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Apurva Tathe

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  1. Hello Everyone, This post is not to compel you for donation but as you can see from the above post from Admin that we are working from the ground and helping everyone to understand this disease rosacea and its associated co-morbidities and it is all free and open to read and we want to give you more things and more insights on that, which still needs to be explored and we want your help in this. If everyone will accept this RRDi as their own and contribute to this organization a little donation for further research, it would be appreciable. Thank you
  2. As I have already discussed in my previous post about antibiotic concern read here and why I am taking this theme and educating everyone because it's not about one person being affected but it's all about community and global issue. Antibiotic resistance has been increasing in recent years and it all comes down to one thing that how we use antibiotics in animal husbandry, agriculture and in infectious diseases and now the time has come when we have very limited numbers of antibiotics being used when the deadly outbreak comes. So we have to secure the antibiotics for future use and how we are misusing antibiotics unnecessarily without even knowing of its harmful effects. Diagrammatic representation of antimicrobial resistance passing in bacterial population (Illustration by Apurva Tathe) Because we rosaceans heavily rely on antibiotics some with prescriptions and some with non-prescriptions. When doctor prescribes us antibiotics it has a dose value and time period that we need to complete in order to get rid of increased number of microbial population that inhabit our skin and become pathogenic because it triggers our inflammatory reaction and the main concern comes when we already have immunocompromised condition. So, if there is a mutant strain of bacteria by chance in a large population because of changes in bacteria due to evolution over the course of time anyway it has a very fewer frequency but bacteria divides rapidly so if you introduce antibiotic, all the antibiotic susceptible bacteria die and mutant bacteria survive now what happens this AMR bacterial strain rapidly grows in population and becomes dominant (Figure). There are two factors that introduce antibiotic resistance in bacteria either the dose value (taking the dose lower that the recommended value) and steady use of antibiotics when not needed further (time period exceeds). So dose value and time span matter a lot in how we use antibiotics. Why I am considering this concern as a global health is without prescription and diagnostic tests, we ourselves rely on antibiotics and we spread this antimicrobial resistance to each other in human-human in communities, in hospitals and we even do not know this and the time comes when the outbreak of disease occurs and the first line of antibiotics and even second line of antibiotics fail to perform because of AMR in bacterial strains. Healthcare has now preserved some third line of antibiotic drugs to treat deadly infections in outbreaks. Next I will take it further to explain how we spread this resistance.
  3. Yes do not heavily rely on heavy doses of antibiotics (read here)without doctor's prescription.but do it with your own body's balance and understanding and use natural things more like the one above suggested you can read this gut connection with SD or yeast overgrowth for more understanding and do let us know about your post implementation status.
  4. When we have rosacea, we normally use antibiotics to treat our rosacea or atleast soothe the condition of rosacea. But do you know what we are doing when we are taking antibiotics? sometimes it is prescribed by doctor or physician or sometimes it is non-prescription because we take it by our own. But do you know the effects of antibiotics we have and what we are doing to other humans and our community? I will start with microflora of our skin. we have a number of bacteria of different classes on our skin. I will take one example of staphylococcus family of bacteria that we find normally on our skin, bacteria do not pose a health problem when normal in number but they become pathogenic and cause infectious diseases when they are frequent in number. Generally, it has been found that chronic skin condition people have frequent more number of bacteria on their skin and when it comes to rosacea, bacteria can worsen the condition of rosacea by increasing the inflammation, we all know this. Antibiotics are only targeted for bacteria, whether you take it orally or topically, when it blocks the bacteria from reproducing it is called bacteriostatic and when it kills the bacteria it is called bactericidal. Antibiotics work by blocking the cell wall synthesis or cell membrane synthesis or mRNA synthesis or protein synthesis or DNA synthesis in bacteria and ultimately bacteria die. Antibiotics are good when it is prescribed by your doctor and when it is given for a period of time with a diagnostic test for a particular bacteria found on your skin but it is a very concern thing when you take it on your own without any test and prescription. Then what happens when you take antibiotics for your roscaea or any other skin diseases whether it is prescribed or non-prescribed? sometimes you take it for a short period of time and sometimes you take it for a long steady period of time. In both the conditions you are exposing your skin bacteria to antibiotics and you are actually educating your bacteria about antibiotics. Then what do bacteria do? some bacteria are blocked and some are killed and some are very smart to get past the effects of antibiotics and survive and become resistant bacteria. Bacteria replicate very rapidly, so the get past bacteria which became resistant actually replicate in frequent numbers and now they are in majority in bacterial pool and they get this resistance through mutating genes and proteins and enzymes which are responsible for blocking antibiotic structure. This is called antibiotic resistance. Now microbes resist the effect of medication, in this case antibiotics to bacteria, which once could successfully treat the condition is called antimicrobial resistance or AMR, because we are actually educating the microbes over the course of time. Now there are so many strains of bacterial species which have become resistant to different antibiotics are multi-drug resistant bacteria. I have taken one example of Staphylococcus family of bacteria which are resistant to penicillin groups and in this class methicillin-resistant staphylococcus bacteria(MRSA) known as superbug which are multi-drug resistant bacteria. After 1980, there are no new classes of antibiotics being produced. Now antibiotics are a very serious concern to consider when it comes to taking it for chronic inflammatory skin diseases and to prevent the unnecessary use of antibiotics and in turn antimicrobial resistance.
  5. Yes, because its all about immune system and HCQ does modulate the immune system in various ways and regulate the overactivity of immune system in some conditions. Not only does it work in getting rid of symptoms but it actually works behind the disease cause.
  6. Does anyone have any experience of doing chemical exfoliation on rosacea skin? Chemical exfoliation is very good for skin once in a while but what about rosacea skin?
  7. I have been noticing the fact that how all the factors come together in an interplay to cause any condition and how paying attention to the factors and working with them would relieve you from the symptoms. My yeast overgrowth was aggravating my flushing, my blood vessels had become very dilated and at one point my skin was a full dry land and I coincidentally conversed with Dr. O’Desky our MAC member and she understood the condition and asked me to do gut cleaning. I was already a little bit resolved with the condition but did gut cleaning and not only gut cleaning but I have had such foods which kept my gut pH alkaline and I was already washing my face and scalp with ketoconazole with zinc pyrithione lotion and now my skin is in good condition not only yeast overgrowth was reduced but my intense prolonged flushing is at bay, meaning very mild flushing and one more thing I have considered, the environmental factor. My skin has withstood the extremities of temperature frequency this season. So I was on with my internal and external cure meanwhile when the favorable temperature stability came it automatically helped to get my skin breathe and respond to the cure. So I observed how gut microbiota and skin microbiota are in close connection with each other and not only skin microbiota but gut microbiota also reacts and responds to the environmental factors. So I concluded how skin microbiota overgrowth and then its stability was responding to gut and temperature changes and how in turn that yeast growth was controlling the already existing inflammation of the skin.
  8. I think he may have an oily skin and oily scalp so using warm to hot water helped him a lot and did not cause much problem but if one has a dry skin and dry scalp this technique would not work and dry out even more and would cause flakiness.
  9. Yes what you have pointed out above is correct. There are more interconnected and internal factors or subordinate factors though which enhance the condition but you sometimes never know what activated this condition and have to go through all the loops. Yes sunscreen is important if you are a very fair skinned person but it all depends on skin makeup (from makeup I am saying composition) because skin of color people like me have more melanin production that kind of gives protection from sun rays and that also depends on how your skin reacts to sunscreen if you have dry or oily skin . I use my homemade zinc sunblock on top of lathered moisturizer since I have a dry skin but you just give it a try buying something. There are recommendations of sunscreens in our rosacea topics. you can read what suits you best.
  10. Yes I also have used shea butter a while back and what helped shea butter in that it soothes out the itching sensation and absorbs in skin like I have applied nothing. It really helped a lot. I also had SD and it went with the use of ketoconazole with zinc pyrithione lotion but this time the experience of dry crusty pimple like rough appearance around the mouth and jaw line really indicates how the yeast overgrowth and rosacea play a vital role in inflammatory response and I agree with you that it has not been ruled out and how treating the secondary condition automatically controlled the primary condition with less flushing experience. So we can observe that besides demodex mites other microbial flora this time fungus can play a vital role in aberrant inflammatory response and fungus may play a role in interacting with resident immune cells.
  11. While talking about rosacea there are so many things and factors to consider. Even if you are trying everything to help control this condition, skipping just one thing is enough for its persistency. A few days ago I suddenly had a sandy rough patchy and scaly skin texture on already flushed skin which was aggravating the condition of inflammation altogether. I already have controlled and managed rosacea but only relapse with the onset of fall and continue with winter but If I describe the condition of my skin, it was a skin barrier texture which was not allowing anything if applying topically. It was as if my skin lipids were severely imbalanced. I could not understand what made this condition to appear but I was on with my internal and external cure. It was a little bit resolved but then I examined the pattern of that condition appeared and did a lot of research and found the pattern resembled to yeast infection may be to blame because I had very rough papules like appearance around my mouth and jawline which was quite itchy and again I remembered how I took the treatment regimen when I had seborrheic dermatitis and It was completely gone. Now I considered my severe scalp dandruff and I correlated everything from my scalp flakiness to my intense flushing and on top of that sandy rough flaky skin. Usually I get flare-ups in this season but do not bother much like pain and burning sensation and pruritus but this time it was bothering much and I decided to give it a try the same treatment regimen I had during Seborrheic dermatitis because the treatment regimen for SD and yeast infection are same so I washed my face at night with Ketoconazole 2% with Zinc Pyrithione 1% lotion and the next morning I found a drastic change in my skin as if it is restored to its natural balance and then I washed my hair with that same lotion and I am going to continue this for few days. The major change and outcome I discovered with respect to overall condition : When I treated this condition with ketoconazole and zinc pyrithione the next day I got very mild flare-up and was not flushing for prolonged period but before that I was getting frequent flare-ups and the flushing was consistent, intense, burning and painful . So I discovered how a yeast or fungal infection can also aggravate the condition of rosacea and even go further can cause the aberrant hyperactive immune function in play. Besides parasites and bacteria how yeast or fungus can play with immune system with respect to rosacea needs to be more discovered.
  12. Thank you so much for this insight. I also have to find out what bothered my skin. I always keep the things in check. I think the gut thing resonated with me a lot because skin and gut has some connection in rosacea. I also do fast but it's been a long time I didn't. I think I need to do it. Thank you so much.
  13. Thank you for this consideration and welcome to the RRDi. I also have seen your work on rosacea on your website and as a practitioner you have lot to tell about different things. I was going to post this as a separate thing but now I can post it here to ask you about this. Recently my skin got very sandy and rough, little swollen appearance out of no where and if I filled air in my mouth like a balloon it had torn down the skin like dry patches. Even if I drink a lot of water, slather my skin with moisturizer. There is no way of sun exposure as harsh to draw moisture out of my skin. But I know a lot of rosaceans experience this thing at times and this condition automatically goes on its own. Now it is fairly settled down on its own but still completely has to go. but it aggravated the condition of rosacea as if triggering. What is the root cause of this and how to care and cure it naturally so that it does not appear next time? Thank you...
  14. Yes they may be linked because roscaea is a kind of chronic inflammatory condition which may or may not be associated with co-morbidities and can occur with other co-expressing conditions. Rosacea can co-exist with other inflammatory conditions. If you are an elderly person and you have been diagnosed with a form of dementia, it is linked to chronic inflammation that means neuroinflammatory condition and neuropeptides are associated with this inflammation because they are the mediators of inflammation and neuropeptides circulate between the brain and peripheral tissues and hence found in the skin and is the cause of your rosacea because chronic skin inflammatory conditions are associated with neuropeptides.
  15. Ok so it has been a long journey for you with respect to rosacea. Yes this theory does not go completely with only fair skin people get rosacea. There are some published research on rosacea in skin of color people. I am an Indian and I also have olive skin with yellow undertone and the bizarre thing is Indian skin is something very acclimatized to sun rays because of its extreme hot and humid climate and we do not get easily anything related to skin but when I got this condition five years ago it was unknown to me and initially it was in an exaggerated condition difficult to control and handle but gradually I understood with trial and error considering my diet what I eat what I apply on my face and environmental and immune conditions. Now still it remits and relapses with frequent episodes but now I know how to manage it.
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