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  2. So going to the gym or exercising to increase muscle mass may improve your rosacea. Just about any physician will tell you that exercise and eating healthy will improve not only health but also your rosacea.
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  4. Admin

    Low Dose Naltrexone

    Dr. Chris Steele talks about LDN.
  5. That has been my question for a number of years when I noticed no activity here at the RRDi, even though having over 1200 members, hardly anyone posts. I have thought during this time obviously rosaceans prefer social media over the forum style posting that has been around for twenty years, which doesn't have the user experience they are accustomed to using social media platforms. I have been browsing and posting a little at Facebook, Reddit, and Twitter and found that the level of education about rosacea is paltry and mostly these groups of rosaceans are into horse paste. They feel very comfortable showing horrible photos of their rosacea which I find really ironic since I heard so many complaints about joining the RRDi and filling out contact information (so we dropped the requirement and only require an email address). The lack of knowledge about rosacea in these social media groups and the spam posts allowed for all sorts of treatment for rosacea, not to mention the advertising, to me is a sad choice rosaceans have made instead of joining together in to a non profit organization for patient advocacy. At least I know where the rosaceans have gone. Very sad.
  6. Admin

    Low Dose Naltrexone

    Flugs at RF has started a thread indicating that low dose Naltrexone helps with phenotype 1 (of course Flugs calls it subtype 1). If you read the entire thread Flugs also takes propranolol (10 mg 3 times daily ), uses IPL (post no 29), however, in post no 49 Flugs writes, "I’ve also dropped all the meds I have tried in the past, none of which seemed to help much anyway... at least not enough for me to want to do something to my heart in order to help my face. So all I’m taking now is LDN and a tablesppon of apple cider vinegar every day." Flugs reports at post no 80, "On the down side though - I have to confess that i have had a few (pretty minor) flushes in the past two or three weeks. Almost always for no apparent reasons. It may still be post IPL recovery, last one was a month ago.. but IPL recoveries used to be waaaayyy worse, so if this is all I get I'm fine with that. I confess I have also been dabbling with (very mild) mandelic acid of late - I think I was overdoing it - Ive dialled back." So Flugs is still trying some other treatments along with LDN. In post 99 he mentions his 12th IPL treatment. At post no 112 Flugs writes, "I am still prone to flushing a little when I get too warm - and also (oddly) when I am trying, and failing, not to fall asleep, such as late at night in front of the tv (that’s always made me flush.. does that happen with anyone else!?) when I say “flushing a little” I mean that my cheeks get red and feel warm, but I can take it down pretty much instantly by cooling them (fan, water spray etc) in some way. Even if I were to leave them be they would go down themselves within a few mins... compare that to the sometimes 12 hour long painful flushes I got when the rosacea arrived two years ago." Judworth who suffers from Neuropathic Rosacea (has lots of posts) reports in the same thread Flug started mentioned above about his experience taking LDN, "Since taking LDN I am cautiously happy to report that I haven't had any facial nerve pain, I still get the warm room flush, but my face is less reactive in general, even after a spell on the computer (which always gave me an element of activity even if it wasn't a full-blown flush)." At post no 117 Judworth writes, "LDN has been a god-send for me, not only calming the skin, stopping my facial nerve pain and halting the burning sensation in my mouth caused by lichen planus, I feel it is somehow re-booting my faulty immune system!" The low dose Naltrexone is usually starting out at 1 mg and gradually increasing to 4.5 mg. Flugs insists that taking more than this won't work (go through his thread which has many other users reporting success with what they call LDN). You may want to show your doctor this pdf: Low-dose Naltrexone (LDN) Fact Sheet 2014 LDN Research Trust LDNNow
  7. image courtesy of IMDB Canadian Egyptian actress Christine Solomon has rosacea. She is reported as stating, "I purchased acne products off the shelf, and that turned out to be a big mistake! My cheeks became inflamed because of the ingredients in those products, and my condition worsened. That’s when I consulted a dermatologist for the first time, and he diagnosed me with rosacea at the age of 14 years old." Ms Solomon is the 2018 spokesperson for the Acne and Rosacea Society of Canada’s Rosacea Awareness Campaign. Canadian Egyptian Actress On Rosacea, Acne and Rosacea Society of Canada
  8. Admin

    Horse Paste for Rosacea?

    Tom Busby, SD poster extraordinare at RF, mentioned in a post on this subject at RF, "an alternative source of ivermectin, on eBay" which is ivermectin powder. I asked Tom whether this would be a good idea since it seems a lot safer to use the horse paste than have to concoct a paste with grain alcohol and his comment is, "horse paste is fairly expensive for a really tiny amount of product.... I have to assume that someone who has some experience formulating hot emulsions (oil in water) could make a non-greasy cream with this ivermectin powder." I would prefer the horse paste for a trial run before purchasing a chemistry set to make this. Most rosaceans are not into a laboratory approach to treatment preferring a pill or a topical than experimenting with such treatments in a lab coat. But, of course, this is the internet, and guess what? Horse paste for rosacea. Watch Mr. Wizard concoct a new rosacea treatment on YouTube. Maybe we will hear reports of this. If you haven't heard of the new TXA treatment, it also requires concocting a rosacea treatment yourself by purchasing powder from Amazon or your local chemical store.
  9. Evidence for a genetic component to rosacea has been hypothesized, with a retrospective study showing that rosacea patients have a greater than fourfold increased odds of having a family member with rosacea (Abram et al., 2010; Steinhoff et al., 2013), but the genes leading to this association are not known....A genome-wide association study was conducted in 22,952 individuals whose genomes showed >97% European ancestry. Because of the sample size needed for this study, cases and controls were identified by an online questionnaire in which participants responded to a survey item on whether a healthcare professional had ever diagnosed them with rosacea. Participants who answered “yes” were defined as “cases” (n=2,618), and those who answered “no” (n=20,334) were defined as “controls”.... Together, these data strongly suggest a role for antigen presentation by class II HLA in the etiology of rosacea. The data presented from this large discovery and replication group provide evidence for a genetic component of rosacea. J Invest Dermatol. 2015 Jun; 135(6): 1548–1555. Assessment of the Genetic Basis of Rosacea by Genome-Wide Association Study Anne Lynn S Chang, Inbar Raber, Jin Xu, Rui Li, Robert Spitale, Julia Chen, Amy K Kiefer, Chao Tian, Nicholas K Eriksson, David A Hinds, and Joyce Y Tung
  10. Rosacea is associated with a number of other diseases, referred to as ‘systemic comorbidities’, which one study reports, “Clinicians must be aware of the potential for systemic comorbidities in rosacea patients, which becomes more likely as disease duration and severity increase.” [1] The following is a growing list: Autoimmune conditions [2] Allergies (airborne, food, etc.) Anxiety Disorder [3] Alzheimer's Disease Cancer Chronic rhinosinusitis (CRS) [4] CKD Cardiovascular diseases [3] Depression/anxiety disorders [3] Dementia Diabetes [3] Dyslipidemia [3] Female hormone imbalance [5] [10] Gastroesophageal Reflux Disease (GERD) and other GI disorders [1] Glioma Hair loss Helicobacter pylori infection [3] Hepatobiliary system disorders [1] Hyperlipidemia [3] Hypertension [6] Inflammatory bowel disease (IBD) HLA-DRA Locus [7] Kidney Disease [8] Low-grade inflammation Mental Health Disorders [9] Metabolic diseases [1] MetS Migraine [31] Multiple sclerosis Obesity [25] Parkinson's disease Psychiatric diseases [3] Respiratory diseases [1] Rheumatoid Arthritis [3] SIBO Ulcerative Colitis [3] Urogenital diseases [10] The above list keeps growing. This complicates the theories on the cause of rosacea increasing the call for further research. However, in one study it was stated, "In this large study of patients with rosacea, atopic dermatitis, and psoriasis, we did not detect an increased 1-year risk of cardiovascular disease after adjusting for confounders." [18] Therefore, papers stating an association of rosacea with other diseases should all be taken with a grain of salt due to 'confounders' since another paper states, "Limitations included the accuracy of the published data, potential patient selection, and possible confounding factors. The true nature of the drawn correlations is uncertain, and causality cannot be established." [26] "In statistics, a confounder (also confounding variable, confounding factor or lurking variable) is a variable that influences both the dependent variable and independent variable causing a spurious association." Wikipedia End Notes [1] Int J Dermatol. 2018 Dec 21;: Systemic comorbidities associated with rosacea: a multicentric retrospective observational study. Aksoy B, Ekiz Ö, Unal E, Ozaydin Yavuz G, Gonul M, Kulcu Cakmak S, Polat M, Bilgic Ö, Baykal Selcuk L, Unal I, Karadag AS, Kilic A, Balta I, Kutlu Ö, Uzuncakmak TK, Gunduz K [2] Dermatol Clin. 2018 Apr;36(2):115-122. doi: 10.1016/j.det.2017.11.006. Epub 2017 Nov 29. Rosacea Comorbidities. Vera N1, Patel NU2, Seminario-Vidal L3. [3] J Am Acad Dermatol. 2018 Apr;78(4):786-792.e8. doi: 10.1016/j.jaad.2017.09.016. Epub 2017 Oct 26. Comorbidities in rosacea: A systematic review and update. Haber R1, El Gemayel M2. [4] There may be a relationship between rosacea and chronic rhinosinusitis (CRS) as the following quote concludes: "Patients with rosacea and CRS manifested severe erythematotelangiectatic rosacea. There was enough evidence to suggest an association between rosacea and CRS. Clinical and radiological assessments of the paranasal sinuses are recommended." Med Princ Pract 2014;23:511-516 (DOI:10.1159/000364905) Rosacea and Chronic Rhinosinusitis: A Case-Controlled Study Al-Balbeesi A.O. Department of Dermatology, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia [5] "There is no research regarding hormones and their effect on rosacea," Dr. Bergfeld said. "However, it has been widely observed that rosacea is often aggravated at menopause and sometimes during mid-cycle." Women May Need Added Therapy, Rosacea Review, NRS [6] Cardiovascular Diseases and Rosacea [7] "The HLA-DRA locus is associated with rosacea as well as with other inflammation-associated disorders, such as inflammatory bowel diseases including ulcerative colitis, Crohn’s disease, and celiac disease....Moreover, Spoendlin et al. found that an increased risk of rosacea was observed particularly during the period of increased gastrointestinal tract inflammation. Thus, the overlap in the genetic relevance of HLA-DRA between rosacea and inflammatory bowel diseases might imply a potential link between these disorders...Patients with rosacea have a higher risk of cardiovascular comorbidities including hypertension, dyslipidemia, and coronary artery disease than that seen in controls. Rosacea severity was also found to be dependent on the presence of cardiovascular comorbidities....In addition, the association between cardiovascular diseases and rosacea might also be explained by enhanced expression of the cathelicidin, which has been observed both in the course of atherosclerosis and rosacea. The GWAS by Chang et al. [20] also revealed that patients with rosacea shared a genetic locus with type 1 diabetes mellitus; this association was further confirmed by a population-based study as well....Patients with rosacea have a significantly increased risk of neurologic disorders such as migraine, depression, complex regional pain syndrome, and glioma...Recently, an increased interest has been shown in the potential associations between neurodegenerative diseases and rosacea....For example,...Parkinson’s disease...dementia, especially Alzheimer disease..." Int J Mol Sci. 2016 Sep; 17(9): 1562. Published online 2016 Sep 15. doi: 10.3390/ijms17091562, PMCID: PMC5037831 Rosacea: Molecular Mechanisms and Management of a Chronic Cutaneous Inflammatory Condition Yu Ri Woo, Ji Hong Lim, Dae Ho Cho, and Hyun Jeong Park, Chris Jackson, Academic Editor [8] Study Finds Possible Link Between Kidney Disease and Rosacea, NRS [9] Clin Exp Dermatol. 2019 Jan 31;: The mental health burden in acne vulgaris and rosacea: an analysis of the US National Inpatient Sample. Singam V, Rastogi S, Patel KR, Lee HH, Silverberg JI [10] J Am Acad Dermatol. 2015 Aug 6; Rosacea is associated with chronic systemic diseases in a skin severity-dependent manner: Results of a case-control study. Rainer BM, Fischer AH, Luz Felipe da Silva D, Kang S, Chien AL
  11. Admin

    Ungex Videos

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  17. The above report was done with 'questionnaires' and was not done with placebo controlled double blind studies. Again, the above study on diet and rosacea is simply anecdotal reports. Another point to question is, does the tea consumed by the respondents to the 'questionnaire' have sugar?
  18. Earlier
  19. "We found that high-frequency intake of fatty food and tea presented a positive correlation with rosacea, while high-frequency dairy product intake showed significant negative correlation with rosacea. Sweet food, coffee and spicy food appeared to be independent of any subset of rosacea in our study. However, high-frequency dairy product intake showed a borderline beneficial effect on rosacea severity. We further analyzed the correlation between diet and the subtype of rosacea. We found that high-frequency fatty intake was associated with erythematotelangiectatic rosacea (ETR) and phymatous rosacea, while high-frequency tea intake was only associated with ETR. In addition, high-frequency dairy product intake showed negative correlations with ETR and papulopustular rosacea. Rosacea is associated with some dietary factors, and our study is valuable in establishing dietary guidelines to prevent and improve rosacea." J Dermatol. 2019 Jan 18. doi: 10.1111/1346-8138.14771. Relationship between rosacea and dietary factors: A multicenter retrospective case-control survey. Yuan X, Huang X, Wang B, Huang YX, Zhang YY, Tang Y, Yang JY, Chen Q, Jian D, Xie HF, Shi W, Li J.
  20. A post by johny at RF recommends a trial diet using the principles of the 'carnivore diet' and states, " if you have decades long skin problems, you probably have issues with plant material. The best evidence is to trial the diet and see for yourself, if you give it an honest effort and don't like it no harm done." A thirty to ninety day trial diet cannot do any permanent damage no matter what proof you come up with, you can always go back to the way you were eating before the trial, and as johny points out, 'no harm done.' There is a huge number of links in a google search on 'carnivore diet' and after reading several articles on this subject, I liked the one by Dave Asprey, Carnivore Diet Results: Why It Works for Some People But Didn’t for Me, who tried eating the carnivore diet for three months, and did notice some improvement which is noted in his article (no mention of rosacea, his improvements included "felt great for the first month") and then explains why modifying the carnivore diet with some tweaks to improve it. Sugar and Carbohydrate are rosacea triggers and any diet that reduces these two items will improve rosacea. Maybe the carnivore diet is something you can at least try and report in this thread your results.
  21. Related Articles A Decade Retrospective Study of Light/Laser Devices in Treating Nasal Rosacea. J Dermatolog Treat. 2019 Feb 07;:1-24 Authors: Zhang Y, Jiang S, Lu Y, Wu Y, Yan H, Xu Y, Xu T, Li Y, Geng L, Gao XH, Chen HD Abstract BACKGROUND: Large-scale retrospective studies of light/laser in treating nasal rosacea were lacking. OBJECTIVE: The study was aimed to perform a decade retrospection of the patients with nasal rosacea who were treated with light/laser devices. METHODS: Methods: A study between 2008 and 2017 was performed retrospectively. Categorization of rosacea type (erythema/telangiectasia, ET; papules/pustules, PP; rhinophyma, RP) was made according to the photographs. Device settings, treatment regimens and treatment sessions of light/laser facilities were summarized. Efficacy was evaluated using a grading scale. RESULTS: In all, 807 patients received light/laser treatments. The subtypes of nasal rosacea were ET (n = 196), PP (n = 95), RP (n = 42), ET + PP (n = 334), ET + RP (n = 15), PP + RP (n = 88), and ET + PP + RP (n = 37). The lesions of ET or PP were mainly treated with non-invasive devices (Intense pulsed light, IPL; Dye pulse light, DPL; Dual wavelength laser system, DW) and those of RP were treated with the Fractional carbon dioxide (FCO2) laser. For the mixed subtypes, the general disposal orders of lesions were ET, PP and later RP. And the fundamental orders of devices application were IPL, DPL, DW and FCO2 laser. For all types of rosacea except for RP (2-4 sessions), most of the patients received 4-6 sessions of treatments. Of all subtypes of ET, PP, RP, ET + PP, ET + RP, PP + RP, ET + PP + RP, the patients who achieved more than 50% improvement accounted for 74.5%, 58.3%, 83.3%, 69.2%, 73.3%, 61.4%, 51.4%, respectively. CONCLUSION: The multiple, sequential light/laser devices can be safely used in nasal rosacea with various degrees efficacies based on different types. PMID: 30732485 [PubMed - as supplied by publisher] {url} = URL to article
  22. Related Articles Assessment of Skin Physiology Change and Safety After Intradermal Injections With Botulinum Toxin: A Randomized, Double-Blind, Placebo-Controlled, Split-Face Pilot Study in Rosacea Patients With Facial Erythema. Dermatol Surg. 2019 Feb 01;: Authors: Kim MJ, Kim JH, Cheon HI, Hur MS, Han SH, Lee YW, Choe YB, Ahn KJ Abstract BACKGROUND: Botulinum toxin (BTX) has been used cosmetically with good clinical efficacy and tolerable safety. OBJECTIVE: This randomized, double-blind, split-face clinical study aimed to investigate the efficacy and safety of intradermal BTX in patients with rosacea. MATERIALS AND METHODS: Twenty-four participants were enrolled and randomly given intradermal injections of BTX and normal saline in both cheeks. Clinician Erythema Assessment (CEA) score, Global Aesthetic Improvement Scale (GAIS) score, skin hydration, transepidermal water loss (TEWL), melanin content, erythema index, elasticity, and sebum secretions were evaluated at baseline and 2, 4, 8, and 12 weeks. RESULTS: On the BTX-treated side, the CEA score significantly decreased and the GAIS score significantly increased. The erythema index decreased at Weeks 4 and 8. Skin elasticity was improved at Weeks 2 and 4 and skin hydration, at Weeks 2, 4, and 8. However, TEWL and sebum secretion did not show significant differences. CONCLUSION: Intradermal BTX injections significantly reduced the erythema on both cheeks and improved skin elasticity and hydration, but not TEWL and sebum secretion. Intradermal BTX injections reduced erythema and rejuvenated the skin effectively and safely in patients with rosacea. PMID: 30730346 [PubMed - as supplied by publisher] {url} = URL to article
  23. Related Articles Metronidazole loaded nanostructured lipid carriers to improve skin deposition and retention in the treatment of rosacea. Drug Dev Ind Pharm. 2019 Feb 06;:1-30 Authors: Shinde UA, Parmar SJ, Easwaran S Abstract The objective of the present investigation was to improve the skin deposition and retention of metronidazole (MTZ) in rosacea therapy, by incorporating it into nanostructured lipid carriers (NLCs). The main challenge in this endeavour was the partial hydrophilicity of MTZ, which mandated careful selection of excipients, including solid and liquid lipids, surfactants, and their ratios in combination. NLCs were produced by the phase inversion temperature method and finally converted into a gel for topical application. The prepared nanoparticles were evaluated for their particle size, zeta potential, entrapment efficiency, solid state characteristics, surface morphology, in vitro drug release, and permeation through excised skin. The gel was additionally characterized for its pH, drug content, viscosity and spreadability. The prepared nanoparticles were spherical and of size below 300nm. Incorporation of judiciously chosen excipients made possible a relatively high entrapment efficiency of almost 40%. The drug release was found to be biphasic, with an initial burst release followed by sustained release up to 8 hours. In comparison to the plain drug gel, which had a tissue deposition of 11.23%, the NLC gel showed a much superior and desirable deposition of 26.41%. The lipophilic nature of the carrier, its size and property of occlusion enabled greater amounts of drug to enter and be retained in the skin, simultaneously minimizing permeation through the skin, i.e., systemic exposure. The results of the study suggest that NLCs of anti-rosacea drugs have the potential to be of use in the therapy of rosacea. PMID: 30727789 [PubMed - as supplied by publisher] {url} = URL to article
  24. Medical News Today has an article by Christian Nordqvist on rosacea [1] that is fairly comprehensive and takes about five minutes to read but isn't keeping up with the phenotype classification of rosacea, refers to 14 million Americans having rosacea (current estimates are 16 million Americans or 415 million worldwide), doesn't get into the many theories on the cause of rosacea, instead discusses five 'factors' that are thought to contribute to rosacea. The article should be updated and I give it a grade C for reporting and keeping up with rosacea. End Notes What is rosacea? Last updated Fri 15 December 2017 By Christian Nordqvist, Reviewed by Cynthia Cobb, APRN, Medical News Today
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    Steroid Rosacea

    Steroid Rosacea image credit: Corinna Kennedy own work 2017 https://upload.wikimedia.org/wikipedia/commons/d/d9/Steroid_Rosacea.jpg
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