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Medical Press article • DoctorsLounge • ooyuz beta • The article concluded: "The use of multiple, sequential light and laser sources with ALA-PDT for rosacea, while well tolerated, did not lead to statistically significant improvements in patient-reported efficacy. Although this retrospective study is limited by a small sample size with disparate patient numbers between groups and no physician-evaluated outcome criteria, it does demonstrate that multiple light sources with PDT can be safely used in a single session." J Cosmet Dermatol. 2016 Jul 4. doi: 10.1111/jocd.12231. Multiple sequential light and laser sources to activate aminolevulinic acid for rosacea. Friedmann DP1, Goldman MP2, Fabi SG2, Guiha I2. Wiley Online Library

UV Safety Month: Rosacea, endometriosis, fibromyalgia, high blood pressure, and allergies By: Bel Marra Health | Health News | Sunday, July 03, 2016

How Your Gut Health Is Linked To Rosacea, by Cybele Fishman, MD, Yahoo Health • August 6, 2015 Also read the article, Do You Have A Gut Feeling About Your Rosacea?

image courtesy of Wikimedia Commons "Probiotic masks, creams or cleansers have been introduced by some cosmeceutical manufacturers based on early research, according to the release..." Probiotic use improved acne, rosacea symptoms by Whitney Bowe, MD, Healio Health, February 7, 2014 Dr. Bowe serves as a volunteer for the RRDi MAC Probiotics in acne and rosacea. Cutis. 2013 Jul;92(1):6-7 Authors: Bowe WP PMID: 23961518 [PubMed] The Beauty of Dirty SkinDirty Looks: The Secret to Beautiful Skin ------------------------------------------------- "Now, emerging research is finding that the benefits of probiotics may extend beyond the digestive tract to the skin. In fact, skin prone to acne or rosacea has shown improvement with daily probiotic use, giving dermatologists reason to consider supplementing traditional acne therapy with a dose of this beneficial bacteria." Could probiotics be the next big thing in acne and rosacea treatments, AAD News ------------------------------------------------ "We’re mainly concentrated on the gut microbiome (because it seems to be linked to so many modern plagues like obesity, depression and loads of autoimmune diseases), but the skin microbiome is now coming into focus, too....I think in five years no one will use antibacterials anymore, but instead try to grow beneficial bacteria... we’re looking forward to prebiotic skincare becoming a wider-researched and formulated area of the beauty industry." Source -------------------------------------------- "The skin microbiota in individuals with rosacea displays changes from that of healthy skin, suggesting that further studies examining a potential role for the skin microbiota in the pathophysiology of rosacea may be warranted. Am J Clin Dermatol. 2019 Sep 09;:Characterization and Analysis of the Skin Microbiota in Rosacea: A Case-Control Study.Rainer BM, Thompson KG, Antonescu C, Florea L, Mongodin EF, Bui J, Fischer AH, Pasieka HB, Garza LA, Kang S, Chien A -------------------------------------------------- One paper describes using probiotic therapy ((Bifidobacterium breve BR03, Lactobacillus salivarius)) along with Oracea for scalp rosacea. ------------------------------------------------- Nonpathogenic E. coli strain Nissle 1917, also known as Mutaflor ------------------------------------------------ Clinical studies were conducted to determine the effect of lactobacillus extract on improvement of skin barrier and reduction of erythema from chemical irritant, skin microflora, and acne. Results show that lactobacillus extract was effective in reducing skin erythema, repairing skin barrier, and reducing skin microflora, thereby exhibiting an effective reduction in acne lesion size and erythema at 5%, but not at 1%. J Cosmet Sci. 2012 Nov-Dec;63(6):385-95.Physiological effect of a probiotic on skin.Muizzuddin N, Maher W, Sullivan M, Schnittger S, Mammone T. ------------------------------------------------ "Further investigation of the ocular surface microbiome, as well as the microbiome of other areas of the body such as the oral mucosa and gut, and their role in the pathophysiology of diseases is a significant, emerging field of research, and may someday enable the development of novel probiotic approaches for the treatment and prevention of ophthalmic diseases" Yale J Biol Med. 2016 Sep; 89(3): 325–330. Published online 2016 Sep 30. PMCID: PMC5045141 Human Microbiota and Ophthalmic Disease Louise J. Lu and Ji Liu ------------------------------------------------- "Oral probiotics can modulate the intestinal microbiome and have demonstrated to be efficacious in treating topical skin conditions, such as atopic dermatitis, acne and rosacea." The Role of Topical Probiotics on Skin Conditions: A Systematic Review of Animal and Human Studies and Implications for Future Therapies. Exp Dermatol. 2019 Sep 08;: Knackstedt R, Knackstedt T, Gatherwright J

Daily Express

myDayton Daily News, Cox Media Group

The principle author of this article is Anna Holmes, PhD. who volunteers on the RRDi MAC

Why I Went On Accutane In My 30s, Yahoo Health, Refinery 29, July 4, 2016

The RRDi is please to announce that Dana Buchbut, MD, has volunteered to serve on the RRDi MAC.

According to an article by Fiscal Standard, "Paratek Pharmaceuticals, Inc. (Partake), formerly Transcept Pharmaceuticals, Inc. is a pharmaceutical company focused on the development and commercialization of antibacterial therapeutics based upon tetracycline chemistry." The article then mentions the following: "Sarecycline is designed for use in the treatment of acne and rosacea." This article further states, "The Company’s sarecycline is a Phase III antibacterial product candidate and was previously known as WC3035."

A recent article has brought back the common question many rosacea sufferers ask: Is Rosacea Caused by Nurture or Nature? According to an article published in 2015, referred to by these news wire sources, the answer is probably a 50-50%. Here is the list of articles published referring to this subject: UV SAFETY MONTH: ROSACEA, ENDOMETRIOSIS, FIBROMYALGIA, HIGH BLOOD PRESSURE, AND ALLERGIES Medical Information Online, July 4, 2016 Rosacea risk linked to genes, obesity, heart disease, and sun exposure By: Devon Andre | Skin Health | Wednesday, June 01, 2016 - 04:00 PM ROSACEA RISK LINKED TO GENES, OBESITY, HEART DISEASE, AND SUN EXPOSURE Headline News, HealthDate: 02.06.2016. Rosacea Caused Half by Nature, Half by Lifestyle: Study US News, Sept. 9, 2015 Rosacea Caused Half by Nature, Half by Lifestyle: Study By Alan Mozes, HealthDay Reporter, Sept 9, 2015 Rosacea Caused Half by Nature, Half by Lifestyle: Study Drugs.com, Sept 9, 2015

As this thread points out, at least five different bacteria have been implicated, suggested or investigated with rosacea. The latest one investigated is Staphylococcus aureus. However, the bacteria theory on the cause of rosacea is still debated and there really is no solid evidence yet.

Honey to the Rescue for Rosacea Patients Honevo, a product composed of 90 percent medical grade kanuka honey and 10 percent glycerin, demonstrated efficacy as a rosacea treatment in a blinded, randomized clinical trial, the results of which were published in BMJ Open. During the trial, participants applied Honevo or cetomacrogol — a non-ionic moisturizing cream used by the control group — twice a day for eight weeks. At the trial’s conclusion, 34.3 percent of the participants in the Honevo group and 17.4 percent of those in the control group showed improvement of greater than or equal to 2 or more on the Investigator Global Assessment of Rosacea Severity Score. However, patients’ self-reports on a dermatology quality-of-life index and on the current severity of symptoms showed no difference in improvement between weeks two and eight. That may suggest some measurement tools need further refinement in future studies, researchers say. MD NEWS, By: Michael Ferguson Friday, July 01, 2016 An article published in Dermatology Times says that "Honey may improve rosacea severity" and referred to an article published in the British Medical Journal Open about a product, Honevo Rosacea, and concludes, "Honevo is an effective treatment for rosacea." [1] Honevo Rosacea is 100% natural and contains just 2 ingredients: pharmaceutical-grade kanuka honey and glycerin manufactured by HoneyLab LTD in New Zealand. If you have used this treatment please find the green reply button and comment. End Notes [1] Honey may improve rosacea severity

Bustle Article

Alternative therapies hold promise for rosacea By Peter Lio, M.D., Dermatology Times

"Botulinum toxin has been used to treat persistent erythema and flushing in rosacea for several years." Botulinum Toxin: An Effective Treatment for Flushing and Persistent Erythema in Rosacea Botulinum Toxin for the Treatment of Refractory Erythema and Flushing of Rosacea Park K.Y.a · Hyun M.Y.a · Jeong S.Y.b · Kim B.J.a · Kim M.N.a · Hong C.K.a Department of Dermatology, Chung-Ang University College of Medicine, and GoodDay Skin and Laser Clinic, Seoul, South Korea Botulin Toxin Use in Rosacea and Facial Flushing Treatment. Open Access Maced J Med Sci. 2019 Sep 30;7(18):2985-2987 Scala J, Vojvodic A, Vojvodic P, Vlaskovic-Jovicevic T, Peric-Hajzler Z, Matovic D, Dimitrijevic S, Vojvodic J, Sijan G, Stepic N, Wollina U, Tirant M, Thuong NV, Fioranelli M, Lotti T

Evaluation of the Inhibitory Effects of Topical Ivermectin on Markers of Rosacea Specific Inflammation.

McDermott Will & Emery - Lexology

TheNational

Rosacea: i sintomi della malattia e i consigli su come prendersi cura della propria pelle In Italian. Open the above article in Google Chrome and an option at the top of the page offers to translate the article into English. or go to Google Translation Help

Missoulian

David Pascoe has a very interesting article on Ivermectin entitled, Ivermectin is a very useful drug indeed.

Van Buren woman in business to cure skin (with video) "Folsom said her products can cure disorders, including eczema, rosacea, acne and psoriasis." Southwest Times Record, Fort Smith, Arkansa

EscherichiaColi Image Wikipedia Commons "Nonpathogenic E. coli strain Nissle 1917, also known as Mutaflor, and E. coli O83:K24:H31 (known as Colinfant) are used as probiotic agents in medicine, mainly for the treatment of various gastroenterological diseases, including inflammatory bowel disease." Wikipedia "RESULTS: Eighty-nine percent of the patients with acne, papular-pustular rosacea and seborrhoic dermatitis responded to E. coli Nissle therapy with significant amelioration or complete recovery in contrast to 56% in the control arm (P < 0.01). Accordingly, in the E. coli Nissle treated patients life quality improved significantly (P < 0.01), and adverse events were not recorded. " World J Gastroenterol. 2016 Jun 21;22(23):5415-21. doi: 10.3748/wjg.v22.i23.5415. Intestinal-borne dermatoses significantly improved by oral application of Escherichia coli Nissle 1917. Manzhalii E, Hornuss D, Stremmel W.