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Dermatological effects of Curcuma species: a systematic review.

Clin Exp Dermatol. 2021 Jan 31;:

Authors: Barbalho SM, de Sousa Gonzaga HF, de Souza GA, de Alvares Goulart R, de Sousa Gonzaga ML, de Alvares Rezende B

Abstract
Curcuma and its derivatives are associated with anti-inflammatory and antioxidant activities in the skin. They can exhibit beneficial effects in wound-healing, prevention of chronic ultraviolet B damages, and may prevent facial redness such as rosacea and flushing. This review aimed to provide an up-to-date and rigorous synthesis of studies that demonstrated the clinical efficacy of curcuminoids in the skin. We evaluated studies published in the MEDLINE-PubMed/PMC (National Library of Medicine) following the PRISMA guidelines for this review. This search included papers published in the last ten years in controlled clinical trials, double-blind and randomized controlled studies, and case studies. The search resulted in twelve studies published in the last ten years. Curcuma species (C. longa and C. aeruginosa) and curcumin were found to produce different dermatological effects. They may influence antioxidant and anti-inflammatory processes in the production of hyaluronan, the increase in the skin's moisture, and the reduction of axillary hair growth. Curcuma also can reduce thickness, pruritus, erythema, burn, and pain in psoriasis, and can improve radio-dermatitis lesions. Our review results show that Curcuma species may play a role in skin health management and may exhibit different dermatological effects, being a new therapeutic arsenal for Dermatology professionals. Nevertheless, more clinical trials should be conducted with humans to establish the best way of delivering and dosages that would be beneficial for different dermatological conditions.

PMID: 33522006 [PubMed - as supplied by publisher]

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