Guide

There is evidence that the demodex density count is higher on rosaceans than on the general population. What are the numbers? To learn what those numbers are we have a post in the members forum of our website which requires you to join as a subscribed active member. Please donate and join by subscribing to our non profit organization for rosacea patient advocacy. Demodectic Rosacea

You may have heard about rosacea rebound with certain rosacea treatments. If not, you should learn what might happen if a certain rosacea treatment has the side effect of rosacea rebound. There is a difference between rosacea rebound and an allergic reaction to a rosacea treatment. To learn more read this article. (requires subscription for members only)

There are over twenty different theories on the cause of rosacea categorized for your investigation. Guests can search through these theories for more information (only members may post). Watch this less than one minute trailer to the longer eleven minute video (keep scrolling down): Here is the full video version (eleven minutes): Join to deep dive into rosacea theories (requires subscription).

Please Note: All the links in the end notes are accessed only by registered subscribed members. Whenever rosacea triggers come up, invariably rosacea diet triggers are discussed. Usually your dermatologist will parrot the NRS trigger list and mention avoiding 'spicy food' or 'wine.' [1] Since rosacea diet triggers invariably come up by these rosacea authorities, is there some sort of nutritional deficiency in rosaceans? There is much debate and controversy regarding this subject, but you may not be aware of this discussion and want to learn more. [2] What the NRS rosacea trigger list omits is that carbohydrate and sugar are in fact just as valid a rosacea trigger as any on the NRS 'official' rosacea trigger list. [3] Liver, Yogurt, Sour Cream, Cheese, Eggplant, and Spinach What is really interesting is how the NRS lists "Liver, Yogurt, Sour Cream, Cheese, Eggplant, and Spinach" as rosacea triggers. [4] Most rosaceans are quite surprised when learning that these foods are listed on the NRS rosacea trigger list. Why do you think these foods are listed? There is a controversy that usually comes up when discussing carbohydrate and sugar as rosacea triggers since the RRDi is the only non profit organization for rosacea that lists these two foods as rosacea diet triggers on its official list. [5] Usually, uninformed rosaceans will argue that carbohydrate is essential for humans which is simply not true. [6] While rosaceans can tolerate some carbohydrate/sugar the overwhelming anecdotal evidence is that these in two foods are rosacea diet triggers. [7] The controversy gets even more heated since the ones who are passionate about this subject are not aware of sugar's addictiveness. [8] There is a lot more information to investigate on rosacea diet triggers and to learn more why not subscribe as a RRDi member for one month and see for yourself how much you can learn. [9] End Notes [1] Spicy Food A Rosacea Trigger? [2] Nutritional Deficiencies? [3] Carbohydrate A Rosacea Trigger Sugar and Rosacea [4] Liver, Yogurt, Sour Cream, Cheese, Eggplant, and Spinach [5] RRDi Official Rosacea Trigger List [6] Carbohydrate Not Essential For Human Survival [7] Carbohydrate & Sugar Avoidance Carbohydrate (anecdotal reports on trigger avoidance) Sugar (anecdotal trigger reports) [8] Sugar (addictive?) More On Sugar And Rosacea Sugar = Rosacea Fire [9] Diet Triggers for Rosacea

Do Rosacea Sufferers have Nutritional Deficiencies? (members only) Rosacea Diet Triggers (guests)

Sirt7 "is member of the mammalian sirtuin family of proteins, which are homologs to the yeast Sir2 protein." [1] The "loss of Sirt7 alleviates the rosacea-like features in mice. Thus, we reveal a SIRT7-TLR2-NF-κB axis that can be targeted for the improvement of rosacea." [2] "Sirtuins are a family of signaling proteins involved in metabolic regulation." [3] "In summary, we demonstrate that loss of SIRT7 reduces embryonic viability and causes premature aging." [4] End Notes [1] Sirtuin 7, Wikipedia [2] PubMed RSS Feed - -Aging-conferred SIRT7 Decline Inhibits Rosacea-like Skin Inflammation via Modulating TLR2-NF-κB Signaling [3] Sirtuin, Wikipedia [4] The EMBO Journal (2016)35:1488-1503 SIRT7 promotes genome integrity and modulates non-homologous end joining DNA repair Berta N Vazquez Joshua K Thackray Nicolas G Simonet Noriko Kane-Goldsmith Paloma Martinez-Redondo Trang Nguyen Samuel Bunting Alejandro Vaquero Jay A Tischfield Lourdes Serrano

The RRDi is pleased to announce that Negar Zabet, Pharmacist, has volunteered to serve on the RRDi MAC to answer questions about prescription treatments for rosacea. You will have to subscribe as a member to ask questions and read her responses.

The RRDi is pleased to announce that Negar Zabet, Pharmacist, has volunteered to serve on the RRDi MAC and we appreciate any volunteer time she has to answer questions from RRDi members. She has published a number of papers on PubMed. Her CV can be downloaded below:

"Given the increasingly widespread use of smartphones, they have the potential to become an important tool in dermatology, especially to reach underserved populations and limit contact during the COVID-19 pandemic. Many of the diverse functions that can be carried out from a smartphone are in the form of apps designed for both patients and providers." Int J Environ Res Public Health. 2022 Mar; 19(6): 3553. Usefulness of Smartphones in Dermatology: A US-Based Review

Topical probiotics in the form of various dermatological formulations are an important part of the treatment of skin conditions. Pharmaceutics. 2022 Mar; 14(3): 557. Topical Probiotics: More Than a Skin Deep

Updates In February 2022 we sectioned off about three quarters of our website to members only and only allow guests to view a portion of our website. At the end of March we switched to a subscription based website for members only and allow 95%e of our website to members only who subscribe at least $2/month donation ($1/month for three or more months). Guests were allowed to post for free in our guest forum if until the end of June 2022. Now guest cannot post period unless they subscribe. Watch Season 2 Episode 3 that explains all this. Since November 2023, due to a generous donation from one of our members, we have opened up the member forum to guests to view and only allow subscriber members to post. My current regimen is using Azelaic Acid generic topical regularly, avoid sugar/carbohydate as much as possible, use the ZZ cream on a regular basis (once a week), stopped drinking alcohol, take loads of vitamins/minerals, drink lots of sugar free seltzer, eating high protein/fat, and continue taking carvedilol. Why not donate $2 and gain access to our member forum and create your own rosacea blog?

"The findings from this study present the concept of the involvement of the gut–brain–skin axis in rosacea." Int J Mol Sci. 2020 Nov 10;21(22):Updates on the Risk of Neuropsychiatric and Gastrointestinal Comorbidities in Rosacea and Its Possible Relationship with the Gut-Brain-Skin Axis.Woo YR, Han YJ, Kim HS, Cho SH, Lee JD Image courtesy of the International Journal of Molecular Sciences, under the terms and conditions of the Creative Commons Attribution (CC BY) license Another paper on the gut-brain axis in the use of treating women with antibiotics in midlife concluded the following: 'In summary, we found that chronic antibiotic use during midlife was associated with minor decreases in cognitive scores assessed a mean of 7 years later. These data provide a better understanding of potential complications of antibiotics throughout life, as well as generate hypotheses about the role of the gut microbiome in cognition." [1] The above can assist you in your search for rosacea topics. However, if you want to deep dive into this register as a member of the RRDi and subscribe, since we have articles related to the above subject and you will be able to access the following: Do You Have A Gut Feeling About Your Rosacea? (members only) Gastrointestinal Rosacea [GR], aka, Gut Rosacea (members only) End Notes [1] See the fifth post dated April 6, 2022 in the following thread: Gastrointestinal Rosacea [GR], aka, Gut Rosacea (members only)

An article on the GUT BRAIN SKIN axis concluded the following: "In summary, we found that chronic antibiotic use during midlife was associated with minor decreases in cognitive scores assessed a mean of 7 years later. These data provide a better understanding of potential complications of antibiotics throughout life, as well as generate hypotheses about the role of the gut microbiome in cognition." PLoS One. 2022; 17(3): e0264649. Association of midlife antibiotic use with subsequent cognitive function in women

The FDA has approved MinoLira for treating acne which is a timed release minocycline hydrochloride tablet manufactured by EpiHealth. (if you are seeing error messages, i.e., see screenshot below, you are not an active member, learn more😞 To learn more register and subscribe to become an active member.

The FDA has approved MinoLira for treating acne which is a timed release minocycline hydrochloride tablet manufactured by EpiHealth. You may learn more about a savings card program on the official web site. It has not been approved for rosacea yet. Minocycline has been used for many years to treat rosacea. You may be interested in asking your dermatologist about minolira (timed released) or simply a generic minocycline which has been used for many years and proven just as effective as taking Oracea (doxycycline).

Ivermectin worthless against COVID in largest clinical trial to date Arstechnica

"This is the first case report of demodicosis associated with wearing a face mask." PubMed RSS Feed - -Demodicosis Associated with Wearing a Face Mask: A Case Report

We have a page on volunteering for the RRDi. We are currently in need of moderators for the Guest and Member Forums. Everyday we receive plenty of guest posts which are mostly in Russian, spam for pornography or selling wares or treatments for rosacea or for just about anything on the internet. We have to flag the spammer and delete the posts. This is a tedious and time consuming volunteer work. Let me ask you, if you were running a non profit for rosacea like the RRDi, would you appreciate getting huge donations from the skin industry like the NRS, the AARS and the ARSC (scroll down to 'Other Non Profit Rosacea Organizations' on this page) or would you prefer an independent rosacea non profit run by volunteers who care about other rosacea sufferers totally independent of the skin industry? If we don't get volunteers to help the RRDi we will be shutting down unless we can get enough donations somehow to pay employees or contractors like the NRS, the AARS and the ARSC does or get enough volunteers to run this non profit. You will always have the NRS, the AARS and the ARSC because they are entrenched with the skin industry sponsoring these non profits for rosacea. The RRDi is the only independent rosacea patient advocacy grassroots non profit for rosacea period. Step up to the plate and volunteer. Or if you prefer your favorite rosacea social media platform, why not Volunteer for the RRDi Social Media accounts?

In 2010 we published our first edition of the Journal of the RRDi through iUniverse, which cost us a significant amount of donated funds. We are now in a position to publish our next edition of the Journal of the RRDi and announcing this in our guest forum first to let guests know that we are accepting author contributions which will be reviewed and possibly published in our journal. We will be doing this totally with volunteers (no one is being paid) including no compensation to the authors we publish in our journal. At this time we are considering some sort of peer review process but as this is a very complicated and costly process, we may opt out if we can't comply with what is normally accepted as a clinical or medical peer review process. [1] "Clinical peer review should be distinguished from the peer review that medical journals use to evaluate the merits of a scientific manuscript, from the peer review process used to evaluate health care research grant applications, and, also, from the process by which clinical teaching might be evaluated. All these forms of peer review are confounded in the term Medical Peer Review." [2] What most rosaceans are totally unaware of is the peer review process is not only complicated but also controversial. For example this paper explains: "It's an example of an open secret in medicine: Many of the articles that appear in scientific journals under the bylines of prominent academics are actually written by ghostwriters in the pay of drug companies. These seemingly objective articles, which doctors around the world use to guide their care of patients, are often part of a marketing campaign by companies to promote a product or play up the condition it treats." [3] The NRS, the AARS, and the ARSC (other rosacea non profit organizations) have engaged in most of the non profit rosacea research that has been done, sponsoring authors with grants that are primarily supported by donations from the skin industry, particularly the pharmaceutical companies that treat rosacea. The RRDi is the only non profit for rosacea that is totally a patient advocacy grassroots non profit that is not supported by the skin industry and functions totally independently. If you would like to submit an article to be published in our next edition of the Journal of the RRDi, please click on the large SUBMIT button on our journal page by registering an account and following the directions on how to submit. Also, if you wish to volunteer as a proof reader, graphic artist or in technical support, please join the RRDi and mention in your profile that you want to volunteer. The RRDi is the lone watchdog on what the other rosacea non profit organizations are doing and is totally independent of the skin industry, even though we have repeatedly asked the pharmaceutical companies to donate to the RRDi. Brady Barrows RRDi Treasurer End Notes [1] Peer Review, Wikipedia [2] Clinical Peer Review, Wikipedia [3] Ghost Story, At Medical Journals, Writers Paid by Industry Play Big Role, December 13, 2005, By ANNA WILDE MATHEWS Staff Reporter of THE WALL STREET JOURNAL, DowJones Reprints • Order a reprint of this article now.

Watch Video Rosacea is associated with a number of other diseases, referred to as ‘systemic comorbidities’, which one study reports, “Clinicians must be aware of the potential for systemic comorbidities in rosacea patients, which becomes more likely as disease duration and severity increase.” We have a post on this with a list of what systemic comorbidities may be involved. To view this post, you will need to register as a subscribed member.

We have an interesting post on anonymity, transparency and posting. Here is the introduction: "You may have some thoughts on the subjects of anonymity, transparency and posting on the internet. This post is our explanation of how we understand these three subjects and if you have any thoughts on this, you are welcome to hit the REPLY TO THIS TOPIC button and add your thoughts." Read More

Freemium vs Subscription About a month ago we started the subscription plan using our Invision Community platform and asked for $12/year which is one dollar a month and received only one donation. About two weeks ago reduced the minimum to $6 and received no results. Yesterday, reduced it to $1 minimum for one month subscription and got one member. So we will try this for thirty days and see how it goes. When a member joins and uses PayPal, the PayPal fee is 51 cents so the RRDi only gets 49 cents as a donation. We had to change this to a two dollar donation to help pay for the PayPal fee for one month access. If you could simply choose a three, six month or twelve month subscription that would really help us out. We will update our progress with our new subscription based rosacea member forum over giving away everything for free. You probably have noticed over the years if you have been on the internet for a while that there is a difference between Freemium vs Subscription models according to Dignitas Digital. We have tried the freemium since 2004 and rosaceans have really changed. While in the past they loved the forum style model that was popular back then and posted freely, now a younger set of rosaceans have emerged totally bent on social media platforms that give freemium and find the forum style platform antiquated and not 'user friendly.' However, the forum style platform has been heavily influenced by the social media platforms and imitate its style. If one can manage a social media platform, this same person can easily click their way through our Invision Community forum style platform, so the question comes down to does the RRDi continue giving away our huge database of rosacea information on our website for free or should we charge for it? You need to clearly understand that social media, while popular, is freemium at a hidden price. While you can give away free information for a while if you have enough money to continue giving it away for free, the point is that giving away anything for free still incurs cost and unless there is enough money to continue giving it away for free, eventually, if the money runs out, the end of the freemium platform also ends. Yes, this is a wordy post, but you should see all the wordy posts we have on rosacea in our subscription based member forum platform. Way more information in logical categories and an excellent rosacea search engine that social media rosacea platforms are wanting. Guests, do you have any comments about any of this (commenting requires a subscription)? Why not try finding the reply to the topic button or the quote button and post your thought or comment and hide behind a cryptic display name that keeps you totally private so no one knows who you are. Would that take you a few minutes of your precious time? Would it cost you what you spend on a cup of coffee? Yes it would. The RRDi would appreciate your comment and allow it to be published in this thread. What an honor you would receive with your cryptic name display (honor? Yes, you are showing with your cryptic display name that you are either humorous or worthy of your comment). A subscription shows you are supporting the RRDi with a minimum donation. Do you think what you have visited as a guest is worth becoming a subscription member? If not, find on the internet what you are searching for with rosacea that gives everything away for free (freemium). Before you go, why not check out our site index to see if what you are searching for has been discussed on our website. Keep coming back to this post to see our progress with the subscription based platform. This post was originally titled "Update on the RRDi Guest Forum 3/12/2022" however we changed the title in August 2022.

We do have a post on alcohol and rosacea but you have to register and become a member to view the post. If you use our search box on the home page at the top and type in 'alcohol' you can read a list of posts on this subject which are numerous and you could search through them but again, you need to register an account and become a member to view most of these posts since guests are only allowed to view a small percentage of our rosacea data. Click here for a blurb about our post on alcohol and rosacea.

Hydroxychloroquine is an essential element of the dermatologist’s therapeutic arsenal. It is indicated as first- or second-line therapy in many photoinduced and photoaggravated inflammatory and granulomatous skin diseases. Using hydroxychloroquine for the treatment and prevention of COVID-19 has proven unsatisfactory and led to supply difficulties. Greater caution is required when recommending large-scale, off-label prescription of hydroxychloroquine to ensure that patients who need this drug have access to it. Hydroxychloroquine: An Essential Drug in Dermatology and Its Controversial Use in COVID-19

Topical creams minimise facemask complications, thereby promoting compliance; topical lidocaine was the most effective in reducing pain and enabling facemask compliance. Topical hydrocortisone, diphenhydramine, and zinc oxide were effective in reducing facial redness, and topical petrolatum produced the best user satisfaction. Facial topical cream promotes facemask tolerability and compliance during COVID-19 pandemic