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Antibiotics targeting brain’s inflammatory response may exacerbate cognitive deficits in children


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Traumatic brain injury (TBI) is one of the leading causes of disability and death in infants and children in the United States, with more than half a million affected annually, according to the Centers for Disease Control and Prevention. Those under age 4 who experience brain trauma can suffer lifelong problems with memory, attention and other executive functions.

While there are no drugs available to treat these injuries, scientists have shown that certain antibiotics -- which inhibit the brain's inflammatory response -- can improve outcomes for adult animal models that have suffered a blow to the head.

However, this treatment seems to negatively affect brains that have not yet developed, according to a new study from Drexel University College of Medicine. When administered to newborn rats immediately after head injury, the FDA-approved antibiotic minocycline exacerbated cognitive deficits, says the study, which was published in the journal Experimental Neurology.

Antibiotics targeting brain’s inflammatory response may exacerbate cognitive deficits in children, Published on January 11, 2017, Drexel University, News-Medical.Net 

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