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  1. Hydroxychloroquine (brand name Plaquenil) [and the related drug, chloroquine (brand name Arelene)] has been in the news for its alleged ability to treat coronavirus, mostly due to President Trump’s advocacy on its use during the pandemic. This subject has ‘divided the medical community’ according to The New York Times. The American Society for Biochemisty and Molecular Biology reports that there are few published papers on this subject, acknowledging that one small study in France was 'encouraging,' however, other reports indicate that hydroxychloroguine are 'not effective for treating coronavirus.' [1] According to Forbes, the FDA "The Food and Drug Administration on Sunday issued an emergency authorization for experimental coronavirus treatments using chloroquine and hydroxychloroquine, anti-malaria drugs touted by President Donald Trump despite inconclusive clinical proof of their efficacy." Hydroxychloroquine has been shown to be effective in treating rosacea. [2] Duffman reported in April 2017, "The only thing that finally worked for me with long lasting, real remission, is plaquenil." [3] Dan Charles, on April 3, 2020, NPR reports, "Dr. Anthony Fauci of the National Institutes of Health was asked March 24 whether the drug was considered a treatment for the novel coronavirus."The answer is no," he said, "and the evidence that you're talking about ... is anecdotal evidence." " James Hamblin, MD, staff writer for The Atlantic, wrote an article on the history of this subject on April 6, 2020 explaining in detail how the president has been advocating the use of this drug for the coronavirus epidemic, and concludes, "It is unclear how hydroxychloroquine would work to treat COVID-19, but the drug is one of many now being urgently studied for the treatment of the disease." [4] One other anti-parasitic drug being studied is ivermectin, another treatment for rosacea. [5] The American Academy of Ophthalmology states on its website concerning hydroxychloroquine and chloroquine that, "These drugs may stop the immune system from going overboard in its attack on the virus." [6] If you are interested in a clinical trial with hydroxychloroquine you may want to contact Elizabeth Oelsner, Columbia University. Of course, you won't be able to know whether you actually receive hydrochloroquine or the placebo. The CDC lists on it's Information for Clinicians on Therapeutic Options for COVID-19 Patients that "Hydroxychloroquine is currently under investigation in clinical trials for pre-exposure or post-exposure prophylaxis of SARS-CoV-2 infection, and treatment of patients with mild, moderate, and severe COVID-19." A Chinese clinical study published in Cell Discovery concluded, "In conclusion, our results show that HCQ can efficiently inhibit SARS-CoV-2 infection in vitro. In combination with its anti-inflammatory function, we predict that the drug has a good potential to combat the disease. This possibility awaits confirmation by clinical trials." [7] Another Chinese study states, "In this study, hydroxychloroquine exhibited better in vitro anti-SARS-CoV-2 activity than chloroquine." [8] The French study that may have started all this states, "In conclusion, we confirm the efficacy of hydroxychloroquine associated with azithromycin in the treatment of COVID-19 and its potential effectiveness in the early impairment of contagiousness. Given the urgent therapeutic need to manage this disease with effective and safe drugs and given the negligible cost of both hydroxychloroquine and azithromycin, we believe that other teams should urgently evaluate this therapeutic strategy both to avoid the spread of the disease and to treat patients before severe irreversible respiratory complications take hold." [9] End notes [1] A small trial finds that hydroxychloroquine is not effective for treating coronavirus, Katherine Seley-Radtke, April 05, 2020, ASBMBTODAY [2] Int Immunopharmacol. 2020 Jan 06;79:106178 Hydroxychloroquine is a novel therapeutic approach for rosacea. Li J, Yuan X, Tang Y, Wang B, Deng Z, Huang Y, Liu F, Zhao Z, Zhang Y [3] Plaquenil (Hydroxychloroquine) [4] Why Does the President Keep Pushing a Malaria Drug?, The Atlantic The Guardian also has its version of the history of this subject. [5] Ivermectin Treats Coronavirus [6] Treating Coronavirus With Plaquenil and Aralen, Reena Mukamal, AAO [7] Cell Discov 6, 16 (2020). Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro Jia Liu, Ruiyuan Cao, Mingyue Xu, Xi Wang, Huanyu Zhang, Hengrui Hu, Yufeng Li, Zhihong Hu, Wu Zhong & Manli Wang [8] ciaa237.pdf [9] COVID-IHU-2-1.pdf
  2. In a related news item, Ivermectin, another anti-parasitic drug, has been purported to treat coronavirus.
  3. In a related news item, Plaquenil (Hydroxychloroquine), another anti-parasitic drug, has been purported to treat coronavirus. Read the third post in this thread.
  4. "It’s still not clear exactly how Ivermectin works. But it appears to stop the processes that allow proteins to move within the virus. These proteins would normally dampen the body’s antiviral response, allowing the virus to replicate and enhance the infection." Head lice drug Ivermectin is being tested as a possible coronavirus treatment, but that’s no reason to buy it, April 6, 2020, Andrew McLachlan, The Conversation "Wagstaff cautions that these are very early test results and much more will need to be done, including clinical trials and human testing and will be necessary before any action can be taken. But, he says, it’s a sign of hope." Researchers discover anti-parasite drug kills coronavirus in lab, Chris Patrick, Sunday, April 5, 2020, Trib
  5. There are multiple news reports that ivermectin, a common drug used to treat rosacea orally and topically, has been found effective in treating the coronavirus (scoll down for more reports). Virus and rosacea has never, ever been ruled out. A collaborative study led by the Monash Biomedicine Discovery Institute and the Doherty Institute found the drug Ivermectin stops coronavirus growing in cell culture." Warning issued as researchers reveal another potential treatment for coronavirus, ABC News Australia "Researchers at Monash University in Melbourne, Australia have discovered that the antiparasitic drug Ivermectin can inhibit replication of SARS-CoV-2, the virus the causes COVID-19, according to a study published Friday in the journal Antiviral Research....Ivermectin has been widely used since the 1980s to treat head lice, scabies and several other infections caused by parasites. The drug is also used to treat the skin condition rosacea." [bold added] ANTI-PARASITE DRUG USED SINCE 1980S MAY HELP STOP CORONAVIRUS, NEW STUDY SAYS BY AILA SLISCO ON 4/3/20 AT 10:46 PM EDT, 3 April 2020, Newsweek The report by Caly et al is published in Antiviral Research, funded by a National Breast Cancer Foundation Fellowship, is cited below: Antiviral Research Available online 3 April 2020 The FDA-approved Drug Ivermectin inhibits the replication of SARS-CoV-2 in vitro Leon Caly, Julian D.Druce, Mike G.Catton, David A.Jans, Kylie M.Wagstaff Science Daily • Drugs.com • Nature World News • EurekaAlert! • Futureism/Neoscope • Pharmaceutical Technology • SciTechDaily • PHARMAfield • The US Sun • Archyde • Metro News • MoneyControl • The Tecake •
  6. There appears to be a shortage of Hydroxychloroquine (HCQ) according to several news sources. So if you somehow receive Hydroxychloroquine (HCQ) treatment for covid19 and your rosacea improves, please find the green reply button in this thead to post your results. Furthermore, virus has never, ever been ruled out in rosacea. End notes Physicians Seek to Reassure Amid Hydroxychloroquine Shortage, Jeff Evans, March 27, 2020, Medscape FDA SAYS THERE'S A SHORTAGE OF HYDROXYCHLOROQUINE AND CHLOROQUINE 'DUE TO A SIGNIFICANT SURGE IN DEMAND, BY KASHMIRA GANDER ON 4/1/20 AT 11:58 AM EDT, Newsweek As Trump touts an unproven coronavirus treatment, supplies evaporate for patients who need those drugs, By Christopher Rowland , March 23, 2020 at 1:02 p.m. CDT, The Washington Post
  7. Frequently some are concerned that if they have a red nose that they will end up like WC Fields, the rosacea poster boy. This is due to a misunderstanding that rosacea progresses in stages which has been debunked. While it is possible if you don't treat your rosacea (or your red nose) it may get worse, it certainly does not mean that it will necessarily get worse or progress into 'stages'. Obviously WC Fields didn't care about whether his nose got redder or turned into rhinophyma, so it is good you are concerned about your red nose. The good thing about rhinophyma or what is more recently classified as Phenotype 5 is that this is the most successfully treated rosacea phenotype (scroll to the subheading TREATMENT in this post for the list).
  8. Coffee Extracts Protect Cells Against Oxidative Stress One of the many theories on the cause of rosacea is the Antioxidant System Defect Hypothesis which is related to Oxidative Stress, Ferritin and Rosacea. One paper concluded the following; "Further experiments using LPS-induced murine macrophages revealed that coffee extracts protect cells against oxidative stress by enhancing the content of the antioxidant GSH and stimulating expressions of the genes related with the cellular antioxidation system. Also, coffee extracts decreased the expression of proinflammatory cytokines and inflammatory mediators in LPS-stimulated RAW 264.7 cells. However, different roasting levels may dilute those effects by decreasing the concentrations of key compounds during the roasting procedures." Journal of Medicinal Food Cellular Antioxidant and Anti-Inflammatory Effects of Coffee Extracts with Different Roasting Levels Jung Soohan, Kim Min Hyung, Park Jae Hee, Jeong Yoonhwa, and Ko Kwang Suk. Journal of Medicinal Food. June 2017, 20(6): 626-635. https://doi.org/10.1089/jmf.2017.3935 Online Ahead of Print: June 5, 2017 Published in Volume: 20 Issue 6: June 1, 2017
  9. Is rosacea a condition or a disease? Technically, it depends on how you are referring to rosacea in a statement. Condition "A medical condition is a broad term that includes all diseases, lesions, disorders, or nonpathologic condition that normally receives medical treatment, such as pregnancy or childbirth." [1] One report says, “rosacea is not actually a disease, but rather a chronic dermatologic condition that predominantly affects the convexities of the central aspect of the face.” [2] “Francis Wilkin of the FDA, whose serious studies have given us impressive insights into the nature and mechanisms of flushing, has proposed some concepts, which are inexplicable to most of us. He avers that rosacea is not a disease but a “condition”. He labels rosacea an ideotype, a cluster of signs and symptoms, apparently not a pathologic entity warranting a specific nosologic status. To be sure, rosacea is a multifactional disorder with many different clinical expressions. Nonetheless, it meets all the classical requirements of a pathologic process, most obviously the presence of chronic inflammation, both clinically and histologically. Calling rosacea a ‘condition’ downgrades the seriousness of the disorder, perhaps implying that it is only a cosmetic nuisance.” [3] Disease "A disease is a particular abnormal condition that negatively affects the structure or function of all or part of an organism, and that is not due to any immediate external injury....The term disease broadly refers to any condition that impairs the normal functioning of the body." [1] “Rosacea is a common and chronic disorder characterized by flushing, erythema, papules, pustules, and telangiectasia on the central part of the face. Because the facial skin of individuals with rosacea is particularly sensitive, irritants can trigger a worsening of the signs and symptoms of the disease.” [4] “Once considered a variant of acne, this common skin disorder seems fairly well entrenched as a disease sui generis.” [5] Terms Condition/Disease Used Interchangeably “Most words of this type in medicine rooted in Latin from thousands of years ago do not have precise definitions!” [6] “The terms disease & condition are often used interchangeably in the literature.” [7] “…this is semantics: disease, affliction or condition all refer to the same meaning.” [8] Conclusion While both Dr. Millikan and Dr. Wilkin refer to rosacea as a 'condition' and not a 'disease, there is no need to feel that somehow makes rosacea less important since the two words are used in most medical literature interchangeably. End Notes [1] Disease, Wikipedia [2] Skinmed 2003;2(1) The Proposed Inflammatory Pathophysiology of Rosacea: Implications for Treatment Larry Millikan, MD [3] A Personal Critique on the State of Knowledge of Rosacea Albert M. Kligman , M.D., Ph.D. Department of Dermatology, University of Pennsylvania, Philadelphia, PA, U.S.A. The William J. Cunliffe Lectureship 2003—Manuscript publikation_kligman.pdf [4] J Dermatolog Treat. 2007;18(3):158-62. Beneficial use of Cetaphil(R) Moisturizing Cream as part of a daily skin care regimen for individuals with rosacea Laquieze S, Czernielewski J, Baltas E. [5] Postgrad Med. 2002 Dec;112(6):51-8, 82; quiz 9. Unraveling the mystery of rosacea, Keys to getting the red out Ken Landow, MD [6] Robert T. Brodell, MD, RRDi MAC, post no 2 [7] Sandra Cremers, M.D., RRDi MAC, post no 3 [8] Marianne Boes, PhD, RRDi MAC (former member), post no 3
  10. There are several acne treatments used to treat rosacea, i.e., Dapsone, Sarecycline, Azithromycin, Minocycline, and the list continues, not to mention the plethora of over the counter acne treatments to consider. A typical example of an acne treatment, Benzaclin, that is also used to treat rosacea is discussed in the following paper: “Based on the theory that rosacea shares the same inflammatory features of acne, a recent study showed that, just as the combination of benzoyl peroxide 1 percent and clindamycin 5 percent gel is a powerful treatment modality for reducing Propionibacterium acnes levels, it also significantly reduces the papules and pustules of rosacea, according to Debra L. Breneman, M.D..… ‘Benzaclin, once daily, was found to be well tolerated and effective in the reduction of papules and pustules in patients with rosacea,’ said Dr. Breneman. ‘This lends credence to the theory that P. acnes is a potential aggravating factor in rosacea. This gives dermatologists a very effective treatment for rosacea.’ ” [1] Herbal Extracts for Acne One report on the 'clinical efficacy of herbal extracts in treatment of mild to moderate acne vulgaris' concludes, "This herbal extracts can be a new therapeutic option for patients with mild to moderate acne vulgaris who are reluctant to use drugs." [2] The herbal extracts include: Mangosteen extract Lithospermum officinale extract Tribulus terrestris L. extract Houttuynia cordata Thunb extract End Notes [1] Dermatology Times Publish date: Apr 1, 2003 P. Acnes Possible Factor in Rosacea BenzaClin a significant Tx in lesion reduction Beth Kapes Another example similar to above paper discussing topical benzoyl peroxide 5%/clindamycin 1% (BP/C) gel (BenzaClin) concluded, "These results showed that BP/C was significantly more effective than vehicle in improving papules and pustules associated with rosacea.' Cutis. 2004 Jun;73(6 Suppl):11-7. Photographic review of results from a clinical study comparing benzoyl peroxide 5%/clindamycin 1% topical gel with vehicle in the treatment of rosacea. Leyden JJ, Thiboutot D, Shalita A. [2] J Dermatolog Treat. 2019 Oct 16:1-5. doi: 10.1080/09546634.2019.1657792. [Epub ahead of print] Clinical efficacy of herbal extracts in treatment of mild to moderate acne vulgaris: an 8-week, double-blinded, randomized, controlled trial. Yang JH, Hwang EJ, Moon J, Yoon JY, Kim JW, Choi S, Cho SI, Suh DH.
  11. image courtesy of WikiMedia Commons The RRDi financial situation is continuously posted at this url and as of this date, March 30, 2020, we have $771.42 in the bank. Based upon how we are spending donations (the income includes the small amount of affiliate fees we receive from Amazon) we will run out of funds in several months. So we are concerned about this and decided to first post this on our website before using the newsletter tool and send this same announcement to the members who have opted to receive our newsletter. You may wonder how much we are spending in donations currently and for the first three months of 2020 we averaged our expenses to $164/month. You can view how we spent donations for last year here. So you can see our current funds will only last us several months at the present rate of expenditure. So let's compare this with how much money the NRS spends its donations (who is one of the other non profit organizations for rosacea). The only way we can get an idea how the NRS spends its donations is to look at the last financial report filed by the NRS as shown on Form 990 that the NRS files with the Internal Revenue Service for 2018 which is available for public viewing (the NRS releases its 2019 Form 990 much later and when it does we always review it since we have been reviewing how the NRS spends its donations since 1998). So let's compare how the NRS spends it donations, that is, the amount each month is spent with what the RRDi spends each month. For 2018, the NRS received in donations a total of $465,042. During this same period the NRS spent a total of $601,532 (yes the NRS can spend more than it takes in because of the assets they own which the NRS draws upon when the expenses are greater than donations). So on average, in 2018 the NRS spent over $50,000 each month! What did the NRS spend most of it donations on? The answer if you investigate is $432,408 was spent for the year (over $36,000 each month on average) on two private contractors owned by the director/president of the NRS, Sam Huff. So if you are happy with how the NRS is spending its donations that is just one of the other non profit organizations for rosacea that will continue if the RRDi runs out of funds and can't pay our monthly expenses. So the comparison is: RRDi spends NRS spends $164/month $50,000/month (of this amount $36,000 is spent on two private contractors owned by Sam Huff) Just for the record, the NRS claims on its Form 990 for 2018 that 25.31% of the total donations received in 2018 were from public support. What is one of the most interesting revelations found on the from its Form 990 for 2018 report is that it reveals how much money was received from the pharmaceutical companies which is shown in a screen shot below: The above screen shot doesn't reveal for how long a period each of the above pharmaceutical companies have been giving the NRS 'excess contributions' but it does reveal the amounts. So if you are happy the way these pharmaceutical companies are contributing to the NRS and the way the NRS is spending its contributions and if the RRDi runs out of funds to keep going, you will surely have the NRS since it has lots of money to spend, especially on two private contractors owned by Sam Huff, the director/president of the NRS. So it is simply up to you whether you want the RRDi to keep going or simply dissolve because of lack of funds. If you want to help out the RRDi there are two options, (1) donate, or, (2) volunteer (and help us get donations). If you have any questions or concerns, why not find the green reply button and post?
  12. image courtesy of Free paper chain v.2 Stock Photo We obviously aren't sure of what community support means to you, but we are trying to figure that out by forming a NON PROFIT organization for rosacea patient advocacy and encouraging rosaceans to come together by joining the RRDi and taking steps to obtain and disseminate community support for those who are suffering from rosacea. What has the RRDi done in this regard? (1) Creating a website with pages of information, a forum of rosacea topics, a community support category, member driven rosacea blogs, galleries and clubs. (2) Journal of the RRDi and the ability for anyone (amateur or professional) to submit a paper on rosacea to be published. (3) A legal non profit organization to allow donations to be tax deductible. (4) Education grants and the ability to volunteer as a grant writer for your non profit organization. (5) A way for you to volunteer to help rosacea sufferers. (6) Attracting sponsors to support our non profit organization. (7) Instructions on how to use our forum. So, what does community support mean to you? Please find the green reply button and post what it means to you? We would love to understand your concerns. You may think that posting in a community of rosacea sufferers your experience with rosacea and getting some feedback is what community support means to you? If so, this is the correct forum category to do that by finding the green reply button and post your concern.
  13. "In a statement released Sunday night, the U.S. Department of Health and Human Services announced it had received 30 million doses of hydroxychloroquine sulfate and one million doses of hloroquine phosphate donated to a national stockpile of potentially life-saving pharmaceuticals and medical supplies. Hydroxychloroquine and chloroquine, which are oral prescription drugs used primarily to prevent and treat malaria, are both being investigated as potential therapeutics for COVID-19." Coronavirus live updates: FDA gives anti-malaria drugs emergency approval to treat COVID-19 The two drugs are being investigated as potential treatments for COVID-19., By Morgan Winsor and Emily Shapiro, March 30, 2020, 8:05 AM, ABC News FDA Letter Virus has never been ruled out in rosacea.
  14. This question was asked and I am sharing my answer here as well. Basically everyone has demodex mites and it has been thought that the mites have some sort of undisclosed symbiotic relationship, i.e., the mites eat sebum which helps the mites and helps the humans keep sebum stasis. One report states, "....Demodex mites were originally perceived to be commensals, having a symbiotic relationship with the human host." - See Jarmuda et al published in the Journal of Medical Microbiology (second article mentioned in this post). While this same report says that 'most human populations' have NOT been sampled for demodex mites the general belief is that demodex are common throughout humanity and pose no problem as a pathogen except in the case of demodectic rosacea as far as known. A Russian study on the mites says, "Demodex folliculorum shows signs of parasitism, while Demodex folliculorum brevis is a saprophyte." It is comparable to bacteria which humans have a relationship with, there is good bacteria and bad bacteria. The probiotic bacteria and the pathogen bacteria. The demodex mites usually pose no problem with the vast majority of humans since they are possibly on everyone. Why they become more numerous seems to be of more importance. For some unknown reason the mites are in higher density in rosacea patients. We don't know if the rosacea cause this increase in mites or does the increase in mites cause the rosacea, the old chicken or egg conundrum? There is evidence that reducing the mite density count improves rosacea. It is clear that the mites like human skin since they eat sebum. Maybe the increase of sugar/carbohydrate in the diet increases sebum which in turn increases the mite population, and voila, the inflammation of rosacea? I don't think all rosacea is demodectic. GUT Rosacea is a different variant, but may be connected or associated. The list of systemic comorbidities with rosacea keeps growing. The gut microbiome is obviously connected with skin microbiome (see my post on this).
  15. The president announced on March 19, 2020 that hydroxychloroquine (Plaquenil) has been approved by the FDA to treat COVID-19. Virus has never been ruled out in rosacea. CNN has a followup report on this. There is a paper that indicates using Hydroxychloroquine (HCQ) to treat rosacea "exerted satisfactory therapeutic effects on erythema and inflammatory lesions of rosacea patients, indicating that it is a promising drug for rosacea in clinical treatment." Duff Man told us about this a while back that it worked for him. Wouldn't it be incredible if any rosaceans who are treated with hydroxycholoroquine for COVID-19 also discovered that their rosacea improves or clears up! Is virus involved in rosacea? If you do take hydroxycholoroquine and your rosacea improves, please let us know.
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