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Brady Barrows

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About Brady Barrows

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  1. MENLO PARK, Calif., July 27, 2017 /PRNewswire/ -- BioPharmX Corporation (NYSE MKT: BPMX), a specialty pharmaceutical company developing products for the dermatology market, today announced that a panel of prominent dermatologists will discuss BPX-01, a unique topical hydrophilic gel formulation of minocycline at the 2017 AAD Summer Meeting tomorrow. BPX-01 is an investigational drug for the treatment of acne and rosacea. Summer AAD Panel to Discuss BPX-01 for Acne and Rosacea, NEWS PROVIDED BY BioPharmX Corporation, Cision, PR Newswire
  2. Rosacea is considered the UK’s most common skin complaint. But what causes its red, itchy patches and how can you get rid of it? Why your diet could be causing rosacea, By Carla Challis, BT Carla doesn't mention sugar or carbohydrate as a rosacea trigger. The NRS still doesn't list sugar or carbohydrate as a rosacea trigger and articles like this one parrot the NRS trigger list.
  3. Rosacea’s red cheeks and nose aren’t caused by heavy drinking, and nor is it down to poor hygiene. We dispel the myths surrounding this common skin condition. Rosacea: the causes and triggers of the skin condition explained, By Carla Challis, BT
  4. Treatment for Phenotype 6

    Phenotype 6 - Ocular manifestations Ocular rosacea is common but often not recognized by the clinician.[1] It may precede, follow, or occur simultaneously with the skin changes typical of rosacea. In the absence of accompanying skin changes, ocular rosacea can be difficult to diagnose, and there is no test that will confirm the diagnosis. Patients usually have mild, nonspecific symptoms, such as burning or stinging of the eyes. A sensation of dryness is common, and tear secretion is frequently decreased. [2] Mild-to-moderate ocular rosacea (including blepharoconjunctivitis, chalazia, and hordeola) occurs frequently, whereas serious disease with the potential for visual loss, such as that which results from keratitis, occurs rarely. Ocular problems occur in at least 50 percent of patients with rosacea. [3] "Although considered a skin disease, rosacea may evolve the eyes in 58-72% of the patients, causing eyelid and ocular surface inflammation. About one third of the patients develop potentially sight-threatening corneal involvement. Untreated rosacea may cause varying degrees of ocular morbidity." [14] One report said, "Patients with rosacea have thinner corneas, which could be attributed to the observed deteriorated tear function parameters." [12] For images of Ocular Rosacea click here: http://goo.gl/ESG4n Links to get you started [5] Dry Eye: Awareness, Diagnosis, and Management All of the ocular rosacea articles at rosacea news Ocular Rosacea: Dr. Eric Jones, MD Ocular Rosacea: Dr. Mark J. Mannis, MD Ocular Rosacea: Curse of the Celts and Celebs, Heather Potter, MD, University of Wisconsin, School of Medicine and Public Health Treatment Treating ocular rosacea (from the AAO) Topical Cyclosporine Proves Beneficial For Ocular Rosacea [6] Avermectin Milbemycin Eyewash for Ocular Rosacea [7] Might consider demodex mite treatment. [8] Terpinen-4-ol (T4O) Pass [11] One report states, "We suggest that a clinically acceptable dosage of PRP provides the ocular surface with the components necessary to restore normal cellular tensegrity and provides a foundation to eliminate the recurrence of the inflammation associated with DES [Dry eye syndrome]." [13] Cliradex [15] Optimel [16] Diagnostic Test There may be a clinical diagnositic test now available for ocular rosacea. [4] One paper suggests, "The abundance of highly fucosylated N-glycans in the control samples and sulfated O-glycans in ocular rosacea patient samples may lead to the discovery of an objective diagnostic marker for the disease." [9] Another paper suggests, "The high abundance of oligosaccharides in the tear fluid of patients with rosacea may lead to an objective diagnostic marker for the disease." [10] "There is not yet a diagnostic test for rosacea. The diagnosis of ocular rosacea relies on observation of clinical features, which can be challenging in up to 90% of patients in whom accompanying roseatic skin changes may be subtle or inexistent." [14] End notes [1] Arch Dermatol 1997;133:89-90.[CrossRef][iSI] [Medline] Ocular rosacea: current concepts and therapy. Kligman AM [2] J Am Acad Dermatol 1992;26:211-214.[iSI] [Medline] Schirmer testing for dry eyes in patients with rosacea. Gudmundsen KJ, O'Donnell BF, Powell FC. [3] Rosacea: A Common, Yet Commonly Overlooked, Condition B. WAYNE BLOUNT, M.D., M.P.H. and ALLEN L. PELLETIER, M.D. Am Fam Physician. 2002 Aug 1;66(3):435-441. [4] Glycomics Analyses of Tear Fluid for the Diagnostic Detection of Ocular Rosacea Hyun Joo An, Milady Ninonuevo, Jennifer Aguilan, Hao Liu,‡ Carlito B. Lebrilla, Lenio S. Alvarenga, and Mark J. Mannis J. Proteome Res., 2005, 4 (6), pp 1981–1987, October 6, 2005, American Chemical Society Trail of Tears May Lead to the First Diagnostic Test for Ocular Rosacea Ocular Rosacea Test Updated: 6/21/2006 9:16:46 AM Dental Care & Health Care Articles [5] Link list courtesy of David Pascoe [6] Topical Cyclosporine Proves Beneficial For Ocular Rosacea Skin and Allergy News, Medical Dermatology BRUCE JANCIN, Skin & Allergy News Digital Network [7] Patent applied for by Galderma David Pascoe's comment on the above patent [8] In vitro and in vivo killing of ocular Demodex by tea tree oil. Gao YY, Di Pascuale MA, Li W, Baradaran-Rafii A, Elizondo A, Kuo CL, Raju VK, Tseng SC. Ocular Surface Center, 7000 SW 97 Avenue, Suite 213, Miami, FL 33173, USA. Br J Ophthalmol. 2005 Nov;89(11):1468-73. [9] Glycomic analysis of tear and saliva in ocular rosacea patients: the search for a biomarker. Vieira AC, An HJ, Ozcan S, Kim JH, Lebrilla CB, Mannis MJ. Ocul Surf. 2012 Jul;10(3):184-92. Epub 2012 May 3. [10] Glycomics Analyses of Tear Fluid for the Diagnostic Detection of Ocular Rosacea Hyun Joo An, Milady Ninonuevo, Jennifer Aguilan,Hao Liu, Carlito B. Lebrilla, Lenio S. Alvarenga,and Mark J. Mannis J. Proteome Res., 2005, 4 (6), pp 1981–1987, DOI: 10.1021/pr0501620, Publication Date (Web): October 6, 2005 [11] In clinical trials as of August 2012: Demodex Blepharitis Treatment Study (DBTS) [12] Can J Ophthalmol. 2012 Dec;47(6):504-8. doi: 10.1016/j.jcjo.2012.07.009. Central corneal thickness in patients with mild to moderate rosacea. Onaran Z, Karabulut AA, Usta G, Ornek K. [13] Optometry. 2012 Mar 30;83(3):111-3. Dry-eye--is inflammation just the tip of the iceberg? Jarka ES, Kahrhoff M, Crane JB. [14] Arq Bras Oftalmol. 2012 Oct;75(5):363-9. Ocular rosacea: a review. Vieira AC, Höfling-Lima AL, Mannis MJ. [15] One report on Cliradex is from yoegan on 5th April 2013 10:01 PM Post #467 [16] judworth says, "For those of you plagued by ocular rosacea (I have MGD) and very red and sore outer lash line, I have been using Optimel for just over 2 weeks, together with a cream cleanser Ilast and the results are very encouraging! I would say the above products have improved my issues by about 70% already (Optimel says improvement by 4 weeks)."
  5. Coke Zero Sugar

    CocaCola has announced a new Coke Zero Sugar brand (a different formula from Coke Zero) today which has been marketed in other countries and will be now marketed in the USA. For you CocaCola lovers who want to avoid sugar you may want to try it out. CocaCola will be eventually drop Coke Zero from its line of products replace it with Coke Zero Sugar. Read this in the Los Angeles Times. I have listed for your convenience the ingredients of Diet Coke, Coke Zero, and Coke Zero Sugar if you are interested in knowing: Diet Coke Ingredients: Carbonated Water, Caramel Color, Aspartame, Phosphoric Acid, Potassium Benzoate (To Protect Taste), Natural Flavors, Citric Acid, Caffeine. Coke Zero Ingredients: Carbonated Water, Caramel Color, Phosphoric Acid, Aspartame, Potassium Benzoate (To Protect Taste), Natural Flavors, Potassium Citrate, Acesulfame Potassium, Caffeine. Coke Zero Sugar Ingredients: Water, Colour (Caramel E150d), Phosphoric Acid, Sweeteners (Aspartame, Acesulfame K), Natural Flavourings Including Caffeine, Acidity Regulator (Sodium Citrate). Contains a Source of Phenylalanine
  6. The Healthy Geezer: Red, bumpy nose is rosacea, not booze, By Fred Cicetti, Times Herald-Record
  7. Treatment for Phenotype 5

    Phymatous (Rhinophyma) [aka Subtype 3] This phenotype responds to treatment very well. Phymatous rosacea is uncommon. The most frequent phymatous manifestation is rhinophyma (known familiarly as "whiskey nose" "brandy nose" or "rum blossom"). In its severe forms, rhinophyma is a disfiguring condition of the nose resulting from hyperplasia of both the sebaceous glands and the connective tissue. Rhinophyma occurs much more often in men than in women (approximate ratio, 20:1), [1] and a number of clinicopathologic variants have been described. [2] Although rhinophyma is often referred to as "end-stage rosacea," it may occur in patients with few or no other features of rosacea. The diagnosis is usually made on a clinical basis, but a biopsy may be necessary to distinguish atypical, or nodular, rhinophyma from lupus pernio (sarcoidosis of the nose); basal-cell, squamous-cell, and sebaceous carcinomas; angiosarcoma; and even nasal lymphoma. [3] Older papers usually mention how rosacea progresses in stages and ends up in subtype 3, but recent studies indicate that this is not necessarily true. One can develop phenotype 5 without going through any 'stages.' [read this post] One report says, "It can affect nose (rhinophyma), chin (gnatophyma), forehead (metophyma), ears (otophyma) and eyelids (blepharophyma). Rhinophyma is the most frequent location..." [15] For images of phenotype 5 (formerly Subtype 3) click below: http://goo.gl/BI2lf; 28 Images of Rhinophyma A classic example of Subtype 3 is WC Fields (the rosacea poster boy): Another classic example is this painting in the Louvre, "The Old Man and His Grandson" by Ghirlandiao around the year 1480. There are Five Variants of Rhinophyma: Glandular Fibrous FibroangiomatousActinic Rhinophymous leishmaniasis This is a great thread to read about Subtype 3. Treatment There are a number of different treatments for rhinophyma, including surgery, but it is better to treat the rosacea before it reaches the advance stage of rhinophyma. However, once rhinophyma has developed it can usually be corrected by surgery using either laser, scapel, or dermabrasion. The good thing about rhinophyma is that though this condition is generally regarded as a severe form of rosacea it is a relatively rare disorder involving thickening of the skin on the nose and the presence of many oil glands and this condition can usually can be corrected. Accutane is usually the drug of choice, but your physician may use other prescription drugs such as antibiotics if you have this skin disorder. Other treatment may involve cryosurgery, dermashaving and electrosurgery. "Coblation of rhinophyma is an effective treatment with few side effects." [4] ""...Initially, the mass was thought to be rhinophyma, but biopsy of the mass revealed noncaseating granulomata consistent with sarcoidosis. The mass resolved following several steroid injections..." [5] Radiofrequency is used to treat rhinophyma. [6]Rhinophyma treated with kilovoltage photons {7]Treatment of rhinophyma with ultrasonic scalpel: case report [8] Radiosurgical excision of rhinophyma. [9] "Surgery is indisputably the treatment of choice for rhinophyma." [10] This report said, "Despite many advances in fundamental understanding, surgical techniques, and related technologies, no single method has been universally embraced and employed as the "gold standard." " [11] Smoothbeam laser [13] Surgical Management [14] Another report says, "Both tangential excision and carbon dioxide laser are well-established, reliable procedures for rhinophymaplasty that preserve the underlying sebaceous gland fundi allowing spontaneous re-epithelialization without scarring with similar outcomes and high patient satisfaction. The original nose shape and nearly normal skin surface texture are preserved by quickly removal of the hypertrophic tissue sparing the pilosebaceous tissue. The CO(2) laser is more capital intensive and results in higher fees compared with the simpler cold blade tangential excision. In our experience the ease of use, accuracy and precision of the lasers offer is not justified by the increased costs." [16] Another report, which says, "a surgical "gold standard" for treating the distorting phymatous skin alterations has not yet been established," it goes on to state, "the combination of a bovine collagen-elastin with simultaneous autologous non-meshed split-thickness skin grafting" was used in a surgery, and "may ultimately avoid the recurrence of rhinophyma and contribute to a full skin repair leading to satisfactory functional and aesthetic outcome." [17] "This report describes a simple, safe, efficient, and cost-effective approach to the treatment of severe rhinophyma using a scalpel and the electroscalpel, instruments readily available in every operating room." [18] Scalpel Excision and Wire Loop Tip Electrosurgery [19] One reports says, "The CO2 laser is more capital intensive and results in higher fees compared with the simpler cold blade tangential excision. In our experience the ease of use, accuracy and precision of the lasers offer is not justified by the increased costs." [20] Salicylic acid 30% • Jojoba oil • Glycolic acid 70% • Baking Soda • Dawn Ultra Low Dose Isotretinoin Another treatment has been reported, coblation. The report says, "A hand-held coblation ‘wand’ emits a slow stream of saline solution – sterilised salt water – from the end that comes into contact with the nose. At the same time, it emits waves of radiofrequency energy to excite the molecules in the solution which ‘sands’ down the tissue. It also uses a low heat to cauterise (clot) any bleeding blood vessels." [12] Anecdotal Reports Nose Swelling, big pores, phymous tissue--please post! End Notes [1] Roberts JO, Ward CM. Rhinophyma. J R Soc Med 1985;78:678-681.[iSI] [Medline] [2] Aloi F, Tomasini C, Soro E, Pippione M. The clinicopathologic spectrum of rhinophyma. J Am Acad Dermatol 2000;42:468-472.[CrossRef][iSI] [Medline] [3] Murphy A, O'Keane JC, Blayney A, Powell FC. Cutaneous presentation of nasal lymphoma: a report of two cases. J Am Acad Dermatol 1998;38:310-313.[iSI] [Medline] [4] Coblation of rhinophyma. Timms M, Roper A, Patrick C.J Laryngol Otol. 2011 Apr 27:1-5. [5] Sarcoidosis of the external nose mimicking rhinophyma. Case report and review of the literature. Goldenberg JD, Kotler HS, Shamsai R, Gruber B.Ann Otol Rhinol Laryngol. 1998 Jun;107(6):514-8. [6] Management of mild to moderate rhinophyma with a radiofrequency. Erisir F, Isildak H, Haciyev Y.J Craniofac Surg. 2009 Mar;20(2):455-6. [7] Rhinophyma treated with kilovoltage photons. Skala M, Delaney G, Towell V, Vladica N.Australas J Dermatol. 2005 May;46(2):88-9. [8] Treatment of rhinophyma with ultrasonic scalpel: case report. Tenna S, Gigliofiorito P, Langella M, Carusi C, Persichetti P.J Plast Reconstr Aesthet Surg. 2009 Jun;62(6):e164-5. Epub 2008 Dec 12. [9] Radiosurgical excision of rhinophyma. Somogyvári K, Battyáni Z, Móricz P, Gerlinger I.Dermatol Surg. 2011 May;37(5):684-7. doi: 10.1111/j.1524-4725.2011.01965.x. Epub 2011 Apr 1. Letter: radiosurgical excision of rhinophyma. Niamtu J 3rd.Dermatol Surg. 2012 May;38(5):816-7. doi: 10.1111/j.1524-4725.2012.02383.x. [10] Rhinophyma in rosacea : What does surgery achieve? Sadick H, Riedel F, Bran G.Hautarzt. 2011 Oct 19. [11] Nuances in the management of rhinophyma. Facial Plast Surg. 2012 Apr;28(2):231-7Authors: Little SC, Stucker FJ, Compton A, Park SS [12] How salt-blasting surgery cured my disfiguring condition called 'drinker's red nose' By ROGER DOBSON Mail Online / Health PUBLISHED: 16:07 EST, 12 May 2012 | UPDATED: 17:23 EST, 12 May 2012 Read more: http://www.dailymail...l#ixzz1uvARY8Et [13] J Dermatolog Treat. 2012 Apr;23(2):153-5. Epub 2010 Oct 22. Moderate rhinophyma successfully treated with a Smoothbeam laser. Chou CL, Chiang YY [14] Conn Med. 2014 Mar;78(3):159-60. Surgical management of rhinophyma: a case report and review of literature. Ferneini EM, Banki M, Paletta F, Ferneini CM. [15] An Bras Dermatol. 2012 Dec;87(6):903-5. Gnatophyma: a rare form of rosacea. Macedo AC, Sakai FD, Vasconcelos RC, Duarte AA. [16] J Craniomaxillofac Surg. 2012 Dec 8. pii: S1010-5182(12)00248-X. doi: 10.1016/j.jcms.2012.11.009. Surgical correction of rhinophyma: Comparison of two methods in a 15-year-long experience. Lazzeri D, Larcher L, Huemer GM, Riml S, Grassetti L, Pantaloni M, Li Q, Zhang YX, Spinelli G, Agostini T. [17] Int J Surg Case Rep. 2012 Nov 10;4(2):200-203. doi: 10.1016/j.ijscr.2012.11.003. [Epub ahead of print] The surgical treatment of rhinophyma-Complete excision and single-step reconstruction by use of a collagen-elastin matrix and an autologous non-meshed split-thickness skin graft. Selig HF, Lumenta DB, Kamolz LP. Aesthetic Plast Surg. 2013 Jan 8. [Epub ahead of print] Optimizing Cosmesis with Conservative Surgical Excision in a Giant Rhinophyma. Lazzeri D, Agostini T, Spinelli G. [18] Aesthetic Plast Surg. 2013 Mar 1. [Epub ahead of print] Management of Severe Rhinophyma With Sculpting Surgical Decortication. Husein-Elahmed H, Armijo-Lozano R. [19] Dermatol Surg. 2013 Apr 5. doi: 10.1111/dsu.12193. [Epub ahead of print] Treatment of Severe Rhinophyma Using Scalpel Excision and Wire Loop Tip Electrosurgery. Prado R, Funke A, Brown M, Ramsey Mellette J. Source Northeast Dermatology Associates, Andover, Massachusetts. [20] J Craniomaxillofac Surg. 2013 Jul;41(5):429-36. doi: 10.1016/j.jcms.2012.11.009. Epub 2012 Dec 8. Surgical correction of rhinophyma: comparison of two methods in a 15-year-long experience. Lazzeri D1, Larcher L, Huemer GM, Riml S, Grassetti L, Pantaloni M, Li Q, Zhang YX, Spinelli G, Agostini T.
  8. Face flushing? You might want to look at what you’re drinking: Alcohol can raise your risk of a skin condition called rosacea, a new study published in the Journal of the American Academy of Dermatology suggests. In the study, researchers quizzed nearly 83,000 people on their alcohol intake every four years. They discovered that the more total alcohol they drank, the more likely they were to develop rosacea over the 14-year follow up. How Booze Can Make Your Face Red, Flushed, and Swollen, BY CHRISTA SGOBBA, Men's Health
  9. In an interview with Linda Stein Gold, MD, Soolantra Cream Clinical Investigator who also volunteers on the RRDi MAC, Dr. Stein Gold says, "I see topical ivermectin therapy as first line therapy for Papulopustular Rosacea." The ZZ cream is an excellent non prescription treatment to consider.
  10. Treatment for Phenotype 2

    Persistent Erythema, Phenotype 2, is the most difficult phenotype to treat. Mirvaso and Rhofade are two treatments for phenotype 2. You should read the posts about Mirvaso and Rhofade. There have been reports of rebound with both, but particularly with Mirvaso (less rebound reports with Rhofade).
  11. Rosacea Clinical Trials

    Rosacea Trial in Austin, Texas
  12. softilly's treatment for erythematotelangiectatic rosacea:
  13. If you’re suffering from rosacea, your doctor might simply tell you that there’s no real way to treat it and that you’ll probably have to deal with it for the rest of your life. But as with most other health conditions, the root cause of rosacea is almost certainly linked to your state of health in general, and particularly your diet and lifestyle. This article will seek to provide some simple, natural remedies to treat your rosacea to not only reduce the symptoms, but hopefully also prevent it from flaring up in the future. 5 Natural Remedies To Treat Rosacea, by Liivi Hess, The Alternative Daily
  14. Botox for Rosacea

    Botox jabs could offer a long-lasting solution for those who suffer the discomfort and embarrassing ‘blushing’ of rosacea. When tiny droplets of the wrinkle-busting nerve toxin are injected in diluted form into the forehead and cheeks, they have been found to reduce the redness which is the main symptom of the incurable skin disease. The breakthrough has been shown in early-stage trials to help all forms of the condition, including those characterised by acne-like spots on the face, and the severe skin-thickening form rhinophyma. Blush like Bridget Jones? A jab of Botox could help reduce redness and cut out acne-like spots, By Sara Malm In San Diego For Mail On Sunday, Daily Mail
  15. Microbiome-based therapeutic strategies

    Rosacea has for over 60 years has been treated with antibiotics. The current strategy is that antibiotics are not targeting microbes but are used for anti-inflammatory effects. However, there are a number of microbes that have been associated with rosacea (Candida Albicans, Chlamydophila pneumoniae, Demodex Mites, Helicobacter Pylori, Propionibacterium acnes, Staphylococcus epidermidis, and list keeps growing). With demodectic rosacea there are at least two microbes associated (Bacillus oleronius and Bartonella quintana [see end note 31 and 68 in this article]). Antibiotic treatment is used for treating other diseases and it is noted that rosacea is improved in many cases as a side note. For example, patients treated with antibiotics for SIBO or IBS who also have rosacea note that rosacea is improved. A paper worth reading on the subject of gut flora discusses the 'metagenome' or the 'second genome' in the human gut which holds microbes containing more genes in the flora in the intestinal system than the rest of our bodies. The paper says, "This creates a huge dataset that has to be disentangled." [see end note 4] The paper discusses how understanding gut flora may be a key to understanding diseases.One study by Nature Publishing Group discusses how recent research suggests that humans might be divided into three types of gut bacteria: Bacteroides, Prevotella and Ruminococcus. This may lead to personalizing medical treatment based upon which type gut microbes you predominantly have. [see end note 5] "The three gut types can explain why the uptake of medicines and nutrients varies from person to person," reports Jeroen Raes, a bioinformatician at Vrije University. [see end note 6] This may develop into a new ‘biological fingerprint’ on the same level as blood types and tissue types. [see end note 7] This may lead to a 'gut type diet' (similar to the blood type diet].
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