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"In conclusion, the present study indicates that the administration of lutein and zeaxanthin provides multiple benefits to the skin...Although these benefits were obtained regardless of whether lutein and zeaxanthin were administered orally or topically, the study demonstrated that an additional benefit is achieved through the simultaneous administration of these xanthophylls by both routes."  Marcello, a lawyer, says, "Ten days ago, I bought Lutein-Z with zeaxanthin (10 mg) from Jamieson brand and started to take it with Canola oil (to improve lutein's absorption). That, of course, was to protect my eyes and nothing else. Then a couple of days later I noticed that I had no more new pustules on my face. Not a single new one !!! I was honestly wondering what was happening, then I realized that the only thing that could explain it was my new intake of lutein. It's been 10 days now since I took my first pill and my face is still completely clear." [post no. 1] Also see post no 20 in this thread] "Lutein from Latin luteus meaning "yellow" is a xanthophyll and one of 600 known naturally occurring carotenoids." Wikipedia"Zeaxanthin is one of the most common carotenoid alcohols found in nature. It is important in the xanthophyll cycle." Wikipedia Lutein is distantly related to isotretinoin since Lutein is a naturally occurring carotenoid (an organic pigment that have vitamin A activity meaning that Lutein can be converted to retinol), while isotretinoin is a retinoid, "a class of chemical compounds that are vitamers of vitamin A or are chemically related to it." Wikipedia This may be related to a deficiency of Vitamin A which has been "associated with chronic malabsorption of lipids, impaired bile production and release, and chronic exposure to oxidants, such as cigarette smoke, and chronic alcoholism (in secondary deficiency). Wikipedia "Dr Lange also likes to add 6 mg of astaxanthin along with some lutein and zeaxanthin in moderate to marked cases of blepharitis for the additional anti inflammatory properties when used together with omega 3." Natural Treatment for Blepharitis by Dr Michael Lange ElaineA says, "My meibomian glands are making the oily tear film much more easily now. And my eyelids feel and look less swollen. My vision seems much sharper as well. Having a working oily tear film really helps the eyes." GolfisGreat (post no 131 at RF) reports, "After just four days I am seeing amazing results. I have suffered with palpular rosacea for twenty years, two to ten spots per day are the norm for me. I have had various success with low dose accutane, tea tree oil every topical that has ever been written about on these boards, though none come close to the results that I have seen so far. I'm taking puritans pride 20mg I'm taking two per day. I am experiencing slightly dry lips, though nothing like as extreme as accutane. I'll report back in a week, I'm already thinking of reducing the dose to 20mg. Good luck to anyone else who tries this." If you decide to try oral Lutein with Zeaxanthin please use our Amazon Affiliate store by clicking on the banners below (we get a small fee if you purchase through our store and you will helping our non profit organization). We have found one topical at Amazon that contains Lutein, Nucerity Rejuvenating Barrier. Another topical containing Lutein is FloraGLO™ Lutein Topical (not available at Amazon). Please post your experience in this thread. Mahalo. The color of an egg yolk is from the xanthophyll carotenoids lutein and zeaxanthin Image courtesy of Wikipedia End Notes  Skin Pharmacol Physiol 2007;20:199–210 DOI: 10.1159/000101807 Beneficial Long-Term Effects of Combined Oral/Topical Antioxidant Treatment with the Carotenoids Lutein and Zeaxanthin on Human Skin: A Double-Blind, Placebo-Controlled Study P. Palombo, G. Fabrizi, V. Ruocco, E. Ruocco, J. Fluhr, R. Roberts, P. Morganti