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Randomized, Phase 2, Dose-Ranging Study in the Treatment of Rosacea With Encapsulated Benzoyl Peroxide Gel.

J Drugs Dermatol. 2014 Jun 1;13(6):685-688

Authors: Leyden JJ

Abstract
OBJECTIVE: Compare the safety and efficacy of 1% and 5% silica encapsulated benzoyl peroxide (E-BPO) in patients with papulopustular rosacea.<BR /> DESIGN: Multi-centered randomized, double blind, vehicle controlled parallel group, 12 week treatment in 92 patients with papulopustular rosacea. Primary endpoints were dichotomized IGA with success defined as clear/near clear and reduction in inflammatory lesions.<BR /> PATIENTS: 92 patients: 74% graded as moderate IGA, 14% severe and 12% mild. The mean inflammatory lesion count was 24.<BR /> INTERVENTION: Once daily treatment for 12 weeks with vehicle, 1% or 5% E-BPO.<BR /> RESULTS: 1% and 5% E-BPO were superior to vehicle in reducing papulopustular lesions <EM>P</EM>=0.01 and <em>P</em>=0.02. 5% E-BPO was superior to vehicle for IGA <em>P</em>=0.0013.<BR /><BR /> <EM>J Drugs Dermatol.</EM> 2014;13(6):685-688.

PMID: 24918558 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/24918558?dopt=Abstract = URL to article

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