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About Matthew

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  • Are you a rosacean?
  1. Hi Dr Goldberg, Thank you for joining the RRDi, Your expertise is much appreciated. Can I please ask you the following questions. 1) In reference to an article from the Dermatology Times. http://www.dermatologytimes.com/dermatolog...p;&pageID=1 The following is a quote "Each technology does something a little different," Dr. Goldberg says. "The yellow LED and IPL both lessen redness” There has been much debate within the Rosacea community about which wavelength and power level provides the most beneficial results for Rosacea. Why is the yellow LED spectrum (around 590nm) affective for reducing redness? Would you be able to show us some supportive evidence or testimonials? I have seen a few studies regarding Red and Infrared LED’s that show evidence of a reduction of inflammation, but no studies conducted on yellow LED’s 2) Why does LED therapy lighten the skin tone? this has been something that many users have commented on. Does this pose any risk to us Rosaceans? 3) I have read that two factors which increase angiogenesis are Fibroblast Growth Factors (FGF) and Vaso-Endothelial Growth Factors (VEGF). In reference to the following NASA study on LED Wound healing in Humans, http://www.lighttherapyproducts.com/LEDNasastudy.html Figure 2 and Figure 3 show the change in VEGF and FGF levels respectively. With reference to Figure 2, the ‘LED only’ curve shows a slight reduction in VEGF levels when compared with the ‘control’ curve (which I assume is good news to us) However, with reference to Figure 3, the ‘LED only’ curve is greater than the ‘control’ curve during the healing process and stays higher on exposure. I would like to know your opinions on whether this stimulation of FGF could contribute to Angiogenesis and just your thoughts in general on LED therapy and angiogenesis. Anxiously awaiting your reply with many thanks, Matthew
  2. INTRODUCTION I have been doing some experimentation with LED therapy and would like to recommend some research be done on human trials, specifically in relation to the reduction of flushing, redness and inflammation associated with Rosacea. SUPPORT ARTICLES Below are a collection on publications that provide some evidence of the benefits of LED therapy: 1) Reduction of PGE(2) Levels (Using 830nm) http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15684758&query_hl=14&itool=pubmed_docsum 2) Reduction of VEGF, Increased cell production rate by 150-200% (Using 680,730,880nm@4J/cm2) http://www.lighttherapyproducts.com/LEDNasastudy.html 3) Reduction of TNFalpha levels which contribute to inflammation http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16503786&query_hl=3&itool=pubmed_docsum 4) Increase in anti-oxidant levels (Using 810nm) http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15954814&query_hl=3&itool=pubmed_docsum 5) Increase in Superoxide Dismutase levels http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12815857&query_hl=59&itool=pubmed_docsum 6) Reduction of acute inflammation (Using 660nm & Suggesting 7.5J/cm2) http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16144480&query_hl=3&itool=pubmed_docsum 7) Inhibiting of the sensitization increase of nociceptors on the inflammatory process (Using Red - 632.8nm@2.5J/cm2) http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15910182&query_hl=3&itool=pubmed_docsum 8) Low-level laser therapy can reduce lipopolysaccharide-induced contractile force dysfunction and TNF-alpha levels in rat diaphragm muscle http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17033742&query_hl=1&itool=pubmed_docsum (Thanks to Dan fries for contributing some of these links) PROCEDURE I have constructed a small diversity of LED arrays, with varying luminosity and wavelengths and would like to see a clinical trial take place. There are many studies around that show LED therapy has beneficial results for the reduction of inflammation but there is such a wide range presented and it would be most greatly appreciated among the Rosacea community if a concrete answer was given. For example ‘X’ wavelength with ‘Y’ power for ‘Z’ amount of time works best and this is the evidence that supports it. I live in the Sydney CBD and would very gratefully construct numerous LED arrays for a willing medical practitioner/dermatologist who could help to find some concrete evidence into which is the best treatment wavelength, strength and exposure time, and prove that it is a beneficial and effective treatment for Rosacea. This could involve a test process with a few trial patients on exposure to a variety of LED arrays of varying wavelength, luminosity and exposure times. It would be excellent if there was a willing medical practitioner/dermatologist in the Sydney CBD area who could devise a number of tests that could prove the validity of the claims that LED therapy is an effective treatment. GOAL AND OUTCOMES The main purpose is to find the most effective arrangement, Strength and wavelength of LED arrays to treat Rosacea as effectively as possible. Once this is found, and supported by a medical practitioner/dermatologist, The RRDi could then release a commercial product based on our findings which could be purchased by Rosacea sufferers, where profits could be used to support the RRDi. I have seen great results from using LED therapy myself and am dedicated to refine the models and produce the best solution possible. Although this is not a cure, which is the most important focal point, it is a very effective treatment. For a small amount of some professionals time, this could prove to help manage rosacea and help to fund the RRDi until a cure is found. Matthew.
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