PubMed RSS Feed - -Optimizing Emollient Therapy for Skin Barrier Repair in Atopic Dermatitis

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Ann Allergy Asthma Immunol. 2022 Jan 19:S1081-1206(22)00015-1. doi: 10.1016/j.anai.2022.01.012. Online ahead of print.

ABSTRACT

OBJECTIVE: We compare here the principal characteristics of over-the-counter moisturizers with physiologic lipid-based barrier repair therapy.

DATA SOURCES: An extended literature revealed that moisturizers are considered standard ancillary therapy for anti-inflammatory skin disorders, like atopic dermatitis (AD). Additional studies have shown that physiologic lipid-based barrier repair therapy can comprise effective, stand-alone therapy for pediatric AD.

RESULTS: Not all moisturizers are beneficial - some negatively impact skin function, and in doing so, they risk inducing or exacerbating inflammation in patients with AD. The frequent self-reported occurrences of 'sensitive skin' in atopics could reflect the potential toxicity of such formulations. A still unanswered question is whether improper formulations could also prove to be counterproductive in other types of sensitive skin, such as rosacea. In contrast, we show how physiologic lipid-based barrier repair therapy (BRT), if comprised of the three, key stratum corneum lipids in sufficient quantities and at an appropriate molar ratio, can correct the barrier abnormality thereby reducing inflammation in AD, and possibly in other inflammatory dermatoses, such as the 'adult' eczemas and possibly even psoriasis.

CONCLUSION: We provide guidelines for the appropriate dispensation of moisturizers and physiologic lipid-based, barrier repair therapy for the treatment of AD. Both OTC (AtopalmÒ) and Rx (EpiCeramÒ) products are available in the USA with these characteristics.

PMID:35065300 | DOI:10.1016/j.anai.2022.01.012

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If you noted the statement in the abstract above which is reproduced for you here: 

 "A still unanswered question is whether improper formulations could also prove to be counterproductive in other types of sensitive skin, such as rosacea."

It is interesting to note a related abstract on the "clinical evidence about objective advantages of skincare routine remains limited despite advertising often claims benefits" and engaging in clinical tests on the skin using tools to collect data on this subject. Read more. 

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