Jump to content
  • Sign Up
Sign in to follow this  
rss

PubMed RSS Feed - -Use of beta-blockers for rosacea-associated facial erythema and flushing: a systematic review and update on proposed mode of action.

Recommended Posts

Related Articles

Use of beta-blockers for rosacea-associated facial erythema and flushing: a systematic review and update on proposed mode of action.

J Am Acad Dermatol. 2020 Apr 29;:

Authors: Logger JGM, Olydam JI, Driessen RJB

Abstract
BACKGROUND: Flushing and erythema are frequent skin symptoms in rosacea. As their adequate treatment remains a clinical challenge, new treatment options are explored, such as oral β-blockers.
OBJECTIVE: To evaluate the efficacy of oral β-blockers for rosacea-associated facial flushing and erythema.
METHODS: PubMed, EMBASE, Web of Science, and Cochrane Library were systematically searched, including studies providing original data on the efficacy of oral β-blockers in rosacea patients with facial flushing and/or persistent erythema. Risk of bias was assessed using the Cochrane Risk of Bias tool, Newcastle-Ottawa scale, and Quality in Prognosis Studies tool.
RESULTS: Nine studies evaluating the use of carvedilol, propranolol, nadolol, and β-blockers in general were included. Articles studying carvedilol and propranolol showed a large reduction of erythema and flushing during treatment with a rapid onset of symptom control. Bradycardia and hypotension were the most commonly described adverse events.
LIMITATIONS: Most studies had a retrospective design with a small sample size, and outcome measurement was often subjective.
CONCLUSION: Oral β-blockers could be an effective treatment option for rosacea patients with facial erythema and flushing that does not respond to conventional therapy. Larger prospective trials with objective outcome assessment are needed to validate the promising results of these studies.

PMID: 32360760 [PubMed - as supplied by publisher]

{url} = URL to article

Share this post


Link to post
Share on other sites

Join the conversation

You can post now and register later. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.

Guest
Reply to this topic...

×   Pasted as rich text.   Paste as plain text instead

  Only 75 emoji are allowed.

×   Your link has been automatically embedded.   Display as a link instead

×   Your previous content has been restored.   Clear editor

×   You cannot paste images directly. Upload or insert images from URL.

Sign in to follow this  

×
×
  • Create New...