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Microorganisms of the Human Microbiome

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For a long time microorganisms of the skin microbiome have been suggested as a cause of rosacea. The list includes, bacteria, virus, and demodex mites. Further, there are some papers that suggest that the gut microbiome may be involved in rosacea. One article comparing identical twins and the skin microbiome reports "Microbial dysbiosis could be one of the factors associated with the pathogenesis of rosacea as well as its comorbidities." [1] This same study concluded, "Our data demonstrate a significant correlation between facial microbiome and severity of rosacea in genetically matched twins and importantly that overall microbiome composition is largely unchanged." Further the study states, "Specifically, we uncovered a positive and a negative association for Gordonia and Geobacillus with rosacea, respectively. Importantly, this was in the background of a largely unchanged microbiome landscape."

A Bias With Bacteria as the Focus of Rosacea Research and the Human Microbiome

This study focuses primarily on bacteria, i.e., Gordonia, Blautia, Chryseobacterium, Wautersiella, Geobacillus and unknown genus (phylum Proteobacteria). Most rosacea research papers have a bias towards bacteria and largely ignore other microorganisms in the microbiome such as virus, archea, fungi, protozoa, helminths, and demodex (the article made a cursory mention of demodex, but little discussion on this subject). [2]

Such bias towards bacteria that ignores these other microorganisms is found in most articles on rosacea since Western Medicine largely ignores these other microorganisms and with very little research. This results with such a paltry knowledge of what might be some significant factors in rosacea other than focusing on bacteria. For example, there are more virus in the human microbiome than bacteria by a factor of ten times yet very little research is done on virus and rosacea. The bias is that bacteria plays a chief role in rosacea resulting in mostly antibiotic treatments and more recently a little probiotic treatment.

Research on Other Microbes Besides Bacteria?

The role of the other microorganisms besides bacteria should warrant more attention but who will pay for such studies? Demodex has been an example of the most researched microorganism other than bacteria studies. [3] This is because there are now treatments for demodectic rosacea so there is motive to fund such studies.

What about research on the other microbes that are in the human microbiome? What role does virus or archea play in rosacea? Do you want to fund such a study? Could 10K members of the RRDi get together and each donate one dollar to fund such a study? Only with your help could we reach such a goal. Think about it. [4]

End Notes

[1] Exp Dermatol. Author manuscript; available in PMC 2019 Jul 16.
Published in final edited form as:
Exp Dermatol. 2018 Mar; 27(3): 295–298.
Characterization of the facial microbiome in twins discordant for rosacea
Asifa K. Zaidi,1 Katrina Spaunhurst, Daniel Sprockett, Yolandas Thomason, Margaret W. Mann, Pingfu Fu, Christine Ammons, Meg Gerstenblith, Marie S. Tuttle, and Daniel L. Popkin

[2] Human Microbiome, Brady Barrows

[3] Demodectic Rosacea

[4] More thoughts on this subject to think about:
Rosacea Research in Perspective of Funding
Rosacea Research in Perspective of Idiopathic Diseases

 

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Yes I think we have to pay attention to the other skin-microbiome interaction also which tend to play a role in rosacea especially I was thinking of bacteriophage (bacteria+virus) which might play a role in rosacea and very few research is going on this rosacea and the idea of research on this theme would open up a new direction for rosacea. Think out loud.

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