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  1. Today
  2. "In conclusion, we have found that LCs are essential for maintaining subbasal nerve health and for regulating ocular surface inflammation in DE disease." PLoS One. 2017; 12(4): e0176153. Published online 2017 Apr 25. doi: 10.1371/journal.pone.0176153 PMCID: PMC5404869 Langerhans cells prevent subbasal nerve damage and upregulate neurotrophic factors in dry eye disease Eun Young Choi, Hyun Goo Kang, Chul Hee Lee, Areum Yeo, Hye Mi Noh, Nayeong Gu, Myoung Joon Kim, Jong Suk Song, Hyeon Chang Kim, and Hyung Keun Lee
  3. Yesterday
  4. "While many people may find their skin gets sensitive and red at times, for people with rosacea these symptoms are more serious and permanent." BEAUTYGLOSSARY: WHAT IS ROSACEA?, Bazaar
  5. "Allergan plc, (NYSE: AGN), a leading global pharmaceutical company, announced that Emmy® and Tony® award-winning actress and singer, Kristin Chenoweth will kick off the "Less Red, More You" campaign today at an exclusive event in New York City. As part of the campaign, Ms. Chenoweth, who suffers from rosacea, will ignite a nationwide conversation about the typically underserved condition while raising awareness for RHOFADE™ cream, a new product indicated for the topical treatment of persistent facial erythema associated with rosacea in adults." Kristin Chenoweth Kicks Off 'Less Red, More You' Campaign To Launch RHOFADE™ (Oxymetazoline HCL) Cream, 1%, PR Newswire
  6. Last week
  7. Surgical treatment of rhinophyma: experience from a German cohort of 70 patients. Eur J Dermatol. 2017 May 19;: Authors: Schweinzer K, Kofler L, Spott C, Krug M, Schulz C, Schnabl SM, Breuninger H, Häfner HM, Eberle FC Abstract Rhinophyma is a deforming soft tissue hyperplasia of the nose and surgical removal represents the treatment of choice. Comprehensive data on surgical therapy and the impact of rhinophyma on patient quality of life are lacking. Patients who received surgery for rhinophyma between 2006 and 2015 were retrospectively evaluated for postoperative complications, clinical outcome, recurrence of rhinophyma, and the impact of rhinophyma on daily life. A total of 143 patients were treated with superficial tumour decortication by scalpel under tumescent anaesthesia. Outcomes were determined by clinical review, clinical files, and a patient questionnaire. Of 143 patients, 70 answered the questionnaire and were included in this study with a mean follow-up time of 54 months. Cosmetic results were evaluated as very good or good in 77% of patients. The majority of patients (87%) were very satisfied or satisfied with the postoperative result. Surgical treatment of rhinophyma improved patients' quality of life in 67% of patients. Recurrence of rhinophyma was detected in 38% of patients. Surgery is an effective therapy for rhinophyma with excellent outcome. PMID: 28524054 [PubMed - as supplied by publisher] {url} = URL to article
  8. Cutaneous adverse effects during ipilimumab treatment for metastatic melanoma: a prospective study. Eur J Dermatol. 2017 May 19;: Authors: Dika E, Ravaioli GM, Fanti PA, Piraccini BM, Lambertini M, Chessa MA, Baraldi C, Ribero S, Andrea A, Melotti B, Patrizi A Abstract Ipilimumab is an immunomodulatory antibody directed against cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), which is administered to patients with advanced melanoma, with a proven positive effect on overall survival. The cutaneous adverse effects (AEs) of ipilimumab are relatively frequent, although described as usually mild and rarely life threatening. To describe a three-year experience of a single institute in detecting and managing cutaneous AEs. A cohort of patients (n = 41) treated with ipilimumab (3 mg/kg/three weeks) for metastatic melanoma, from 2013 to 2016, was investigated for adverse cutaneous events. On dermatological evaluation, 34.1% of the patients in our series developed cutaneous AEs: rash (7.3%; n = 3), folliculitis (7.3%; n = 3), mucositis (2.4%; n = 1), rosacea (2.4%; n = 1), eczema (2.4%; n = 1), acneiform eruption (2.4%; n = 1), syringometaplasia mucinosa (2.4%; n = 1), Stevens-Johnson syndrome (2.4%; n = 1), and vitiligo (4.9%; n = 2). These were all Grade 1 and 2 AEs, except for the case of Stevens-Johnson syndrome (Grade 4). On a patient-reported scale, 4.9% (n = 2) and 9.8% (n = 4) of the patients complained of severe xerosis and pruritus, respectively. Ipilimumab was relatively well tolerated in our series, mainly causing mild cutaneous AEs, which, in our experience, responded satisfactorily to conventional therapies. Only in one case the treatment was discontinued, due to Grade 4 side effects. PMID: 28524050 [PubMed - as supplied by publisher] {url} = URL to article
  9. Related Articles Oxymetazoline cream (Rhofade) for rosacea. Med Lett Drugs Ther. 2017 May 22;59(1521):84-86 Authors: PMID: 28520699 [PubMed - in process] {url} = URL to article
  10. Related Articles Comparison table: some topical drugs for rosacea. Med Lett Drugs Ther. 2017 May 22;59(1521):e92 Authors: PMID: 28520703 [PubMed - in process] {url} = URL to article
  11. "When treating rosacea, I always prescribe topical agents first and, if necessary, add an oral medication. I wean my patients off of oral medication as soon as possible and use a maintenance topical regimen to keep their skin clear," says Carin H. Gribetz, MD, assistant clinical professor of dermatology at Mount Sinai Hospital in New York. A Side-by-Side Look at the Most Common Rosacea Treatments, by Elizabeth Szaluta, MPH, Medscape
  12. A Link to One Type in Particular Has Been Established. Patients with rosacea often experience flushing and paroxysmal burning of the face and chest—a phenotype termed "neurogenic rosacea." Intriguingly, patients with neurogenic rosacea also may have a higher prevalence of migraines (recurrent headaches and nausea, triggered by light or sound). Graeme M. Lipper, MD, Medscape, News & Perspective > Viewpoints Prevalence and Risk of Migraine in Patients With Rosacea: A Population-Based Cohort Study Egeberg A, Ashina M, Gaist D, Gislason GH, Thyssen JP J Am Acad Dermatol. 2017;76:454-458.
  13. Earlier
  14. Thats a nice improvement Brady. I take it that Avar is a green coloured cream which masks the redness somewhat as well as being antibacterial and anti inflammatory? What about your diet. Do you still have to avoid carbs while using Avar?
  15. Thought I would update my Soolantra thread. I stopped Soolantra as you can review on February 13. I then got some samples from my dermatologist with the following prescription treatments: Avar-e Green Color Corrective Emolilent Cream (sodium sulfacetamide 10%, sulfur 5%) Ovace Plus Cream (sodium sulfacetamide 10%) Ovace Plus Lotion (sodium sulfacetamide 9.8%) My dermatologist gave me a number of Soolantra samples too! In March, April and through today I would try the above three samples alternatively as well as use Soolantra once in a while (about once a week). I have found that the Avar-e Green seems to work the best for me. However the other day I got a sunburn because I go to the beach and swim just about every day and really got burnt. Not good for rosacea. But I have enclosed some update photos. I will continue to use this thread to post my regimen.
  16. I see. I know that low carb/high protein helps control my rosacea. I think that Soolantra works for some just like just about every other treatment or rosacea. I do think it is worth trying out since so many say it works for them. Soolantra is definitely one of the treatments in the armamentarium for rosacea.
  17. Related Articles Inhibition of mast cell infiltration in an LL-37-induced rosacea mouse model using topical brimonidine tartrate 0.33% gel. Exp Dermatol. 2017 May 13;: Authors: Kim M, Kim J, Jeong SW, Jo H, Woo YR, Park HJ PMID: 28500634 [PubMed - as supplied by publisher] {url} = URL to article
  18. "Rosacea can be referred to as “adult acne” and this is a different entity altogether – rosacea is an inflammatory condition that can cause redness and/or acne-like bumps on the face. It can be triggered by sun exposure, stress, spicy foods and alcohol. There are topical and oral treatment options available depending on disease severity." DocTalk: Dr. Megan Joint, By Katie Green, Observer-Reporter
  19. "“I immediately notice the quality of the skin and hair, which gives me tremendous insight into the patient’s diet and stress levels,” says Whitney Bowe, MD, a board-certified Dermatologist in New York City." This Is the First Thing Your Dermatologist Notices About You BY AUBREY ALMANZA, Reader's Digest
  20. "At the age of 46, Pamela was suffering from an advanced form of rosacea called rhinophyma. However, the cause of this unusual growth of nose condition is unknown, but it commonly develops after rosacea begins on the face between the ages of 25 and 50. She tried every medicine prescribed by the doctor but nothing worked. She was suffering from an unfortunate medical condition. After her interview being telecasted on TV, she was offered free surgery by Dr. Ann Zedlitz to correct the growth of her nose! And today, after her surgery she looks like this now!" HER NOSE STARTED TO GROW UNCONTROLLABLY AT AGE 15, TODAY SHE LOOKS LIKE THIS By Akanksha Manhas, PagalParrot More on Phenotype Phymatous
  21. Related Articles The Role of Skin Care in Optimizing Treatment of Acne and Rosacea. Skin Therapy Lett. 2017 May;22(3):5-7 Authors: Zip C Abstract A triad approach to the treatment of acne and rosacea has been recommended. This integrated management approach includes patient education, selection of therapeutic agents, and initiation of an appropriate skin care regime. Proper skin care in patients undergoing treatment of both acne and rosacea includes use of products formulated for sensitive skin that cleanse, moisturize and photoprotect the skin. Both acne and rosacea are associated with epidermal barrier dysfunction, which can be mitigated by suitable skin care practices. Appropriate skin care recommendations for patients with acne and rosacea will be discussed. PMID: 28492949 [PubMed - in process] {url} = URL to article
  22. Laser is usually the preferred way to remove spider veins. Joe Niamtu, III, MD, show how he does it with the handy dandy Iridex 940 laser:
  23. Tom Busby, expert extraordinaire at RF, wrote "VeinWave, or the newer version, VeinGogh, will remove facial spider veins. A needle about the size of a human hair, with a small electric current, heats up the vein and coagulates the blood. Then the blood is reabsorbed and the skin is clear." 4th June 2013 03:32 AM Post #7 "Vein wave is a through the skin radiofrequency treatment for small visible veins. This has very little recovery and little bruising and works fairly well, the main issue is to find an office that has a machine made within the last year (only 5 in US) as previous models were underpowered and may not have resulted in complete treatment." Jordan Knepper, MD Ann Arbor Vascular Surgeon, realself, July 26th, 2016 "There are many ways to remove surface veins. I would suggest laser therapy instead of vein wave to eliminate facial spider veins. Laser can be more powerful than RF." Dr. Karamanoukian, Los Angeles, realself, January 4, 2017 Albert Malvehy, MD, treats this unwanted occurrence using foam sclerotherapy.
  24. Rosacea Therapeutics Market Pipeline Review H1 2017
  25. Looks like the NRS is responding to the new phenotype classification of rosacea by the ROSCO panel with this abstract. We await the full article to view all the content.
  26. Related Articles The Role of Skin Care in Optimizing Treatment of Acne and Rosacea. Skin Therapy Lett. 2017 May;22(3):5-7 Authors: Zup C Abstract A triad approach to the treatment of acne and rosacea has been recommended. This integrated management approach includes patient education, selection of therapeutic agents, and initiation of an appropriate skin care regime. Proper skin care in patients undergoing treatment of both acne and rosacea includes use of products formulated for sensitive skin that cleanse, moisturize and photoprotect the skin. Both acne and rosacea are associated with epidermal barrier dysfunction, which can be mitigated by suitable skin care practices. Appropriate skin care recommendations for patients with acne and rosacea will be discussed. PMID: 28486718 [PubMed - in process] {url} = URL to article
  27. Related Articles Updating the diagnosis, classification and assessment of rosacea by effacement of subtypes. Br J Dermatol. 2017 May 06;: Authors: Wilkin J Abstract Tan, et al.,(ROSCO) propose to "transition beyond a subtype classification", which they ascribe to the National Rosacea Society's Classification of Rosacea (NRSCOR), asserting "Subtype classification may not fully cover the range of clinical presentations and is likely to confound severity assessment, whereas a phenotype-based approach could improve patient outcomes by addressing an individual patient's clinical presentation and concerns"(1). NRSCOR did not invent the phenotypic subtypes, described by expert dermatologists over preceding decades, but sought a common terminology for use in communicating ideas about rosacea (compare use in Fig. 1 by ROSCO). NRSCOR emphasized the potential evolution from one phenotypic subtype to another, and that phenotypic subtypes can occur together. ROSCO's claimed 'phenotypic approach' seems to be simply the elimination of these phenotypic subtypes. This article is protected by copyright. All rights reserved. PMID: 28477357 [PubMed - as supplied by publisher] {url} = URL to article
  28. Importance There is a limited therapeutic armamentarium for recalcitrant cases of childhood rosacea. Observations We report the case of a 12-year-old girl who presented with severe ocular and cutaneous rosacea unresponsive to oral doxycycline, oral isotretinoin, and topical tacrolimus. A biopsy specimen showed numerous mites within the folliculosebaceous unit. Treatment with a single dose of oral ivermectin achieved resolution of her symptoms. Conclusions and Relevance The causative role of Demodex folliculorum should be considered in immunocompetent children with rosacea or rosacea-like refractory eruptions. In such cases, treatment with ivermectin can be beneficial. Case Report/Case Series The cutting Edge January 2014 Severe Demodexfolliculorum–Associated Oculocutaneous Rosacea in a Girl Successfully Treated With Ivermectin Megan Brown, MD; Angela Hernández-Martín, MD; Ana Clement, MD; et al PubMed
  29. Related Articles More than meets the (painful red) eye. Aust Fam Physician. 2016 Jun;45(6):383-4 Authors: Navaratna AF, Walsh A, Magin P PMID: 27622227 [PubMed - indexed for MEDLINE] {url} = URL to article
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