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    • This topic has been researched a lot. There are many, many published articles on this subject. We even have our own extensive post on this subject.   Think about it, is this what you as a rosacea sufferer want clinical studies and scientific medical journals to spend money on? The above article was published by the Dermatology Online Journal. 
    • Front Immunol. 2024 Feb 29;15:1382092. doi: 10.3389/fimmu.2024.1382092. eCollection 2024. ABSTRACT [This corrects the article DOI: 10.3389/fimmu.2023.1285951.]. PMID:38487539 | PMC:PMC10938264 | DOI:10.3389/fimmu.2024.1382092 {url} = URL to article
    • Another study on bacteria and rosacea which adds cutibacterium acens being LOWER and substantiating other papers that staphylococcus epidermis is higher in the 17  in the case group who had rosacea. No mention of other microbes, which is generally what western medicine focuses on including studies on rosacea. There are three other bacteria that are mentioned in rosacea studies which we list in this category Wouldn't it be incredible if 10,000 rosaceans got together and each one donated just one dollar and sponsored through a legal non profit organization for rosacea to investigate microbes other than bacteria, i.e., virus, archea, or for that matter whatever the 10,000 rosaceans wanted investigated by a show of hands? Could rosaceans actually come together and do their own rosacea research?  
    • Dermatol Online J. 2023 Oct 15;29(5). doi: 10.5070/D329562420. NO ABSTRACT PMID:38478655 | DOI:10.5070/D329562420 {url} = URL to article
    • Dermatol Online J. 2023 Dec 15;29(6). doi: 10.5070/D329662989. ABSTRACT Research in dermatology education highlights the lack of skin of color (SOC) instruction for medical students, leading to concerning healthcare outcomes. Because of the already limited opportunity for students to have dedicated teaching in pathophysiology, management, and treatment of dermatologic diseases in medical school, we developed an educational module that addresses these gaps. We created a one-hour virtual lecture for medical students focused on common skin diseases tested on the United States Medical Licensing Examination with visual images across all skin types. A questionnaire was administered before and after the educational module to assess outcomes comparing disease identification in lighter (Fitzpatrick scale I-III) versus darker (Fitzpatrick scale IV-VI) skin tones and to determine medical school student attitudes. An analysis of 43 examination scores before, and after attending the educational module determined rosacea, psoriasis, and basal cell carcinoma to be conditions in SOC patients that demonstrated the most significant improvement (47.3%, 54.9%, and 30.8%, respectively). Our results also highlighted worse performance outcomes for diseases in SOC in the pre-examination questionnaire. Thus, our study indicates that a concise education module focused on disease presentations inclusive of all skin types may efficiently increase students' ability to identify diseases commonly misdiagnosed in the clinical setting. PMID:38478660 | DOI:10.5070/D329662989 {url} = URL to article
    • The conclusion of this study is mind boggling. Just think about it for a few seconds. So much for WC Fields as the rosacea poster boy. 
    • We have tried over the last twenty years to figure out how to get rosacea sufferers to come together into a patient advocacy non profit organization, to fulfill our MISSION STATEMENT. Currently we are only allowing subscribed members to post. We have a few active members but so far, as of this date, March 12. 2024, none of our few active members post.  If you have an idea on how we can get members to post, why not find the reply to this topic button (only subscribed members can post) and tell us what you think? So if you only post on social media rosacea websites, why do you feel comfortable doing this? What is it about our forum style website that makes you feel uncomfortable to post?   We could use some young rosacea blood to stimulate posts and keep our non profit going.  You want to run this non profit?  Post and tell us what you think. Post. 
    • J Eur Acad Dermatol Venereol. 2024 Mar 12. doi: 10.1111/jdv.19913. Online ahead of print. ABSTRACT BACKGROUND: Itch as the most common symptom in dermatology has been shown to be related to psychological factors such as stress, anxiety and depression. Moreover, associations were found between perceived stigmatization and itch. However, studies investigating the differences between patients with dermatoses with and without itch regarding perceived stress, stigmatization, anxiety and depression are missing. Therefore, one of the aims of the second study of the European Society for Dermatology and Psychiatry (ESDaP study II) was to investigate these relationships in a large cohort of patients with different itchy dermatoses. RESULTS: 3399 patients with 14 different itchy dermatoses were recruited at 22 centres in 17 European countries. They filled in questionnaires to assess perceived stigmatization, stress, signs of clinically relevant anxiety or depression, itch-related quality of life, the overall health status, itch duration, frequency and intensity. The most significant association between the severity of itching and the perception of stress was observed among individuals with rosacea (correlation coefficient r = 0.314). Similarly, the strongest links between itch intensity and experiences of stigmatization, anxiety, and depression were found in patients with seborrheic dermatitis (correlation coefficients r = 0.317, r = 0.356, and r = 0.400, respectively). Utilizing a stepwise linear regression analysis, it was determined that within the entire patient cohort, 9.3% of the variation in itch intensity could be accounted for by factors including gender, levels of anxiety, depression, and perceived stigmatization. Females and individuals with elevated anxiety, depression, and perceived stigmatization scores reported more pronounced itch intensities compared to those with contrary attributes. CONCLUSION: This study underscores the connection between experiencing itch and its intensity and the psychological strain it places on individuals. Consequently, psychological interventions should encompass both addressing the itch itself and the interconnected psychological factors. In specific cases, it becomes imperative for dermatologists to direct individuals towards suitable healthcare resources to undergo further psychological assessment. PMID:38468596 | DOI:10.1111/jdv.19913 {url} = URL to article
    • J Clin Aesthet Dermatol. 2023 Dec;16(12 Suppl 2):S14-S15. NO ABSTRACT PMID:38464742 | PMC:PMC10919953 {url} = URL to article
    • Eur J Dermatol. 2023 Dec 1;33(6):612-617. doi: 10.1684/ejd.2023.4619. ABSTRACT Rosacea is a chronic inflammatory skin disorder that significantly impairs quality of life, however, its pathophysiology is still unclear. Previous studies have suspected that the bacterial -microbiome plays a causative role in the disease. To investigate whether there are differences in the abundance and diversity of facial bacterial microbiomes between rosacea patients and healthy controls. Samples of facial microorganisms from subjects were collected with sterile swabs, and the V3 and V4 regions of bacterial 16S rRNA were amplified and sequenced using the MiSeq platform of the Illumina system. A total of 44 samples qualified (including 17 in the case group and 27 in the control group), comprising 2,048 operational taxonomic units belonging to 40 phyla and 1,312 species that were clustered. The alpha diversity in patients with rosacea was higher than that in healthy controls, but this difference was not statistically significant. In addition, compared with healthy individuals, the mean relative abundance of Cutibacterium acens was significantly lower (61.79% vs 79.69%, p=0.014) and that of Staphylococcus epidermidis was higher (19.64% vs 6.48%, p=0.036) in rosacea patients. Changes in microbial abundance and diversity correlate with the pathogenesis of rosacea. PMID:38465541 | DOI:10.1684/ejd.2023.4619 {url} = URL to article
    • We have added Tumid lupus as a Rosacea mimic to our official list. 
    • The above video was made a while ago, I think in 2021. If you think you know how to run a patient advocacy non profit organization why not join and take over. If your ideas are better then serve on the board of directors and help us. Maybe you can get the skin industry to sponsor your ideas and then get paid as the NRS runs its non profit that is run by businessmen and dermatologists. Maybe you could get a dermatologist on our board. But before you do, you might want to read all our rules, mission statement, charter, privacy policy, and legal disclaimer to see what is involved. You can make a lot of money running a non profit since many non profits have salaried directors and employees. Non profits make billions of dollars and pay lot of money out for services and salaries. We could setup the RRDi in your home state or country and you run it! I can teach you what you need to know about our financial situation and how you can continue receiving donations. We did receive six thousand dollars over the hears in grants from Galderma, but getting volunteer grant writers is like pulling teeth. Maybe you know how to get grants?
    • The RRDi has stopped reviewing the NRS with regard to how it spends its donations since rosaceans could care less. The last review above is for 2020 but since rosaceans could care less, there is no point it being the lone watchdog on the NRS. Let Samuel and Andrew Huff who sit on the board of directors of this non profit keep getting around 60% of the expenditures of the NRS through their profit organizations which is legal and rosaceans keep donating to the NRS and think this is how a non profit for rosacea should be run. I imagine Sam and Andrew have nice homes, expensive vehicles and take nice vacations. Good for Sam and Andrew who know how to get rosaceans to donate to their 'non profit' for rosacea. The skin industry loves the NRS and continues to give the vast majority of the donations since the public donates about 23.58% of the total donations which means 76.42% of the donations to the NRS are sponsored by the skin industry over period from 1998 through 2020. Rosaceans love it that the NRS is run by businessmen and dermatologists and is not a patient advocacy non profit but instead a non profit supported mainly by the skin industry. It is so sad that rosaceans don't want to come together in a united non profit group that supports patient advocacy for rosacea, engaging in their own research, not relying on the skin industry. So sad. 
    • Allergol Immunopathol (Madr). 2024 Mar 1;52(2):23-31. doi: 10.15586/aei.v52i2.978. eCollection 2024. ABSTRACT Morbihan syndrome (MS) is characterized by solid facial edema, usually related to rosacea or acne vulgaris. The facial edema deforms the patient's features, can impair peripheral vision, and affects quality of life. Its pathophysiology remains unclear. The disease usually has a slow and chronic course. MS most commonly affects middle-aged Caucasian men with rosacea and is rare in people below 20 years of age. MS is a diagnosis of exclusion. There is no standard treatment for MS, though systemic isotretinoin and antihistamines are mainly used. We present the case of an adolescent girl with MS nonresponding to 19 months of isotretinoin treatment with add-on antihistamines. Therapy with monthly administration of omalizumab (anti-IgE) for 6 months was an effective therapeutic option, improving the quality of life. Our case is the second description of omalizumab use in Morbihan syndrome, the first in an adolescent. PMID:38459887 | DOI:10.15586/aei.v52i2.978 {url} = URL to article
    • JMIR Med Inform. 2024 Mar 8;12:e57654. doi: 10.2196/57654. ABSTRACT [This corrects the article DOI: 10.2196/23415.]. PMID:38457810 | DOI:10.2196/57654 {url} = URL to article url to original article
    • J Cutan Med Surg. 2024 Mar 7:12034754241229365. doi: 10.1177/12034754241229365. Online ahead of print. ABSTRACT Rosacea is a chronic inflammatory condition of which there is no cure. The pathogenesis of rosacea is likely multifactorial, involving genetic and environmental contributions. Current understanding suggests that pro-inflammatory pathways involving cathelicidins and inflammasome complexes are central to rosacea pathogenesis. Common rosacea triggers modulate these pathways in a complex manner, which may contribute to the varying severity and clinical presentations of rosacea. Established and emerging rosacea treatments may owe their efficacy to their ability to target different players in these pro-inflammatory pathways. Improving our molecular understanding of rosacea will guide the development of new therapies and the use of combination therapies. PMID:38450615 | DOI:10.1177/12034754241229365 {url} = URL to article
    • J Clin Aesthet Dermatol. 2024 Feb;17(2):47-51. ABSTRACT OBJECTIVE: Erythematotelangiectatic rosacea (ETR) is recognized by flushing, persistent centrofacial erythema, and telangiectasia. Many lines of topical treatments have been used for ETR with variable outcomes. We aimed to evaluate the efficacy of 10% topical tranexamic acid (TXA) with and without microneedling in treating ETR. METHODS: All patients received treatment on both sides of the face, the right side was treated with microneedling combined with 10% topical TXA, and the left side was treated with 10% topical TXA only. All patients received three sessions at two weeks intervals. The final evaluation was done three months after the last treatment session. RESULTS: The study included 45 females. Their age ranged between 20 and 48 years. The duration of the disease ranged from two months to five years. Both sides of the face showed improvement after treatment. There was a clinically and dermoscopic significant improvement in the side treated with microneedling + TXA compared to the side of the face treated with TXA alone. LIMITATIONS: The small sample size and the lack of long-term follow-up. CONCLUSION: This study showed that TXA is an effective and safe treatment modality for ETR. Microneedling can enhance the delivery of TXA and lead to better outcomes regarding erythema and telangiectasia. PMID:38444423 | PMC:PMC10911261 {url} = URL to article
    • J Clin Aesthet Dermatol. 2024 Feb;17(2):32-42. ABSTRACT OBJECTIVE: Our aim was to review the current and emerging dermatological applications of the novel thermomechanical fractional injury (TMFI) device, Tixel® (Novoxel, Netanya, Israel). METHODS: A systematic review of PubMed using the search terms of "Tixel", "thermomechanical fractional", ["thermomechanical ablation" and "skin"], and ["thermomechanical ablation" and "dermatology"]. RESULTS: Thirty-six articles matched our inquiry. Fifteen articles did not meet inclusion criteria. Of the remaining 21 articles, eight were related to device-assisted drug delivery, seven related to photoaging, and seven related to scientific/ preclinical exploration. Preclinical studies have shown ablative and non-ablative microchannel formation similar to that of CO₂ laser but without charring, with clinical studies demonstrating efficacy for a wide range of applications including rhytides, hypertrophic scarring, infantile hemangiomas, and acne/rosacea. The treatment is well tolerated with minimal discomfort and downtime, showing promise for pain-averse and pediatric populations. Few adverse events have been reported, with a high degree of safety demonstrated in all Fitzpatrick types. LIMITATIONS: Heterogeneous result reporting among studies. Limited number of randomized controlled trials. CONCLUSION: Tixel® is an emerging TMFI device with a wide range of current and potential applications, including device-assisted drug delivery and treatment of rhytides, photoaging, and scars among other conditions. The device has both ablative and non-ablative settings and has been safely used in all Fitzpatrick skin types. Larger and randomized controlled trials are needed to compare this device to current standard of care treatments. PMID:38444425 | PMC:PMC10911265 {url} = URL to article
    • J Invest Dermatol. 2024 Mar 4:S0022-202X(24)00170-2. doi: 10.1016/j.jid.2024.02.012. Online ahead of print. ABSTRACT Rosacea is a chronic inflammatory skin disorder characterized by immune response-dependent erythema and pustules. S100 calcium binding protein A9 (S100A9), a pro-inflammatory alarmin, has been associated with various inflammation-related diseases. However, the specific role of S100A9 in rosacea remains unexplored. Therefore, our objective was to unravel the role of S100A9 in the pathogenesis of rosacea and its underlying molecular mechanisms. Here, we show that expression levels of S100A9 were elevated in both the lesions and serum of PPR patients, as well as in lesions of the LL37-induced rosacea-like mouse model. Moreover, the upregulation of S100A9 was correlated with clinical severity and levels of inflammatory cytokines. Additionally, we demonstrated that S100A9 promoted the production of pro-inflammatory factors in HaCaT cells by activating TLR4/MyD88/NF-κB signaling pathways. Notably, inhibition of S100A9 suppressed the progression of rosacea-like dermatitis and inflammatory responses in the LL37-induced rosacea-like mouse model via TLR4/MyD88/NF-κB signaling pathways. In conclusion, this study illustrated that S100A9 participates in the pathogenesis of rosacea by upregulating TLR4/MyD88/NF-κB signaling pathways, thereby promoting rosacea-associated skin inflammation. These results not only expand our understanding of the potential role of S100A9 in the development of rosacea, but also offers greater insight toward targeted therapies. PMID:38447867 | DOI:10.1016/j.jid.2024.02.012 {url} = URL to article
    • Front Public Health. 2024 Feb 19;12:1320932. doi: 10.3389/fpubh.2024.1320932. eCollection 2024. ABSTRACT BACKGROUNDS: Observational studies have shown that cigarette smoking is inversely associated with risk of rosacea, However, it remains uncertain whether this association is causal or it is a result of reverse causation, and whether this association is affected by drinking behaviors. METHODS: This study utilized the summary-level data from the largest genome-wide association study (GWAS) for smoking, alcohol consumption, and rosacea. The objective was to investigate the effect of genetically predicted exposures to smoking and alcohol consumption on the risk of developing rosacea. Two-sample bidirectional Mendelian randomization (MR) was applied, accompanied by sensitive analyses to validate the robustness of findings. Furthermore, multivariable MR was conducted to evaluate the direct impact of smoking on rosacea. RESULTS: A decreased risk of rosacea was observed in individuals with genetically predicted lifetime smoking [odds ratio (OR)MR - IVW = 0.53; 95% confidence interval (CI), 0.318-0.897; P = 0.017], and number of cigarettes per day (ORMR - IVW = 0.55; 95% CI, 0.358-0.845; P = 0.006). However, no significant associations were found between initiation of regular smoking, smoking cessation, smoking initiation, alcohol consumption and rosacea. Reverse MR analysis did not show any associations between genetic liability toward rosacea and smoking or alcohol drinking. Importantly, the effect of lifetime smoking and the number of cigarettes per day on rosacea remained significant even after adjusting for alcohol consumption in multivariable MR analysis. CONCLUSION: Smoking was causally related to a lower risk of rosacea, while alcohol consumption does not appear to be associated with risk of rosacea. PMID:38439759 | PMC:PMC10909955 | DOI:10.3389/fpubh.2024.1320932 {url} = URL to article
    • J Osteopath Med. 2024 Mar 5. doi: 10.1515/jom-2023-0269. Online ahead of print. NO ABSTRACT PMID:38436596 | DOI:10.1515/jom-2023-0269 {url} = URL to article
    • As you can see, this case of a Filipino woman in her forties went through many treatments until she got a correct diagnosis of tinea faciei with steroid rosacea, it is important to get a correct diagnosis. Learn more. 
    • What about Botox for rosacea? Answer
    • Ocul Surf. 2024 Mar 1:S1542-0124(24)00028-4. doi: 10.1016/j.jtos.2024.02.006. Online ahead of print. ABSTRACT PURPOSE: Chronic inflammation is a predisposing factor for metaplastic changes and ultimately dysplasia. We describe cases of OSSN occurring in the setting of chronic ocular surface inflammation. METHODS: Sixteen eyes from 14 individuals were included from one ocular oncology clinic between 2010 and 2023. Patients presented with ocular surface squamous neoplasia (OSSN) in the setting of chronic inflammation. The diagnosis of OSSN was made using anterior segment high-resolution optical coherence tomography (HR-OCT) and confirmed by histopathological analysis in all cases. RESULTS: Median age on presentation was 61 [IQR 47.5-69.2] years. Eleven (86%) individuals were male and five (36%) identified as White Hispanic. Ten eyes were referred with ocular surface diagnoses including pannus (n = 4), scarring (n = 3), pterygium (n = 2), and herpetic keratitis (n = 1). Only six eyes were referred as possible neoplasia. All individuals had a history of ocular surface inflammation. The most common inflammatory conditions were ocular rosacea (seven individuals) and atopic keratoconjunctivitis (AKC) (five individuals). Two individuals were found to have bilateral OSSN, one in the setting of ocular rosacea and the other in the setting of AKC. All 16 eyes from 14 individuals were suspected to have OSSN based on HR-OCT findings which guided the location of the incisional biopsies that subsequently confirmed histopathological diagnosis in all cases. CONCLUSION: OSSN may arise in the setting of chronic inflammation on the ocular surface. Identification of the tumor can be challenging in these cases, and HR-OCT can be a key diagnostic tool in detecting OSSN. PMID:38432640 | DOI:10.1016/j.jtos.2024.02.006 {url} = URL to article
    • Skin Res Technol. 2024 Mar;30(3):e13616. doi: 10.1111/srt.13616. ABSTRACT OBJECTIVE: To investigate the life, sleep quality and anxiety of rosacea patients in Yunnan and the improvement of these aspects after treatment. METHODS: A total of 141 patients with rosacea and 123 healthy controls were included in our study. The quality of life, sleep quality and anxiety of patients with rosacea and healthy controls were investigated by the Rosacea Severity Scores (RSSs), the Medical Outcomes Study 36-item short-form health survey (SF-36), the Pittsburgh Sleep Quality Index (PSQI) and Self-rating Anxiety Scale (SAS). The quality of life, sleep quality and anxiety of patients with rosacea were assessed again after treatment. RESULTS: Compared with healthy controls, patients with rosacea had significantly lower physical component scores (PCS) and mental component scores (MCS) but higher PSQI and SAS scores. After treatment, rosacea patients showed significantly higher MCS but lower PSQI and SAS scores. Correlation analysis showed a significant correlation between PCS, MCS, PSQI, SAS and RSSs. CONCLUSIONS: Patients with rosacea have a lower quality of life and sleep quality and tend to be more anxious than healthy controls. In addition, the mental quality of life, sleep quality and anxiety of rosacea patients can be significantly improved after treatment. Therefore, it is important to pay attention to the psychological status of rosacea patients. Psychological counseling and intervention are necessary to better prevent and treat rosacea. PMID:38424730 | DOI:10.1111/srt.13616 {url} = URL to article
    • Int J Dermatol. 2024 Mar 1. doi: 10.1111/ijd.17114. Online ahead of print. NO ABSTRACT PMID:38429862 | DOI:10.1111/ijd.17114 {url} = URL to article
    • Australas J Dermatol. 2024 Feb 28. doi: 10.1111/ajd.14224. Online ahead of print. ABSTRACT BACKGROUND: Atrophic acne scarring is a common sequela of inflammatory acne, causing significant problems for affected patients. Although prolonged inflammation and subsequent aberrant tissue regeneration are considered the underlying pathogenesis, the role of epidermal stem cells, which are crucial to the regeneration of pilosebaceous units, remains unknown. OBJECTIVES: To examine the changes occurring in epidermal stem cells in atrophic acne scars. METHODS: Changes in collagen, elastic fibre and human leukocyte antigen (HLA)-DR expression were analysed in normal skin and inflammatory acne lesions at days 1, 3 and 7 after development. The expression of epidermal stem cell markers and proliferation markers was compared between normal skin and mature atrophic acne scar tissue. RESULTS: In acne lesions, inflammation had invaded into pilosebaceous units over time. Their normal structure had been destructed and replaced with a reduced amount of collagen and elastic fibre. Expression of stem cell markers including CD34, p63, leucine-rich repeat-containing G protein-coupled receptor (LGR)6 and LGR5, which are expressed in the interfollicular epidermis, isthmus and bulge of hair follicles, significantly decreased in atrophic acne scar tissue compared to normal skin. Epidermal proliferation was significantly reduced in scar tissue. CONCLUSIONS: These findings suggest that as inflammatory acne lesions progress, inflammation gradually infiltrates the pilosebaceous unit and affects the resident stem cells. This disruption impedes the normal regeneration of the interfollicular epidermis and adnexal structures, resulting in atrophic acne scars. PMID:38419202 | DOI:10.1111/ajd.14224 {url} = URL to article
    • J Dermatol. 2024 Feb 29. doi: 10.1111/1346-8138.17168. Online ahead of print. ABSTRACT Rosacea is a chronic inflammatory skin disease. Systemic inflammation plays a vital role in the pathogenesis of rosacea. Many studies have reported hematological parameters as biomarkers for diseases with inflammatory processes. However, the diagnostic value of hematological parameters in rosacea remains a puzzle. This study involved 462 patients with rosacea, including erythematotelangiectatic rosacea (ETR, n = 179), papulopustular rosacea (PPR, n = 250), and phymatous rosacea (PhR, n = 33), and 924 healthy control subjects. Demographic, clinical, and laboratory information was collected and compared between rosacea subtypes. The hematological parameters of the patients and the healthy controls were compared retrospectively. The platelet volume (MPV) and platelet crit (PCT) were significantly upregulated, and the lower red cell distribution width (RDW) was significantly downregulated in rosacea compared to healthy controls, and they were identified as the diagnostic biomarkers for rosacea with area under the curve values of 0.828, 0.742, and 0.787, respectively. Comparing the hematological parameters among the three rosacea subtypes, we found that platelet-to-lymphocyte ratio and platelet-to-neutrophil ratio values in the ETR group were significantly higher than those in the PPR and PhR groups. The correlation between hematological parameters and clinical scores showed that RDW was negatively correlated with the Clinician Erythema Assessment score. However, there was no significant correlation between the Investigator Global Assessment score and hematological parameters. In conclusion, PCT, MPV, and RDW have diagnostic value for rosacea, and RDW is correlated with the severity of rosacea erythema, implying the potential applications of PCT, MPV, and RDW in the diagnosis and monitoring of rosacea. PMID:38421898 | DOI:10.1111/1346-8138.17168 {url} = URL to article
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