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Hydroxychloroquine Suppresses LL37-induced Mast Cells

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A recent study published International Immunopharmacology that hydroxychloroquine "improved rosacea in rosacea-like mice and mast cells (MCs)" and investigated "the effects of HCQ treatment for rosacea patients". The paper concludes, "In vitro, HCQ suppresses LL37-induced MCs activation in vitro, including the release of inflammatory factors, chemotaxis, degranulation and calcium influx. Moreover, HCQ attenuated LL37-mediated MCs activation partly via inhibiting KCa3.1-mediated calcium signaling. Thus, these evidences suggest HCQ ameliorated rosacea-like dermatitis may be by regulating immune response of MCs. Finally, the 8-week HCQ treatment exerted satisfactory therapeutic effects on erythema and inflammatory lesions of rosacea patients, indicating that it is a promising drug for rosacea in clinical treatment."

Since hydroxychloroquine is available worldwide in generic form we should hear more reports from rosaceans who will ask their physician for a prescription to confirm these results. Duff Man reported in 2017 that this worked for him. Another thread at RF in 2010/2011 has a few others who have tried it discuss their experience. antwantsclear [post no 240 and post no 243] reports taking hydroxychloroquine starting in 2011 and continues to use it for flushing. 

One paper published in the Archives of Dermatology, January 2011, indicates that 3 out of 5 patients with neurogenic rosacea were successful using hydroxychloroquine. 

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