for a PhD trained investigator like myself it is difficult to judge how safe it would be to inject the drugs you mention in skin (to prevent regrowth of blood vessels). I think you make a very good argument though. Before wondering whether it would be a safe treatment, one should find out if your idea has merit. One can test your hypothesis in a model situation (i.e. in skin explants from afflicted human skin; systemic concerns, of what side-effects the drugs have on blood vessels elsewhere in the body are there by taken out of consideration) and see if bloodvessel growth is inhibited after treatment. it would be exciting to find out whether this is the case or not. In the event of positive outcome, safety should be tested for, which can initially be done in animal models that harbor pieces of human skin. eventually one has to test in human skin of afflicted rosacea individuals obviously, which is a long, very long road to go, but that is true for all new treatments.