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  1. Thanks Rory. Looking forward to your results. Did you see this paper about demodex brevis: Demodex Brevis Higher Count Than Demodex Folliculorum in Cylindrical Dandruff Patients
  2. Actually I ran this by my dermatologist who was well aware that Rosaceans were using horse paste topically since he read about it in a journal. There are some dermatologists who are up to date with what is going on and then there are others who are in the dark. He told me that when prescribing Soolantra to his rosacea patients that about one in four patients were successful using it. He gave me a Rx for Soolantra and I tried it and I think now it was the inactive ingredients in Soolantra that irritated my skin. Galderma (or another pharmaceutical company) will probably eventually make an ivermectin gel with a very simple inactive ingredient list to compete with the horse paste that everyone is raving about. Galderma knows what is going on with rosaceans and obviously saw a slight dip in Soolantra sales due to thousands using horse paste. They know that a significant number of rosacea patients are not able to tolerate the inactive ingredients in Soolantra.
  3. Rory, thanks for clearing this up that you are taking the horse paste orally. We do have a thread dedicated to taking ivermectin orally. While many may think that taking oral ivermectin isn't a good idea, the fact is that oral ivermectin has been given to millions of people worldwide and there are long term studies on oral ivermectin in children. However, the RRDi recommends you check with your physician when embarking on this form of treatment as a precaution. It would be better you post in the oral ivermectin thread since this thread is about using horse paste topically. Thanks.
  4. The RRDi is pleased to announce that Apurva Tathe has been appointed to serve on the RRDi Board of Directors. She has a masters of science in biotechnology and is an excellent addition to the board.
  5. What I mean is, you are using the Bimectin topically, correct?
  6. The Bimectin is topical, correct? Does it list the inactive ingredients?
  7. Admin

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  8. We have some instructions provided by IPS on how to use our forum. For example, watch this video on how to change your display name: Editing your profile Sending/Receiving messages General Posting Control Previewing post content Managing followed content How to Use CLUBS Two Factor Authentication Viewing Attachments Reputation & Reactions Custom Profile Fields User Ranks Post color highlighting Profile Completion Other Profile Settings
  9. "The mechanism of action (MOA) of Soolantra® (ivermectin) Cream, 1% in treating rosacea lesions is unknown." However, we are concentrating on an investigation into the 'basis for the vehicle' statement by Galderma regarding Soolantra. In the Soolantra News post if you scroll down to Cetaphil Base, Galderma, on its Mechanism of Action page, posts : "Soolantra Cream combats inflammatory lesions of rosacea with a formulation designed for tolerability, utilizing Cetaphil® Moisturizing Cream as the basis for the vehicle." However, now this page is no longer available, but we have a screen shot of the Way Back Machine on August 21, 2018 which shows you the statement below: Soolantra mechanism of action (MOA) (Way Back Machine url) Actually after a careful search, Galderma has moved the statement that Cetaphil is the 'basis for the vehicle' statement to this page: https://www.soolantra.com/hcp/about-soolantra-cream SOOLANTRA (ivermectin) cream, 1% is a white to pale yellow hydrophilic cream. Each gram of SOOLANTRA cream contains 10 mg of ivermectin. It is intended for topical use. While the claim by Galderma that utilizing Cetaphil is 'basis for the vehicle' we have investigated and notice the differences with the inactive ingredients in Soolantra with the ingredients in Cetaphil below. SOOLANTRA cream contains the following inactive ingredients: carbomer copolymer type B, cetyl alcohol, citric acid monohydrate, dimethicone, edetate disodium, glycerin, isopropyl palmitate, methylparaben, oleyl alcohol, phenoxyethanol, polyoxyl 20 cetostearyl ether, propylene glycol, propylparaben, purified water, sodium hydroxide, sorbitan monostearate, and stearyl alcohol. Source Cetaphil Moisturizing Cream Ingredients: Water, Glycerin, Petrolatum, Dicaprylyl Ether, Dimethicone, Glyceryl Stearate, Cetyl Alcohol, Prunus Amygdalus Dulcis (Sweet Almond) Oil, PEG-30 Stearate, Tocopheryl Acetate, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Dimethiconol, Benzyl Alcohol, Phenoxyethanol, Glyceryl Acrylate/Acrylic Acid Copolymer, Propylene Glycol, Disodium EDTA, Sodium Hydroxide Source Compare Soolantra inactive ingredients to Cetaphil Moisturizing Cream Ingredients Google Sheet
  10. What is interesting is that Galderma claims Soolantra's base is Cetaphil. However, we did an investigation and compared Cetaphil's ingredients with the list shown in Soolantra and discovered there is a difference. For more information: Soolantra mechanism of action (MOA) SOOLANTRA (ivermectin) cream, 1% is a white to pale yellow hydrophilic cream. Each gram of SOOLANTRA cream contains 10 mg of ivermectin. It is intended for topical use. SOOLANTRA cream contains the following inactive ingredients: carbomer copolymer type B, cetyl alcohol, citric acid monohydrate, dimethicone, edetate disodium, glycerin, isopropyl palmitate, methylparaben, oleyl alcohol, phenoxyethanol, polyoxyl 20 cetostearyl ether, propylene glycol, propylparaben, purified water, sodium hydroxide, sorbitan monostearate, and stearyl alcohol. Source Cetaphil Moisturizing Cream Ingredients: Water, Glycerin, Petrolatum, Dicaprylyl Ether, Dimethicone, Glyceryl Stearate, Cetyl Alcohol, Prunus Amygdalus Dulcis (Sweet Almond) Oil, PEG-30 Stearate, Tocopheryl Acetate, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Dimethiconol, Benzyl Alcohol, Phenoxyethanol, Glyceryl Acrylate/Acrylic Acid Copolymer, Propylene Glycol, Disodium EDTA, Sodium Hydroxide Source Compare Soolantra inactive ingredients to Cetaphil Moisturizing Cream Ingredients Google Sheet
  11. With regard to flushing, it would be good to read this post. There are a number of drugs used to avoid flushing. There are also a number of other non prescription treatments to avoid flushing which are found here.
  12. Apurva, You may be interested in reading this post, Liver, Yogurt, Sour Cream, Cheese, Eggplant, and Spinach, in the research articles section of our website to get an understanding between the difference of a rosacea flareup trigger vs a flushing trigger.
  13. "In 2016, the definition of sensitive skin (SS) was established by a special interest group from the International Forum for the Study of Itch. SS is defined as a syndrome defined by the appearance of unpleasant sensations (stinging, burning, pain, pruritus, and tingling sensations) in response to stimuli that would not normally cause such sensations.....To our knowledge, only 2 transcriptomic studies have been performed for SS. ...As previously done with rosacea, these two studies provide very interesting data allowing, orientating and suggesting further research. Transcriptomic studies on larger populations are needed but these studies give key data to focus on some pathogenic mechanisms." Front Med (Lausanne). 2019; 6: 115. Sensitive Skin: Lessons From Transcriptomic Studies Adeline Bataille, Christelle Le Gall-Ianotto, Emmanuelle Genin, and Laurent Misery What if a non profit organization for rosacea gathered together 10,000 members, and each member donated one dollar and everyone agreed that a study on transcriptomic research be conducted? Could that be done? It is all up to you whether you think this would be worth investigating.
  14. An article published in the Daily Mail, Nerve injection that can stop the nightmare of hot flushes, by Robert Dobson, states, "An injection in the neck might ease the symptoms of hot flushes....known as a stellate ganglion nerve block." Many rosaceans are more concerned with avoiding flushing than with anything else. What exactly is stellate ganglion nerve block? The Cleveland Clinic answers, "A stellate ganglion block is used to diagnose or treat circulation problems or nerve injuries..." Cedars-Sinai states, "A stellate ganglion block (sympathetic block) is an injection of local anesthetic into the front of the neck." Rehabilitation & Orthopaedic Institute, University of Maryland states, "A stellate ganglion block is an injection of local anesthetic (numbing medicine) to block the sympathetic nerves located on either side of the voice box in the neck." One paper on this subject states, "Due to a high risk of side effects, for example, pneumothorax and vascular puncture, an image-guided approach is strongly suggested, even with the "safer" C6 approach." [1] "The inputs from sympathetic ganglia have been known to be involved in the pathophysiology of various conditions like complex regional pain syndrome (CRPS)" [2] Stellate ganglion block (SGB) "Stellate ganglion, also known as the cervicothoracic ganglion,....SGB is the oldest and most common sympathetic block that is applied today....There is a broad range of case studies that report the effectiveness of SGB in many different conditions. The outcomes may look promising, but expanding the indications of SGB needs more randomized, controlled studies." [2] End Notes [1] Treasure Island (FL): StatPearls Publishing; 2019 Jan-. Stellate Ganglion Blocks Emanuele Piraccini; Ke-Vin Chang. [2] J Pain Res. 2017; 10: 2815–2826. Ganglion blocks as a treatment of pain: current perspectives Osman Hakan Gunduz and Ozge Kenis-Coskun
  15. This article is found here.
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