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Am J Ophthalmol. 2021 Dec 20:S0002-9394(21)00643-7. doi: 10.1016/j.ajo.2021.12.004. Online ahead of print.


PURPOSE: To describe clinical, meibographic and interferometric signs in children with ocular rosacea.

DESIGN: Prospective case-control study METHODS: Setting: Monocentric (Fondation Ophtalmologique Rothschild, Paris, France) Population: 42 children with ocular rosacea and 44 healthy volunteers (median age 10 and 11 y.o., respectively).

INTERVENTION: Infrared meibography images of lower lids and tear lipid layer thickness measurement with the LipiView II® device (Tearscience).

MAIN OUTCOME: Clinical severity was graded on a 0-4 scale, and compared to meiboscores (0-4) and tear film lipid layer thickness (0-100nm).

RESULTS: 7 patients presented with a unilateral disease and 29 had an asymmetrical form. 24 patients had an associated cutaneous rosacea. 10/84 eyes presented with a loss of vision < 20/25. Mean clinical severity grade was 2.5 ± 1.4. Meibographic abnomalities were significantly more important in children with ocular rosacea (mean meiboscore 2.1 ± 1.36) than in healthy volunteers (0.61 ± 0.78), p-value <0.001. Clinical severity (r=+0.44; p<0.001), duration of the disease (r= +0.28, p = 0.011) and a past history of chalazia (r= +0.30, p = 0.006) were correlated to meibographic severity. Mean lipid layer thickness was not significantly different between cases and controls (74.4 ± 18.7 nm and 76.6 ± 18 nm, respectively; p = 0.47).

CONCLUSION: Meibomian structural alterations in children can be severe, and are correlated to ocular rosacea severity. Meibography is an essential tool for diagnosis and follow-up, whereas tear film interferometry contribution is uncertain.

PMID:34942110 | DOI:10.1016/j.ajo.2021.12.004

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