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  1. The answer to the question is to social media platforms. This post is about rosacea and social media platforms where all the rosaceans have gone and is an in-depth deep dive into this subject. Before we look at some of the data on this it would be good to go back in time and look at the history of the internet and rosacea, before the advent of social media. Sixteen years ago when the RRDi was founded by rosacea sufferers with the motive to form a grassroots patient advocacy group that could have a united voice to the medical community who at that time didn’t take any rosacea
  2. "Patients with rosacea have elevated levels of cathelicidin and elevated levels of stratum corneum tryptic enzymes (SCTEs). Cathelicidin is cleaved into the antimicrobial peptide LL-37 by both kallikrein 5 and kallikrein 7 serine proteases. Excessive production of LL-37 is suspected to be a contributing cause in all subtypes of Rosacea. Antibiotics have been used in the past to treat rosacea, but antibiotics may only work because they inhibit some SCTEs." [1] "In mice, injection of onabotulinum toxin A significantly reduced LL-37-induced skin erythema, mast cell degranulation, and mRNA ex
  3. I decided to try this and bought the Tea Tree Essential Oil for $9 shown above and added one tablespoon into six ounces of baby shampoo and just tried my first treatment to my scalp and face. Kept this mixture on my scalp for five minutes and rinsed. Will update my progress.
  4. Admin

    Brady's Blog

    Just made this video about Rx treatments for rosacea.
  5. "Arthralgia and myalgia had the same percentage as reported by the control group and in normal populations; however, Raynaud's phenomenon was slightly greater than reported in the 2 control group and the general populations. There could be an inverse relationship between Raynaud's treatment with vasodilators and rosacea flushing symptom." A Clinico-Pathological Investigation of Rosacea with Particular Regard to Systemic Diseases, Dr. Mustafa Hassan Marai
  6. We are compiling a list of arachnicide treatments for rosacea. If you have one we missed, please reply to this post. That is what volunteering is all about, helping other rosaceans find information to treat and ultimately cure rosacea. Arachnicide Treatments for Rosacea Anti-Parasitic Prescription Agents for Rosacea Azelaic Acid Benzyl Benzoate Borax Crotamiton Demodex Solutions Diatomaceous earth IPL Ivermectin Oral Ivermectin and Metronidazole Ornidazole tablets (500 mg twice a day) and recombinant bovine basic fibroblast growth f
  7. Raynaud syndrome on female airman's hand image courtesy of Wikimedia Commons Eilleen66 [post no 5] points out at RF, "I was pointing out the coincidence that a lot of people who have rosacea also have Raynauds type symptoms." So I thought I would do a little research on this using the search tool here at the RRDi website by simply typing in 'Raynaud' and see what comes up. Didn't do a Google search, since that takes more time and effort. Are you up to the task of really investigating this subject, googling it, and then add to this thread? Not many are really into doing rosacea research
  8. "The findings from this study present the concept of the involvement of the gut–brain–skin axis in rosacea." Int J Mol Sci. 2020 Nov 10;21(22):Updates on the Risk of Neuropsychiatric and Gastrointestinal Comorbidities in Rosacea and Its Possible Relationship with the Gut-Brain-Skin Axis.Woo YR, Han YJ, Kim HS, Cho SH, Lee JD Image courtesy of the International Journal of Molecular Sciences, under the terms and conditions of the Creative Commons Attribution (CC BY) license
  9. On report on this subject states, "the risks of some comorbidities in patients with rosacea are somewhat contradictory, depending upon the study design. Moreover, pathomechanisms associated with the comorbidities of patients with rosacea remain poorly elucidated." Int J Mol Sci. 2020 Nov 10;21(22): Updates on the Risk of Neuropsychiatric and Gastrointestinal Comorbidities in Rosacea and Its Possible Relationship with the Gut-Brain-Skin Axis. Woo YR, Han YJ, Kim HS, Cho SH, Lee JD
  10. A paper recommends "light-emitting diodes therapy combining blue (480 nm) and red (650 nm) light" that "this kind of treatment could represent an effective, safer, and well-tolerated approach for the treatment of such conditions [rosacea]". J Med Case Rep. 2020 Jan 28;14(1):22 Coupled blue and red light-emitting diodes therapy efficacy in patients with rosacea: two case reports. Sorbellini E, De Padova MP, Rinaldi F
  11. The Avenova Pure Hypochorous Spray only costs $29.99 Active Skin Repair Hypochorous Spray only costs $24.99 Heyedrate Hypochlorous Lid and Lash Cleanse only costs $15.17
  12. Clinical Reset by CelleRx according to the manufacturer is "A powerful daily mist, Clinical Reset’s hero ingredient; Hypochlorous Acid (HOCl), eradicates the leading causes of redness, irritation and skin damage without stripping the skin. Part of your immune system’s natural response, HOCl is a naturally occurring compound produced by your white blood cells to fight trauma and infection." Cost: $54 at this page. Ingredients:Pure hypochlorous acid, .01% as a preservative in saline. What is hypochlorous acid? "In a recent study, a saline hygiene solution preserved with pure hy
  13. Now available announced by Vyne Therapeutics. Ask your dermatologist. Post your experience in this thread. Find the reply button. "The Company also announced that the annual list price of ZILXI will be $485 per 30-gram canister, in parity with the wholesale price of AMZEEQ® (minocycline) topical foam, 4%, the Company's topical minocycline indicated for the treatment of inflammatory lesions of non-nodular moderate to severe acne vulgaris in adults and pediatric patients 9 years of age and older." PR Newswire Association LLC. All Rights Reserved. A Cision company We have been fo
  14. "In a later population-based cohort study of 50,000 Danish patients with rosacea by Egeberg et al., the prevalence of celiac disease (CeD), Crohn’s disease (CD), ulcerative colitis (UC), small intestinal bacterial overgrowth (SIBO), and irritable bowel syndrome (IBS) were all significantly higher among patients with rosacea as compared with controls. These studies, and many others, substantiate the notion of a gut–skin axis. In fact, Nam et al. go a step further, describing the “gut–brain–skin axis” based on clinical evidence demonstrating amelioration of cutaneous inflammation following the a
  15. Dermadexin (also known as Pruridexin or Helioclin® Dermatitis SD Cream) is a topical treatment for dermatitis and seborrhoeic dermatitis developed by Astion Pharma with a unique mechanism of action using a Fatty acid amide hydrolase (FAAH) inhibitor and a NF-kappa B (NF-kB) inhibitor designated as pyridine-3-carboxamide glyceryl monocaprylate (P3CGM), which has an excellent topical safety profile demonstrating a broad range in pre-clinical studies. [1] It was announced in August 2015 that the FDA accepted 510(k) submission for Dermadexin. [2] There is now available an over the counte
  16. While there are reports of successfully using isotretinoin for rosacea that are positive, there are also negative reports like this one. The video below by Leginairerpg is discussing high dose isotretinoin and is NOT discussing low dose isotretinoin which is one of the current state of the art 'off label' treatments for rosacea. Video by Legionnairerpg About: This video deals with the effects of ROACCUTANE. If you have spots, don't take this drug, it's the worst you can do for your mind and your body. I m a french victim of this "medic", i fight now for the truth. Rea
  17. "Inflammatory conditions such as rosacea, granuloma annulare, and hidradenitis suppurativa benefit from lower oral isotretinoin dosage of 0.3-1 mg/kg/day, whereas, hyperkeratotic diseases such as psoriasis and pityriasis rubra pilaris, consistently respond better to higher dosages of up to 2-4 mg/kg/day for lesion clearance." Arch Dermatol Res. 2020 Nov 05;: Oral isotretinoin for the treatment of dermatologic conditions other than acne: a systematic review and discussion of future directions. Chu S, Michelle L, Ekelem C, Sung CT, Rojek N, Mesinkovska NA
  18. "Azelaic acid 15% foam used off-label might be a useful treatment or adjunctive therapy for folliculitis." [1] "Off-label prescribing is when a physician gives you a drug that the U.S. Food and Drug Administration (FDA) has approved to treat a condition different than your condition. This practice is legal and common. In fact, one in five prescriptions written today are for off-label use." [2] In one clinical trial using azelaic acid for demodectic folliculitis it states, "The purpose of this study is to measure the effects of azelaic acid on Demodex folliculorum counts and disease c
  19. "Of note, the data available so far suggest that therapeutic efficacy of HCQ in COVID-19 is well overshadowed by its ineffectiveness and detrimental effects as shown by some of the above-referred studies. Therefore, it is suggested to avoid use of HCQ for COVID-19 patients (unless necessary) until clear, sufficient, well-conducted, randomized, and controlled clinical data is available to reach the right conclusions." Front Pharmacol. 2020; 11: 582025.Available Compounds With Therapeutic Potential Against COVID-19: Antimicrobial Therapies, Supportive Care, and Probable VaccinesRajnish
  20. "Till date, chloroquine is verified effective against COVID-19 in vitro through influencing bis (monoacylglycero) phosphate entry by controlling the endocytic pathway (Carrière et al., 2020). The use of chloroquine against COVID-19 might be a risk and require continuous monitoring until confirmed clinical evidence are available." Front Pharmacol. 2020; 11: 582025.Available Compounds With Therapeutic Potential Against COVID-19: Antimicrobial Therapies, Supportive Care, and Probable VaccinesRajnish Kumar, Janmejai Kumar Srivastava, Rachana Singh, Mohammed Haris Siddiqui, Rasha A. Ma
  21. "One of the recent in vitro studies conducted by Clay et al. (2020) confirmed the antiviral activity of ivermectin against SARS-CoV-2. The SARS-CoV-2 infected Vero/hSLAM cells were subjected to 5 µM ivermectin for 48 h. The study indicates about 5,000-fold decrease in viral RNA as compared to the control. This was the first study to assess and demonstrate the effectiveness of ivermectin in COVID-19." Front Pharmacol. 2020; 11: 582025. Available Compounds With Therapeutic Potential Against COVID-19: Antimicrobial Therapies, Supportive Care, and Probable Vaccines Rajnish Kumar, Janme
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