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  1. That is difficult to follow. In a paper by Powell, et al, it is stated that the mites "secrete bioactive molecules that reduced TLR2 expression in Sebocytes." The 'bioactive molecules' that the mites secrete keep the innate immune system from reacting to the mites when in normal numbers on normal skin, so my question is what causes the demodex to proliferate in greater numbers to what you say, "cause inflammatory immune response and inflammatory immune response" ? Could you better explain what you mean by "self-antigen presentation to immune cells rather than non-self which is false immune response? ?
  2. While it has been reported that topical ivermectin has better results than topical metronidazole, there is a paper you should consider reading if you are considering taking oral ivermectin and metronidazole. A paper published by the International Journal of Infectious Diseases that compared taking 200 micro-grams Ivermectin per Kilogram of body weight of oral ivermectin once a week in one group (1) of sixty rosacea patients with another group (2) of sixty rosacea patients who received a combined therapy of the same amount of ivermectin along with 250 mg of oral metronidazole three times a day. The results were that the second group improved better than the first group. For more information Some may concerned about taking ivermectin orally. It is interesting to note that ivermectin has been around since the late 1970s and half "of the 2015 Nobel Prize in Physiology or Medicine was awarded jointly to Campbell and Ōmura for discovering avermectin, 'the derivatives of which have radically lowered the incidence of river blindness and lymphatic filariasis, as well as showing efficacy against an expanding number of other parasitic diseases' " Wikipedia Ivermectin is "a dihydro derivative of avermectin—originating solely from a single microorganism isolated at the Kitasato Intitute, Tokyo, Japan from Japanese soil...originally introduced as a veterinary drug...has led many to describe it as a “wonder” drug....few drugs that can seriously lay claim to the title of ‘Wonder drug’, penicillin and aspirin being two that have perhaps had greatest beneficial impact on the health and wellbeing of Mankind....But ivermectin can also be considered alongside those worthy contenders, based on its versatility, safety and the beneficial impact that it has had, and continues to have, worldwide—especially on hundreds of millions of the world’s poorest people....Despite decades of searching around the world, the Japanese microorganism remains the only source of avermectin ever found. Originating from a single Japanese soil sample and the outcome of the innovative, international collaborative research partnership to find new antiparasitics, the extremely safe and more effective avermectin derivative, ivermectin, was initially introduced as a commercial product for Animal Health in 1981." [1] While there are no long term clinical studies done on ivermectin use with rosacea, there are papers showing the long term effects of oral ivermectin in school-age and pre-school children treated for helminths. [2] There are also papers written about the long term effects of treating humans with ivermectin on other parasites. 'Intriguingly, IVM has a diverse range of effects in many different organisms, far beyond the endoparasites and ectoparasites it was developed to control. For example, IVM has been shown to regulate glucose and cholesterol levels in diabetic mice, to suppress malignant cell proliferation in various cancers, to inhibit viral replication in several flaviviruses, and to reduce survival in major insect vectors of malaria and trypanosomiasis. Clearly, much remains to be learned about this versatile drug, but the promise of more sustainable strategies for current helminth-control programmes and novel applications to improve and democratise human health, are compelling arguments to pursue this cause." [3] With the craze of rosaceans using horse paste to treat rosacea topically, there is one report of oral horse paste treatment for Lyme disease in Facebook by a poster. [4] So there are a substantial number of humans globally who have taken oral ivermectin. More information on oral ivermectin. ElaineA has a post worth reading on this subject, Oral Ivermectin, getting diagnosed and a prescription. End Notes [1] Proc Jpn Acad Ser B Phys Biol Sci. 2011 Feb 10; 87(2): 13–28. doi: 10.2183/pjab.87.13 PMCID: PMC3043740; PMID: 21321478 Ivermectin, ‘Wonder drug’ from Japan: the human use perspective Andy CRUMP and Satoshi ŌMURA [2] PLoS Negl Trop Dis. 2008 Sep; 2(9): e293. Published online 2008 Sep 10. doi: 10.1371/journal.pntd.0000293 PMCID: PMC2553482; PMID: 18820741 Impact of Long-Term Treatment with Ivermectin on the Prevalence and Intensity of Soil-Transmitted Helminth Infections Ana Lucia Moncayo, Maritza Vaca, Leila Amorim, Alejandro Rodriguez, Silvia Erazo, Gisela Oviedo, Isabel Quinzo, Margarita Padilla, Martha Chico, Raquel Lovato, Eduardo Gomez, Mauricio L. Barreto, and Philip J. Cooper [3] Trends in Parasitology Volume 33, Issue 6, June 2017, Pages 463-472 Ivermectin – Old Drug, New Tricks? Roz Laing. Victoria Gillan. Eileen Devaney [4] Post number five in this thread
  3. This post has been promoted to an article.
  4. Thanks Apurva for your research and investigation into this. Hope some substantiate your findings.
  5. Hi Peter, This question comes up a lot about coffee and is a FAQ answered here. We hope you continue to post and ask questions. As for cigars, we have no data on cigars and rosacea but obviously is probably not a healthy habit to keep. As for creams for rosacea, suggest you search our non prescription forum or check out our online store.
  6. Image courtesy of Wikimedia Commons The American Academy of Dermatologists is one of the premier, most distinguished organizations that produces a medical journal and sponsors conventions for their prestigious members each year. The AAD is a 501 c 3 non profit organization that in 2015 received $33 million dollars in revenue and spent $34 million dollars in expenses. If you carefully review the total amount of research grants spent in 2015 in its Form 990 you will see it spent a little over $1 million dollars so that amounts to 3 percent of its revenue. What that means, to put this into perspective about research, is that for every dollar received by the AAD three cents is spent on research. What amount went to rosacea research is anyone's guess, but if you have the volunteer spirit you could figure that out and report what you find in this thread. If you have the heart to figure out how much was spent on actual rosacea research by the AAD in 2015 you would probably find that the amount was not very much. The AAD focuses a lot on many other skin diseases, but sometimes has articles on rosacea in its journal.
  7. The skin industry, of course, is the primary sponsor of rosacea research papers published in the medical journals, as Dr. Kligman points out and comments that such papers are "perhaps not the most credible source of unbiased research.' It takes a lot of deep investigation to find the source of funding of a clinical paper published in a medical journal but if you have the time and patience you can discover who funded the research paper published. For example if you check out this article published in the Dermatology Online Journal you can find that one of the authors, Eckert M. Mendieta works at the Department of Dermatology, Clínica Dermitek, which is part of the 'skin industry.' Dermatol Online J. 2016 Aug 15;22(8). pii: 13030/qt9ks1c48n. Treatment of rosacea with topical ivermectin cream: a series of 34 cases. Mendieta Eckert M, Landa Gundin N. While we have reviewed who is funding rosacea research we are still grateful for ANY rosacea research funding and can glean useful information from these published papers. The status quo research papers are without a doubt funded primarily by the skin industry, included in this are the few non profit organizations for rosacea since with the exception of the RRDi, is funded primarily by the pharmaceutical skin industry. Joel T. Bamford, MD, wrote an article in the Journal of the Rosacea Research & Development Institute, Is it possible for rosaceans to do research?, which encourages his recommendation that Rosaceans should get together and sponsor their own research independent of the skin industry. What a novel idea? And that is why the RRDi was formed so that a non profit organization for rosacea should be established by Rosaceans who suffer from rosacea, and not like the other non profit organizations for rosacea who are established and run by NON rosaceans. If enough rosaceans got together, say 10,000 members, and each donated one dollar, they could sponsor their own double blind, placebo controlled, peer-reviewed rosacea research clinical papers.
  8. Positive Anecdotal Reports of Soolantra MagnificenT, the Rosacea Forum, posts, "I have been using it for 4 weeks now, and I am literally shocked how my skin improved during this time. There are no more discolorations, redness decreased by 70% (I'm pinkish now, but it looks healthy), I can take a shower without going super red, and in general I no longer feel this discomfort, tightness, and dryness. After a disastrous experience with Mirvaso, I need to pay thanks to the creators of this drug, it gave me a relief I needed so much."
  9. Thanks for you post. Never heard of seborrheic blepharitis. I have heard of seborrheic dermatitis. When I used the search feature at Wikipedia for seborrheic blepharitis, it redirected me to 'blepharitis' and I found this quote, "Different variations of blepharitis can be classified as seborrheic, staphylococcal, mixed, posterior or meibomitis, or parasitic."
  10. Anecdotal Reports of Using Horse Paste for Rosacea - You Decide Positive or Negative? Found one neutral anecdotal report at Rosacea Tips and Support Group, Facebook but you will just have to find it. The RRDi complies with requests for removal of certain published material on the internet from our website. However, for those of you who may not understand the legality of this issue, you may want to read these two answers to the following two questions: Can You Quote or Use Someone Else’s Facebook Posting? Question: Is it illegal to quote someone without permission? It is ironic that those who have issues with quoting a neutral report of using horse paste on this website have no issues with Facebook publishing their name and medical issue for all to see in a private group.
  11. Negative Anecdotal Reports of Using Horse Paste for Rosacea There are a few negative reports at Facebook Groups, i.e., Rosacea (English), Rosacea (English), Rosacea Tips and Support Groups, as well as Reddit r/Rosacea, but you will have to join these groups to find the negative anecdotal reports since they are few are far between. Of course, you will always find negative reports, just like you do with Soolantra and any other rosacea treatment. If there are more negative ones or a significant number of them then you should be wary. So far, with horse paste the negative ones are few. The RRDi complies with requests for removal of certain published material on the internet from our website. However, for those of you who may not understand the legality of this issue, you may want to read these two answers to the following two questions: Can You Quote or Use Someone Else’s Facebook Posting? Question: Is it illegal to quote someone without permission? It is ironic that those who have issues with quoting a negative report of using horse paste on this website have no issues with Facebook publishing their name and medical issue for all to see in a private group.
  12. Positive Anecdotal Reports of Using Horse Paste for Rosacea There are many, many positive reports at Facebook Groups, i.e., Rosacea (English), Rosacea (English), Rosacea Tips and Support Groups, as well as Reddit r/Rosacea, but you will have to join these groups to read the anecdotal reports. The RRDi complies with requests for removal of certain published material on the internet from our website. However, for those of you who may not understand the legality of this issue, you may want to read these two answers to the following two questions: Can You Quote or Use Someone Else’s Facebook Posting? Question: Is it illegal to quote someone without permission? It is ironic that those who have issues with quoting a positive report of using horse paste on this website have no issues with Facebook publishing their name and medical issue for all to see in a private group.
  13. "Scientists have shown that transplanting gut bacteria, from an animal that is vulnerable to social stress to a non-stressed animal, can cause vulnerable behavior in the recipient. The research reveals details of biological interactions between the brain and gut that may someday lead to probiotic treatments for human psychiatric disorders such as depression." Transplanting gut bacteria alters depression-related behavior, brain inflammation in animals Knowledge of stress biology may eventually yield bacterial treatments for psychiatric disordersChildren's Hospital of Philadelphia, ScienceDaily
  14. So, we suggest that the combined therapy works better than ivermectin alone on cases with different skin lesions and anterior blepharitis. In conclusion, the combined therapy was superior in decreasing the D. folliculorum count in all groups and in reducing the mite count to the normal level in rosacea and in blepharitis lesions, while the two regimens were comparable in reducing the mite count to the normal level in acne and peri-oral dermatitis lesions. International Journal of Infectious Diseases Volume 17, Issue 5, May 2013, Pages e343-e347 Evaluation of the efficacy of oral ivermectin in comparison with ivermectin–metronidazole combined therapy in the treatment of ocular and skin lesions of Demodex folliculorum Doaa Abdel-Badie Salema, Atef El-shazly, Nairmen Nabih, Youssef El-Bayoumy, Sameh Salehc
  15. I just checked this post today, May 6, which has not been a month since I initially posted this vent I am still on, and there has been 68 views of this post totaled up today. So since Apurva Tathe is the only one who replied to this thread (just in case you don't know how to reply to this thread there is a green button at the top of the thread to the right - see below) I thought maybe some of you need some help understanding how a forum works with replying to a post? Or you can scroll all the way to the bottom of the thread and you will see 'Reply to this topic' and just start typing (in both cases you need to be registered and logged in). Anyway, I thought I would continue my vent. I have been browsing Reddit and Facebook to see where all the rosaceans have gone and have discovered that there are some huge rosacea groups formed and how these are extremely popular to use. For example, at Reddit r/rosacea has 7.9K members (I tried posting there and one of the moderators was extremely rude and would not reason with me and denigrated the RRDi repeatedly so I simply left this group). I joined Reddit r/SkincareAddition (954K members) and am appalled that anyone can try to sort through this group for help with rosacea since it covers so many different skin conditions. Facebook Rosacea (in English) has 6.6K members, while Rosacea Tips and Support Group has 7.4K members. Facebook to me has a friendlier atmosphere over Reddit (for example, I simply recommended that in one of the many inquiries, IS THIS ROSACEA?, to see a dermatologist I was chastised and rudely told to mind my own business). So far, in Facebook the rosaceans there are more respectful and kindlier than the Reddit rosaceans. The most appalling discovery in all this is the lack of rosacea knowledge. Most rosacea newbies, of course, haven't a clue what rosacea is, and the vast majority are trying to learn about it through Reddit or Facebook and the search feature at either one is dreadful. Of course, they don't know what to search for in the first place, but the most FAQs are, Is this Rosacea?, What Moisturizer?, Should I get Laser? (or LED or IPL, etc.), What is Horse Paste?, Asking about Rosacea Triggers, especially IS COFFEE A TRIGGER?, and usually asking about a particularly over the counter treatment for rosacea or a particular prescription treatment. As you can see, the RRDi has been answering these questions since 2004 and has grouped all these questions into logical categories and areas in the member forum or in the research articles. Why rosaceans prefer Facebook and Reddit over having all these questions in a forum in categories boggles my mind. What is it about Facebook and Reddit that appeals to these rosacea newbies? It is so difficult to find what you are looking for in either one. Total chaos yet rosaceans love it. Your thoughts on all this? Second, is the fact that since the 1200 plus members of the RRDi simply don't want to volunteer and post or do anything, the funds are dwindling and since our non profit is so transparent you can view the financial situation that the RRDi is in. At the present rate of spending, we have enough to last a little over a year. I am hoping for a donation from Demodex Solutions, but Walter apparently hasn't had the success he used to have when the ZZ cream was one of the more popular demodectic rosacea treatment around (horse paste has taken over), so I can't count on his support. There simply isn't enough members purchasing our Amazon Affiliate items to keep the RRDi afloat. There simply are no donations to speak of in the last few years. Members don't donate. If the 1200+ members each donated a dollar that would keep us going for over a year and half. Going through the hoops to get a Galderma Education Grant is a huge amount of volunteer time and I may try going through the hoops again but you should try it and see how difficult Galderma makes this process and they only offer the RRDi a $2K grant if you qualify. Would anyone of you want to volunteer to do this and keep half the money (the RRDi has to keep half to keep this ship afloat!!!). However, if you can get one of these education grants from Galderma through the RRDi you can keep half the money which means $1K in your pocket! We have been offering this for a long time and some volunteers have tried and given up rather quickly because you really have to be patient and meticulous to follow all the instructions from Galderma, not to mention the multiple forms and bureaucratic steps required to get the grant. All you do is contact me and I will set you on course on how to do this. So the handwriting is on the wall. The days of the RRDi are numbered since volunteering is just not popular anymore as it was in 2004 when the RRDi started. There are no Warren Stuarts or other helpful volunteers. The other board members are busy and involved with their own responsibilities to be able to volunteer very much at all. The MAC Members are the same. Actually the MAC Members are one of the Crown Jewels of the RRDi, however, I cannot really bother them since when I do some quit and want their name removed so I have learned to not bother them unless I have something pertinent to their speciality like asking them a question I know they know the answer. It is amazing they have offered to volunteer for the RRDi and give me their personal contact information and I can ask them rosacea questions. What a resource! Then there is the wealth of rosacea data on this website. Huge amount of rosacea data. All this will be gone unless we either (1) get volunteers to keep this going, (2) get some donations to keep this going, or, (3) you come up with another solution. This is not to mention why the RRDi was formed in the first place, which a lot of you rosacea newbies haven't a clue about. We do have a history of the RRDi if you are interested. So since I did mention this, yes, this is still a venting session for me, you may need to understand rosacea research and get a perspective on this. First read the post, Rosacea Research in Perspective of Funding and then read Rosacea Research in Perspective of Idiopathic Diseases. Do you really want the NRS and the AARS to keep the status quo rosacea research that the pharmaceutical companies keep funding? Do you want a non profit organization for rosacea patient advocacy to fund some novel rosacea research? Unless you form another non profit organization for rosacea that is better than the RRDi, at this point, the RRDi is the only choice. So please consider what is in this entire thread, about what I just vented about and please post a comment in this thread. Do you have any thoughts on this?
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