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Microscale coiling in bis-imidazolium supramolecular hydrogel fibres induced by the release of a cationic serine protease inhibitor.

Chem Commun (Camb). 2017 Apr 07;:

Authors: Limón D, Jiménez-Newman C, Calpena AC, González-Campo A, Amabilino DB, Pérez-García L

Abstract
Gels formed by a gemini dicationic amphiphile incorporate a serine protease inhibitor, which could be used in a new approach to the treatment of Rosacea, within the fibres as well as in the space between them, affecting a number of gel properties but most importantly inducing remarkable fibre coiling at the microscopic level as a result of drug release from the gel. Drug release and skin permeation experiments show its potential for topical administration.

PMID: 28387417 [PubMed - as supplied by publisher]

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