated about its timing.
  9. Apurva, You may be interested in reading this post, Liver, Yogurt, Sour Cream, Cheese, Eggplant, and Spinach, in the research articles section of our website to get an understanding between the difference of a rosacea flareup trigger vs a flushing trigger.
  10. "In 2016, the definition of sensitive skin (SS) was established by a special interest group from the International Forum for the Study of Itch. SS is defined as a syndrome defined by the appearance of unpleasant sensations (stinging, burning, pain, pruritus, and tingling sensations) in response to stimuli that would not normally cause such sensations.....To our knowledge, only 2 transcriptomic studies have been performed for SS. ...As previously done with rosacea, these two studies provide very interesting data allowing, orientating and suggesting further research. Transcriptomic studies on larger populations are needed but these studies give key data to focus on some pathogenic mechanisms." Front Med (Lausanne). 2019; 6: 115. Sensitive Skin: Lessons From Transcriptomic Studies Adeline Bataille, Christelle Le Gall-Ianotto, Emmanuelle Genin, and Laurent Misery What if a non profit organization for rosacea gathered together 10,000 members, and each member donated one dollar and everyone agreed that a study on transcriptomic research be conducted? Could that be done? It is all up to you whether you think this would be worth investigating.
  11. An article published in the Daily Mail, Nerve injection that can stop the nightmare of hot flushes, by Robert Dobson, states, "An injection in the neck might ease the symptoms of hot flushes....known as a stellate ganglion nerve block." Many rosaceans are more concerned with avoiding flushing than with anything else. What exactly is stellate ganglion nerve block? The Cleveland Clinic answers, "A stellate ganglion block is used to diagnose or treat circulation problems or nerve injuries..." Cedars-Sinai states, "A stellate ganglion block (sympathetic block) is an injection of local anesthetic into the front of the neck." Rehabilitation & Orthopaedic Institute, University of Maryland states, "A stellate ganglion block is an injection of local anesthetic (numbing medicine) to block the sympathetic nerves located on either side of the voice box in the neck." One paper on this subject states, "Due to a high risk of side effects, for example, pneumothorax and vascular puncture, an image-guided approach is strongly suggested, even with the "safer" C6 approach." [1] "The inputs from sympathetic ganglia have been known to be involved in the pathophysiology of various conditions like complex regional pain syndrome (CRPS)" [2] Stellate ganglion block (SGB) "Stellate ganglion, also known as the cervicothoracic ganglion,....SGB is the oldest and most common sympathetic block that is applied today....There is a broad range of case studies that report the effectiveness of SGB in many different conditions. The outcomes may look promising, but expanding the indications of SGB needs more randomized, controlled studies." [2] End Notes [1] Treasure Island (FL): StatPearls Publishing; 2019 Jan-. Stellate Ganglion Blocks Emanuele Piraccini; Ke-Vin Chang. [2] J Pain Res. 2017; 10: 2815–2826. Ganglion blocks as a treatment of pain: current perspectives Osman Hakan Gunduz and Ozge Kenis-Coskun
  12. This article is found here.
  13. Rory, You will probably have better results using the horse paste over Soolantra, mainly because the horse paste is stronger ivermectin 1.87% over Soolantra's 1% and also because the inactive ingredients in the horse paste are simpler than Soolantra's list of inactive ingredients. So what brand of horse paste did you order? Also please be sure to post your results of taking oral ivermectin in the oral ivermectin post here. Just look at this comparison of horse paste inactive ingredients over Soolantra's inactive ingredients to see the difference: Eqvalan inactive ingredients: Hydrogenated Castor Oil, Titanium Dioxide (E171) 2.0% w/w., Hyprolose, Propylene Glycol Agri-Mectin inactive ingredients: Corn Oil, Polysorbate 80, Apple Flavor, and Aerosil. Soolantra's inactive ingredients: carbomer copolymer type B, cetyl alcohol, citric acid monohydrate, dimethicone, edetate disodium, glycerin, isopropyl palmitate, methylparaben, oleyl alcohol, phenoxyethanol, polyoxyl 20 cetostearyl ether, propylene glycol, propylparaben, purified water, sodium hydroxide, sorbitan monostearate, and stearyl alcohol. This simple comparison explains why more positive results are with horse paste because of its simple inactive ingredient list compared to the huge number of inactive ingredients in Soolantra which may explain why some like you and me may have a side effect of dryness or whatever. Probably the other horse paste brands have few inactive ingredients just as the two we did find above. The most popular horse paste, Durvet Paste doesn't list the inactive ingredients but it probably is a list of only three "Proprietary Components". Just about everyone reports it takes 12 weeks for clearance, but so do the positive reports using Soolantra, 12 weeks.
  14. I've tried Soolantra a couple of times. Lasted at best about 2 months but my face couldn't handle it. No idea why maybe its the propylene glycol in it. Im going to try the oral route and see what happens. I've ordered the paste. One thing i noticed each time I used Soolantra was that my face was in good condition for a while after i stopped using it. So i do think demodex has some part to play for me.
  15. In the past, the general consensus has been that more women have rosacea than men, particularly in certain variants of rosacea. We will use this post to collect papers on this subject. If you find any papers on this subject, please post in this thread. Severity Scores One report concluded, "Self-assessment severity scores were significantly higher in men (3.6 ± 1.3) than women (3.2 ± 1.0; P = .04).The authors conclude that rosacea is more severe in men and younger patients." [1] End Notes Dermatol Clin. 2018 Apr;36(2):97-102. doi: 10.1016/j.det.2017.11.004. Epub 2017 Dec 16. Measurement of Disease Severity in a Population of Rosacea Patients. Alinia H, Tuchayi SM, James SM, Cardwell LA, Nanda S, Bahrami N, Awosika O, Richardson I, Huang KE, Feldman SR.
  16. Rory, Soolantra is 1% ivermectin and the active ingredient.
  17. Haven't heard of this lutein stuff Brady. Havent really been around much lately. So youre still using zz, using some topical peroxide, low carb diet and lutein. Hell of a life, eh. Topical ivermectin may be the best option but some of us cant tolerate it. Im not sure any derm would be able to answer that question. Probably better to ask a vet.
  18. I have been taking the lutein/zeaxanthin which seems to dry up my skin some. Wrote a post about oral ivermectin. I would run this by my dermatologist before ingesting it. Topical ivermectin seems the best route.
  19. Response to 'Letter to the editor' by Wienholtz et al. entitled 'The many faces of rosacea: liberal diagnostic criteria have ramifications on disease prevalence and accuracy'. J Eur Acad Dermatol Venereol. 2019 Jun 14;: Authors: Tizek L, Schielein MC, Seifert F, Biedermann T, Böhner A, Zink A Abstract We thank Wienholtz et al.1 for their comments on our article entitled 'Skin disease are more common than we think: screening results of an unreferred population at the Munich Oktoberfest'. Rosacea is a common inflammatory skin disease with a widely ranging prevalence in different countries (less than 1% to 22%), but even within Germany (2.3% to 12.3%).There might be several reasons for these different findings: examined study population, primary or secondary data source, or as mentioned by Wienholtz et al., a lacking research-based classification system. This article is protected by copyright. All rights reserved. PMID: 31199525 [PubMed - as supplied by publisher] {url} = URL to article
  20. The many faces of rosacea: liberal diagnostic criteria have ramifications on disease prevalence and accuracy. J Eur Acad Dermatol Venereol. 2019 Jun 14;: Authors: Wienholtz N, Egeberg A, Thyssen JP Abstract We read with great interest the article by Tizek et al., which suggests that certain skin diseases are more common in Germany than previously thought. We were particularly interested in the finding that 25.5% of study participants fulfilled the criteria for rosacea based on dermatologist examination. The authors rightfully suggest that the high rosacea prevalence may be explained by the effect of intense (acute or chronic) ultraviolet exposure and high age of study participants. This article is protected by copyright. All rights reserved. PMID: 31199527 [PubMed - as supplied by publisher] {url} = URL to article
  21. Related Articles A case series of demodicosis in children. Pediatr Dermatol. 2019 Jun 13;: Authors: Douglas A, Zaenglein AL Abstract Demodex mites are commensal inhabitants of the pilosebaceous unit that are typically absent or at low numbers in childhood. When they are present, they can cause a primary eruption or exacerbate an underlying facial dermatosis. Here we report five cases of demodicosis occurring in childhood, the clinical presentations, and responses to treatment. Papulopustular lesions predominate, prompting the advice "pustules on noses, think demodicosis!" PMID: 31197860 [PubMed - as supplied by publisher] {url} = URL to article
  22. Related Articles Minocycline-Induced Hyperpigmentation. J Am Osteopath Assoc. 2018 Jul 01;118(7):492 Authors: Skorin L, Norberg S PMID: 29946676 [PubMed - indexed for MEDLINE] {url} = URL to article
  23. There are a lot of comments on Amazon from people who have taken it orally for Scabies. Most of the rosacea comments are using it topically but i did see a couple who use it successfully by mouth. The problem for some people maybe propylene glycol (PG), which is an ingredient in both Soolantra and the horse paste. For some people PG can cause allergic reactions, dryness and inflammation. Taking the horse paste orally may be an alternative. But i don't recommend it. What do you think Brady? Have you ever thought about ingesting it? I know you're an oily like me which according to studies means that we most likely harbour a lot more demodex mites than normal skin.
  24. First off, if you don't know what Erythromelalgia is, it is listed as a rosacea mimic and should be ruled out in a differential diagnosis of rosacea. Someone kindly pointed out to me that The Erythromelalgia Association website is very user friendly and was impressed with the free Guide it offers on its website indicating to me that the RRDi needs to be more 'user friendly' and offering such a guide. So I decided to investigate and contacted TEA and asked for a copy of the latest Form 990 which was emailed to me and I have given a cursory investigation and am very impressed with how this 501 c 3 non profit organization spends its donations. First off, the board of directors are all volunteers. They have managed to bring in 3000 members, and more importantly in 2018 received over $50K in donations! They spent $103K which breaks down to this: $75,000 for Grants and similar amounts paid (list in Schedule O) "Gift for research directly related to erythromelalgia" $13,398 for Professional fees and other payments to independent contractors $14,230 for Printing, publications, postage, and shipping (newsletter) $884 for other expenses Total Expenses $103,512 Download Form 990 for 2018 and read it yourself: Form990Package.2018.pdf So this is definitely how a non profit organization should be run and I give the highest marks possible to TEA for how it is helping Erythromelalgia sufferers. We wish that the members of the RRDi would be interested in imitating the TEA and help make the RRDi just like how TEA is run. The RRDi is very similar in how the board of directors are volunteers. We just need volunteers to step up to plate like the TEA volunteers are doing. It would be good for members of the RRDi to ask questions about the above or comment on this post.
  25. "Better efficacy with IVM 1% cream (QD) compared to MTZ 0.75% cream (BID) contributes to an improved quality of life with significantly more patients achieving an MCID in DLQI score at week 16 and higher mean EQ-5D score. IVM 1% cream is thus a better alternative than MTZ 0.75% cream for severe papulopustular rosacea patients." Dermatol Ther (Heidelb). 2016 Sep; 6(3): 427–436. Superior Efficacy with Ivermectin 1% Cream Compared to Metronidazole 0.75% Cream Contributes to a Better Quality of Life in Patients with Severe Papulopustular Rosacea: A Subanalysis of the Randomized, Investigator-Blinded ATTRACT Study Martin Schaller, Thomas Dirschka, Lajos Kemény, Philippe Briantais, and Jean Jacovella -------------------------------------- "Ivermectin 1% cream was significantly superior to MTZ 0·75% cream and achieved high patient satisfaction." Br J Dermatol. 2015 Apr;172(4):1103-10. doi: 10.1111/bjd.13408. Epub 2015 Feb 11. Superiority of ivermectin 1% cream over metronidazole 0·75% cream in treating inflammatory lesions of rosacea: a randomized, investigator-blinded trial. Taieb A, Ortonne JP, Ruzicka T, Roszkiewicz J, Berth-Jones J, Peirone MH, Jacovella J; Ivermectin Phase III study group. --------------------------------------- "Topical ivermectin is an effective option in the treatment of papulopustular rosacea. Although ivermectin seems to be more effective than topical metronidazole, with both treatment options about two-thirds of patient relapsed within 36 weeks after discontinuation of treatment." Dermatol Ther (Heidelb). 2018 Sep;8(3):379-387. doi: 10.1007/s13555-018-0249-y. Epub 2018 Jun 25. Topical Ivermectin in the Treatment of Papulopustular Rosacea: A Systematic Review of Evidence and Clinical Guideline Recommendations. Ebbelaar CCF, Venema AW, Van Dijk MR. --------------------------------------- "Ivermectin 1% cream QD appears to be a more effective topical treatment than other current options for the inflammatory lesions of rosacea, with at least an equivalent safety and tolerability profile, and could provide physicians and dermatologists with an alternative first-line treatment option." Springerplus. 2016 Jul 22;5(1):1151. doi: 10.1186/s40064-016-2819-8. eCollection 2016. The efficacy, safety, and tolerability of ivermectin compared with current topical treatments for the inflammatory lesions of rosacea: a network meta-analysis. Siddiqui K, Stein Gold L, Gill J.
  26. Another study showing the superiority of ivermectin over metronidazole has been published by NEJH Journal Watch. 399 rosacea patients enrolled in a study who were judged clear after receiving 16 weeks of ivermectin treatment and stopped the ivermectin treatment. Those that had a greater IGA score of ≤2 (which means some pimples/redness returned) "resumed their original topical treatment until remission was again obtained" whether it was ivermectin or metronidazole. The study showed that the relapse rate of rosacea was more days than those using the metronidazole treatment, in other words, the number of days to the relapse of rosacea was higher in the ivermectin group than the metronidazole group. The study concluded, "The relapse rate by study end at 36 weeks was lower for IVER recipients (62.7%) than MET recipients (68.4%)." Metronidazole vs. Ivermectin Mark V. Dahl, MD reviewing Taieb A et al. J Eur Acad Dermatol Venereol 2015 Dec 21 Which drug for remission of rosacea? ------------------------------------------------ "The results of this relapse study showed that an initial successful treatment with ivermectin 1% cream QD significantly extended remission of rosacea compared with initial treatment with metronidazole 0.75% cream BID following treatment cessation." J Eur Acad Dermatol Venereol. 2016 May;30(5):829-36. doi: 10.1111/jdv.13537. Epub 2015 Dec 21. Maintenance of remission following successful treatment of papulopustular rosacea with ivermectin 1% cream vs. metronidazole 0.75% cream: 36-week extension of the ATTRACT randomized study. Taieb A, Khemis A, Ruzicka T, Barańska-Rybak W, Berth-Jones J, Schauber J, Briantais P, Jacovella J, Passeron T; Ivermectin Phase III Study Group -----------------------------------------------
  27. Image courtesy of Wikimedia Commons Acyclovir Amytriptyline Antibiotics Anti-Flushing Drugs Apple Cider Vinegar Histame Lutein with Zeaxanthin Low Dose Naltrexone Mastic Gum and HCL Supplements MSM and Grapefruit Seed Extract Niacinamide Oil of Oregano Oral Ivermectin for Rosacea Plaquenil (Hydroxychloroquine) Probiotics Prednisone (not a long term solution) Retinaldehyde Retinoids (low dose has become quite popular) Rosadyn Spironolactone Supplements (Vitamins/minerals) The list just keeps growing.... (prescription)
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