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Brady Barrows

New Supramolecular Hydrogels for Rosacea

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"Due to the design of the gelator, drug release was up to 10 times faster and retention of the drug within the skin was up to 20 times more effective than that observed for commercial products."  Source

We will learn more about these new 'Cationic Supramolecular Hydrogels' in the future. Kate Lawrence, Chemistry Views, writes, "Effective drug delivery using cationic supramolecular gels could be associated with intermolecular reactions as well as the lack of coulombic attraction between the gelator and the drug. A rabbit model was developed based on the decrease of erythema (redness of the skin) after inducing vasodilation (widening of blood vessels), and in vivo experiments demonstrated the efficacy of the hydrogels. This, combined with the straightforward preparation of thermoreversible supramolecular hydrogels at room temperature, provides an option for industrial-scale production of dermatological formulations to treat rosacea and other chronic skin diseases."

Langmuir, American Chemistry Society, reports that "hybrid peptide hydrogels show antibacterial activity."

Another design "novel supramolecular gels in ethanol-water mixtures...seem to promote the retention of the drug inside the skin....effective in vivo anti-inflammatory activity was observed, especially with the indomethacin-incorporated gel, which indicates that these supramolecular hydrogels are a good option for the delivery of poor water soluble drugs for the treatment of acute inflammation or other skin diseases." 
Novel nanostructured supramolecular hydrogels for the topical delivery of anionic drugs.  

The good news about these new supramolecular hydrogels is  "the potential opening up of alternative strategies in therapy."
Cationic nioplexes in supramolecular hydrogels as hybrid materials to deliver nucleic acids

 

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