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Angiogenesis & VEGF

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"Vascular endothelial growth factor (VEGF), originally known as vascular permeability factor (VPF), is a signal protein produced by cells that stimulates vasculogenesis and angiogenesis." Wikipedia

"Angiogenesis is a physiological process involving the growth of new blood vessels from pre-existing vessels. Though there has been some debate over this, vasculogenesis is the term used for spontaneous bloodvessel formation, and intussusception is the term for new blood vessel formation by splitting off existing ones. Angiogenesis is a normal process in growth and development, as well as in wound healing. However, this is also a fundamental step in the transition of tumors from a dormant state to a malignant state. VEGF (Vascular Endothelial Growth Factor) has been demonstrated to be a major contributor to angiogenesis, increasing the number of capillaries in a given network." [1]

"Vascular endothelial growth factor (VEGF ) is an important signaling protein involved in both vasculogenesis (the de novo formation of the embryonic circulatory system) and angiogenesis (the growth of blood vessels from pre-existing vasculature). As its name implies, VEGF activity has been mostly studied on cells of the vascular endothelium, although it does have effects on a number of other cell types (e.g. stimulation monocyte/macrophage migration, neurons, cancer cells, kidney epithelial cells). In vitro, VEGF has been shown to stimulate endothelial cell mitogenesis and cell migration. VEGF is also a vasodilator and increases microvascular permeability and was originally referred to as vascular permeability factor." [2]

"Dr. Sandra Cremers, assistant professor of ophthalmology at Harvard Medical School, was awarded $25,000 for a study evaluating the role of angiogenesis (new blood vessel formation) in ocular rosacea. Dr. Cremers will investigate the levels of angiogenesis markers, such as vascular endothelial growth factor (VEGF ), in the conjunctiva and eyelids of patients with severe ocular rosacea, compared with normal subjects. She postulates that defining the role of angiogenesis in the development of ocular rosacea may bring focus to future research on this common rosacea subtype, and eventually lead to the development of an effective treatment." [3]

Dr. Cremers is a volunteer RRDi MAC member.

"Recently an increased of VEGF in Rosacea, a major mitogen for dermal microvascular endothelial cells is also reported." [4]

"VEGF, IL-2, IL-8 may be directly related to the mechanism of the development of cardiovascular disease in rosacea patients" [5]

Dobesilate

"The principal subtype of rosacea includes erythematotelangiestatic rosacea, which is characterized by uncontrolled angiogenesis. Angiogenic growth factors such as fibroblast growth factors (FGF) and vascular endothelial growth factor (VEGF) are currently targets of intense effort to inhibit deregulated blood vessel formation in diseases such as cancer. Here we report a 33-years-old woman with erythematotelangestatic rosacea who responds to a daily treatment of topically applied dobesilate, an inhibitor of FGF, with an improvement in erythema and telangectasia after two weeks. Thus, dobesilate might be useful in the treatment of rosacea and other diseases that depend on pathologic angiogenesis." [6]

"It should be also taken into account that, being FGF a necessary mediator of VEGF activity, dobesilate also inhibits this last signalling system, as it has been also recently described. The case report presented here is a representative example of five enrolled rosacea patients from a study directed to assess the long-term clinical benefit of dobesilate in rosacea. Taken together these data support a new therapeutic modality for a safe and efficient topical treatment of rosacea." [7]

End Notes

[1] http://en.wikipedia....ki/Angiogenesis

[2] http://en.wikipedia.org/wiki/VEGF

[3] http://www.rosacea.o...arded/index.php

[4] New aspects of the pathogenesis of rosacea
Sabine Fimmel, Mohamed Badawy Abdel-Naser, Heinz Kutzner, Albert M. Kligman, Christos C. Zouboulis
Arch Dermatol Res, DOI 10.1007/s00403-007-0816-z, 5 June 2007, Revised 28 September 2007 / Accepted 19 November 2007, Springer - Verlag 2007 Full Text

[5] VEGF and Rosacea

[6] Eur J Med Res. 2005 Oct 18;10(10):454-6.
Therapeutic response of rosacea to dobesilate.
Cuevas P, Arrazola JM.

[7] BMJ Case Rep. 2011; 2011: bcr0820114579.
Published online 2011 Oct 19. doi:  10.1136/bcr.08.2011.4579
PMCID: PMC3207764
Long-term effectiveness of dobesilate in the treatment of papulopustular rosacea
Pedro Cuevas, Javier Angulo, and Guillermo Giménez-Gallego

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"VEGF, IL-2, IL-8 may be directly related to the mechanism of the development of cardiovascular disease in rosacea patients"

RISK-FSCTORS OF CARDIOVASCULAR DISEASE IN PATIENTS WITH ROSACEA.
Georgian Med News. 2017 Jan;(262):49-52
Tsiskarishvili T, Katsitadze A, Tsiskarishvili NI, Chigladze V

"Recently, the role of vasoactive peptides has been increasingly discussed in the pathogenesis of rosacea. The most attention is paid to the growth factor of the vascular endothelium (VEGF). VEGF affects angiogenesis and survival of immature blood vessels."

Georgian Med News. 2018 Feb;(Issue):94-97.
[THE ROLE OF SOME VAZOACTIVE PEPTIDES IN THE PATHOGENESIS OF EARLY FORMES OF ROSACEA AND THE HEMOSTASIS SYSTEM].
Tsiskarishvili T1, Katsitadze A1, Tsiskarishvili NV1, Tsiskarishvili NI1.

J Dermatol. 2017 Jul;44(7):836-837. doi: 10.1111/1346-8138.13665.
Identification of an epidermal marker for reddened skin: Vascular endothelial growth factor A.
Kajiya K1, Kajiya-Sawane M1, Ono T1, Sato K2.

"Over the counter cosmetics sold for local treatment of slight to moderate rosacea often state the claim of actively modulating rosacea pathogenesis. Factors involved in the pathogenesis of this common yet complex skin disorder include kallikrein-related peptidase 5 (KLK5), LL-37, as well as protease-activated receptor 2 (PAR2) and vascular endothelial growth factor (VEGF)......We show evidence explaining the anti-inflammatory effect of Dermasence Refining Gel in rosacea pathogenesis in vitro. The adjunctive use of DRG in mild to moderate rosacea as a topical cosmetic seems medically reasonable."

J Cosmet Dermatol. 2017 Dec;16(4):e31-e36. doi: 10.1111/jocd.12323. Epub 2017 Mar 27.
Dermasence refining gel modulates pathogenetic factors of rosacea in vitro.
Borelli C1, Becker B2, Thude S3, Fehrenbacher B1, Isermann D4.

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