Guide

An interesting article in our member forum worth reading is, Specialized Pro-resolving Mediators for Rosacea?

Lipoxygenase image courtesy of Wikimedia Commons In an article published in National Geographic, a new approach is discussed to treating inflammatory diseases (one theory is that rosacea is an inflammatory disease) using Specialized Pro-resolving Mediators (SPM) which were discovered in the 1990s by Charles Serhan, a professor of anesthesia at Harvard Medical School. [1] Prominent SMP members include the resolvins and protectins. [2] "SPM join the long list of other physiological agents which tend to limit inflammation (see Inflammation § Resolution) including glucocorticoids, interleukin 10 (an anti-inflammatory cytokine), interleukin 1 receptor antagonist (an inhibitor of the action of pro-inflammatory cytokine, interleukin 1), annexin A1 (an inhibitor of formation of pro-inflammatory metabolites of polyunsaturated fatty acids), and the gaseous resolvins, carbon monoxide (see Carbon monoxide § Physiology), nitric oxide (see Nitric oxide § Biological functions), and hydrogen sulfide (see Hydrogen sulfide § Function in the body and Hydrogen sulfide § Involvement in diseases)." [2] The cytokines mentioned above are related to the Immune System Disorder theory of rosacea. [3] Serhan was searching for fatty lipid molecules when he identified lipoxin that seemed to reduce inflammation. "Scientists speculate that one way lipoxins and other pro-resolution molecules work is by interacting with immune cells called macrophages." [1] "A lipoxin (LX or Lx), an acronym for lipoxygenase interaction product, is a bioactive autacoid metabolite of arachidonic acid made by various cell types." [4] "SPMs are being tested extensively in animal models of diseases like cancer and sepsis, and more modestly in small patient trials studying eczema and periodontal disease." [1] Whether SMPs are ever being considered to treat rosacea remains to be seen. Could a non profit organization for rosacea patient advocacy like the RRDi engage in a small patient trial studying rosacea? Depends if you can get enough members to get together to sponsor such a trial. Learn more about rosacea research. End Notes [1] The end of inflammation? New approach could treat dozens of diseases., Connie Chang, National Geographic Published March 4, 2022 [2] Specialized Pro-resolving Mediators, Wikipedia [3] Innate Immune Response Disorder Theory [4] Lipoxin, Wikipedia

Therefore, KLK5 inhibitors are considered as therapeutic agents for improving the underlying pathophysiology and clinical manifestation of rosacea. Here, we isolated the active constituents of Artemisia lavandulaefolia (A. lavandulaefolia) and investigated their inhibitory effect on KLK5 protease activity. PubMed RSS Feed - -Chlorogenic Acid Isomers Isolated from Artemisia lavandulaefolia Exhibit Anti-Rosacea Effects In Vitro ------------------------------------------------------------------- Artemisia lavandulaefolia has been known to use in the traditional medical practices. Extract of Artemisia lavandulaefolia Inhibits In Vitro Angiogenesis in Human Umbilical Vein Endothelial Cells ------------------------------------------------------------------- "Artemisia is a large, diverse genus of plants with between 200 and 400 species belonging to the daisy family Asteraceae. Common names for various species in the genus include mugwort, wormwood, and sagebrush." Wikipedia

Herein, we report the cases of 3 patients who presented with erythema on their hands and feet after dupilumab injections. Asia Pac Allergy. 2022 Jan; 12(1): e1. Acral erythema arising in patients with atopic dermatitis after dupilumab therapy: A case report of 3 patients Young Jae Kim, Mi Young Lee, and Chong Hyun Won

An article on cosmeceuticals concluded, "Most people choose to use natural beautifying items for healthcare purposes. Now currently, there is an extremely large interest in everyday natural beauty care merchandise. Sound teeth, gleaming hair, and shining skin are noteworthy for the attractiveness of the human frame. Various herbal elements/additives used in natural formulations contain bleaching agents, fixed oils, perfuming agents, waxes, antioxidants, protective agents, herbal colorants, critical oils, and plant fabrics that include leaves, gums, mucilage, etc. Herbal formulations comprising herbal substances are side lining synthetic ingredients quite successfully. On the basis of data represented here indicated the use of herbal medicines and bioactive compounds for cosmetic purpose and treatment of various diseases and it relies upon on the correcting redient requirements and superiority of product. Herbal cosmetics must undergo proper control measures for protection as it is of outstanding significance." Molecules. 2022 Feb; 27(3): 828. Bioactive-Based Cosmeceuticals: An Update on Emerging Trends Anju Goyal, Aditya Sharma, Jasanpreet Kaur, Sapna Kumari, Madhukar Garg, Rakesh K. Sindhu, Md. Habibur Rahman,Muhammad Furqan Akhtar, Priti Tagde, Agnieszka Najda, Barbara Banach-Albińska, Katarzyna Masternak,8 Ibtesam S. Alanazi,9 Hanan R. H. Mohamed, Attalla F. El-kott, Muddaser Shah, Mousa O. Germoush, Hamdan S. Al-malky, Salman H. Abukhuwayjah, Ahmed E. Altyar, Simona G. Bungau, Mohamed M. Abdel-Daim "Cosmeceuticals are cosmetic products with bioactive ingredients purported to have medical benefits. There are no legal requirements to prove that these products live up to their claims. The name is a portmanteau of "cosmetics" and "pharmaceuticals". "Nutricosmetics" are related dietary supplement or food or beverage products with additives that are marketed as having medical benefits that affect appearance." Cosmeceutical, Wikipedia

If you have registered an account with the RRDi you probably are in the inactive member group. The definition of an inactive member is one who has not posted in the last thirty days. Beginning in February 2022 we have basically allowed guests and inactive members to view about 5% of our website. We now have switched to a subscription based website so that active members can view the entire website if they donated $1/month. We have had to do this to assure we can continue to publish this website though Invision Community hosting services. If we don't have enough paid subscriptions to keep our non profit organization functioning through this website we will deem this to mean not enough rosaceans want to keep this going and simply shut down. Another option to become an active member who does NOT want to post is simply donate $12 and we will note this on your registered account and you will gain 12 months of full access to the site. If you are having any issues logging into your account, use our contact form and give us your email address you used to register your account and we can help you login by resetting your password. If you have any questions about any of this, find the reply to this topic button and post.

"Natural coumarins present in a variety of foods and herbs are a class of chemically diverse compounds with important biological effects, useful for health promotion and the prevention of various diseases. The most important adverse effects of coumarins are represented by hepatotoxicity favored by the ingestion of large doses and possible genetic polymorphism of CYP2A6 and dermatological phototoxic reactions. A better understanding of the safety profile of coumarins present in nutraceuticals is necessary for a safer use of these valuable natural compounds." Front Pharmacol. 2022; 13: 803338. Safety Profile of Nutraceuticals Rich in Coumarins: An Update Simona Codruta Heghes, Oliviu Vostinaru, Cristina Mogosan, Doina Miere, Cristina Adela Iuga, Lorena Filip

Our website is now a subscription based members only website. 95% of our website requires a donation of $12/year so we can keep this website going. Guests can only view about 5% of our website. Please register and donate $12 for a twelve month subscription. Thanks for your donation! We had to switch to a subscription based website as a last resort to see if we can keep this website going. If we don't get enough subscriptions or receive donations to keep our non profit organization website going we will be closing up shop here and no more non profit organization for rosacea patient advocacy. Why not find the reply to this topic button and post your comment or question?

Scroll below to understand what guests can view and what subscribed active members can view. Our website is now a subscription based members only website. 95% of our website requires a donation of $2 ($1/month for three or more months) to be able to post so we can keep this website going. Guests and inactive members may view about 95% of our website. Please register and donate $2 for a one month subscription. A minimum of one month is required which is just two dollars a month. Thanks for your donation! About the RRDi. We need 100 active subscribers! Guests May View the Following Without Registering (95% of our website) Home • Welcome • Blogs • Clubs • Site Index • Cause of Rosacea • Demodectic Rosacea • Misdiagnosed Rosacea • Phenotypes • Rosacea is a chronic inflammatory disease • MAC • Donate • Why Form Another Non Profit for Rosacea Sufferers? • Store • About • Amazon Associates • Board of Directors • Charter • Contact • Financial • Journal of the RRDi • Legal Disclaimer • Links • Member Information • Message from the Founder • Mission • Publications • Official Documents • Rules • Sponsors • Volunteers • Guidelines • Staff Directory • Recent Activity • Famous Rosaceans • Search • Leaderboard • Downloads • 5Min • Alabama • Amazon • Apple • ATP • Benefit Risk Ratio in Rosacea • Butterfly • Carbohydrate • Comorbidities • Conditions • Demodectic Rosacea Articles • Demodex Solutions • Donation Sample Letter • Final Appeal • Google Workspace • Grassroots • Guest Forum • Guidestar • GUT Rosacea • Hawaii • How To Videos • Invision Community • Isotretinoin • Ivermectin • MAC Alphabetical List • MAC Information • Mimics • Mirvaso • Mobile App • Most Private Rosacea Community • Newsletter • Non Profit • Nutrition • Oracea • Rebound • Recalcitrant • Remission • RSS • Is this Rosacea? • Rosaceans • RRF • Social Media • Soolantra • Sponsors • Square • Stages of Rosacea • Steroids • Store Video • Stripe • Subtypes • Sugar • Survey • Tee Shirts • Theories • Topics • Triggers • Videos • Why • ZZ Cream Registered Active Members and Guests Have Access to the Following (95% of our website) Over 7K posts & articles of rosacea information! • All Pages/Posts Guests Can Access (see the list above)• All the Subforums in Photo Dynamic Therapy (PDT) • All the Subforums in Non Prescription • All the Subforums in Prescription • All Subforums of Rosacea Theories • All the Subforums in Rosacea Topics • All Subforums in Trigger Avoidance • All the Topics in Ask the Board • All the Topics in Ask the MAC • Announcements and News • Articles (Rosacea) • Community Support • Co-Existing Conditions • Cosmetics • Demodectic Rosacea Forum • Diagnosis • FAQs Subforum • Funding Committee • Finding Rosacea Topics on a Mobile Device • Grant Writers Public Forum • Inactive Members • Member Forum • Newbie Rosaceans • OFF TOPIC • Probiotics • Public Relations • Phenotypes, Subtypes, Rosacea Variants & Mimics Subforum • Rosacea in the News • Rosacea Research • Rosacea in Remission • Rosacea & Psychology • Rosacea Topics • RSS • Secondary Therapy • Triggers • Error Messages If you are seeing error messages when trying to access areas only registered active members are allowed to enter since these areas are not open to guests or inactive registered members. Read more about error messages. Member Information

There is now a a minocycline extended-release oral capsule, similar to doxycycline (Oracea). For more information.

Again, as with all clinical papers on this subject the authors have no clue about carbohydrate and sugar avoidance.

"Dermatophytes (from Greek δέρμα derma "skin" (GEN δέρματος dermatos) and φυτόν phyton "plant") are a common label for a group of fungus of Arthrodermataceae that commonly causes skin disease in animals and humans. Traditionally, these anamorphic (asexual or imperfect fungi) mold genera are: Microsporum, Epidermophyton and Trichophyton. There are about 40 species in these three genera.." [1] 'Dermatophytoses are superficial fungal infections caused by dermatophytes affecting the skin, hair and/or nails. They are also termed as tinea infections. Dermatophytes are filamentous fungi that invade and feed on keratinized tissue like skin, hair and nails, causing an infection." [2] 'Topical anti-fungal therapy forms the mainstay of treatment in localized and naive dermatophytic infections. Topical anti-fungal agents are recommended for dermatophytoses affecting skin and presenting as localized infections. Systemic drugs are indicated for more extensive infections." [2] "In addition to causing symptomatic infections with different severity degrees, dermatophytes also colonize 30%–70% of the human population without causing clinical disease, thus these keratin parasites could be considered as a component of the human microbiota. Strikingly, the presence of dermatophyte in the skin, either in commensal or pathogenic relationship with susceptible hosts, has been related to asthma, allergy or eczematous skin." [3] "Successful treatment of these conditions depends first on accurate diagnosis, which is often quickly accomplished with a KOH examination." [4] "Diagnosis can be confirmed by direct microscopic examination with a potassium hydroxide preparation or by culture with the dermatophyte test medium." [5] "Dermatophyte infections can be readily diagnosed based on the history, physical examination, and potassium hydroxide (KOH) microscopy. Diagnosis occasionally requires Wood's lamp examination and fungal culture or histologic examination." [6] End Notes [1] Dermatophytes, Wikipedia [2] J Fungi (Basel). 2022 Jan; 8(1): 39. Pathogenesis, Immunology and Management of Dermatophytosis Shishira R. Jartarkar, Anant Patil, Yaser Goldust, Clay J. Cockerell, Robert A. Schwartz, Stephan Grabbe, and Mohamad Goldust [3] Front Immunol. 2020 Dec 2;11:605644. Skin Immunity to Dermatophytes: From Experimental Infection Models to Human Disease Verónica L Burstein, Ignacio Beccacece, Lorena Guasconi, Cristian J Mena, Laura Cervi, Laura S Chiapello [4] Postgrad Med. 1998 Feb;103(2):191-2, 197-200, 205. Common dermatophyte infections. A simple diagnostic test and current management J T Crissey [5] Postgrad Med. 1990 Apr;87(5):205-14. Superficial fungal infections. A practical guide for primary care physicians D M Pariser [6] Am Fam Physician. 2003 Jan 1;67(1):101-8. Dermatophyte infections Barry L Hainer

"Several compounds present in plants have been shown to have positive effects on skin health as well as photoprotective properties. It has been shown that several classes of secondary metabolites, such as alkaloids, carotenoids and phenolic compounds, provide protection against UVR damage in the skin. These compounds can absorb UVR, block it and stop the mechanisms by which UVR damages the skin. Mexican plant biodiversity is a valuable source of secondary metabolites with photoprotective effects. Several Mexican plants produce unique molecules or mixtures with significant antioxidant and photoprotection properties. Due to their outstanding mechanisms of action, crude plant extracts, isolated compounds from plants or mixtures could all be potential ingredients in a new generation of sunscreens. In addition to their strong antioxidant and photoprotective properties, they also prevent photoaging and skin cancers. Furthermore, most of them have little to no side effects, making them a safe option for sunscreens." Plants (Basel). 2022 Jan; 11(2): 220. Plant Secondary Metabolites against Skin Photodamage: Mexican Plants, a Potential Source of UV-Radiation Protectant Molecules Ana Mariel Torres-Contreras, Antoni Garcia-Baeza, Heriberto Rafael Vidal-Limon, Isaias Balderas-Renteria, Mónica A. Ramírez-Cabrera, and Karla Ramirez-Estrada Image of Portulaca oleracea flower courtesy of Wikimedia Commons

If you noted the statement in the abstract above which is reproduced for you here: "A still unanswered question is whether improper formulations could also prove to be counterproductive in other types of sensitive skin, such as rosacea." It is interesting to note a related abstract on the "clinical evidence about objective advantages of skincare routine remains limited despite advertising often claims benefits" and engaging in clinical tests on the skin using tools to collect data on this subject. Read more. More on Sensitive Skin

Liposomated means "incorporated into liposomes" according to Wiktionary and Wordsense. Liposome is "an aqueous compartment enclosed by a bimolecular membrane, typically of phospholipid; a lipid vesicle." The Visioscan® VC 20 plus is a unique UVA-light video camera with high resolution to study the skin surface directly. More Info. The above report mentions that "clinical evidence about objective advantages of skincare routine remains limited despite advertising often claims benefits." Two of the authors of the paper are affiliated with Nanovex Biotechnologies, Asturias, Spain which according to its website "works in the design and development of different nanovesicles to encapsulate different compounds.' The other two authors of the paper are associated with Clinica Dermatologica Internacional, Madrid, Spain. Wouldn't it be novel for the RRDi to independently sponsor a paper like this to evaluate skincare routines using similar equipment conducted by independent clinicians that are not affiliated with the skin industry? Would you help in sponsoring such a study? If enough members of the RRDi got together and decided this is what needs to be done it would take about $10K. The RRDi has currently 1600 plus members which would mean that each member would need to contribute $6.25 (less than a meal at a fast food chain). Can you see how a non profit organization has power if the members simply got together and decided to do something. What about you? Can you find the reply to this post button and make a comment about this?

Chronic Mucocutaneous Candidiasis (CMC) has been associated with "Rosacea-Like Demodicosis" in at least one paper. Forum Home > Forums > Member Forum > Rosacea Topics > Rosacea Theories > Various Environmental Stimuli Theories > Microorganisms > Fungus > Chronic Mucocutaneous Candidiasis and Rosacea CMC has now been added to the list of systemic cormorbidities in rosacea.

Just an update on our financial situation. Since Invision Community has raised the price of hosting our website on their servers from $30/month to $49/month we won't be able to keep the website going in about a year. If you appreciate all the videos and content on our website, we rely totally on the public for donations since we have appealed to the skin industry for donations which hasn't worked. We have appealed on our website for our members who number now over 1600 plus and we rarely if ever get donations from a member, we will simply have to close down the website if we do not receive donations to cover our expenses, particularly our hosting fee for the website. No one at the RRDi staff receives a dime since all are volunteer. Our funds are low and we are very transparent when it comes to our financial situation. If you have any questions or concerns why not reply to this thread as a guest and post?

"The digital divide refers to the gap between those who benefit from the Digital Age and those who do not.[1][2] People without access to the Internet and other information and communication technologies (ICTs) are put at a socio-economic disadvantage, as they are unable or less able to obtain digital information, shop online, participate democratically, or learn and offer skills. This resulted in programs to give computers and related services to people without access" [1] A paper in China reviews data how the covid pandemic increased the digital divide using a cosmetic course at the center of the study. [2] End Notes [1] Digital Divide, Wikipedia [2] Digital Divide in Online Education During the COVID-19 Pandemic: A Cosmetic Course From the View of the Regional Socioeconomic Distribution

A recent finding in a study led by Harvard researchers and published Tuesday in JAMA Network Open is mentioned in an article by Beth Mole at Ars Techinca, Nocebo responses explain up to 76% of COVID vaccine side effects.

The RRDi has an official list of famous rosaceans which you can view here: https://irosacea.org/famous/ If you know any of these famous rosaceans it would be appreciated if you could contact the one you know and ask if this famous rosacean would volunteer to serve on the RRDi board of directors. Wouldn't it be incredible if a famous rosacean supports the RRDi? If you know of a famous rosacean that we have not included on our official famous rosacean list please just find the reply to this topic button and type in the name and the reference on the internet that substantiates this famous person has rosacea and we will be happy to add your famous rosacean to our list once we have confirmed your nomination that this is absolutely true. You can remain totally anonymous since guests can post without registering and hide behind a cryptic display name. of your choosing.

Chronic Mucocutaneous Candidiasis (CMC) has been associated with "Rosacea-Like Demodicosis" in at least one paper. To view this subject and read the post you will need to join the RRDi to view: Forum Home > Forums > Member Forum > Rosacea Topics > Rosacea Theories > Various Environmental Stimuli Theories > Microorganisms > Fungus > Chronic Mucocutaneous Candidiasis and Rosacea CMC has now been added to the list of systemic cormorbidities in rosacea.

Chronic Mucocutaneous Candidiasis (CMC) has been associated with "Rosacea-Like Demodicosis" in at least one paper. CMC is "is an immune disorder of T cells, it is characterized by chronic infections with Candida that are limited to mucosal surfaces, skin, and nails. It can also be associated with other types of infections, such as human papilloma virus. An association with chromosome 2 has been identified." [1] "Heterozygous missense STAT1 mutations leading to a gain of function (GOF) are the most frequent genetic cause of chronic mucocutaneous candidiasis (CMC). We describe the case of a patient presenting a new GOF mutation of STAT1 with the clinical symptoms of CMC, recurrent pneumonia, and persistent central erythema with papulopustules with ocular involvement related to rosacea-like demodicosis.' [2] "Signal transducer and activator of transcription 1 (STAT1) is a transcription factor which in humans is encoded by the STAT1 gene. It is a member of the STAT protein family." [3] "Rosacea-Like Demodicosis" is a synonym for demodectic rosacea. CMC has now been added to the list of systemic cormorbidities in rosacea. End Notes All images courtesy of Wikimedia Commons [1] Chronic Mucocutaneous Candidiasis, Wikipedia [2] Front Immunol. 2021; 12: 760019. Case Report: A New Gain-of-Function Mutation of STAT1 Identified in a Patient With Chronic Mucocutaneous Candidiasis and Rosacea-Like Demodicosis: An Emerging Association Martin Martinot, Anne Sophie Korganow, Mathieu Wald, Julie Second, Elodie Birckel, Antoine Mahé, Laurent Souply, Mahsa Mohseni-Zadeh, Laure Droy, Julien Tarabeux, Satoshi Okada, Mélanie Migaud, Anne Puel, Aurelien Guffroy [3] STAT1, Wikipedia

"It has been reported that, because of occlusive effects of masks on the skin, some dermatitis of the face, such as acne, rosacea and seborrheic dermatitis, often worsen." Mycopathologia. 2021 Dec 29 : 1–2. “Mask” Tinea: An Increasing Infection during COVID-19 Pandemic Paolo Bortoluzzi, Vinicio Boneschi, and Stefano Veraldi ------------------------------------------------------------------ "For occupations that require employees to be physically present at the workplace, such as, in the healthcare or service industries, this entails several hours of facial mask use every day. This extended mask wear can lead to prolonged cutaneous occlusion and contact with sensitizing chemicals. As a result, several dermatoses have been observed with facial mask use, including, irritant contact dermatitis, allergic contact dermatitis, flare of rosacea, and contact urticaria. A previous study found that skin adverse effects, including itching, rash, and acne, were common with N95 respirator use but not with surgical mask use." J Clin Aesthet Dermatol. 2021 Oct; 14(10): 32–34. Facial Mask-related Acne and Acneiform Eruption During the Coronavirus Disease 2019 Pandemic: A Case Series Subuhi Kaul, MD, Ishmeet Kaur, MD, and Deepak Jakhar, MD ----------------------------------------------------------------- A total of 954 cases of dermatological adverse effects were reported. Over 17 different adverse facial reactions were found, including the top 10 in order: itch (370, 38.8%), indentation/ear pain (102, 10.7%), discomfort (90, 9.4%), erythema (72, 7.5%), dryness (62, 6.5%), rash (60, 6.3%), scarring (42, 4.4%), desquamation (22, 2.3%), pain (19, 2.0%), burning (19, 2.0%), and wheals (7, 0.7%). Face masks can increase acne (n=44), rosacea (n=14), and seborrheic dermatitis (n=9). J Clin Aesthet Dermatol. 2021 Sep; 14(9 Suppl 1): S39–S45. Adverse Effects of COVID-19 and Face Masks: A Systematic Review Akshitha Thatiparthi, BS, Jeffrey Liu, BS, Amylee Martin, BS, and Jashin J. Wu, MD ---------------------------------------------------------------- There is a real evidence of the rising prevalence of irritant and allergic contact dermatitis in response to the COVID-19 pandemic. The most commonly recorded symptoms are dryness, itch and redness of the skin. Nasal bridge, cheeks, forehead and hands represent the mainly affected skin sites. Curr Treat Options Allergy. 2022 Feb 10 : 1–8. Impact in Contact Dermatitis during and after SARS-CoV2 Pandemic Graziella Babino, MD, Giuseppe Argenziano, MD, PhD, and Anna Balato, MD, PhD

The financial situation of the RRDi is posted on our website at the following url: https://irosacea.org/financial We are transparent with our expenses so the public can see how we spend every dollar. We have made special efforts to reduce our expenses to the bare minimum. Register our domains, web hosting, our post office box, and registration fee for being a non profit organization are our main expanses. We operate on a shoe string budget since we totally rely on the public for donations to keep going. If you appreciate the rosacea content on our website we would appreciate your contributing to help us pay our bills. No individual on the RRDi staff makes a dime off of this non profit and everyone is a volunteer. You can rest assured that our non profit organization for rosacea does not use the donations to profit personally in any way. If you have any questions or concerns about our financial situation, please find the reply to this topic button on your device and post. You don't have to register to post and guests are welcome to post. We encourage guests to post. If the 1600 plus members of the RRDi would each donate one dollar a year that would keep our non profit organization for rosacea going for over a year! That is less than a cup of coffee. Do you appreciate the RRDi and want to help keep our non profit grassroots organization for rosacea going? Donate a dollar, please.