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  1. This article is found here.
  2. Rory, You will probably have better results using the horse paste over Soolantra, mainly because the horse paste is stronger ivermectin 1.87% over Soolantra's 1% and also because the inactive ingredients in the horse paste are simpler than Soolantra's list of inactive ingredients. So what brand of horse paste did you order? Also please be sure to post your results of taking oral ivermectin in the oral ivermectin post here. Just look at this comparison of horse paste inactive ingredients over Soolantra's inactive ingredients to see the difference: Eqvalan inactive ingredients: Hydrogenated Castor Oil, Titanium Dioxide (E171) 2.0% w/w., Hyprolose, Propylene Glycol Agri-Mectin inactive ingredients: Corn Oil, Polysorbate 80, Apple Flavor, and Aerosil. Soolantra's inactive ingredients: carbomer copolymer type B, cetyl alcohol, citric acid monohydrate, dimethicone, edetate disodium, glycerin, isopropyl palmitate, methylparaben, oleyl alcohol, phenoxyethanol, polyoxyl 20 cetostearyl ether, propylene glycol, propylparaben, purified water, sodium hydroxide, sorbitan monostearate, and stearyl alcohol. This simple comparison explains why more positive results are with horse paste because of its simple inactive ingredient list compared to the huge number of inactive ingredients in Soolantra which may explain why some like you and me may have a side effect of dryness or whatever. Probably the other horse paste brands have few inactive ingredients just as the two we did find above. The most popular horse paste, Durvet Paste doesn't list the inactive ingredients but it probably is a list of only three "Proprietary Components". Just about everyone reports it takes 12 weeks for clearance, but so do the positive reports using Soolantra, 12 weeks.
  3. In the past, the general consensus has been that more women have rosacea than men, particularly in certain variants of rosacea. We will use this post to collect papers on this subject. If you find any papers on this subject, please post in this thread. Severity Scores One report concluded, "Self-assessment severity scores were significantly higher in men (3.6 ± 1.3) than women (3.2 ± 1.0; P = .04).The authors conclude that rosacea is more severe in men and younger patients." [1] End Notes Dermatol Clin. 2018 Apr;36(2):97-102. doi: 10.1016/j.det.2017.11.004. Epub 2017 Dec 16. Measurement of Disease Severity in a Population of Rosacea Patients. Alinia H, Tuchayi SM, James SM, Cardwell LA, Nanda S, Bahrami N, Awosika O, Richardson I, Huang KE, Feldman SR.
  4. Rory, Soolantra is 1% ivermectin and the active ingredient.
  5. I have been taking the lutein/zeaxanthin which seems to dry up my skin some. Wrote a post about oral ivermectin. I would run this by my dermatologist before ingesting it. Topical ivermectin seems the best route.
  6. First off, if you don't know what Erythromelalgia is, it is listed as a rosacea mimic and should be ruled out in a differential diagnosis of rosacea. Someone kindly pointed out to me that The Erythromelalgia Association website is very user friendly and was impressed with the free Guide it offers on its website indicating to me that the RRDi needs to be more 'user friendly' and offering such a guide. So I decided to investigate and contacted TEA and asked for a copy of the latest Form 990 which was emailed to me and I have given a cursory investigation and am very impressed with how this 501 c 3 non profit organization spends its donations. First off, the board of directors are all volunteers. They have managed to bring in 3000 members, and more importantly in 2018 received over $50K in donations! They spent $103K which breaks down to this: $75,000 for Grants and similar amounts paid (list in Schedule O) "Gift for research directly related to erythromelalgia" $13,398 for Professional fees and other payments to independent contractors $14,230 for Printing, publications, postage, and shipping (newsletter) $884 for other expenses Total Expenses $103,512 Download Form 990 for 2018 and read it yourself: Form990Package.2018.pdf So this is definitely how a non profit organization should be run and I give the highest marks possible to TEA for how it is helping Erythromelalgia sufferers. We wish that the members of the RRDi would be interested in imitating the TEA and help make the RRDi just like how TEA is run. The RRDi is very similar in how the board of directors are volunteers. We just need volunteers to step up to plate like the TEA volunteers are doing. It would be good for members of the RRDi to ask questions about the above or comment on this post.
  7. "Better efficacy with IVM 1% cream (QD) compared to MTZ 0.75% cream (BID) contributes to an improved quality of life with significantly more patients achieving an MCID in DLQI score at week 16 and higher mean EQ-5D score. IVM 1% cream is thus a better alternative than MTZ 0.75% cream for severe papulopustular rosacea patients." Dermatol Ther (Heidelb). 2016 Sep; 6(3): 427–436. Superior Efficacy with Ivermectin 1% Cream Compared to Metronidazole 0.75% Cream Contributes to a Better Quality of Life in Patients with Severe Papulopustular Rosacea: A Subanalysis of the Randomized, Investigator-Blinded ATTRACT Study Martin Schaller, Thomas Dirschka, Lajos Kemény, Philippe Briantais, and Jean Jacovella -------------------------------------- "Ivermectin 1% cream was significantly superior to MTZ 0·75% cream and achieved high patient satisfaction." Br J Dermatol. 2015 Apr;172(4):1103-10. doi: 10.1111/bjd.13408. Epub 2015 Feb 11. Superiority of ivermectin 1% cream over metronidazole 0·75% cream in treating inflammatory lesions of rosacea: a randomized, investigator-blinded trial. Taieb A, Ortonne JP, Ruzicka T, Roszkiewicz J, Berth-Jones J, Peirone MH, Jacovella J; Ivermectin Phase III study group. --------------------------------------- "Topical ivermectin is an effective option in the treatment of papulopustular rosacea. Although ivermectin seems to be more effective than topical metronidazole, with both treatment options about two-thirds of patient relapsed within 36 weeks after discontinuation of treatment." Dermatol Ther (Heidelb). 2018 Sep;8(3):379-387. doi: 10.1007/s13555-018-0249-y. Epub 2018 Jun 25. Topical Ivermectin in the Treatment of Papulopustular Rosacea: A Systematic Review of Evidence and Clinical Guideline Recommendations. Ebbelaar CCF, Venema AW, Van Dijk MR. --------------------------------------- "Ivermectin 1% cream QD appears to be a more effective topical treatment than other current options for the inflammatory lesions of rosacea, with at least an equivalent safety and tolerability profile, and could provide physicians and dermatologists with an alternative first-line treatment option." Springerplus. 2016 Jul 22;5(1):1151. doi: 10.1186/s40064-016-2819-8. eCollection 2016. The efficacy, safety, and tolerability of ivermectin compared with current topical treatments for the inflammatory lesions of rosacea: a network meta-analysis. Siddiqui K, Stein Gold L, Gill J.
  8. Another study showing the superiority of ivermectin over metronidazole has been published by NEJH Journal Watch. 399 rosacea patients enrolled in a study who were judged clear after receiving 16 weeks of ivermectin treatment and stopped the ivermectin treatment. Those that had a greater IGA score of ≤2 (which means some pimples/redness returned) "resumed their original topical treatment until remission was again obtained" whether it was ivermectin or metronidazole. The study showed that the relapse rate of rosacea was more days than those using the metronidazole treatment, in other words, the number of days to the relapse of rosacea was higher in the ivermectin group than the metronidazole group. The study concluded, "The relapse rate by study end at 36 weeks was lower for IVER recipients (62.7%) than MET recipients (68.4%)." Metronidazole vs. Ivermectin Mark V. Dahl, MD reviewing Taieb A et al. J Eur Acad Dermatol Venereol 2015 Dec 21 Which drug for remission of rosacea? ------------------------------------------------ "The results of this relapse study showed that an initial successful treatment with ivermectin 1% cream QD significantly extended remission of rosacea compared with initial treatment with metronidazole 0.75% cream BID following treatment cessation." J Eur Acad Dermatol Venereol. 2016 May;30(5):829-36. doi: 10.1111/jdv.13537. Epub 2015 Dec 21. Maintenance of remission following successful treatment of papulopustular rosacea with ivermectin 1% cream vs. metronidazole 0.75% cream: 36-week extension of the ATTRACT randomized study. Taieb A, Khemis A, Ruzicka T, Barańska-Rybak W, Berth-Jones J, Schauber J, Briantais P, Jacovella J, Passeron T; Ivermectin Phase III Study Group -----------------------------------------------
  9. Image courtesy of Wikimedia Commons Acyclovir Amytriptyline Antibiotics Anti-Flushing Drugs Apple Cider Vinegar Histame Lutein with Zeaxanthin Low Dose Naltrexone Mastic Gum and HCL Supplements MSM and Grapefruit Seed Extract Niacinamide Oil of Oregano Oral Ivermectin for Rosacea Plaquenil (Hydroxychloroquine) Probiotics Prednisone (not a long term solution) Retinaldehyde Retinoids (low dose has become quite popular) Rosadyn Spironolactone Supplements (Vitamins/minerals) The list just keeps growing.... (prescription)
  10. 3.6. OS and Angiogenesis Associated with Rosacea Rosacea is a common chronic inflammatory dermatosis, clinically characterized by erythema of the central face, episodic flushing, papules, and pustules. Skin care and pharmacologic treatments are the pillars of effective management of rosacea. Apart from existing topical agents (sodium sulfacetamide, azelaic acid, metronidazole, and the alpha-adrenergic agonist brimonidine) and systemic medications (tetracyclines, beta-blockers and isotretinoin), new therapies including serine protease inhibitors and mast cell stabilizers may ameliorate rosacea symptoms. However, some of these approaches have not been approved by the Food and Drug Administration. Though the exact pathogenesis of rosacea needs to be clarified, OS and oxidation of lipids are considered as crucial factors to trigger and aggravate the inflammatory processes of rosacea. Increased OS and decreased antioxidants are determined in systemic circulation of rosacea. OS, in addition, is complicated in vascular changes, inflammation, and oxidative tissue damage in rosacea. Therefore, antioxidants may be a potential strategy for treating rosacea. As an essential process in chronic inflammatory dermatoses, angiogenesis also contributes to the development of rosacea. Amal et al. reported that VEGF expression elevated in cutaneous lesions of rosacea and was consistent with vascular histological changes which clinically presented as erythema and telangiectasia. VEGF, indeed, has an important impact on the angiogenesis process, responsible for telangiectasia and increased vascular permeability, leading to cutaneous inflammation and the presence of papules, pustules, and nodules in rosacea. Thus, attenuation of OS and VEGF may be relevant approaches for the therapy of rosacea. However, more research should be carried out to clarify the relationship of OS and angiogenesis and provide a novel therapeutic way for rosacea. Oxid Med Cell Longev. 2019; 2019: 2304018. Emerging Roles of Redox-Mediated Angiogenesis and Oxidative Stress in Dermatoses Dehai Xian, Jing Song, Lingyu Yang, Xia Xiong, Rui Lai, and Jianqiao Zhong
  11. Diffuse lissamine green staining in a person with severe dry eye. Image Wikimedia Commons A paper published in the Journal of Women's Health addresses the prevalence of DED in women and highlights a significant opportunity for action if earlier diagnosis and treatment of this common but burdensome condition is obtained that could significantly improve a woman's quality of life. As the Mayo Clinic observes, "Ocular rosacea may affect the surface of your eye (cornea), particularly when you have dry eyes from a deficiency of tears." The comprehensive paper concludes, "Women are diagnosed with DED at earlier ages, and progression to severe forms of the disease is more prevalent in women than men. Thus, earlier diagnosis of DED in women may result in a significant improvement in their quality of life." If you have rosacea and DED it would be prudent to see your dermatologist as soon as possible. J Womens Health (Larchmt). 2019 Apr 1; 28(4): 502–514. Dry Eye Disease: Consideration for Women's Health Cynthia Matossian, MD, FACS, Marguerite McDonald, MD, FACS, Kendall E. Donaldson, MD, MS, Kelly K. Nichols, OD, MPH, PhD, Sarah MacIver, OD, and Preeya K. Gupta, MD
  12. image Wikimedia Commons Someone at RF posted a subject, 'Random flareup from steak alleviated with propranolol?' and here was my response: beherenow, glad the propranolol helped your flareup. It is important to eliminate what actual food is triggering your flareup, as well as defining the flareup, whether you mean a rosacea flareup or a flushing flareup, since flareup means different things to Rosaceans. For example, while you mention celery juice and a lot of water, understanding what an elimination diet is all about will help, since not everyone agrees what an elimination diet is. For example, there are a number of lists proposed what food/drink triggers rosacea, the most known list is the NRS list. Steak/hambuger is not on the list, and you would be hard pressed to find any rosacea trigger list or anecdotal report with steak/hamburger mentioned, but I urge you to find some to substantiate your suggestion. However, LIVER is at the top of the the NRS list. Trigger factors that are listed are all anecdotal or taken from patient histories and therefore possibly helpful, but extremely subjective. There has never been one rosacea diet trigger factor that produces a rosacea flareup in every rosacean, not one. Any proposed rosacea diet trigger is just that, a proposed factor. It may be helpful to others to read about such diet triggers to see if avoiding 'steak/hamburger' or whatever improves their rosacea flareups or it may not. For example, on the NRS list rosaceans have reported that Liver, Yogurt, Sour Cream, Cheese, Eggplant, and Spinach are "Factors That May Trigger Rosacea Flare-Ups," however, you will be hard pressed to find any clinical study indicating scientific proof, and the key word is MAY. Another factor to consider is that rosacea diet triggers may be cumulative over a certain number of days. You have to consider what you have been eating/drinking cumulatively over the last three to five days. For example, let's say you have been eating/drinking fruit smoothies as well as celery juice over the past three to five days and have accumulated a huge amount of fructose (which is converted to glucose) in your blood. Fructose, as well as any other sugar is also a rosacea diet trigger proposed by the RRDi which the NRS totally ignores. So there is a lot to consider in determining what is actually triggering your flareup when it comes to rosacea diet triggers. Drugs, and as you mentioned the environment, stress, and a lot other factors are proposed to be rosacea trigger factors.
  13. Ivermectin treatment for rosacea was first announced by Galderma in its February 2015 release of Soolantra. Since then this prescription topical treatment for rosacea has had much success. Sometime around 2017 the first reports of using horse paste topically for rosacea containing 1.87% ivermectin began circulating in rosacea social media groups and this has spread further so that thousands have reported success in treating their rosacea. There are some reports of using oral ivermectin to treat rosacea. There are reports that oral ivermectin along with oral metronidazole is more effective than oral ivermectin alone. The RRDi recommends that if you decide to treat your rosacea with ivermectin to discuss this with your physician, preferably a dermatologist, since not only is ivermectin prescribed as a prescription medication for rosacea, it is easily available online without a prescription.
  14. Found this discussion pertinent to this thread. If anyone has anything to post about using any of the Kiss products for rosacea other than mchatham, please share.
  15. Autosensitization dermatitis when it appears on the face can be indistinguishable from rosacea, hence a rosacea mimic. "Autosensitization dermatitis presents with the development of widespread dermatitis or dermatitis distant from a local inflammatory focus, a process referred to as autoeczematization." Wikipedia "The term autosensitization dermatitis was coined in 1921 by Whitfield to describe reaction patterns ranging from a generalized, erythematous, morbilliform, and urticarial eruption after blunt trauma to a generalized, petechial, papulovesicular dermatitis after the acute irritation of chronic stasis dermatitis." Chapter 17. Autosensitization Dermatitis, Fitzpatrick's Dermatology in General Medicine, Donald V. Belsito A case in point is recorded in the Journal of the American Academy of Dermatology about a 46 year old woman who was initially diagnosed with rosacea and later diagnosed with Autosensitization dermatitis.
  16. A new rosacea mimic has emerged called Autosensitization dermatitis which is indistinguishable from rosacea when it appears on the face. It is now added to the list of skin conditions that need to be differentiated from rosacea, which list keeps growing. So what is it? "Autosensitization dermatitis, or id reaction, is a cutaneous phenomenon in which an acute secondary dermatitis develops at a location distant from a primary inflammatory focus." [1] The case of a 46-year-old woman (with photos) published in the Journal of the American Academy of Dermatology was initially diagnosed as papulopustular rosacea but resistant to all usual treatments for this disease which included topical and oral metronidazole, several oral tetracyclines, isotretinoin, ivermectin, topical dapsone with oral metronidazole. Later, she was found to have a rosacea-like id reaction in response to an oral infection after treatment with amoxicillin-clavulanate. This case indicates that there are difficult cases to treat due to not obtaining a correct diagnosis initially. End Notes [1] JAAD Case Rep. 2019 May; 5(5): 410–412.Autosensitization dermatitis: A case of rosacea-like id reactionSarah D. Ferree, BA, Connie Yang, BA, and Arianne Shadi Kourosh, MD, MPH
  17. "Our results demonstrate that in eyelashes with CD, the prevalence of Demodex brevis is higher than that of Demodex folliculorum. We also found that the number of Demodex spp. increases with age and that females are attacked more easily than males by Demodex spp. In patients with CD eyelashes, the severity of eyelid congestion was exacerbated by the prevalence and number of Demodex spp." J Ophthalmol. 2019; 2019: 8949683. The Prevalence of Demodex folliculorum and Demodex brevis in Cylindrical Dandruff Patients Jing Zhong, Yiwei Tan, Saiqun Li, Lulu Peng, Bowen Wang, Yuqing Deng, and Jin Yuan
  18. "Sarecycline (trade name Seysara; development code WC-3035) is a tetracycline-derived antibiotic. In the United States, it was approved by the FDA in October 2018 for the treatment of moderate to severe acne vulgaris". Wikipedia "There are currently no clinical trials underway assessing sarecycline in rosacea.....For moderate to severe and inflammatory acne vulgaris, oral antibacterials are standard care components, with tetracyclines and macrolides usually preferred. However, these agents have certain limitations, among which are photosensitivity (tetracyclines), adverse vestibular effects (minocycline), gastrointestinal disturbances (particularly with macrolides and doxycycline), dysbiosis and microbial resistance concerns." Drugs. 2019; 79(3): 325–329.Sarecycline: First Global ApprovalEmma D. Deeks
  19. "Concurrent improvement of ocular surface conditions observed in patients treated for rosacea of their face, led to the potential implementation of intense pulsed light (IPL) for the treatment of MGD (meibomian gland dysfunction). IPL has been widely used in dermatology to treat various conditions such as rosacea, benign vascular lesions, and pigmented lesions....Patients with low meibum expressibility and tear film instability experienced greater improvement in symptoms after IPL treatment. The improvement in meibum expressibility was also associated with a decrease in tear inflammatory cytokine levels. Therefore, meibum expressibility improvement might be a good therapeutic target of IPL treatment in patients with MGD and DED, and could be an indicator of ocular surface inflammation during IPL treatment." Sci Rep. 2019; 9: 7648. Meibum Expressibility Improvement as a Therapeutic Target of Intense Pulsed Light Treatment in Meibomian Gland Dysfunction and Its Association with Tear Inflammatory Cytokines Moonjung Choi, Soo Jung Han, Yong Woo Ji, Young Joon Choi, Ikhyun Jun, Mutlaq Hamad Alotaibi, Byung Yi Ko, Eung Kweon Kim, Tae-im Kim, Sang Min Nam, and Kyoung Yul Seo
  20. Lex Gillies, Beauty Blogger, has a new article published in Refinery29, Have Chronic Rosacea – This Is The Only Skincare Routine That Helps.
  21. image courtesy of WikiMedia Commons A clinical study has confirmed that the most common allergens rosacea patients suffer contact dermatitis are the following ingredients: Octyl Gallate Dodecyl Gallate tert-Butylhydroquinone Thimerosal Euxyl K400 (Methyldibromo glutaronitrile) Cocamidopropyl betaine (CAPB) 2,6-Di-tert-butyl-4-cresol (Butylated hydroxytoluene) The study concluded, "This study shows that rosacea patients show a strikingly high prevalence of contact sensitization to cosmetic allergens. We recommend the additional use of cosmetic series for patch testing, and the careful use of cosmetics in rosacea patients if cosmetic contact sensitivity is suspected." [1] End Notes [1] J Cosmet Dermatol. 2019 May 20;: Contact sensitization to cosmetic series of allergens in patients with rosacea: A prospective controlled study. Ozbagcivan O, Akarsu S, Dolas N, Fetil E
  22. Thanks for your clearer explanation. If I understand correctly the steps would be the following in your case: (1) Demodex are living in normal numbers without any indication of rosacea. These mites secrete bioactive molecules that inhibit TLR2 expression in sebocytes. (2) You have immunocompromised cellular immunity, due to whatever, i.e., stress, poor diet, lack of exercise, virus, flu, and the list goes on and on.... (3) The mites increase in number (4) The immune system goes into hyperdrive due to the higher density of mites resulting in inflammation (reciprocal correlation) further increasing the mites density numbers Please correct me if I got this wrong.
  23. For years, the RRDi has quoted posts of rosacea sufferers from other websites, particularly RF. We never have received any complaints. Recently the RRDi posted some quotes of rosacea sufferers from Facebook with the names to acknowledge the source of the quote and discovered that some of the posts at Facebook groups are in a private exclusive group and you have to get permission to quote these particular posts. The RRDi did not know that private Facebook groups are different from public Facebook groups. Our intent was to help rosacea sufferers. One particular project was to get a list of the positive posts about using horse paste and some negative posts. We didn't realize that this offended the posters who gladly posted in their private, exclusive group that either the horse paste worked for them or it was a negative post about horse paste. So upon request, we have removed all these posts. There are other interesting posts in these private, exclusive Facebook groups that we gleaned by browsing these groups and posted and quoted these helpful items here and have removed the names of the posters upon request. Our intent was not to hurt or embarrass any rosacea sufferer. Our intent is to help rosacea sufferers. The RRDi complies with requests for removal of certain published material on the internet from our website. Our legal disclaimer clearly outlines the step for takedown procedures. We have a solid privacy policy and respect everyone's privacy. However, for those of you who may not understand the legality of this issue, you may want to read these two answers to the following two questions: Can You Quote or Use Someone Else’s Facebook Posting? Question: Is it illegal to quote someone without permission?
  24. That is difficult to follow. In a paper by Powell, et al, it is stated that the mites "secrete bioactive molecules that reduced TLR2 expression in Sebocytes." The 'bioactive molecules' that the mites secrete keep the innate immune system from reacting to the mites when in normal numbers on normal skin, so my question is what causes the demodex to proliferate in greater numbers to what you say, "cause inflammatory immune response" ? Could you better explain what you mean by "self-antigen presentation to immune cells rather than non-self which is false immune response? ?
  25. While it has been reported that topical ivermectin has better results than topical metronidazole for rosacea, there is a paper you should consider reading if you are considering taking oral ivermectin and metronidazole for rosacea. Oral Ivermectin for Rosacea A paper published by the International Journal of Infectious Diseases that compared taking 200 micro-grams Ivermectin per Kilogram of body weight of oral ivermectin once a week in one group (1) of sixty rosacea patients with another group (2) of sixty rosacea patients who received a combined therapy of the same amount of ivermectin along with 250 mg of oral metronidazole three times a day. The results were that the second group (2) improved better than the first group. For more information Ivermectin History Some may be concerned about taking ivermectin orally. It is interesting to note that ivermectin has been around since the late 1970s and half "of the 2015 Nobel Prize in Physiology or Medicine was awarded jointly to Campbell and Ōmura for discovering avermectin, 'the derivatives of which have radically lowered the incidence of river blindness and lymphatic filariasis, as well as showing efficacy against an expanding number of other parasitic diseases' " Wikipedia Ivermectin is "a dihydro derivative of avermectin—originating solely from a single microorganism isolated at the Kitasato Intitute, Tokyo, Japan from Japanese soil...originally introduced as a veterinary drug...has led many to describe it as a “wonder” drug....few drugs that can seriously lay claim to the title of ‘Wonder drug’, penicillin and aspirin being two that have perhaps had greatest beneficial impact on the health and wellbeing of Mankind....But ivermectin can also be considered alongside those worthy contenders, based on its versatility, safety and the beneficial impact that it has had, and continues to have, worldwide—especially on hundreds of millions of the world’s poorest people....Despite decades of searching around the world, the Japanese microorganism remains the only source of avermectin ever found. Originating from a single Japanese soil sample and the outcome of the innovative, international collaborative research partnership to find new antiparasitics, the extremely safe and more effective avermectin derivative, ivermectin, was initially introduced as a commercial product for Animal Health in 1981." [1] While there are no long term clinical studies done on ivermectin use with rosacea, there are papers showing the long term effects of oral ivermectin in school-age and pre-school children treated for helminths. [2] There are also papers written about the long term effects of treating humans with ivermectin on other parasites, i.e., scabies. 'Intriguingly, IVM has a diverse range of effects in many different organisms, far beyond the endoparasites and ectoparasites it was developed to control. For example, IVM has been shown to regulate glucose and cholesterol levels in diabetic mice, to suppress malignant cell proliferation in various cancers, to inhibit viral replication in several flaviviruses, and to reduce survival in major insect vectors of malaria and trypanosomiasis. Clearly, much remains to be learned about this versatile drug, but the promise of more sustainable strategies for current helminth-control programmes and novel applications to improve and democratise human health, are compelling arguments to pursue this cause." [3] "Evidence suggests that oral ivermectin may be a safe and effective treatment for scabies". One article says "A Single, Oral Dose of Ivermectin Cures Scabies". [4] Two oral doses of ivermectin was found to be just as effective as a single topical application of permethrin in treating scabies. [5] "When given orally, ivermectin can be used for treating head or pubic lice and scabies (an itchy, highly contagious skin disease caused by mites burrowing in the skin). Oral ivermectin is useful to control outbreaks of scabies in nursing homes where whole-body application of topical agents is difficult. Ivermectin's greatest impact on human health has been in Africa. Since 1987, in addition to its use for other parasitic infestations, ivermectin has been used extensively to control onchocerciasis with 1.4 billion treatments so far. Onchocerciasis is also called "river blindness" because the blackfly that transmits the disease breeds in fast-moving streams and rivers." [6] In an article in The New York Times, Scabies Means Misery. This Pill Can End It., it states, "Nonetheless, the drug is considered safe enough to give to almost everyone except the youngest infants and pregnant women." So there are a substantial number of humans globally who have taken oral ivermectin. Horse Paste With the craze of rosaceans using horse paste to treat rosacea topically (containing 1.87% ivermectin), there is at least one report of oral horse paste treatment for Lyme disease in Facebook by a poster. [7] Another website suggests taking oral ivermectin and using topical horse paste to treat scabies. [8] Anecdotal Reports ElaineA has a post worth reading on this subject, Oral Ivermectin, getting diagnosed and a prescription. Another poster, eringael, reports success using oral ivermectin/metronidazole. She also has some incredible photos in this thread worth looking at. More information on oral ivermectin. End Notes [1] Proc Jpn Acad Ser B Phys Biol Sci. 2011 Feb 10; 87(2): 13–28. doi: 10.2183/pjab.87.13 PMCID: PMC3043740; PMID: 21321478 Ivermectin, ‘Wonder drug’ from Japan: the human use perspective Andy CRUMP and Satoshi ŌMURA "When doctors in the USA prescribe ivermectin for scabies that is called an "off-label" use. This is not unusual and it is generally legal. Once a drug has been FDA approved for one disease or use, a doctor can prescribe it for any other use they choose to. Read more about "off-label use" in Wikipedia here. Wikipedia says "Off-label use is generally legal unless it violates specific ethical guidelines or safety regulations, but it does carry health risks and differences in legal liability." In other words, if the doctor thinks it is unethical to prescribe ivermectin or that he might get sued for prescribing it, he probably won't." In Depth Information On Ivermectin, MaximPulse, Green Dept [2] PLoS Negl Trop Dis. 2008 Sep; 2(9): e293. Published online 2008 Sep 10. doi: 10.1371/journal.pntd.0000293 PMCID: PMC2553482; PMID: 18820741 Impact of Long-Term Treatment with Ivermectin on the Prevalence and Intensity of Soil-Transmitted Helminth Infections Ana Lucia Moncayo, Maritza Vaca, Leila Amorim, Alejandro Rodriguez, Silvia Erazo, Gisela Oviedo, Isabel Quinzo, Margarita Padilla, Martha Chico, Raquel Lovato, Eduardo Gomez, Mauricio L. Barreto, and Philip J. Cooper [3] Trends in Parasitology Volume 33, Issue 6, June 2017, Pages 463-472 Ivermectin – Old Drug, New Tricks? Roz Laing. Victoria Gillan. Eileen Devaney [4] CDC, Scabies, Medications A Single, Oral Dose of Ivermectin Cures Scabies NEJM Journal Watch, September 1, 1995 [5] Ann Parasitol. 2013;59(4):189-94. The efficacy of permethrin 5% vs. oral ivermectin for the treatment of scabies. Ranjkesh MR, Naghili B, Goldust M, Rezaee E. [6] Oops! I Just Took My Dog's Heartworm Medicine Ivermectin Safety, National Capitol Poison Control [7] Post number five in this thread (posted May 2, 2019) [8] Ivermectin to cure scabies, Maximpulse, Green Dept
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