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Soolantra Mechanism of Action

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"The mechanism of action (MOA) of Soolantra® (ivermectin) Cream, 1% in treating rosacea lesions is unknown."

However, we are concentrating on an investigation into the 'basis for the vehicle' statement by Galderma regarding Soolantra. 

In the Soolantra News post if you scroll down to Cetaphil Base, Galderma, on its Mechanism of Action page, posts : "Soolantra Cream combats inflammatory lesions of rosacea with a formulation designed for tolerability, utilizing Cetaphil® Moisturizing Cream as the basis for the vehicle." However, now this page is no longer available, but we have a screen shot of the Way Back Machine on August 21, 2018 which shows you the statement below: 

soolantra_MOA.png

Soolantra mechanism of action (MOA) (Way Back Machine url) 

Actually after a careful search, Galderma has moved the statement that Cetaphil is the 'basis for the vehicle' statement to this page: 

https://www.soolantra.com/hcp/about-soolantra-cream

soolantra_MOA2.png

SOOLANTRA (ivermectin) cream, 1% is a white to pale yellow hydrophilic cream. Each gram of SOOLANTRA cream contains 10 mg of ivermectin. It is intended for topical use.

While the claim by Galderma that utilizing Cetaphil is 'basis for the vehicle' we have investigated and notice the differences with the inactive ingredients in Soolantra with the ingredients in Cetaphil below. 

SOOLANTRA cream contains the following inactive ingredients: carbomer copolymer type B, cetyl alcohol, citric acid monohydrate, dimethicone, edetate disodium, glycerin, isopropyl palmitate, methylparaben, oleyl alcohol, phenoxyethanol, polyoxyl 20 cetostearyl ether, propylene glycol, propylparaben, purified water, sodium hydroxide, sorbitan monostearate, and stearyl alcohol.
Source

Cetaphil Moisturizing Cream Ingredients: Water, Glycerin, Petrolatum, Dicaprylyl Ether, Dimethicone, Glyceryl Stearate, Cetyl Alcohol, Prunus Amygdalus Dulcis (Sweet Almond) Oil, PEG-30 Stearate, Tocopheryl Acetate, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Dimethiconol, Benzyl Alcohol, Phenoxyethanol, Glyceryl Acrylate/Acrylic Acid Copolymer, Propylene Glycol, Disodium EDTA, Sodium Hydroxide
Source

Compare Soolantra inactive ingredients to Cetaphil Moisturizing Cream Ingredients Google Sheet

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