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Rory

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Everything posted by Rory

  1. The benzoyl peroxide only clears papules/pustules for me. It doesn't have any effect on reducing redness in my case but it can increase redness if I leave in on too long. Short contact therapy can be a good alternative for those with sensitive skin but if you're only dealing with subtype 1 rosacea (red face) then I don't think it will help.
  2. Just to clarify my case Andy, I only wanted to know for sure if demodex played some role for me. I wasn't able to do this with Soolantra because my face reacted badly to it. In fact my face pretty much reacts to any topical. I can get about a 90% clearance of my face with 5% benzoyl peroxide but I only leave it on for about half an hour. Any longer will cause irritation. My little experiment with the horse paste was just to see if I could get 100% clearance.
  3. Over the space of 2 months I took a dose of the horse paste every 5 or 6 days. In that timeframe I used 2 syringes, which is enough for two 600kg horses. I didn't see any difference.
  4. And thats exactly the problem with Brevis. We have no way to check the levels of this parasite in rosacea. This study was able to check them by extracting eyelashes and found large numbers of brevis at the root. But what type of test is used to count them in the skin. Surface tests will only count folliculorum levels and Soolantra won't have much of a problem killing them. But i have my doubts that it is able to kill brevis.
  5. Well, I think oral ivermectin should be more common as a rosacea treatment. Rosacea skin has a damaged barrier and topicals can be extremely difficult for many to tolerate. Also, topical treatments can be very slow to take effect as seen in a Galderma study of Soolantra where 30% of trial participants took up to a year to achieve clear/almost clear results. Then there is demodex brevis. A much smaller cousin of demodex folliculorum, which lives deeper in the pores. Little is known about brevis and, unlike folliculorum, it doesn't appear to exit pores at night to mate. If this is indeed the case then how do we kill it with a topical which may not penetrate the skin deep enough to reach it. I think the horse paste is more of a hit in the States than in Europe. Its down to the crazy prescrition medication prices Americans pay, whereas in Europe Soolatra is many times cheaper. Ivermectin, as far as i know, is not water soluble. So any topical gel version of Soolantra will need one of those irritataing oil soluble excipients to disolve it. The horse paste looks like a gel but i have seen comments from people saying that it feels and looks like vaseline after applying it. Anyway, I'll give it a couple of months and I'll post my results on the page you mentioned.
  6. Yes I'm ingesting it. I took a 250 lb dose. No, i dont weigh 250 lb. I just like the idea if a large dose. Each syringe has enough for a 1250 lb horse, so thats 5 doses per syringe.
  7. No, its the oral, apple flavoured horse paste with the syringe. You have a picture of it at the top of this page. The ingredients are not listed on the box.
  8. I ordered Bimectin Brady. It arrived 2 days ago. Not easy to get cause its not available in some european countries. I took a dose yesterday on an empty stomach with plenty of water. Not exactly sure when i should take the next dose, maybe in a few days or next week. So, all i can do now is wait and see what happens.
  9. I've tried Soolantra a couple of times. Lasted at best about 2 months but my face couldn't handle it. No idea why maybe its the propylene glycol in it. Im going to try the oral route and see what happens. I've ordered the paste. One thing i noticed each time I used Soolantra was that my face was in good condition for a while after i stopped using it. So i do think demodex has some part to play for me.
  10. Haven't heard of this lutein stuff Brady. Havent really been around much lately. So youre still using zz, using some topical peroxide, low carb diet and lutein. Hell of a life, eh. Topical ivermectin may be the best option but some of us cant tolerate it. Im not sure any derm would be able to answer that question. Probably better to ask a vet.
  11. There are a lot of comments on Amazon from people who have taken it orally for Scabies. Most of the rosacea comments are using it topically but i did see a couple who use it successfully by mouth. The problem for some people maybe propylene glycol (PG), which is an ingredient in both Soolantra and the horse paste. For some people PG can cause allergic reactions, dryness and inflammation. Taking the horse paste orally may be an alternative. But i don't recommend it. What do you think Brady? Have you ever thought about ingesting it? I know you're an oily like me which according to studies means that we most likely harbour a lot more demodex mites than normal skin.
  12. Thanks Brady for the info. I've never had much of a problem resisting sugar. As you know there are a host of high glycemic foods which we must also avoid which have nothing to do with sugar. This is where I have the problem. In my opinion Acne is primarily a disorder of hyperkeratinization within and around the sebaceous follicle. This one event leads to the others. In my experience a low carb diet reduces the flakeyness of my face and in turn the breakouts also. Its nice to see from reading your last post that research recognizes a connection between diet and hyperkeratinization. But as you know low carb or even zero carb diets may not be the whole answer. Some of us also need an adjuvant topical treatment. I think the reason why we also need to topically treat the problem is because hyperkeratinization impairs the skins barrier and disables the skin's antimicrobial defense . Exactly how a low carb diet can slow down keratinization is the big unknown. I believe once science finds the answer to this, it will be a huge step forward in developing a new treatment for diet related Acne. Anyway, I'm going out for a beer. I don't care if I have a few new papules tomorrow as a result, I just want to have a beer.
  13. Yes I've seen a few studies which found a link between high carbs and Acne. The problem for me is the treatment. Its a pain in the ass trying to resist the temptations of a plethora of beautiful foods. Its only in the last decade that science has cautiously accepted this acne subtype exists, after decades of denying a connection. For that reason, those of us in this subtype could be waiting a long time to find a treatment which will allow us to eat what we want without breaking out.
  14. The research only found a connection between sun damage and subtype 1 rosacea, not papulopustular rosacea. Unfortunately the research on diet and Acne is pretty slim. So it looks like we will just have to suffer on with our insipid meals.
  15. Did you suffer from mild, moderate or severe Acne as a teenager Brady?
  16. Thats a nice improvement Brady. I take it that Avar is a green coloured cream which masks the redness somewhat as well as being antibacterial and anti inflammatory? What about your diet. Do you still have to avoid carbs while using Avar?
  17. Well done Brady. I think you have given Soolantra a fair go. You should have seen something really good by now so I don't blame you for ditching it. I have a similar problem with it and at the moment I need to use Tacrolimus to keep the inflammation at bay. I don't think I'm going to last much longer. Anyway I'm curious. Your Derm doesn't seem to be having huge success with his patients on Soolantra. 25% is quite a low success rate, especially when compared to the 70% success rate in the one year study. Of course I accept that a certain percentage could have ditched it too early in their treatments, but 1 in 4 is still quite low. You told your Derm that you have good results with sulfur so obviously he prescribed what you wanted. But I'd love to know what your Derm is having most success with treating the 3 out of 4 who failed on Soolantra.
  18. I guess some could be sceptical about Soolantra's ability to kill demodex. Especially since there are no studies to prove it. Sometimes oral meds don't work as well, or even not at all, when transformed into a topical device. But I believe there is some proof that Soolantra is as effective as oral ivermectin. You may have read this study http://www.sciencedirect.com/science/article/pii/S120197121201315X It compares oral ivermectin to oral ivermectin and metronidazole in the reduction of demodex and improvement of symptoms in 4 different skin conditions. The author of this study did make one observartion which is very much identical to so many testimonials we read about from users of Soolantra. Here is a paragraph from the study: "In the cases who received ivermectin alone, there was a gradual reduction in the mean follicle mite count at the first week visit . However, rebound elevation in the mite count was evident in the third week in some patients with rosacea and those with anterior blepharitis lesions." This was only a 4 week study so obviously there was no report of a 6th week rebound.
  19. Brady, from your last 2 posts would I be correct in saying you're not convinced that Soolantra kills demodex?
  20. Sorry Brady but I didn't say that those using Soolantra would notice a better improvement with a low carb diet. I was referring to the 30% of participants in the Soolantra study who failed to see any improvement. 70% of participants were clear/almost clear without any mention of a diet. Also, I have no idea what most of your last post has to do with my previous post. What exactly Soolantra does for Rosacea may very well still be a little up in the air. My previous post was specifically looking at your case, where it seems that Soolantra or ZZ cream will treat your secondary symptoms, and diet addresses the primary cause. Or maybe it's the other way round. I was hoping that Soolantra could have treated both aspects of your Rosacea, but that doesn't seem to be the case so far. Like I've said, there have been some people on the Soolantra thread who have reported being able to eat and drink whatever they want while using Soolantra. But I guess this may not apply to all of us.
  21. I noticed where some people reported being able to eat anything after treatment with Soolantra. But i can see that you haven't been that lucky. There was no mention of any kind of diet used in the Soolantra studies.But maybe the 30% who failed to see any improvement could have benefited from restricting carbs. From what I understand so far about you, neither ZZ cream nor Soolantra would help if you didn't adhere to a low carb diet. If that's the case then Its somewhat disappointing because it shows that you still haven't got to the route cause of your particular type of Rosacea.
  22. What I find odd are the ups and downs you're experiencing with Soolantra. I have read many stories of people having these ups and downs with ZZ cream which is believed to be a purge or Demodex die-off. But since you were using ZZ for years before starting Soolantra, I would have thought the purge or die-off or whatever the ups and downs really are, were well behind you. Did you suffer flares when you started ZZ cream years ago?
  23. Looks good Brady. I'm curious. How would you compare compare your results so far with Soolantra to years of using ZZ cream? I started Soolantra again 2 weeks ago.
  24. I tried it on 2 occasions and I think the max I lasted was about 6 or 7 weeks. I may even try It a third time.
  25. http://onlinelibrary.wiley.com/doi/10.1111/all.13118/full Galderma have been studying the anti inflammatory effects of Soolantra. IMO this is what differentiates the 40% who cleared in 3 months and the 30% who cleared in 12 months. It now seems clear that the 30% were dealing with far more than just Demodex. After reading this new research, I sometimes wonder if it's such a good idea to wash one's face in the morning after applying Soolantra the night before. Particularly if you belong to the 30%. In effect, washing away the anti inflammatory effects at the start of a new day. Just a thought.
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