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An Emerging Treatment: Topical Ivermectin for Papulopustular Rosacea.

J Dermatolog Treat. 2014 Nov 26;:1-8

Authors: Abokwidir M, Fleischer AB

Abstract
Abstract Ivermectin shows broad-spectrum anti-parasitic activity. It kills the Demodex mites that reside in the pilosebaceous units of patients with papulopustular rosacea. Ivermectin also has anti-inflammatory effects, it decreases cellular and humoral immune responses. Inflammatory mechanisms appear to play a dominant role in development of rosacea inflammatory lesions. Additionally, there is some evidence that it has antimicrobial activity, against Myobacterium tuberculosis and Chlamydia trachomatis. In recent clinical studies of ivermectin on rosacea show that it was superior to vehicle in reducing inflammatory lesion counts, and tolerability was excellent.Ivermectin displays antimicrobial, antiparasitic, antibacterial, and anti-inflammatory activities.

PMID: 25424053 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/25424053?dopt=Abstract = URL to article