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Tranexamic Acid Solution

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There is a new cheap treatment using tranexamic acid solution (Transamin inj/sol 500 mg/5 mL) infused wet dressing for erythematotelangiectatic rosacea. The results of an unblinded study of 20 patients resulted with "All patients were improved in the end of the therapy....The improvement lasted more than four months." [1]

Another clinical paper on TXA says, "Finally, TXA repressed the angiogenesis by reducing the number of CD31+ cell and downregulating the expression levels of VEGF in rosacea. In conclusion, our finding defines a treatment mechanism by which TXA ameliorates rosacea symptoms by regulating the immune response and angiogenesis." [2]

Microneedling with tranexamic acid solution was an effective treatment for women with erythematotelangiectatic rosacea, according to late-breaking research presented at the American Academy of Dermatology Annual Meeting. [3]

"Topical tranexamic acid could improve the epidermal permeability barrier function and clinical signs of rosacea, likely resulting from inhibition of PAR-2 activation and consequent calcium influx. Thus, tranexamic acid could serve as an adjuvant therapy for rosacea." [4]

"Taken together, we report that TA solution soaking is an easy, safe and non-costly approach to improve skin rosacea rapidly, although further randomized controlled trials should be conducted." [5]

"Also, recent studies demonstrated that tranexamic acid inhibits epidermal PAR-2 expression which is elevated in rosacea patients (Zhong et al., 2015). Taken together, these results suggest that combination treatment of minocycline, propranolol, and tranexamic acid may be a possible strategy for treatment of rosacea, especially that involving severe flushing, refractory erythema, and sen- sitive skin." [6]

We have started a list of TXA over the counter products available through our Amazon Affiliate program if you scroll down to the second comment in this post.

A thread at RF discusses this subject. Any new information will be posted in this thread. If you have something to add please reply to this thread. In this thread, jrlhamcat2 [post no 47] reports, "I've soaked one side of my face about 6 times over around 10 days now. My skin has been getting less red and the flushing has been less frequent and less intense, but on both sides of my face, not just the one I've been treating."

jrlhamcat2 [post no 60] reports, "so far it seems like this is a good treatment for reducing subtype one symptoms." 


End Notes

[1] J Cosmet Dermatol. 2018 Aug 11;:
The new therapeutic choice of tranexamic acid solution in treatment of erythematotelangiectatic rosacea.
Bageorgou F, Vasalou V, Tzanetakou V, Kontochristopoulos G

[2] Int Immunopharmacol. 2018 Dec 19;67:326-334
Tranexamic acid ameliorates rosacea symptoms through regulating immune response and angiogenesis.
Li Y, Xie H, Deng Z, Wang B, Tang Y, Zhao Z, Yuan X, Zuo Z, Xu S, Zhang Y, Li J

[3] Microneedling with tranexamic acid solution
By Admin, March 8, 2017 in Rosacea in the News, RRDi Forum

[4] DERMATOLOGICA SINICA 33 (2015) 112e117
Topical tranexamic acid improves the permeability barrier in rosacea
Shaomin Zhong, Nan Sun, Huixian Liu, Yueqing Niu, Can Chen, Yan Wu

[5] Letters to the Editor, 40 (1), Pages 70-71, (2012) The Journal of Dermatology, Japanese Dermatological Association 
Tranexamic acid solution soaking is an excellent approach for rosacea patients: A preliminary observation in six patients
Myoung Shin KIM, Sung Eun CHANG, Sik HAW, Hana BAK, Youn Jin KIM, Mi Woo LEE

[6] Dermatologic Therapy, 30(3), e12439. doi:10.1111/dth.12439. August 2016
Combination treatment of propranolol, minocycline, and tranexamic acid for effective control of rosacea
Kwon, H. J., Suh, J. H., Ko, E. J., & Kim, B. J. 

[7] See fourth post in this thread

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