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Coronavirus and Rosacea


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Image courtesy of Wikimedia Commons

A "study demonstrated a significant impact of the COVID-19 pandemic on the public interest in dermatology." This same report stated that in some periods during 2020 that "An initial decrease in interest was followed by a significant increase for acne, comedones, melasma, rosacea, botox, dermaroller, and peeling." [1] 

"Of note, some patients with COVID-19 with previous skin conditions such as rosacea, acne, eczema, and atopic dermatitis experienced a flare during the course of their disease." [2] 

"In some COVID-19 patients, preexisting skin diseases, such as atopic dermatitis, psoriasis, and rosacea have been exacerbated."

Treatments for Rosacea and for Covid-19
These are the list of treatments for rosacea that are being investigated to treat the coronavirus

Azithromycin for Coronavirus

Chloroquine for Coronavirus 

Doxycycline for Coronavirus

Hydroxychloroquine for Coronavirus  

Ivermectin for Coronavirus

Metronidazole and Coronavirus

Naltrexone and Ketamine for COVID-19

Tetracycline for Coronavirus

We will keep you updated on these treatments in the above posts. If you have anything to add to these treatments we are not aware of, please volunteer and post by finding the 'reply to this topic' button what you know. Scrolling through the posts in this thread will keep you updated on this subject. 

Virus and rosacea has never, ever been ruled out
320px-3D_medical_animation_coronavirus_structure.jpg
Cross-sectional model of a coronavirus, Image courtesy of Wikimedia Commons

Etcetera 

Protection of skin barrier for Coronavirus with Personal Protective Equipment

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End Notes

[1] Dermatol Ther. 2021 Feb 17;:
Public Interest in Dermatologic Symptoms, Conditions, Treatments, and Procedures during the COVID-19 Pandemic: Insights from Google Trends.
Esen-Salman K, Akın-Çakıcı Ö, KardeŞ S, Salman A

[2] Am J Clin Dermatol. 2020 Aug 31 : 1–13.doi: 10.1007/s40257-020-00558-4
Cutaneous Manifestations of COVID-19: An Evidence-Based Review
Giulia Daneshgaran, Danielle P. Dubin, and Daniel J. Gould

[3] Clin Dermatol. 2021 Feb 16
Immunosuppressive/Immunomodulatory Therapies in Dermatology and COVID-19
Parvin Mansouri, MD, Susan Farshi, MD, MPH, Nahid Nickhah, MD, Niloufar Najar Nobari, MD, Reza Chalangari, MD, and Mohammad Ali Nilforoushzadeh, MD

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Skin Manifestations in Coronavirus

"The novel coronavirus may cause dermatological symptoms such as pseudo-frostbite, hives and persistent, sometimes painful redness, as symptoms that affect the body outside the respiratory system continue to be found that may be associated with coronavirus infections, according to the French National Union of Dermatologists-Venereologists (SNDV – skin and sexually transmitted disease doctors)." 

Dermatological symptoms may be the latest new coronavirus symptom
Pseudo-frostbite, hives and redness may appear with or without respiratory symptoms.
By TZVI JOFFRE   APRIL 12, 2020 17:54, The Jerusalem Post

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"The symptoms range from hives to measles-like rashes to a condition resembling frostbite."

Coronavirus News: Skin rashes emerge as possible symptom of COVID-19, dermatologists say, April 18, 2020, Jory Rand, Eyewitness News, WABC-TV 7

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"There have been increasing reports of dermatologic manifestations of coronavirus disease 2019 (COVID-19). The first case series of dermatologic manifestations included 18 Italian patients with erythematous, urticarial, and vesicular rashes, often on the trunk. Other reports include drug hypersensitivity, urticaria, apetechial rash mimicking dengue, and acro-ischemia. It is important to further characterize dermatologic manifestations of COVID-19 in order to understand the relationship between the virus and skin, and determine whether cutaneous manifestations of COVID-19 may assist with early disease detection. To date, collecting cases of dermatologic manifestations of COVID-19 has been challenging given their relative infrequency and the rapid spread of COVID-19."

Freeman EE, McMahon DE, Fitzgerald ME, Fox LP, Rosenbach M, Takeshita J, French LE, Thiers BH, Hruza GJ, The AAD COVID-19 Registry: Crowdsourcing Dermatology in the Age of COVID-19, Journal of the American Academy of Dermatology (2020), doi: https://doi.org/10.1016/ j.jaad.2020.04.045.

Other dermatological papers related to this subject are cited at the University of Nottingham

The Science Times reports, "Two different Chinese doctors who were both critically ill from the coronavirus have actually seen their skin turn dark right after being brought back to life from the brink of death. Dr. Hu Weifeng and Dr. Yi Fan, had previously caught the virus when they were treating patients at the Wuhan Central Hospital back in January." - Another report about this from the New York Post.

"Skin manifestations were observed in about one-fifth of a group of patients with COVID-19 in the Alessandro Manzoni Hospital in Lecco, in northern Italy.",
Skin manifestations are emerging in the coronavirus pandemic, The Hospitalist

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"A variety of repurposed drugs and investigational drugs such as remdesivir, chloroquine, hydroxychloroquine, ritonavir, lopinavir, interferon‐beta, and other potential drugs have been studied for COVID19 treatment. We reviewed the potential dermatological side‐effects of these drugs."

Dermatol Ther. 2020 May 22 : e13476.doi: 10.1111/dth.13476 [Epub ahead of print]
Cutaneous sıde‐effects of the potential COVID‐19 drugs
Ümit Türsen, Belma Türsen, Torello Lotti 

==============================================

"The US now has more hydroxychloroquine than it knows what to do with following a series of studies that concluded the drug is an ineffective and potentially dangerous treatment for COVID-19. The federal government, which started stockpiling the drug in March, now has 63 million surplus doses of the drug, donated by companies including Novartis, and another 2 million doses of chloroquine, the New York Times reports. Some 31 million doses from the Strategic National Stockpile were distributed before the FDA withdrew its emergency authorization of the drug to treat the coronavirus. President Trump championed the drug for months, hailing it as a possible "game-changer" and announcing that he was taking it himself."

US Is Stuck With 63M Doses of Hydroxychloroquine, Rob Quinn, Newser

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With the recent news that oral hydroxycholoroquine is just as effective as oral doxycycline for rosacea, maybe we will be hearing more anecdotal reports of hydroxycholoroquine improving rosaceaA report published in the Journal of the American Academy of Dermatology reports that oral hydroxychloroquine is just as effective as oral doxycycline. [see post no 7 in this thread by scrolling down for the clinical paper source associated with this]

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The controversy about hydroxychloroquine continues.

"Not all researchers have given up on the drug, however, and recent developments show it is not yet dead as a potential weapon against COVID-19, especially as a preventative in people not yet exposed to the virus." 

Hydroxychloroquine is not dead yet, Lisa Cavazuti, NBC News

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"Once praised as a miracle cure for covid-19, an antimalarial drug called hydroxychloroquine has rarely been out of the headlines since the start of the pandemic. It was hoped it might find a new use as a therapy in patients who are unwell with the novel coronavirus. But in recent weeks a scientific picture has emerged of a treatment that does not appear to be helping patients at all, and might even be causing harm.

Whether it helps seems clear now: it doesn’t. When it comes to the harm, though, it turns out that the scientific literature may be misleading. On June 4th the Lancet, a respected medical journal, retracted a high-profile paper published only a month previously. This had suggested that hydroxychloroquine and its analogue, chloroquine, actually increased the death rate in hospitals when taken by those with covid-19. This led the World Health Organisation to halt its trials of the drug. It also caused considerable concern to patients and to those enrolled on other such trials."

Hydroxychloroquine is embroiled in yet more controversy, The Economist

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Every dermatological disease assessed had a significant increase in TME when compared to the prior year. This increase was most significant for acne vulgaris (808%), psoriasis (792%), malignant skin neoplasms (716%), atopic dermatitis (609%), rosacea (566%) and contact dermatitis (529%). 

Published online 2021 Aug 19. doi: 10.1016/j.jid.2021.07.109

LB767 A multicenter analysis of patients using telemedicine for dermatological conditions during the COVID-19 pandemic

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'In conclusion, dermatologic patients had generally positive attitudes towards COVID-19 vaccination, and their preferences were affected by age.'

Attitudes of Dermatologic Patients Towards COVID-19 Vaccines: a Questionnaire-Based Survey

"COVID-19 knows no borders. During an international medical crisis, the global perspectives and insights from those in our field are invaluable. For instance, the regional differences observed in regard dermatologic manifestations of COVID-19, such as pernio-like lesions, could provide insight into various pathogenic mechanisms of COVID-19. Furthermore, it seems that a hybrid of teledermatology and in-person visits may be most ideal to reduce contact and potential transmission while also ensuring timely diagnosis and treatment of urgent skin disorders. Although responses to the pandemic varied depending on government leadership, culture, and resources, the lessons learned and experiences of dermatologists during this time can serve as a guidepost to help our field address new challenges as cases continue to escalate in parts of the world."

How Coronavirus Disease 2019 Changed Dermatology Practice in 1 Year Around the WorldPerspectives from 11 Countries

 

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