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Guide

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  1. Welcome to the RRDi. Tell us about your rosacea please with a post. 

  2. Get free samples of Roversol for rosacea while supplies last.
  3. This topic has been researched a lot. There are many, many published articles on this subject. We even have our own extensive post on this subject. Think about it, is this what you as a rosacea sufferer want clinical studies and scientific medical journals to spend money on? The above article was published by the Dermatology Online Journal.
  4. Another study on bacteria and rosacea which adds cutibacterium acens being LOWER and substantiating other papers that staphylococcus epidermis is higher in the 17 in the case group who had rosacea. No mention of other microbes, which is generally what western medicine focuses on including studies on rosacea. There are three other bacteria that are mentioned in rosacea studies which we list in this category Wouldn't it be incredible if 10,000 rosaceans got together and each one donated just one dollar and sponsored through a legal non profit organization for rosacea to investigate microbes other than bacteria, i.e., virus, archea, or for that matter whatever the 10,000 rosaceans wanted investigated by a show of hands? Could rosaceans actually come together and do their own rosacea research?
  5. The conclusion of this study is mind boggling. Just think about it for a few seconds. So much for WC Fields as the rosacea poster boy.
  6. We have tried over the last twenty years to figure out how to get rosacea sufferers to come together into a patient advocacy non profit organization, to fulfill our MISSION STATEMENT. Currently we are only allowing subscribed members to post. We have a few active members but so far, as of this date, March 12. 2024, none of our few active members post. If you have an idea on how we can get members to post, why not find the reply to this topic button (only subscribed members can post) and tell us what you think? So if you only post on social media rosacea websites, why do you feel comfortable doing this? What is it about our forum style website that makes you feel uncomfortable to post? We could use some young rosacea blood to stimulate posts and keep our non profit going. You want to run this non profit? Post and tell us what you think. Post.
  7. We have added Tumid lupus as a Rosacea mimic to our official list.
  8. The above video was made a while ago, I think in 2021. If you think you know how to run a patient advocacy non profit organization why not join and take over. If your ideas are better then serve on the board of directors and help us. Maybe you can get the skin industry to sponsor your ideas and then get paid as the NRS runs its non profit that is run by businessmen and dermatologists. Maybe you could get a dermatologist on our board. But before you do, you might want to read all our rules, mission statement, charter, privacy policy, and legal disclaimer to see what is involved. You can make a lot of money running a non profit since many non profits have salaried directors and employees. Non profits make billions of dollars and pay lot of money out for services and salaries. We could setup the RRDi in your home state or country and you run it! I can teach you what you need to know about our financial situation and how you can continue receiving donations. We did receive six thousand dollars over the hears in grants from Galderma, but getting volunteer grant writers is like pulling teeth. Maybe you know how to get grants?
  9. The RRDi has stopped reviewing the NRS with regard to how it spends its donations since rosaceans could care less. The last review above is for 2020 but since rosaceans could care less, there is no point it being the lone watchdog on the NRS. Let Samuel and Andrew Huff who sit on the board of directors of this non profit keep getting around 60% of the expenditures of the NRS through their profit organizations which is legal and rosaceans keep donating to the NRS and think this is how a non profit for rosacea should be run. I imagine Sam and Andrew have nice homes, expensive vehicles and take nice vacations. Good for Sam and Andrew who know how to get rosaceans to donate to their 'non profit' for rosacea. The skin industry loves the NRS and continues to give the vast majority of the donations since the public donates about 23.58% of the total donations which means 76.42% of the donations to the NRS are sponsored by the skin industry over period from 1998 through 2020. Rosaceans love it that the NRS is run by businessmen and dermatologists and is not a patient advocacy non profit but instead a non profit supported mainly by the skin industry. It is so sad that rosaceans don't want to come together in a united non profit group that supports patient advocacy for rosacea, engaging in their own research, not relying on the skin industry. So sad.
  10. As you can see, this case of a Filipino woman in her forties went through many treatments until she got a correct diagnosis of tinea faciei with steroid rosacea, it is important to get a correct diagnosis. Learn more.
  11. What about Botox for rosacea? Answer
  12. This is an example of clinicians who still rely on the Subtype classification of rosacea which was abandoned several years ago. ETR is subtype 1. The new classification of rosacea into phenotypes separates this subtype into two phenotypes: (2) Persistent Erythema (3) Telangiectasia Dapsone has been used to treat Granulomatous Rosacea [also known as Lupoid rosacea] [1] as well as PPR [2] [1] Hautarzt. 2013 Apr;64(4):226-8. doi: 10.1007/s00105-013-2556-7. Successful treatment of granulomatous rosacea with dapsone. Ehmann LM, Meller S, Homey B. Hautklinik des Universitätsklinikums Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Deutschland. PubMed RSS Feed - - Dapsone  for Unresponsive Granulomatous Rosacea. [2] Dapsone Gel in the Treatment of Papulopustular Rosacea: A Double-Blind Randomized Clinical Trial.
  13. This test seems to have cornered the diagnosis of different skin diseases. Gate Recurrent Unit [GRU] "introduced in 2014 by Kyunghyun Cho et al." Wikipedia Maybe we will hear more about this in diagnosing rosacea?
  14. This is a new variant of demodicidosis (demodectic rosacea). The variants keep growing.
  15. The RRDi has an extensive list of non prescription treatments for rosacea including natural treatments. Click Here
  16. What is a bi-directional two-sample Mendelian randomization (2SMR) analysis? Answer: Mendelian randomisation is a statistical approach that uses genetics to provide information about the relationship between an exposure and outcome (a type of instrumental variable analysis) [1] Additionally, bi-directional Mendelian randomisation can be used to assess in which direction causality is most likely to flow (1). In bi-directional Mendelian randomisation, Mendelian randomisation analyses are performed in both directions (exposure to outcome, and outcome to exposure). [1] The summary concludes that there is 'evidence for the causality between GM [gut microbiota] and inflammatory skin diseases.' [1] End Notes [1] Making sense of Mendelian randomisation and its use in health research A short overview Sean Harrison, Laura Howe and Alisha R. Davies
  17. This article says acne can appear on the truncal area of the body. Whether rosacea could also involve the truncal area hasn't been investigated or confirmed, however the NHS article above says rosacea can appear on the chest, so that at least confirms the chest area. Is it a big stretch to say rosacea also appears on the truncal area? Any comments?
  18. We are careful who we put on our links page since we do not want to appear to be a commercial site or influenced in any way with the skin industry (unless the skin industry donates or sponsors our own independent rosacea research). This Korean Acne and Rosacea Society is sponsored by Galderma and the research appears to be with no conflict of interest so we are listing this society on our links page.
  19. This article is some good research since rosacea is an ISD (Inflammatory Skin Diseases). I have always known that the human microbiome is important to understanding rosacea. Since the skin comprises the largest organ it makes sense that the different microbes existing in this organ would interact and be important to understanding why an inflammatory response is indicated in rosacea. Could rosacea actually be the result of various microbes interplaying or could it actually be just one microbe that is triggering it? In normal skin without rosacea, these various microbes seem to live together without an inflammatory response or initiating an immune system response. There may be other factors that would contribute to upsetting the skin microbiome, i.e., age, diet and exercise, lifestyle, stress, cormobidities, co-existing conditions, medications, etc., which complicates the issue, but nevertheless, rosacea is a skin disease and microbes may play a part in triggering it. The classic example proving this point is that antibiotics have been used to treat rosacea for decades and more recently treatment for the eradication of demodex mites are just two microbes worth considering, bacteria and demodex, which the vast majority of rosacea research has focused on. There is little, if any, research done on rosacea involving other microbes, i.e., virus, archaea, fungi, protozoa, helminths, parasites, etc., and the list of microbes on the skin microbiome could include other microbes not yet considered since the bias in rosacea research has mainly focused on bacteria as the culprit. since antibiotic treatment does indeed clears rosacea, but overtime complicates the issue with side effects worse than the actual disease. If you note, the research in this article is Chinese and apparently no conflict of interest is involved, for example, the skin industry in western medicine probably didn't give these researchers a dime. Bravo for such research. If only the RRDi could engage in such novel research. The following reveals who funded this research: "This work was supported by the Chengdu University of Traditional Chinese Medicine “Xinglin Scholars” Discipline Talent Research Improvement Program, Project Number: QJJJ2021001; Chengdu University of Traditional Chinese Medicine “Foundation Thickening” Action Plan (2023-42); Chengdu University of Traditional Chinese Medicine Hospital’s “Hundred Person Plan” (21-L03 and 22-B09). “Young Qihuang” Scholars of the State Administration of Traditional Chinese Medicine (2022-256)" Read the full article. Furthermore, we also know that Gut Rosacea is related to this subject. For example, this research paper states, "Accumulating evidence shows that dysregulation of intestinal flora is associated with inflammatory skin diseases, specifically atopic dermatitis (AD), psoriasis (PSO), and rosacea (ROS). However, the causality is still unclear." [1] This same article notes that "A total of 24 specific gut microbiota species related to AD, PSO, and ROS were identified by 2SMR analysis." [1] Can you see we need more research and that rosaceans could be involved with such novel research rather than letting the skin industry in western medicine sponsor the vast amount of rosacea research? Could rosaceans actually be united into sponsoring their own rosacea research? End Notes [1] PubMed RSS Feed - -The associations between gut microbiota and inflammatory skin diseases: a bi-directional two-sample Mendelian randomization study  
  20. Rosacea of the scalp: Results from a retrospective and prospective randomized controlled study
  21. Just an update on the RRDi. As the end of 2023 was getting closer, there simply wasn't enough donations to keep our website going, not to mention other costs to keep a legal 501 C 3 non profit going. There hasn't been any activity in our member forum for some time now, many months. i was resigned to close up the RRDi since members don't post, only a few donate a few dollars a month. Then in October 2023 one of our members, David Peterson, donated $1000 which kept us going for another year. You can view our financial situation since we are transparent. I have devoted hundreds of volunteer hours for the RRDi in the hopes that some new members might turn our non profit into an active rosacea research and development but so far just haven't been able to generate the support we need to engage with anyone coming forward to volunteer and help. The other board members don't post. I haven't posted for sometime now and feel that since there really isn't anyone considering volunteering to actively support the mission of the RRDi, it may be time to simply shut it down. If you are an active member (there are only a few subscribers) could you post your thought on this? I am trying to be positive, but it looks rather bleak that rosacea sufferers want to unite and do anything except post on social media about rosacea. Actually engaging in rosacea research is left to the skin industry. Rosaceans just like rosacea social media sites and hang out there and do absolutely nothing about uniting as rosacea sufferers and doing anything but post in their favorite rosacea social media. Sure hope this thread generates some posts from anyone else, but I am losing hope.
  22. First off what are 'stages' of rosacea? Usually in past literature on rosacea, stages refer to the 'subtypes' of rosacea that are progressive as though a rosacea sufferer 'steps' through each 'stage' of a subtype or diagnostic features of rosacea usually from mild to worse. Stages of Rosacea a Myth that has been Debunked In many reports on rosacea, especially those written in the past, rosacea is spoken of as progressing in stages and that the progression leads to rhinophyma (Phenotype 5). For example, note this report from Better Medicine, Heathgrades, discussing the 'stages of rosacea" from mild to moderate to severe to rhinophyma rosacea, implying that rosacea progresses in stages. [1] A CNN Health Report on the Stages of Rosacea in 2017 continues this myth. You may find similar reports that imply or state that rosacea progresses into stages. Harvard Medical School continues to refer to the four stages of rosacea. [6] The term 'stages' of rosacea has been used extensively in rosacea papers in the past and continues to be used to describe an implied progression from mild to worse skin conditions. [7] However, current thought on this subject is far from this idea and simply isn't proven to be true. This is an example of the 'butterfly effect in rosacea" due to 'initial conditions' of a false myth. Papers that Debunk This False Myth “The notion that the erythematotelangiectatic stage generally transforms into the papulo-pustular, inflammatory stage is simply wrong and grossly misleading. Firstly, the papulo-pustular stage mainly occurs in males in whom rosacea is a more serious disease at all stages. The papulo-pustular stage is actually uncommon in females.” [2] “Rosacea is often divided into four stages, according to the progressive nature of the condition. However, the progression is not absolute. For unknown reasons, certain patients may skip a stage. Others experience ocular symptoms as the first manifestation of the condition.” [3] One report concluded that "A small proportion of rosacea subjects may progress between subtypes." [4] "Although rosacea findings may change over time, no proven natural progression exists.[5] Phenotype Classification vs Subtype Classification Also, there is controversy on the classification of rosacea into subtypes and variants which is related to this subject. Current types are now considered to be phenotypes, so the subtype classification is not the current classification. The Phenotype classification is superior to the subtype classification. There is no data suggesting that you move progressively through the six phenotypes of rosacea. While you may have more than one phenotype at the same time, there is nothing indicating you will progress in stages through each one. How does the phenotype classification work? Conclusion While any rosacea sufferer may indeed have a case of rosacea that gets worse, it does not mean that every rosacea sufferer progresses from a mild stage of rosacea into stages that get worse. The consensus is that if you fail to treat rosacea it may get worse, but not necessarily in 'stages' which is usually referring to the former subtypes and now is considered the phenotypes of rosacea. However, the consensus is that a rosacea sufferer does not necessarily move from one 'stage' into a more progressively worse 'stage' or that every rosacea suffer does this, furthermore, only a small percentage progresses from one 'stage' into another 'stage.' Reply to this Topic There is a reply to this topic button somewhere on the device you are reading this post. End Notes [1] "In the early stage, rosacea causes redness that comes and goes on the cheeks, nose, forehead, or chin....As rosacea gets worse, the facial redness grows more noticeable and long-lasting...In the most advanced stage of rosacea, the skin is a deep shade of red....In advanced rosacea, the nose sometimes grows red, swollen, and bumpy, a condition called rhinophyma. The Stages of Rosacea, Linda Wasmer Smith, Better Medicine, Heathgrades Other papers and sites that refer to the stages of rosacea: "It progresses in stages known as pre-rosacea, mild rosacea, moderate rosacea and severe rosacea and has periods of exacerbation and remission." The Four Stages of Rosacea, Pulse Light Clinic, 31 March 2015, Rosacea Nutritional Advice "Several classifications of the disease exist. In France, Edouard Grosshans described four stages…German schools described only 3 stages, like experts from the National Rosacea Society (NRS), who described four subtypes…" Ann Dermatol Venereol. 2014 Sep;141 Suppl 2:S151-7. doi: 10.1016/S0151-9638(14)70152-8. [Signs and symptoms of rosacea] J-L Schmutz "4 progressive stages of rosacea and symptoms may vary depending on the stage." Rosacea, SummitMD Dermatology [2] A Personal Critique on the State of Knowledge of Rosacea Albert M. Kligman , M.D., Ph.D. Department of Dermatology, University of Pennsylvania, Philadelphia, PA, U.S.A. The William J. Cunliffe Lectureship 2003—Manuscript publikation_kligman.pdf [3] Consult Your Pharmacist Differentiating Between Rosacea and Acne W. Steven Pray, PhD, DPh; Joshua J. Pray, PharmD candidate :U.S. Pharmacist [4] Br J Dermatol. 2013 Apr 21. doi: 10.1111/bjd.12385. [Epub ahead of print] An observational cross-sectional survey of rosacea: Clinical associations and progression between subtypes. Tan J, Blume-Peytavi U, Ortonne JP, Wilhelm K, Marticou L, Baltas E, Rivier M, Petit L, Martel P. Department of Medicine, University of Western Ontario, London, Ontario and Windsor Clinical Research Inc., Windsor, Ontario, Canada. [5] Am Fam Physician. 2015 Aug 1;92(3):187-196. Rosacea: Diagnosis and Treatment LINDA K. OGE', MD, HERBERT L. MUNCIE, MD, AMANDA R. PHILLIPS-SAVOY, MD, MPH [6] Rosacea, Harvard Health Publishing, Harvard Medical School [7] United European Gastroenterol J. 2015 Feb; 3(1): 17–24 refers to the 'four stages of rosacea' in its article on H pylori with the following statement: There are four stages of rosacea: I: frequent flushing, irritation caused by topical preparations II: facial erythema that becomes more persistent, slight telangiectasias, increased skin sensitivity III: persistent, spreading erythema, oedema, papules, pustules, enlarged pores, ocular changes IV: tissue hyperplasia, fibroplasias, rhinophyma) and connective-sebaceous hypertrophy may occur with possible deformation of the affected skin in the late stages. Helicobacter pylori infection but not small intestinal bacterial overgrowth may play a pathogenic role in rosacea AG Gravina, A Federico, E Ruocco, A Lo Schiavo, M Masarone, C Tuccillo, F Peccerillo, A Miranda, L Romano, C de Sio, I de Sio,1 M Persico, V Ruocco, G Riegler, C Loguercio, and M Romano Edited October 12, 2021 by Guide
  23. "Rosacea is a common inflammatory skin disorder mediated by the dysregulation of both keratinocytes and T cells. Here, we report that aquaporin 3 (AQP3), a channel protein that mediates the transport of water/glycerol, was highly expressed in the epidermis and CD4+ T cells of both rosacea patients and experimental mice....Our findings reveal that AQP3-mediated activation of NF-κB in keratinocytes and activation of STAT3 in CD4+ T cells acted synergistically and contributed to the inflammation in rosacea." [1] "Aquaporin 3 (AQP-3) is the protein product of the human AQP3 gene." [2] "Aquaporins (AQPs) are water channels that facilitate transepithelial water transport across plasma membranes following an osmotic gradient [3]. AQPs are glycosylated integral membrane proteins and widely expressed in bacteria (for review [4]), yeast [5], plants [6] (for review [7]), and mammals..." [3] Obviously we need more rosacea research on this subject. Do you want to support such targeted research? Join the RRDi and post in this thread. A Graphical abstract of AQP3 [4] End Notes [1] PubMed RSS Feed - -Targeting Aquaporin-3 Attenuates Skin Inflammation in Rosacea [2] Aquaporin-3, Wikipedia [3] Aquaporin-3 in Cancer Saw Marlar, Helene H. Jensen, Frédéric H. Login, and Lene N. Nejsum Int J Mol Sci. 2017 Oct; 18(10): 2106. Published online 2017 Oct 7. doi: 10.3390/ijms18102106 [4] Biochimica et Biophysica Acta (BBA) - Biomembranes Volume 1861, Issue 4, 1 April 2019, Pages 768-775 Single-channel permeability and glycerol affinity of human aquaglyceroporin AQP3 Roberto A. Rodriguez, Huiyun Liang, Liao Y. Chen, Germán Plascencia-Villa, George Perry
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