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Minocycline Topicals for Rosacea

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There has been at least three pharmaceutical companies researching and testing a topical minocycline foam or gel for rosacea. We await to see the results of these clinical trials and if these are effective.

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(1) FMX103 Topical Minocycline FoamFoamix Ltd

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(2) BPX-04 Minocycline Topical Gel 1%BioPharmX, Inc.

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(3) HY-01 Minocycline Gel 3%, Hovione

 

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A paper published in the British Journal of Dermatology concluded that after treatment with 1% and 3% Minocycline Topical Gel, this resulted with a "significantly decreased inflammatory lesion counts and a significantly larger proportion of subjects achieved IGA success at week 12 in the 3% topical minocycline group. These findings support further evaluation of minocycline gel for the treatment of inflammatory lesions associated with papulopustular rosacea."

Metronidazole will be having some competition. 

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foamix_logo.jpg.b7fe788391363851a7e3f0d3

Results of Two Phase 3, Randomized, Clinical Trials, FMX103 1.5%, conclusion: 

FMX103 1.5% was efficacious for moderate-to-severe papulopustular rosacea, while maintaining a favorable safety profile

The authors of the paper add this limitation, "The generalizability of these data from a controlled clinical trial should be examined in a real-world setting."

For more information

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"Webster et al. report a multicentre, randomized, double‐masked, parallel‐group, vehicle‐controlled study to evaluate the safety and efficacy of minocycline gel 1% and 3%. Topical minocycline had insignificant systemic absorption but produced significant reductions in mean inflammatory lesion counts with both the 1% and 3% concentrations. The response rate in the vehicle group was quite high, as is often the case in diseases with fluctuating inflammation. However, the 3% concentration of minocycline showed a significantly greater proportion of patients achieving Investigator's Global Assessment success at week 12 compared with vehicle. A topical minocycline foam formulation is in development, and this may provide a further useful option for treating papulopustular rosacea. How topical minocycline compares with other topical rosacea treatments is as yet unclear."

Br J Dermatol. 2020 Mar 18;:
Expanding treatment options for rosacea.
Hampton PJ

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