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Apurva Tathe

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  1. Yes I guess the mites can spread from the skin contact if the mites are in aggressive number on your face because as far as I know even on your face the mites will not stay at one place they tend to go from one place to another. normal skin also has demodex but in lower numbers but it has found the cause of rosacea with increased number of demodex.Don't cancel the trip. Better to consult dermatologist to find the better treatment for your rosacea.
  2. Yes I think we have to pay attention to the other skin-microbiome interaction also which tend to play a role in rosacea especially I was thinking of bacteriophage (bacteria+virus) which might play a role in rosacea and very few research is going on this rosacea and the idea of research on this theme would open up a new direction for rosacea. Think out loud.
  3. In my opinion, if we do research on the causes of rosacea we ultimately will go deep into the ground picture such as on cell and molecular and immunological level. If we find the main factors behind this condition, We then can cover everything in a broad picture to be focused on. First we have to find the root cause of this disease and everything will come into place.
  4. Yes I know it's not rosacea but erythema (redness). I know there are so many conditions which look like rosacea but they are not but we do not know the underlying cause might correlate.it might be a co existing condition occurs with rosacea. I haven't done anything for it. It is slowly decreasing itself.
  5. has anyone noticed something experiencing this unusual condition with them? First time I have seen something like this and the thing is erythema is extended to arms and the redness is not causing any pain and itchiness and the startling thing is I get intense erythema on my right cheek than my left cheek and the erythema on my right hand is more than the left hand. So I was observing, has right face erythema anything to do with right hand erythema? Does it have any connection in common?
  6. Ok I guess you are ingesting it orally? and if you are ingesting it orally, it has residual effects means it is stored in body fat and then progressively released to work and taking too often will cause build up. So you have mentioned that you have already taken your first dose so wait for one week and see the results and then follow the next dose and the recommended dose is 200 mcg(micrograms) per kilogram body weight but slight point difference will be ok but ask and consult your physician before you take any treatment.
  7. There are so many alcohols in Soolantra's inactive ingredients which cause dryness and flakiness of skin which in turn cause itching and irritation and redness. Parabens and propylene glycol are also there which tend to penetrate the skin to help allow other ingredients to enter and this may be the reason your skin reacted and couldn't handle because everyone's skin reacts differently to chemicals.
  8. Yes admin I had learned about the difference when I got rosacea sometimes It was sudden intense redness and bump and sometimes it was episodic redness so I researched about it because it happens with me with the onset of autumn. When the autumn starts I get sudden intense flare with redness and bumps and then the redness and bumps last longer and take time to go and during full autumn and winter after that flare-up, I get short episodic flushing very frequently which looks like it is blushing. but it is all unexpected and unanticipated about its timing.
  9. Yes, I had also mentioned this in my previous post quoting someone's question about tobacco and cigar causing him rosacea and I had said that you have to figure it out which food or item is triggering your rosacea and I had given my example of leaving non-veg (pointing out meat) which was causing me flare-ups and then recently I read about red meat causes skin inflammation. So the point is if any food items or drinks or smoke are triggering your rosacea and are not listed anywhere but you have to keep an eye on your diet because everyone's body reacts differently to what they eat.
  10. Yes, This is exactly what I was trying to explain but the first time I explained was very short and to the point and I realized it was hard to understand and then I explained one by one according to the questions you asked. No, you got it right. Thank you
  11. A paper in 2017 continues to explain the quandary. "Many studies have shown higher density of the parasites in diseased inflammatory skin than in normal skin, but whether it is the cause or result of the inflammation remains unclear." [6] A paper in 2018 may help to resolve this issue because for the first time it has been discovered that Demodex mites secrete bioactive molecules that reduced TLR2 expression in sebocytes. [7] So while the jury is still out on this subject, What do you think? Which comes first, the demodex or the rosacea? Does it even matter? With your above statement I highlighted and giving my view on this topic which comes first, I am also stating the same thing that I think demodex came first well it is not experiment or evidence based but with the experience I have had. Human Permanent Ectoparasites; Recent Advances on Biology and Clinical Significance of Demodex Mites: Narrative Review Article With this journal which you quoted in your article , "Many studies have shown higher density of the parasites in diseased inflammatory skin than in normal skin, but whether it is the cause or result of the inflammation remains unclear." So I was elaborating this sentence that higher density might be the result of inflammation (inflammatory immune response) and then subsequently the cause of inflammation. So I explained this with the term “reciprocal correlation”. And let’s say if the higher density is the result of inflammation, so the altered cutaneous immune responses are the cause of persistent inflammation and that is what I was trying to state in my post but then I read the above journal in detail after your question and I found the confirmation of my expression with these sentences of journal “ Studies indicate increased number of D. folliculorum in immunocompromised patients” and “It remains to be determined which kind of cellular immunity may foster mites’ proliferation” and my statement “the false immune response(altered immune response) might be the cause of increasing number of demodex” state the same thing. Thank you for questions because what I was stating is experience based but after thoroughly reading the reference journals from your article I found the confirmation of the same thing.
  12. In my view, normal skin also has demodex mites but less in number so they can't activate pro-inflammatory cytokines but when the number is more they activate it. so logically when the normal skin flora has demodex before rosacea has occured so demodex apparently came first and because demodex mites cause inflammatory immune response and inflammatory immune response is not just related to mites but self-antigen presentation to immune cells rather than non-self which is false immune response or we call it autoimmune response and attacks to healthy cells and so the false immune response might be the cause of increasing number of demodex .So demodex and rosacea have reciprocity with each other to increase its effects and outcomes.
  13. 1. Introduction Rosacea is a chronic skin inflammatory disease characterized by dilated visible blood vessels causing erythema(redness), telangiectasia, papulopustules and elevated lesion(1). The pathology of rosacea is yet to understand completely but the evidence suggests that the genetic and environmental factors may cause the altered immune system leading to rosacea (2). There are so many oral and topical therapies used for the treatment of rosacea but natural plant components are also emerging as an effective medicine to improve the condition of disease. In this category, a plant species Callistemon viminalis or Melaleuca viminalis commonly known as weeping bottlebrush (2) has shown antimicrobial, antiinflammatory and antioxidant properties. However, its role and effects on rosacea remain unknown and need to be investigated. Callistemon viminalis, is a plant from Myrtaceae family and native to Australia and commonly occurs along watercourses on the coastal plains and it is also widely grown in tropical and temperate region (3,4). Extracts of C. viminalis contain triterpenoids, polyphenols, flavonoids, steroids, alkaloids and tannin (5). Essential Oils : The chemical constituents of the essential oils are : monoterpene hydrocarbons, α-and β-pinene was found to have anti-inflammatory and anti-microbial effects (6,7,11). oxygenated monoterpenes, 1,8-cineole has a very good anti-inflammatory effects. It was found to suppress pro-inflammatory cytokine expression in mice(8). α-terpineol has also disinfectant and antioxidant properties(9) and terpinene-4-ol had shown the activity of suppressing pro-inflammatory mediators. In-vitro study was conducted to show the effectiveness of terpinene-4-ol in penetrating the skin (10,11). Different parts of plant shows good antibacterial, antifungal and antioxidant activities. For example extraction from leaves(experimental part) has a rich amount of 1,8-cineole and Sesquiterpenes which have good antimicrobial activity against some species such as: Saccharomyces cerevisiae, Staphylococcus aureus and Escherichia coli and n-hexane of leaf extracts showed potential activity against skin pathogen (5). There are a number of monoterpenes, sesquiterpenes and polyphenols present in the plant but only a few important are pointed out in this article. 2. Method and Application To investigate the effects of Callistemon viminalis on rosacea, the leaf part was considered as the main experimental source.The extraction of essential oil from the leaves here was done by maceration method to make infused oil using coconut oil as the coconut oil has also a soothing effect on rosacea. Concentrated essential oils may cause irritation to inflammed skin. So to test the effects of leaves, infused oil was made using dried leaves. The dried leaves were put in a jar with coconut oil and was kept under the sun from 10-20 days to few weeks. This infused oil has a very strong smell and It was applied on inflamed skin daily for 4-5 months and the results were astounding.The dry leaves contain more antioxidant properties and it is known that the antioxidants play an essential role in oxidative stress of cells by donating electrons to free radicals and thereby reducing the inflammation. Antioxidants are like soldiers always protecting our skin cells from the damaging effects of free radicals. 3. Result This oil showed astonishing effects on frequent flushing and contraction and reduction in dilated blood vessels and decreased erythema. Molecular Test : It should be molecularly tested to see the effects of chemical compounds on proinflammatory mediators and signaling pathways which cause rosacea. Note : Before you use this oil take a patch test on your hand first and see if you have any allergy or sensitivity and if you do make it more diluted with coconut oil. This is good for type I rosacea. 4. References 1. https://www.mayoclinic.org/diseases-conditions/rosacea/symptoms-causes/syc-20353815 2. https://www.sciencedirect.com/science/article/pii/S0022202X15526900 3. https://en.wikipedia.org/wiki/Melaleuca_viminalis 4. https://www.anbg.gov.au/gnp/gnp12/callistemon-viminalis.html 5. https://www.sciencedirect.com/science/article/pii/S1995764517303905#bib8 6. https://pubchem.ncbi.nlm.nih.gov/compound/alpha-Pinene 7. https://www.mdpi.com/1420-3049/17/6/6305 8. https://www.sciencedirect.com/topics/medicine-and-dentistry/cineole 9. https://pubchem.ncbi.nlm.nih.gov/compound/alpha-TERPINEOL#section=Overview 10.https://pubchem.ncbi.nlm.nih.gov/compound/Terpinen-4-ol#section=Absorption- Distribution-and-Excretion 11. https://www.aciar.gov.au/publication/Melaleucas-their-botany-essential-oils-and-uses
  14. It happens sometimes. You know I have been non-vegetarian since childhood and My skin was also flawless now it's been 4 years I have rosacea with some other co-existing conditions and how did I get I do not know so throughout this journey it has been trial and error period.first I left non-veg to see if it has any effects on rosacea and trust me it helped me in reducing my frequent flare-ups. this is just an example, other than that I have systematically managed my diet and routine. What I am trying to tell you is sometimes the things and foods which we had in past that wasn't bothering at all then, sometimes bother now. so you have to keep an eye on things which you consume to see whether it has any increasing effects on your rosacea.
  15. Yes it can, because coffee contains caffeine and cigar contains nicotine and both are chemicals which increase blood pressure. A single full-size cigar can contain nearly as much nicotine as does a pack of cigarettes but coffee is good if you are taking once a day and not more than that.because caffeine and nicotine both can prolong the frequency and period of flushing.
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