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Bionect Krem

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$18.99 NOTE: Our shopping cart is disabled. We are using it to display affiliate items which if you click on PURCHASE in the PRODUCT INFORMATION by scrolling below or click on the Amazon banner the RRDi receives a small affiliate fee upon completion of your purchase. Mahalo.
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"Finally, a formulation of low molecular weight hyaluronic acid sodium salt 0.2% cream (Bionect® Cream, Innocutis Holdings, Charleston, SC, USA) applied twice daily for 8 weeks showed a statistically significant reduction in papules, erythema, burning, stinging, and dryness in a small study. Along with excellent tolerability, a reduction in papules, erythema, burning/stinging, and dryness was clearly apparent by week 4 and remained by the final visit at week 8. Notably, erythema was reduced by the greatest amount, with an approximate 50% improvement by week 2. This study demonstrates the importance of skin barrier maintenance and repair in the pathogenesis of rosacea. With a hydrophilic structure, low molecular weight hyaluronic acid penetrates the stratum corneum where it interacts with fibrin and collagen to support remodeling of the extracellular matrix. This mechanism, along with induction of the antimicrobial peptide β-defensin 2 release from keratinocytes, ultimately accelerates re-epithelialization and reduces pain and edema." Source
BIONECT is indicated for the dressing and management of partial to full thickness dermal ulcers
Wounds including cuts, abrasions, donor sites, and post-operative incisions
Irritations of the skin, and first and second degree burns
The dressing is intended to cover a wound or burn on a patient's skin, and protect against abrasion, friction, and desiccation.


  • NOTE: Our shopping cart is disabled. Ignore the OUT OF STOCK message. We are using it to display affiliate items which if you click on PURCHASE in the PRODUCT INFORMATION by scrolling below or click on the Amazon banner the RRDi receives a small affiliate fee upon completion of your purchase. Mahalo.

About Bionect Krem

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"Finally, a formulation of low molecular weight hyaluronic acid sodium salt 0.2% cream (Bionect® Cream, Innocutis Holdings, Charleston, SC, USA) applied twice daily for 8 weeks showed a statistically significant reduction in papules, erythema, burning, stinging, and dryness in a small study. Along with excellent tolerability, a reduction in papules, erythema, burning/stinging, and dryness was clearly apparent by week 4 and remained by the final visit at week 8. Notably, erythema was reduced by the greatest amount, with an approximate 50% improvement by week 2. This study demonstrates the importance of skin barrier maintenance and repair in the pathogenesis of rosacea. With a hydrophilic structure, low molecular weight hyaluronic acid penetrates the stratum corneum where it interacts with fibrin and collagen to support remodeling of the extracellular matrix. This mechanism, along with induction of the antimicrobial peptide β-defensin 2 release from keratinocytes, ultimately accelerates re-epithelialization and reduces pain and edema." Source

BIONECT is indicated for the dressing and management of partial to full thickness dermal ulcers
Wounds including cuts, abrasions, donor sites, and post-operative incisions
Irritations of the skin, and first and second degree burns
The dressing is intended to cover a wound or burn on a patient's skin, and protect against abrasion, friction, and desiccation.

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