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Gold Nanoparticles Treatment for Rosacea

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Synthesized Gold Nanoparticles (GNP) which are coated with a mixture of hydroxyl- and carboxyl terminated thiolates (GNP.OH/COOH) and with the serine protease inhibitor 4-(2-aminoethyl) benzenesulfonyl fluoride hydrochloride (AEBSF·HCl) are being studied as "a new intracellular delivery strategy for both small drugs and antibodies in the treatment of skin diseases such as Rosacea." [1]

"Nanotechnology is one of the most exigent and fastest growing branches in the field of science and engineering. 16th century people already used noble gold nanoparticles for the medical and staining purpose. They have proved to be very useful for stomatology, pharmacy and implantology tissue engineering.....Gold nanoparticles have bactericidal effect against animal pathogens, food pathogens and it has other pharmacological activities." [2]

"Anostructured supramolecular hydrogels and gold nanoparticles, as two kinds of nanomaterials, were synthsized, characterized and evaluated for their potential as drug delivery systems. Two bis-imidazolium cationic surfactants (1·2Br and 2·2Br) were used as low molecular weight gelators that can incorporate anionic neutral and cationic drugs which can be used in the treatment of skin diseases such as Rosacea and Psoriasis.....Gold nanoparticles (GNP) for the treatment of Rosacea were designed and synthesized using thiolated PEG molecules of sufficient length with a mixture of hydroxyl and carboxyl groups on their surface (GNP.OH/COOH)." [3]

"Under dark field illumination, gold nanoparticles are up to a million times brighter than organic dyes due to the particles’ large optical scattering cross-section at the plasmon resonance wavelength. A low concentration of gold conjugates on the order of nM is sufficient to produce a sharp image. Gold nanoparticles are also resistant to photo-blinking and photo-bleaching, allowing continuous and extended cell imaging, tracking, and analysis." [4]

End Notes

[1] Multifunctional serine protease inhibitor-coated water-soluble gold nanoparticles as a novel targeted approach for the treatment of inflammatory skin diseases.
Bioconjug Chem. 2018 Feb 06;:
Limon D, Fabrega MJ, Calpena AC, Badía J, Baldoma L, Pérez-García L

[2] Biochem Biophys Rep. 2017 Sep; 11: 46–57.
Published online 2017 Jun 21. doi:  10.1016/j.bbrep.2017.06.004
PMCID: PMC5614687
Phyto-assisted synthesis, characterization and applications of gold nanoparticles – A review
J. Santhoshkumar, S. Rajeshkumar, and S. Venkat Kumar

[3] Micro- and nanomaterials for drug delivery in skin diseases, Limón Magaña, David, Deposit Digital, Universitat de Barcelona

[4]  i-colloidTM Gold Nanoparticle Cell Imaging Kit
40 nm Gold Nanoparticles

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