Guide

"...But did you also know that retinol is used for acne, brown spots and rosacea?....There are also different strengths of retinol..." What Every Skin Care Product Junkie Should Know About Retinol, News Tribune, Illinois

"The aim of this prospective study was to evaluate the impact of the skin conditions of patients with various skin diseases affecting their face (scars, acne, rosacea, melasma, vitiligo, hypo or hyperpigmentation, lentigines, etc) on their QOL and the improvement afforded by the use of corrective makeup for 1 month after being instructed on how to use it by a medical cosmetician during an initial medical consultation....Our results suggest that dermatologists should encourage patients with disfiguring dermatoses to utilize appropriate and safe makeup to improve their appearance and their QOL. Corrective makeup can also complement the treatment of face dermatological diseases in order to improve patient’s adherence." Clin Cosmet Investig Dermatol. 2012; 5: 123–128. Published online 2012 Sep 7. doi: 10.2147/CCID.S33172 PMCID: PMC3459545 Interest of corrective makeup in the management of patients in dermatology S Seité, P Deshayes, B Dréno, L Misery, P Reygagne, P Saiag, F Stengel, AM Roguedas-Contios, and A Rougier

"The literature documents significant emotional benefits using medical therapy in conditions such as acne, psoriasis, vitiligo, and rosacea, but there is little evidence documenting similar results with the use of cosmetic camouflage.....Cosmetic camouflage provides a significant emotional benefit for patients with facial skin conditions, and this is substantiated by a literature review and personal experience....Camouflage therapy serves as a mechanism to help give immediate satisfaction to patients, although many physicians/residents do not consider this as a validated therapy....It is important for dermatologists to provide this option to patients upon initial consultation because it provides immediate results and can be helpful while awaiting effects from medical treatment.....By increasing awareness and knowledge of cosmetic camouflage, physicians will be able to offer additional services and treatment options for patients suffering from skin lesions causing emotional distress, help to build confidence in the patient-physician relationship, improve patient QoL, and increase compliance with concurrent medical therapies." Clin Cosmet Investig Dermatol. 2012; 5: 173–182. Published online 2012 Nov 1. doi: 10.2147/CCID.S33860 PMCID: PMC3496327 Emotional benefit of cosmetic camouflage in the treatment of facial skin conditions: personal experience and review Lauren L Levy and Jason J Emer The RRDi has collected a number of cosmetics to consider in your search by using our affiliate store.

"Dry eye is one of the most commonly encountered problems in ophthalmology....Patient-specific considerations involve relevant history of autoimmune disease, refractive surgery or use of oral medications, and allergies or rosacea.....Given a complex presentation and a variety of signs and symptoms, it would be beneficial if there was an inexpensive, readily available, and reproducible diagnostic test for dry eye." Dovepress Diagnosis of dry eye disease and emerging technologies Maya Salomon-Ben Zeev, Darby Douglas Miller, Robert Latkany

"Although there are many conditions for the dysfunction of the meibomian glands, one particular skin condition, rosacea, can block the functioning of the meibomian gland. The species Demodex folliculorum found in follicles of the hair and in meibomian glands is present in larger quantities in rosacea patients. The over deposit of these species may possibly prompt the immune system, as in many rosacea patients the eyes may appear red or watery (ocular rosacea) and patients have a feeling of irritation in the eyes. The two species of Demodex, the genus of tiny mites, are responsible for blepharitis. Anterior blepharitis is caused by Demodex folliculorum and posterior blepharitis is caused by Demodex brevis. While the Demodex mite creates direct damage, it also carries the bacteria Staphylococci that cause Staphylococcal infections." Blepharitis Types and Causes, By Susha Cheriyedath, MSc, News Medical Life Sciences A recent report concluded, "As a result, the Demodex count was significantly higher in the primary demodicosis and rosacea patients than the control group. We think that every Demodex-positive patients should be evaluated for also eyelash mites to prevent a possible chronic blepharitis." Reply to this Topic There is a reply to this topic button somewhere on the device you are reading this post. If you never heard about this topic and you learned about it here first, wouldn't it be a gracious act on your part to show your appreciation for this topic by registering with just your email address and show your appreciation with a post? And if registering is too much to ask, could you post your appreciation for this topic by finding the START NEW TOPIC button in our guest forum where you don't have to register? We know how many have viewed this topic because our forum software shows the number of views. However, most rosaceans don't engage or show their appreciation for our website and the RRDi would simply ask that you show your appreciation, please, simply by a post.

Purpose: To evaluate the efficacy of Farmaka Rosacea Cream (FRC), a novel topical formulation for rosacea....Conclusion: Improvement of rosacea symptoms was noted with FRC application. The main film-forming ingredients of FRC (trehalose, cholesterol, ceramide, and fatty acids), combined with other soothing and calming ingredients and ultraviolet filters, could explain its efficacy. What we know about trehalose from PubMed, PLOS and Wikipedia. Hydramemory Cream Gel or Maxclinic Trehalose Vita Drop Cream contains trehalose. Dovepress Preliminary open-label clinical evaluation of the soothing and reepithelialization properties of a novel topical formulation for rosacea Adele Sparavigna, Beatrice Tenconi, Ileana De Ponti PubMed FRC Dermalex which is the brand name contains FRC.

"Natural cosmeceutical options serve as an additional branch of the market available to rosacea patients. Natural ingredients reported in the literature that provide hydrating, anti-inflammatory, and antioxidant properties capable of calming the inflammatory manifestations of rosacea include colloidal oatmeal, niacinamide, feverfew, licorice, teas, coffeeberry, aloe vera, chamomile, turmeric, and mushroom extracts.43 Further, a novel topical lotion (Redness Neutralizer®, SkinCeuticals, New York, NY, USA) containing caffeine, zinc gluconate, bisabolol, Eperua falcata bark extract, and palmitoyl tripeptide-8, was used twice daily in a group of 25 patients with PPR who had been previously treated successfully with topical or oral therapy, but were unsatisfied with the remaining background erythema. All efficacy categories demonstrated statistically significant improvement between baseline and follow-up at weeks 4 and 8. Although one patient developed burning and increased erythema and withdrew from the study, the remaining 24 patients found the treatment very tolerable without clinical signs of irritation. Overall, 95% of patients were satisfied with the products and the results after 8 weeks of twice-daily use. In another single-center, open-label study, a group of 30 patients with rosacea of variable severity were treated with 4% Quassia amara extract topical gel for 6 weeks. Reportedly, Q. amara possesses antiparasitic and anti-inflammatory properties that have the capability to decrease the inflammatory response with few complications. Efficacy comparable with that of first-line topical treatments like azelaic acid and metronidazole was observed after Q. amara treatment, with superb tolerability. Finally, a formulation of low molecular weight hyaluronic acid sodium salt 0.2% cream (Bionect® Cream, Innocutis Holdings, Charleston, SC, USA) applied twice daily for 8 weeks showed a statistically significant reduction in papules, erythema, burning, stinging, and dryness in a small study. Along with excellent tolerability, a reduction in papules, erythema, burning/stinging, and dryness was clearly apparent by week 4 and remained by the final visit at week 8. Notably, erythema was reduced by the greatest amount, with an approximate 50% improvement by week 2. This study demonstrates the importance of skin barrier maintenance and repair in the pathogenesis of rosacea. With a hydrophilic structure, low molecular weight hyaluronic acid penetrates the stratum corneum where it interacts with fibrin and collagen to support remodeling of the extracellular matrix. This mechanism, along with induction of the antimicrobial peptide ²-defensin 2 release from keratinocytes, ultimately accelerates re-epithelialization and reduces pain and edema." Dovepress Update on the management of rosacea Allison P Weinkle, Vladyslava Doktor, Jason Emer Accepted for publication 13 January 2015 Published 7 April 2015 Volume 2015:8 Pages 159—177 DOI https://doi.org/10.2147/CCID.S58940

A study published in 2015 by a group in Europe that "proposed a dermocosmetic active ingredient to mitigate some aspects of the rosacea and particularly for erythematotelangiectatic rosacea [ETR]." Using a patented process of three basic ingredients, rosmarinic acid, gallic acid, and caffeic acid (hence the acronym RGC with the trade name Endothelyol) this group formulated a serum (calling it RGC Serum) to treat ETR and tested it on volunteers. The report concluded, "these studies have shown that RGC active could be a dermocosmetic help, especially for erythematotelangiectatic rosacea armamentarium. Indeed, 2% of RGC topically applied on face for 28 days improved erythematotelangiectatic rosacea symptoms either by decreasing them (in half of the volunteers, vessels are less visible) or by limiting their development (any neovessels seen). RGC acts by decreasing inflammation (inhibition of IL-8 and TNF release), decreasing degranulation of mast cells (inhibition of histamine release), and limiting the angiogenesis process (inhibition of VEGF production and neovessel formation)." Dovepress Combination of new multifunctional molecules for erythematotelangiectatic rosacea disorder Hanane Chajra, Mahdi Nadim, Daniel Auriol, Kuno Schweikert, Fabrice Lefevre Accepted for publication 6 August 2015 Published 1 October 2015 Volume 2015:8 Pages 501—510 DOI https://doi.org/10.2147/CCID.S92326 ProTec Ingredia, part of the LPC Group, reports on its website that "Endothelyol is an active ingredient to reduce skin redness and rosacea. It works by targeting VEGF, Histamine, TNF-alpha, Interleukin 8 and Prostaglandin E2." You can download a pdf of this product to review which points to Induchem as the manufacturer and sells Endothelyol to cosmetic companies on this page. Givaudan Active Beauty apparently sells Endothlyol according to Coptis and Prospector. SVR Sensifine AR One product that contains Endothelyol is SVR Sensifine AR.

"85% of patients displaying positive responses to brimonidine tartrate.....Emphasizing that this clinical therapy is not intended to eradicate papules, pustules or phymatous changes of rosacea, or to eradicate oiliness on the face, is important....In our clinics, approximately 4%–15% of patients have complained of worsening erythema or flushing, and some of these patients decided to discontinue treatment with brimonidine tartrate, which led to resolution of these side effects usually within 4–24 hours....Sometimes the initial cause of the flare was that the patient had applied too much of the medication, too frequently, without applying sunscreen or without continuing to avoid common triggers of rosacea flushing. This highlights the importance of providing clear and comprehensive counseling to the patient....Brimonidine tartrate has been associated with temporary worsening of erythema in a few cases (approximately 12 hours after the initial application)....In order to see the true measure of response on an individual basis, a small sample of brimonidine tartrate can be provided for the patient to try at home and to monitor their response over a few days. In the authors’ opinion, there has been a predictable response in each individual patient, and this response has continued with subsequent applications. Most of the adverse events related to brimonidine tartrate have occurred within the first 1–2 weeks, and none of the adverse events have produced long-term sequelae that adversely affect the course of the disease." Dovepress The role of brimonidine tartrate gel in the treatment of rosacea J Mark Jackson, Melissa Knuckles, John Paul Minni, Sandra Marchese Johnson,, Kevin Tate Belasco Accepted for publication 24 April 2015 Published 23 October 2015 Volume 2015:8 Pages 529—538 DOI https://doi.org/10.2147/CCID.S58920

"The role of ivermectin in the treatment of rosacea may be as an anti-inflammatory and anti-parasitic agent targeting Demodex mites. In comparing topical ivermectin and metronidazole, ivermectin was more effective; this treatment modality boasted more improved quality of life, reduced lesion counts, and more favorable participant and physician assessment of disease severity. Patients who received ivermectin 1% cream had an acceptable safety profile. Ivermectin is efficacious in decreasing inflammatory lesion counts and erythema." [1] "Head-to-head trials show that azelaic acid and ivermectin might be slightly better than metronidazole." [2] [1] Dovepress New developments in the treatment of rosacea – role of once-daily ivermectin cream Leah A Cardwell, Hossein Alinia, Sara Moradi Tuchayi, Steven R Feldman Accepted for publication 11 January 2016 Published 18 March 2016 Volume 2016:9 Pages 71—77 DOI https://doi.org/10.2147/CCID.S98091 [2] Topical treatments for rosacea. Can Fam Physician. 2019 11;65(11):803 Authors: Fritsch P, Kolber MR, Korownyk C

Rosacea-prone sensitive skin requires high sun-protection factor (SPF) moisturizers. This study evaluated Daylong Extreme SPF 50+ lotion, a novel cream containing five ultraviolet filters, two emollients, and three skin conditioners....Most subjects said that the product was pleasant, did not irritate the skin or cause stinging/burning, was easy to apply, quickly absorbed, and nongreasy, improved skin moisturization, helped prevent sun-provoked facial redness, did not worsen rosacea, and was easily incorporated into their skincare regimen. Half would switch to the product, and 80% of subjects would buy and recommend the product. Dovepress Evaluation of a novel very high sun-protection-factor moisturizer in adults with rosacea-prone sensitive skin Mathieu Grivet-Seyve, Francine Santoro, Nadège Lachmann Received 21 February 2017 Accepted for publication 5 May 2017 Published 10 June 2017 Volume 2017:10 Pages 211—219 DOI https://doi.org/10.2147/CCID.S134857

There is a clear association between dry eye disease (DED) and skin inflammatory diseases occurring in close proximity to the eyelids, such as facial skin rosacea. Intense pulsed light (IPL) is widely accepted as a treatment for skin rosacea. A number of recent studies demonstrated that, in patients suffering from meibomian gland dysfunction (MGD), IPL therapy also reduces signs and symptoms of DED. Despite these encouraging results, in the context of DED and MGD, the mechanisms of action of IPL are not well understood. Dovepress Intense pulsed light for evaporative dry eye disease Steven J Dell Received 18 April 2017 Accepted for publication 13 May 2017 Published 20 June 2017 Volume 2017:11 Pages 1167—1173 DOI https://doi.org/10.2147/OPTH.S139894 Checked for plagiarism Yes Review by Single-blind Peer reviewers approved by Dr Amy Norman Peer reviewer comments 2 Editor who approved publication: Dr Scott Fraser -------------------------------------------------------- Prospective evaluation of intense pulsed light and meibomian gland expression efficacy on relieving signs and symptoms of dry eye disease due to meibomian gland dysfunction Steven J Dell, Ronald N Gaster, Sheila C Barbarino, Derek N Cunningham Reply to this Topic There is a reply to this topic button somewhere on the device you are reading this post. If you never heard about this topic and you learned about it here first, wouldn't it be a gracious act on your part to show your appreciation for this topic by registering with just your email address and show your appreciation with a post? And if registering is too much to ask, could you post your appreciation for this topic by finding the START NEW TOPIC button in our guest forum where you don't have to register? We know how many have viewed this topic because our forum software shows the number of views. However, most rosaceans don't engage or show their appreciation for our website and the RRDi would simply ask that you show your appreciation, please, simply by a post.

"Further experiments using LPS-induced murine macrophages revealed that coffee extracts protect cells against oxidative stress by enhancing the content of the antioxidant GSH and stimulating expressions of the genes related with the cellular antioxidation system. Also, coffee extracts decreased the expression of proinflammatory cytokines and inflammatory mediators in LPS-stimulated RAW 264.7 cells. However, different roasting levels may dilute those effects by decreasing the concentrations of key compounds during the roasting procedures." Journal of Medicinal Food Cellular Antioxidant and Anti-Inflammatory Effects of Coffee Extracts with Different Roasting Levels Jung Soohan, Kim Min Hyung, Park Jae Hee, Jeong Yoonhwa, and Ko Kwang Suk. Journal of Medicinal Food. June 2017, 20(6): 626-635. https://doi.org/10.1089/jmf.2017.3935 Online Ahead of Print: June 5, 2017 Published in Volume: 20 Issue 6: June 1, 2017

In 2007, Gallo, et al, wrote a paper that suggested that an over production of cathlecidin may be associated with the cause of rosacea. For more info.

There are hundreds of images of rosacea in a google search. Or you can view 4 different types of rosacea shown in a article on rosacea by clicking here. So now you know what rosacea looks like, so what is rosacea?

"Overall, the results of this study suggest that ivermectin treatment prevents the augmentation of the cathelicidin immune pathway, which has a positive impact on the downstream inflammatory pathway (e.g., decreased IL-8, IL-6 and CCL2 secretion). These results suggest that ivermectin can prevent the inflammatory effects of rosacea triggered by abnormal LL-37 processing, through the inhibition of KLK5and CAMP gene expression in the epidermis." Dermatol Ther (Heidelb). 2017 Jun; 7(2): 213–225. Published online 2017 Feb 27. doi: 10.1007/s13555-017-0176-3 PMCID: PMC5453918 Topical Treatment of Rosacea with Ivermectin Inhibits Gene Expression of Cathelicidin Innate Immune Mediators, LL-37 and KLK5, in Reconstructed and Ex Vivo Skin Models Séverine Thibaut de Ménonville,corresponding author Carine Rosignoli, Estelle Soares, Manon Roquet, Béatrice Bertino, Jean-Paul Chappuis, Claire Defoin-Platel/Chaussade, and David Piwnica More on Cathelicidin

"Overall, the results of this study suggest that ivermectin treatment prevents the augmentation of the cathelicidin immune pathway, which has a positive impact on the downstream inflammatory pathway (e.g., decreased IL-8, IL-6 and CCL2 secretion). These results suggest that ivermectin can prevent the inflammatory effects of rosacea triggered by abnormal LL-37 processing, through the inhibition of KLK5and CAMP gene expression in the epidermis." Dermatol Ther (Heidelb). 2017 Jun; 7(2): 213–225. Published online 2017 Feb 27. doi: 10.1007/s13555-017-0176-3 PMCID: PMC5453918 Topical Treatment of Rosacea with Ivermectin Inhibits Gene Expression of Cathelicidin Innate Immune Mediators, LL-37 and KLK5, in Reconstructed and Ex Vivo Skin Models Séverine Thibaut de Ménonville,corresponding author Carine Rosignoli, Estelle Soares, Manon Roquet, Béatrice Bertino, Jean-Paul Chappuis, Claire Defoin-Platel/Chaussade, and David Piwnica

RRDi Affiliate Store Sunscreens

RRDi Affiliate Store Oral Non Prescription treatments

We have a category of cleansers in our affiliate store. Warning Just a tip, rosaceans usually have very sensitive skin, so you need to be wary of cleansers. One report concluded, "excessive cleansing habits were substantial risk factors for the incidence and progression of rosacea," [1] So make sure the cleanser you choose is calming and won't further damage your rosacea sensitive skin. End notes [1] Arch Dermatol Res. 2020 Jun 27;: Excessive cleansing: an underestimating risk factor of rosacea in Chinese population. Li G, Wang B, Zhao Z, Shi W, Jian D, Xie H, Huang Y, Li J

We have a category of moisturizers listed in our affiliate store.

Our affiliate store has a large number of over the counter, non prescription treatments for rosacea. It is categorized into Amazon and Demodex Solutions. It is further categorized into the following: Creams Balms Lotions, Oils, Ointments Gels and many other categories.

There are a number of rosacea mimics to rule out as well as photosensitivity diseases to consider.

Here is a partial list of photosensitivity diseases to rule out with rosacea: Abstract Photosensitivity refers to various symptoms, diseases and conditions (photodermatoses) caused or exacerbated by exposure to sunlight. It is classified into the following groups: Primary photodermatoses: Polymorphic light eruption. Juvenile spring eruption. Actinic folliculitis. Actinic prurigo. Solar urticaria. Chronic actinic/photosensitivity dermatitis. Hydroa vacciniforme (associated with Epstein-Barr virus). Exogenous photodermatoses: Drug-induced photosensitivity: common photosensitising drugs are thiazides, tetracyclines, non-steroidal anti-inflammatory drugs (NSAIDs), phenothiazines, voriconazole, quinine, vemurafenib. Photocontact dermatitis: due to phototoxic chemicals such as psoralens in plants, vegetables, fruit; fragrances in cosmetics; sunscreen chemicals; dyes and disinfectants. Pseudoporphyria: induced by drugs and/or renal insufficiency. Photoexacerbated dermatoses: Lupus erythematosus. Dermatomyositis. Darier disease. Rosacea. Pemphigus vulgaris. Pemphigus foliaceus. Atopic dermatitis. Psoriasis. Metabolic photodermatoses (rare): Porphyria cutanea tarda. Erythropoietic protoporphyria. Variegate porphyria. Erythropoietic porphyria (Gunther disease). Genetic photodermatoses (very rare): Xeroderma pigmentosum. Bloom syndrome. Rothmund Thomson syndrome. Cockayne syndrome. Photosensitivity. Oakley A, James W. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2017-. 2017 Feb 7., Copyright © 2017, StatPearls Publishing LLC.

Seborrheic Dermatitis is a rosacea mimic and/or a co-existing condition. Sometimes it looks like rosacea, but usually can be differentiated.