dfries2003
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Hi Dr Stratton & all,
Thanks so much for your comments. I also believe strongly that additional research and/or studies are the best way to address the issue of any potential link between Cpn and rosacea.
BTW, I also believe Steve posted his question prior to your reply in the Rosacea and Chlamydia pneumoniae thread and also prior to my editing out the information about NAC. Sorry for the confusion. I've since moved the information about a potential link between Cpn and Rosacea to the RSRP wiki to avoid having old copies of the pdf floating around:
http://rosacea-research.org/wiki/index.php...ydia_pneumoniae
JimK, founder of the website cpnhelp.org asked me to put together a page as well for the cpnhelp website identifying the support for a potential link between Chlamydia pneumonaie and rosacea. He also made quite a few very helpful suggestions for doing so, and I believe this new page presents a much clearer case for a potential link:
http://www.cpnhelp.org/chlamydia_pneumoniae_an_0
The page was just added to cpnhelp today and we are soliciting input for changes to strengthen the case further. We'd of course appreciate any suggestions from you and other members of the RRDi MAC as well.
Thanks again...
Dan
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Hi Doctors,
Thanks so much for your explanations. I found them very interesting. But I'm curious. Along these lines, given recent studies like the following which suggest that "vascular endothelial growth factor (VEGF) protein is a key biomarker for sepsis", in addition to other studies that suggest that elevated MMPs are also the rule with sepsis, why wouldn't medical researchers immediately suspect the potential involvement of any bacteria (such as C. pneumoniae) known to persist in the blood vessels themselves in all diseases that involve increased VEGF production, leaking blood vessels and destruction of surrounding tissues (i.e. Macular Degeneration, MS, Crohn's Disease, Interstitial Cystitis, and Rosacea)?
New Study Finds Key Role For VEGF In Onset Of Sepsis
FYI, I had an interesting discussion about this (posting as Red) with Dr Wheldon, Microbiologist and FCRPATH (posting as DW) on Cpnhelp starting at the following link:
http://www.cpnhelp.org/?q=multiple_scleros...ge#comment-9230
It seems so obvious to me. Am I missing something?
Dan
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Thank you again Dr Stratton. Since discusions about NAC alone therapy were really just speculations mostly on my part, I've removed this discussion from the document I put together linking Cpn and Rosacea:
http://rosacea-research.org/wiki/index.php...ydia_pneumoniae
Thanks again so much for your input.
All, I (as Red) had an interesting exchange with Dr Wheldon (as DW) on cpnhelp over the weekend relating to the underlying pathology in many of the chronic disorders that have been linked with Chlamydia pneumoniae, namely a pathology of small blood vessel disease or vasculitis, localized tissue destruction, and nerve involvement. Evidently this pathology can be found in inflammatory disorders such as multiple sclerosis, Crohn's disease and interstitial cystitis as well as rosacea:
http://www.cpnhelp.org/?q=multiple_sclerosis_damage
Dan
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Hi All,
And welcome Dr Stratton. Its good to see you on board. I personally cannot thank you enough for all your efforts in studying Cpn and its potential involvements in inflammatory diseases.
Although I still have a ways to go in treatment, my rosacea is now pretty much gone except on occasion. And although I started treatment with great hopes that the link between rosacea and Cpn was a strong possibility and have seen same wonderful results in treatment so far myself, I was greatly encouraged recently when I made contact with one patient on an early Vanderbilt anti-Cpn protocol who reported that her rosacea disappeared completely in 2004 with Cpn treatment and has not returned since (I use the nic "Red" when posting on cpnhelp):
http://www.cpnhelp.org/?q=no_herx_ing_no_metronidaz
She (Astrodiana) wrote:
"My rosacea began at about age 40 and disappeared thelast year I was on the cPn protocol, age 54. it beganwith flushing and burning, usually when I was active,but there was no predicting when it might happen. Itwas mainly on my face, but sometimes down my neck,and after a couple of years of this, it progressed toa few broken blood vessels and occasional breakoutsaround my mouth and chin usually. I would describe itas cycstic acne...and my skin had always been veryclear. I used to love the sun and tan well, but afterthe rosacea began, I would just break capillairieswhen I would be out in the sun. Went to thedermatologist, and began taking minocycline 100mgsdaily and using topical metrogel on my face day andnight - this was age 43. I was told to avoid hotshowers and baths and hot drinks, alcohol, and spiceyfoods...I don't drink but I had one sip of wine acouple of times on holidays and went into a full flareup of the skin. The dermatologist also told me thatsinus problems go hand in hand with rosacea, and isure had those. Her treatments seemed to do little ornothing for my rosacea, but when I mentioned to myholistic MD that I had been dx'd with rheumatoidarthritis at age 26, he talked about The Road BackFoundation having found that many cases of RA could betreated with minocycline for at least 48 weeks and seeat least some imrpovement, all the way up to remission(back then, they did not realize it was MYCOPLASMSthey were attacking the the minocin)...since I hadalready been on the minocin for about 5 months at thattime, my MD suggested that I stay on it, add DHEA andsee what it could do for my rosacea. I stayed on theMinocin @ 100mgs daily for one year. At the end ofthat time, my RA was gone! Sed rate normal, RA factorGONE, and seemingly complete healing. I have had nosigns of RA since then.But the rosacea stayed with me...and was only slightlyless likely to flare with the use of metrogel day andnight. I found that an injection of Medrol forallergies given by my internist works well to calmdown and clear the skin of rosacea symptoms...and fora few years I got those shots as often as he wouldgive them to me...every two months. It now seems tohave disappeared completely, and that happenedsometime in 2004, a few months after I finished myprotocol. 2004 was the first year i could go withoutthe shot of medrol and not have the rosacea flaringup. The last two years, I have only gotten one shot ayear, during tree pollen season in Spring. I justlooked in the mirror...the broken capillaries are gonefrom my face and around my nose, and there are only afew very faint traces of broken blood vessles left onmy nose. I flush still, probably once every fewmonths, but it goes away and leaves no other skinproblems behind.Not sure what ocular rosacea is, but i imagine if itis bloodshot eyes, YES - I had that as often as itwould flare. My eyes would get dry and itch a lottoo. All gone now"And further wrote:
" haven't thought about it until you asked...which isGOOD, I guess - but I actually CAN use just aboutanything on my face now - and usually just use thesafeguard soap in the shower to wash my face or alight facial cleanser... before, could never even usemakeup, a moisturizer, any product made for senstiveskin. If I tried to make my face up, I would be sobroken out by the time I got to wherever I was going,I looked worse than with no make up. Rosacea andvanity cannot coexist. the best I could hope for wasclean.The fact that my skin is clear now is a bonus I neverexpected or dared to consider. I am also verysurprised that the broken capillaries are gone...thatis something NOBODY told me could happen. I can nowwear make-up or look good without it. I can travelwithout a lot of junk in my cosmetic bag that won'thelp anyway. yes....YES!!! I go like "normal people"now!"Oh to be able to throw away all the special cleansers and moisturizers and just wash my face in the shower, with safeguard soap no less...
FYI, in order to prevent issues of versioning, I've moved the pdf doc above linking Cpn with Rosacea to the RSRP pages. I've also updated the doc to include some additional information to try to strengthen the link according to some of the comments above. The RSRP page on Cpn can be found at this link:
http://rosacea-research.org/wiki/index.php...ydia_pneumoniae
I've also blogged a chronicle of my treatment for Cpn and Rosacea on the cpnhelp website in hopes that it may help other rosaceans in the future:. I'll continue to update this chronicle as I continue treatment:
http://www.cpnhelp.org/?q=cpn_treatment_for_rosacea
Dan
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Thanks Steve.
All,
I've found some studies which also seem to suggest that in addition to being antichlamydial, N-acetyl cysteine seems to have antiangiogenic properties:
http://ajp.amjpathol.org/cgi/content/full/164/5/1683
N-Acetyl-Cysteine Promotes Angiostatin Production and Vascular Collapse in an Orthotopic Model of Breast Cancer
http://www.ncbi.nlm.nih.gov/entrez/query.f...l=pubmed_docsum The induction of vascular endothelial growth factor by ultrafine carbon black contributes to the increase of alveolar-capillary permeability
http://www.ncbi.nlm.nih.gov/entrez/query.f...l=pubmed_docsum Inhibition of angiogenesis-driven Kaposi's sarcoma tumor growth in nude mice by oral N-acetylcysteine
http://www.ncbi.nlm.nih.gov/entrez/query.f...l=pubmed_DocSum Vascular endothelial growth factor (VEGF) and melanoma. N-acetylcysteine downregulates VEGF production in vitro
And studies seem to suggest that NAC can reduce upgregulated inducible nitric oxide (iNOS) production:
http://www.ncbi.nlm.nih.gov/entrez/query.f...l=pubmed_docsum N-acetylcysteine prevents nitrosative stress-associated depression of blood pressure and heart rate in streptozotocin diabetic rats
http://www.ncbi.nlm.nih.gov/entrez/query.f...l=pubmed_docsum Protective effects of N-acetylcysteine treatment post acute paraquat intoxication in rats and in human lung epithelial cells
Rosacea and Chlamydia pneumoniae
in Ask the MAC
Posted
Hi All,
I just noticed the Fernandez-Obregon / Patton study I orignally referenced which implicated C. pneumoniae with rosacea has now been included in the current issue (Feb 2007) of Cutis (Cutaneous Medicine for the Practicioner):
http://www.cutis.com/asp/archive/article.a...mp;FileType=abs
The abstract on Cutis now also states: "These preliminary data suggest the need for further investigation with clinical trials to study long-term tolerability and efficacy and also strongly implicate C pneumoniae in the pathogenesis of acne rosacea.".
Strongly implicated! Alright. Of course as Dr Stratton's research indicates, single antibiotic therapy is very unlikely to eradicate a persistent C. pneumoniae infection. Still, hopefully this article will help generate some research interest.
BTW, although it was also pointed out in the linkout above, I've recently created a page pointing out the potential link between C. pneumoniae and rosacea for cpnhelp.org, and I believe this page better explains the potential link than my original attempt:
http://www.cpnhelp.org/chlamydia_pneumoniae_an_0
Dan