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Real life experience on effectiveness and tolerability of topical ivermectin in papulopustular rosacea and anti-parasitic effect on Demodex mites.

Dermatol Ther. 2019 Oct 03;:e13093

Authors: Trave I, Merlo G, Cozzani E, Parodi A

Abstract
BACKGROUND: Ivermectin is a drug approved for the treatment of papulopustular rosacea. Although clinical guidelines recommend the use of ivermectin as the first-line treatment in patients with almost clear and mild rosacea, studies concerning its use on them are lacking.
OBJECTIVE: This study investigated the effectiveness and the tolerability of ivermectin in almost clear to severe rosacea and assessed the anti-parasitic effect on Demodex mites.
METHODS: This is a retrospective study based on 50 patients affected by papulopustular rosacea and treated with topical ivermectin 1% once daily over 16 weeks. The disease severity, the patient-examined improvement and the safety assessment of patients were evaluated. Demodex mites were studied with the standardized skin surface biopsy.
RESULTS: Papulopustular rosacea to all severity achieved a therapeutic success. The number of inflammatory lesions was significantly decreased in almost clear (P<0.0001), mild, moderate and severe (P<0.001) forms. A complete remission of inflammatory lesions was achieved by almost clear (p<0,001) and mild (p=0,005) with 82% with none-to-mild cutaneous adverse events. Thirty-two percent were positive for Demodex mites and all of them turned negative after 16 weeks.
CONCLUSION: Ivermectin is an effective treatment not only in moderate-severe papulopustular rosacea but also in almost clear/mild rosacea. This article is protected by copyright. All rights reserved.

PMID: 31579993 [PubMed - as supplied by publisher]

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