Jump to content
  • Sign Up
Sign in to follow this  

APOSEC for Rosacea Research

Recommended Posts

"APOSEC is a substance obtained from white blood corpuscles." [1] It is a biologic drug in clinical trials used in heart attacks, strokes, spinal cord injuries and for healing wounds. A paper suggests that APOSEC may help treat contact dermatitis. [2] APOSEC has shown to "induce angiogenesis, vasodilation, exert anti-microbial effects, inhibit thrombus formation, enhance the release of neurotrophic factors, and much more". [3] Watch this white board animation that explains APOSEC:

Since APOSEC may inhibit inflammation [2], who would sponsor any research related to rosacea on this? Could 10K members of the RRDi each donate a dollar to offer a clinician a motive to investigate this subject?

APOSEC is listed as one of the Biologic Treatments for Rosacea

What is APOSEC? 
"Secretome of Apoptotic Peripheral Blood Cells (APOSEC)" [4]

Would you like to sponsor research into this independently as a group of rosacea patient advocates in solidarity?  If we could gather 10K members into the RRDi and we all agreed to sponsor research into APOSEC for rosacea and each member donated one US$ dollar we could offer this to a clinician to investigate. At the very least, can you find the green reply button in this post and comment on this subject? 

End Notes

[1] Biologic drug APOSEC offers possible new treatments for dermal wounds, Medical University of Vienna, Science Daily

[2] Laggner, M., et al. (2020) Therapeutic potential of lipids obtained from γ-irradiated PBMCs in dendritic cell mediated skin inflammation. EBioMedicine. doi.org/10.1016/j.ebiom.2020.102774.

]3] Explain Secretome APOSEC, Focus Wound Healing, The Healing Power from Within, aposcience

[4] "Cell culture supernatants derived from irradiated apoptotic peripheral blood mononuclear cells (APOSEC)..." 
Basic Res Cardiol. 2011 Nov;106(6):1283-97.  doi: 10.1007/s00395-011-0224-6. Epub 2011 Sep 28.
Secretome of Apoptotic Peripheral Blood Cells (APOSEC) Confers Cytoprotection to Cardiomyocytes and Inhibits Tissue Remodelling After Acute Myocardial Infarction: A Preclinical Study
Michael Lichtenauer, Michael Mildner, Konrad Hoetzenecker, Matthias Zimmermann, Bruno Karl Podesser, Wolfgang Sipos, Ervin Berényi, Martin Dworschak, Erwin Tschachler, Mariann Gyöngyösi, Hendrik Jan Ankersmit

"paracrine factors secreted from apoptotic peripheral blood mononuclear cells (APOSEC)"

Basic Res Cardiol. 2012 Sep; 107(5): 292.
Secretome of apoptotic peripheral blood cells (APOSEC) attenuates microvascular obstruction in a porcine closed chest reperfused acute myocardial infarction model: role of platelet aggregation and vasodilation
K. Hoetzenecker, A. Assinger, M. Lichtenauer, M. Mildner, T. Schweiger, P. Starlinger, A. Jakab, E. Berényi, N. Pavo, M. Zimmermann, C. Gabriel, C. Plass, M. Gyöngyösi, I. Volf, H. J. Ankersmit

Share this post

Link to post
Share on other sites

Join the conversation

You can post now and register later. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.

Reply to this topic...

×   Pasted as rich text.   Paste as plain text instead

  Only 75 emoji are allowed.

×   Your link has been automatically embedded.   Display as a link instead

×   Your previous content has been restored.   Clear editor

×   You cannot paste images directly. Upload or insert images from URL.

Sign in to follow this  

  • Create New...