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    • Have a good weekend! Sent from my SM-N910V using Tapatalk
    • Can Demodex Mites Transfer From Pets to Humans?
    • Antonia,  The general consensus is that the mites on cats or dogs are a different species, however, as pointed out above, scabies and other demodex can infect a human from a pet. There should be more research on this but as it stands now the data shows that the species of mites on humans are different than on pets, generally speaking. Each mammal usually has its own species of demodex mites. The point of this post is that since we do know that mites can travel from pets to humans, there is a possibility that demodex do indeed infect humans from pets. You certainly don't want to be infected with scabies. 
    • I agree good post I am trying Soolantra now so I will post updates soon. Sent from my SM-N910V using Tapatalk
    • I get a itchy skin and hives during the summer from my cat I got it so bad I had to take steriods to help clear up my skin. I dont get it from any other cats just him. I wont get rid of him he means too much to me so I tolerate it. Do you think he has these mites or? Sent from my SM-N910V using Tapatalk
    • Can you send me the Amazon link for the injectable one? Sent from my SM-N910V using Tapatalk
    • Everyone on here and in this support group should post something on here, in a world with people who dont have Rosacea and doctors giving you pills and cream saying there is no cure which I heard from my skin doctor often, this is a way to vent and relate and meet. Sent from my SM-N910V using Tapatalk
    • Hello Apurva, I have had Rosacea since my 20's, I probably saw a skin doctor in my 30's and been on Doyxcycline for over 10 years I believe. It's been a frustrating blur but in a nutshell too long. I have a fan at work I turn on no matter how cold I am to cool down my flares. I get red at home too not just work but atleast at home its easier to deal with. I am sorry you are dealing with this too, I feel your pain believe me! They say Rosacea mainly affects fair skin, I am part spanish and german I have olive skin so that theory isn't true. Tell me about your history if you wish. Sent from my SM-N910V using Tapatalk
    • May be It's not about eating blueberry bar and then getting red blotchy cheeks.sometimes the environmental factors are the triggers. because there are so many factors which trigger rosacea inflammation. genetic, environmental, your immune system, microbial flora of your skin, food triggers and many more. and the condition you described that when you do not eat and you just seat at work not taking stress even if in relaxed state you get red for no reason and this happens to me exactly. So I think the environmental factor may work here because with the onset of fall and continue with winter our body adjusts with the temperature called thermoregulation.You can read about it here : https://irosacea.org/forums/topic/4120-autumn-and-rosacea-flare-ups/?tab=comments#comment-5278 Could you please tell me when did your rosacea condition start? you are new to this condition or it's been a long?
    • I didn't read this till after my previous post. Good you are taking Tumeric and probiotics. Keep taking them. 
    • Not sure which Blueberry Kind bar you are eating but I found the above Nutrition Facts Label to show you how much carbohydrate is in this bar which shows 24 grams in a 35 gram serving. You can subtract the 2.5 grams of dietary fiber since fiber has no significant energy to consider.* So technically the above serving is 21.5 grams of carbohydrate in a 35 gram serving. That means this bar is 61% carbohydrate. This is a high carbohydrate food. When you carefully go through the Nutrition Facts Label for everything you eat in a day, you are probably, without a doubt eating a high carbohydrate diet. There is ample evidence that sugar/carbohydrate is a rosacea trigger in anecdotal reports. For that matter, any proposed rosacea trigger is based upon surveys or anecdotal reports, therefore, listing sugar/carbohydrate as a rosacea trigger is just as valid as any other proposed rosacea trigger, no matter who makes the list.  So usually the question is what should you eat for thirty days to see if reducing sugar/carbohydrate improves your skin?  Eat high protein and fat. Eating high protein/fat for thirty days poses absolutely no health risk contrary to what you might learn from any source. After the thirty days you can then decide based upon what you learn whether this improves your rosacea and other issues. This will not be easy because sugar is an addiction. So you simply have to balance whether having your skin issues improve is worth the effort to get off of sugar for just thirty days.  Also since you are taking doxycycline, you will need to build up your good flora with probiotics, which is now an accepted medical treatment for rosacea. Short term antibiotics for rosacea may be required to control rosacea, but long term antibiotic treatment for rosacea can produce some unwanted side effects and risks. You need to decide whether taking long term antibiotics are worth those side effects and risks. Probiotics offer an alternative.  How long did you use Soolantra? Why did you stop using it?  It is good you are taking supplements, herbals and vitamins. Have you read this post? Don't give up, you will find a way to control your rosacea and other issues.  *To learn why fiber is not a significant source of energy, read the article, Carbohydrate Not Essential For Human Survival  
    • Methanobrevibacter smithii image courtesy of Cedars Sinai The human microbiome includes the skin which contains a number of different microbes. [1] One microbe that has generally been totally ignored is archea, which has never been ruled out as having anything to do with rosacea. "Methanobrevibacter smithii is the predominant archaeon in the human gut." The general public has little if any knowledge of this microbe which has been known to exist in the human microbiome for some time now. "Archaea are a major part of Earth's life. They are part of the microbiota of all organisms. In the human microbiota, they are important in the gut, mouth, and on the skin. They may play roles in the carbon cycle and the nitrogen cycle." [2] The chief reason that archea is basically totally ignored as having anything to do with rosacea is that there is no known archea human pathogen. Furthermore, due to the bias the scientific community has towards bacteria which focuses research on bacteria ignoring most of the other microbes, including archea, little is known about archea.    "A deeper knowledge of human microbiome composition and microbe-host interactions will contribute to clarify the mechanism of development of rosacea and possibly will provide innovative therapeutic approaches." [3] Basically we have no idea what role archea plays in the skin microbiome due to a lack of investigation into this subject. Hence, little is known of what role archea may play in rosacea. There is absolutely no motive to investigate this since who would fund such a study? Hopefully someday some research will discover the role archea plays in the human microbiome and whatever revelations are discovered may alter our understanding of archea.  Do you want to fund such a study? Could 10K members of the RRDi get together and each donate one dollar to fund such a study? Only with your help could we reach such a goal. Think about it. [4] End Notes [1] "Microorganisms inhabiting superficial skin layers are known as skin microbiota and include bacteria, viruses, archaea and fungi." Future Microbiol. 2013 Feb;8(2):209-22. doi: 10.2217/fmb.12.141. Skin microbiota: overview and role in the skin diseases acne vulgaris and rosacea. Murillo N, Raoult D. "In the GI tract, the microbiome is made up of trillions of microbes including bacteria and other microbes such as fungi and archaea. The skin is also colonized by an equally complex microbiome that varies with host genetic and environmental influences. Emerging research suggests that the collection of microbial communities that populate the skin and GI tract, rather than single microorganisms alone, is responsible for disease." Dermatol Pract Concept. 2017;7(4):31–37. Published 2017 Oct 31. doi:10.5826/dpc.0704a08 Diet and rosacea: the role of dietary change in the management of rosacea Emma Weiss and Rajani Katta "Human skin hosts a diverse ecosystem of bacteria, fungi, viruses, mites, and archaea."  Skin Microbiota and Your Health, by Chris Kresser, Kresser Institute [2] Archea, Wikipedia [3] Journal of Clinical Gastroenterology 48 Suppl 1, Proceedings From The 7th Probiotics, Prebiotics & New Foods Meeting Held In Rome On September 8-10, 2013:S85-S86 · November 2014; DOI: 10.1097/MCG.0000000000000241  Skin Microbiome and Skin Disease The Example of Rosacea Mauro Picardo [4] More thoughts on this subject to think about:Rosacea Research in Perspective of FundingRosacea Research in Perspective of Idiopathic Diseases
    • A paper written in 2017 about diet and rosacea never once mentions sugar/carbohydrate as a rosacea trigger and parrots the diet triggers promoted by the NRS while admitting that "Dietary triggers are also frequently cited by patients, although there is a lack of research in this area. In one survey by the National Rosacea Society of over 400 patients, 78% had altered their diet due to rosacea. Of this group, 95% reported a subsequent reduction in flares." The NRS has never listed sugar/carbohydrate as a rosacea trigger, even though the number of anecdotal reports continue to grow that indeed sugar/carbohydrate is just as valid a rosacea trigger as any of the other NRS proposed triggers. The paper about diet and rosacea is cited below:  Dermatol Pract Concept. 2017;7(4):31–37. Published 2017 Oct 31. doi:10.5826/dpc.0704a08 Diet and rosacea: the role of dietary change in the management of rosacea Emma Weiss and Rajani Katta
    • I also am trying Tumeric Supplements now and a probotics. Sent from my SM-N910V using Tapatalk
    • Hello thank you for replying. I just ate a Blueberry Kind Bar and got red blotchy cheeks, so much for "good grains". I tried Finacea, Mirvaso, trying Soolantra all generic brands. Natural products I tried pumpkin seed extract, licorice root, Madagascar Centella, vitamins a thru all. I am not sure I have those 2 autoimmune diseases but a skin doctor told me maybe I have one of those too being I flare get red no matter what I eat and even if I dont eat I sit at work and can get red for mo reason (not stress). I am taking Doxycycline right now my doctor tried to switch me over to Minocycline which was a nightmare my skin freaked out so I am back on Doxycycline. I cant even find a local doctor to help or make a diagnosis if I have them besides Rosacea. I am premenopausal and I hear that as a excuse from doctors. I dont see why no matter what I do or dont do my skin is like this. I wil try no sugar. Sent from my SM-N910V using Tapatalk
    • Welcome to the RRDi community support. If you are suffering from rosacea plus gastatory face flushing* and erythromelagia, we can only empathize with your situation. Your condition is extreme and quite unusual. Not many rosaceans are suffering as much as you are suffering. Have you tried avoiding sugar and carbohydrate or at the very least reduced your intake to see if this improves your situation? Sugar is the fire that burns rosacea. It is not expensive to avoid sugar, in fact, you will save money avoiding sugar. Basically, all you do it eat high protein/fat for thirty days to see if your skin improves. Eating high protein/fat for just thirty days and drinking lots of water is not a health risk since it is only temporary. You may learn that you need more protein/fat instead of the high sugar/carbohydrate to control your rosacea. For example, you may not know how eating macaroni and cheese is a high carbohydrate meal. Our bodies are mostly water, protein and fat and carbohydrate only takes a very small percentage of our body mass. It is simply something that you can rule out to see if this helps your skin.  In order to recommend topicals, we would need to know what topicals you have tried. Also what oral medications or vitamins/supplements or any other oral treatments have you tried?  How long have you been suffering from this?  * "Gustatory flushing affects both sides of the face and is associated with excessive salivation, tear production and nasal secretion with no history of parotid gland injury. This may be reproduced by chewing a chilli pepper and holding it in the mouth for 5 minutes." Flushing, DermNet NZ
    • Thank you any help would be appreciated. Sent from my SM-N910V using Tapatalk
    • Hello I am new to this site and suffer with Rosacea plus I believe one of those other autoimmune diseases. No matter what I eat either my nose gets super red or chin or cheeks. There is absolutely no help available for us. I am tired of being on antibodotics and creams that hardly help or dry my skin out. You would think they would have discovered some cure by now. Rosacea is sadly overlooked and the suffering of anyone who has it. I understand everyones frustration and feelings. I dont know about you but I tried a gluten free diet, no dairy/cheese not only is that expensive it didnt help much. Does anyone else have any ideas or suggestions? I hope you are all okay and know you are not alone!   Sent from my SM-N910V using Tapatalk    
    • Related Articles Characterization and Analysis of the Skin Microbiota in Rosacea: Impact of Systemic Antibiotics. J Clin Med. 2020 Jan 09;9(1): Authors: Woo YR, Lee SH, Cho SH, Lee JD, Kim HS Abstract Systemic antibiotics are extensively used to control the papules and pustules of rosacea. Hence, it is crucial to understand their impact on the rosacea skin microbiota which is thought to be perturbed. The purpose of this study was to compare the makeup and diversity of the skin microbiota in rosacea before and after taking oral antibiotics. We also compared the skin microbiota at baseline according to age and rosacea severity. A longitudinal cohort study was performed on 12 rosacea patients with papules/pustules and no recent use of oral and topical antimicrobials/retinoids. Patients were prescribed oral doxycycline, 100 mg, twice daily for six weeks. Skin areas on the cheek and nose were sampled for 16S ribosomal RNA gene sequencing at baseline, and after six weeks of doxycycline treatment. Eleven females and one male aged 20-79 (median 51) with a median Investigator's Global Assessment score of 3 (moderate) were enrolled. At baseline, Staphylococcus epidermidis was the most dominant species followed by Cutibacterium acnes (formerly Propionibacterium acnes). In the 60 Over-age group, the prevalence of Cutibacterium acnes was lower than that of the 60 & Under-age group. Rosacea severity increased with age and was associated with a decrease in the relative abundance of Cutibacterium acnes and an increase of Snodgrassella alvi. Across all subjects, antibiotic treatment reduced clinical rosacea grades and was associated with an increase in the relative abundance of Weissella confusa (P = 0.008, 95% CI 0.13% to 0.61%). Bacterial diversity (alpha diversity) was not significantly altered by antibiotics treatment. Principal coordinates analysis showed mild clustering of samples by patient (ANOSIM, Analysis of Similarity, R = 0.119, P = 0.16) and scant clustering with treatment (ANOSIM, R = 0.002; P = 0.5). In conclusion, we believe that rosacea has a unique age-dependent characteristic (i.e., severity). Although we were not able to pinpoint a causative microbiota, our study provides a glimpse into the skin microbiota in rosacea and its modulation by systemic antibiotics. PMID: 31936625 [PubMed] {url} = URL to article
    • Related Articles Huge rhinophyma in a complicated patient successfully treated with CO2 laser. Dermatol Ther. 2019 05;32(3):e12850 Authors: Tortorella R, Mori E, Rovesti M, Casanova D, D'Astolto R, Scrivani S, Bertolani M, Zucchi A, Feliciani C PMID: 30714265 [PubMed - indexed for MEDLINE] {url} = URL to article
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    • Related Articles Topical 10% Tranexamic acid for erythematotelangiectatic steriod induced rosacea. J Am Acad Dermatol. 2020 Jan 10;: Authors: Jakhar D, Kaur I, Misri R PMID: 31931084 [PubMed - as supplied by publisher] {url} = URL to article
    • Colorized electron micrograph showing malaria parasite [protozoa] Image courtesy of Wikimedia Commons Protozoa and rosacea has not been considered in any clinical paper known to date. However, there is a "link between protozoa, vitamin B12 deficiency, acne and depression" according to at least one clinical paper. [1] This same source states the following about rosacea:  "Rosacea is another inflammatory skin disease that causes facial redness but it is different from acne, the common denomination being inflammation. Metronidazole, a synthetic antibacterial and antiprotozoal agent of the nitroimidazole class, is used against protozoa such as Trichomonas vaginalis,  amebiasis, and giardiasis. Metronidazole is extremely effective against anaerobic bacterial infections and is also used to treat Crohn’s disease, antibiotic-associated diarrhea and rosacea. The nitroimidazoles class of agents used to treat G. lamblia infection includes metronidazole, tinidazole, ornidazole, and secnidazole. This class was discovered in 1955 and was found to be highly effective against several protozoan infections." [1] "Protozoa constitute a group of microorganisms, also known as protists, some of which are responsible for serious diseases in humans, such as malaria and Chagas' disease and inflammatory disease conditions." [1] A significant number of deaths due to diarrhea are caused by three protozoas - Entamoeba, Cryptosporidium, and Giardia.  The human microbiome includes a number of different microbes, including protozoa. The NRS substantiates that protozoa are included in the human microbiome by publishing this statement,  "Microbes include bacteria, fungi, protozoa [bold added] and others, and may be found in greatest concentrations in the ears, nose, mouth, vagina, digestive tract, anus and the skin." [2] Very little is known about protozoa and rosacea. What exactly are protozoa? "Protozoa (also protozoan, plural protozoans) is an informal term for single-celled eukaryotes, either free-living or parasitic, which feed on organic matter such as other microorganisms or organic tissues and debris. Historically, the protozoa were regarded as "one-celled animals", because they often possess animal-like behaviors, such as motility and predation, and lack a cell wall, as found in plants and many algae.  Although the traditional practice of grouping protozoa with animals is no longer considered valid, the term continues to be used in a loose way to identify single-celled organisms that can move independently and feed by heterotrophy." Wikipedia Treatment Used for Malaria Have Proved Successful in Rosacea There has been some treatments for malaria [protozoa] that have been used to treat rosacea such as mepacrine, chloroquine, and hydroxychloroquine that have proved successful in some rosacea patients.   Protozoa has never been ruled out as having a connection with rosacea. There simply isn't much data on this subject.  There needs to be more clinical studies done on protozoa and rosacea. Since protozoa has never been ruled out in causing rosacea, who would support such an investigation? Would you? Just think if 10K members of the RRDi each donated one dollar and insisted on supporting a reputable clinician to study protozoa and rosacea, what might be discovered?  End Notes [1] Research, September 2015; DOI: 10.13140/RG.2.1.1087.9200 PROTOZOAL LINK BETWEEN SEVERE ACNE, RISK OF ATTEMPTED SUICIDE AND IMMUNE SUPPRESSION: A direct peripheral blood test to confirm microparasitic infections,  Beldeu Singh [2] The Ecology Of Your Face: Demodex, Rosacea And You, National Rosacea Society
    • I hope others try this. I was just pointing out I couldn't find any essential oil available. Are the leaves available for purchase somewhere?
    • Yes I know this very well it has its medicinal properties and used for food and pharmaceutical industry considering its compounds but not much research has been done on this plant when it comes to skin diseases especially for rosacea and the link you provided It is already mentioned in my articles reference note. Yes you can not find the essential oil online that is why how I made this concoction oil I have explained this in my article.
    • There are some papers indicating using mepacrine for the treatment of rosacea. One paper published in The Lancet, May 1952 written by Borrie Peter and another paper published in 1955.  Another paper mentions using mepacrine and chloroquine in combination to treat rosacea. [1] Scarlet Letters has an interesting article discussing using mepacrine and plaquenil in treating rosacea.  End Notes [1] Br J Dermatol. 1955 Dec;67(12):421-5. Mepacrine and chloroquine in the treatment of rosacea. BRODTHAGEN H.
    • "Considering properties of the identified major compounds, essential oils of both studied myrtaceae could be used in the medicine field including the food, pharmaceutical and cosmetic industry."  https://www.sciencedirect.com/science/article/pii/S222116911630404X Amazon doesn't sell Callistemon viminalis essential oil. A google search doesn't show how to purchase it either. Maybe someone can find it?  
    • I would like all of you to test this natural extract for your rosacea inflammed skin. Its extract has high antimicrobial and anti-inflammatory effects and has shown some strong effects towards some bacterial species found on skin. You can use it as a pure essential oil or better make a concoction with your preferred oil. Your contribution would mean a lot and help me recognize my work and research on this. I am soon coming with other natural products for rosacea. Comment your experience.
    • A recent study published International Immunopharmacology that hydroxychloroquine "improved rosacea in rosacea-like mice and mast cells (MCs)" and investigated "the effects of HCQ treatment for rosacea patients". The paper concludes, "In vitro, HCQ suppresses LL37-induced MCs activation in vitro, including the release of inflammatory factors, chemotaxis, degranulation and calcium influx. Moreover, HCQ attenuated LL37-mediated MCs activation partly via inhibiting KCa3.1-mediated calcium signaling. Thus, these evidences suggest HCQ ameliorated rosacea-like dermatitis may be by regulating immune response of MCs. Finally, the 8-week HCQ treatment exerted satisfactory therapeutic effects on erythema and inflammatory lesions of rosacea patients, indicating that it is a promising drug for rosacea in clinical treatment." Since hydroxychloroquine is available worldwide in generic form we should hear more reports from rosaceans who will ask their physician for a prescription to confirm these results. Duff Man reported in 2017 that this worked for him. Another thread at RF in 2010/2011 has a few others who have tried it discuss their experience. antwantsclear [post no 240 and post no 243] reports taking hydroxychloroquine starting in 2011 and continues to use it for flushing.  One paper published in the Archives of Dermatology, January 2011, indicates that 3 out of 5 patients with neurogenic rosacea were successful using hydroxychloroquine. 
    • Duff Man told us in 2917 that Plaquenil (Hydroxychloroquine) which has been used to treat lupus works for rosacea. A recent paper published confirms this and states, " Finally, the 8-week HCQ treatment exerted satisfactory therapeutic effects on erythema and inflammatory lesions of rosacea patients, indicating that it is a promising drug for rosacea in clinical treatment." Since Hydroxychlorquine is available in a generic prescription and is available around the world in such brand names as Plaquenil, Hydroquin, Axemal, Dolquine, Quensyl, and Quinoric rosaaceans can refer to this paper and ask their physician for a prescription for an eight week course. We should be hearing reports whether more report success with this treatment.  Hydroxychloroquine Suppresses LL37-induced Mast Cells Mepacrine  
    • Related Articles Dermoscopy of idiopathic facial aseptic granuloma: report of 2 cases. Clin Exp Dermatol. 2020 Jan 10;: Authors: Salerni G, Peralta R, Bertaina C, Gorosito M, Fernández-Bussy R Abstract Idiopathic facial aseptic granuloma (IFAG) is an uncommon childhood condition, characterized by one or more asymptomatic erythematous-violaceous nodules, usually located on the cheeks and eyelid [1]. IFAG heals spontaneously usually without scarring after a few months to a year. The pathogenesis of this disease is unclear; the most current hypothesis is that represents a form of paediatric rosacea [2]. PMID: 31919863 [PubMed - as supplied by publisher] {url} = URL to article
    • Hydroxychloroquine is a novel therapeutic approach for rosacea. Int Immunopharmacol. 2020 Jan 06;79:106178 Authors: Li J, Yuan X, Tang Y, Wang B, Deng Z, Huang Y, Liu F, Zhao Z, Zhang Y Abstract Rosacea is a chronic inflammatory disease in face. Hydroxychloroquine (HCQ), an anti-malaria drug, was reported to have anti-inflammation activities. However, the role of HCQ on rosacea remains unclear. In this study, we revealed the potential molecular mechanism by which HCQ improved rosacea in rosacea-like mice and mast cells (MCs). Moreover, the effects of HCQ treatment for rosacea patients were investigated. In this study, we found HCQ ameliorated the rosacea-like phenotype and MCs infiltration. The elevated pro-inflammatory factors and mast cell protease were significantly inhibited by HCQ treatment in rosacea-like mice. In vitro, HCQ suppresses LL37-induced MCs activation in vitro, including the release of inflammatory factors, chemotaxis, degranulation and calcium influx. Moreover, HCQ attenuated LL37-mediated MCs activation partly via inhibiting KCa3.1-mediated calcium signaling. Thus, these evidences suggest HCQ ameliorated rosacea-like dermatitis may be by regulating immune response of MCs. Finally, the 8-week HCQ treatment exerted satisfactory therapeutic effects on erythema and inflammatory lesions of rosacea patients, indicating that it is a promising drug for rosacea in clinical treatment. PMID: 31918061 [PubMed - as supplied by publisher] {url} = URL to article
    • Related Articles The importance of good photography in clinical trials and in the clinic. Br J Dermatol. 2019 05;180(5):978 Authors: Tanghetti E PMID: 31025752 [PubMed - indexed for MEDLINE] {url} = URL to article
    • A paper published in the British Journal of Dermatology concluded that after treatment with 1% and 3% Minocycline Topical Gel, this resulted with a "significantly decreased inflammatory lesion counts and a significantly larger proportion of subjects achieved IGA success at week 12 in the 3% topical minocycline group. These findings support further evaluation of minocycline gel for the treatment of inflammatory lesions associated with papulopustular rosacea." Metronidazole will be having some competition. 
    • A Multicenter, Randomized, Double-Masked, Parallel Group, Vehicle-Controlled Phase 2b Study to evaluate the safety and efficacy of 1% and 3% topical Minocycline Gel in patients with Papulopustular Rosacea. Br J Dermatol. 2020 Jan 06;: Authors: Webster G, Draelos ZD, Graber E, Lee MS, Dhawan S, Salman M, Magrath GN Abstract BACKGROUND: Papulopustular rosacea is characterized by chronic facial erythema and inflammatory facial lesions. Minocycline has anti-inflammatory properties which may be effective in the treatment of rosacea inflammatory lesions. OBJECTIVE: To assess the safety and efficacy of once-daily Minocycline Gel 1% and 3% in subjects with papulopustular rosacea. METHODS: This was a prospective, double-blinded study conducted at 26 sites in the United States. Subjects with papulopustular rosacea and between 12 and 40 inflammatory lesions were randomized to either 1% minocycline, 3% minocycline, or vehicle. The study product was applied to the face at bedtime for 12 weeks. The primary endpoints was the mean change in inflammatory lesions at week 12. Key secondary endpoints included success on the investigator global assessments (IGA). RESULTS: 270 subjects were randomized. The baseline mean lesion count was 24.6, 25.1, and 24.3 in the 1% minocycline, 3% minocycline, and vehicle groups, respectively. At week 12, mean inflammatory lesion count had decreased by 12.64 (1% minocycline), 13.09 (3% minocycline), and 7.92 (vehicle). The minocycline treatment arms significantly decreased inflammatory lesions when compared to vehicle (p=0.01, 95% CI -7.930 to -0.871 for 1% minocycline and p=0.007, 95% CI -8.319 to -1.310 for 3% minocycline). The proportion of subjects achieving IGA success was 38.9% in the 1% minocycline group (p=0.34, OR 1.396 and OR 95% CI 0.708 to 2.751 vs. vehicle), 46.2% in the 3% minocycline group (p=0.04, OR 2.028 and OR 95% CI 1.040 to 3.952 vs. vehicle), and 30.8% in the vehicle group. CONCLUSION: 1% and 3% topical minocycline gel appears safe and tolerable. 1% and 3% topical minocycline gel significantly decreased inflammatory lesion counts and a significantly larger proportion of subjects achieved IGA success at week 12 in the 3% topical minocycline group. These findings support further evaluation of minocycline gel for the treatment of inflammatory lesions associated with papulopustular rosacea. PMID: 31907924 [PubMed - as supplied by publisher] {url} = URL to article
    • Dry skin (Xeroderma) can be a co-existing condition with rosacea. When treating rosacea with topicals or oral treatments, a common side effect is dry skin, and if one already has dry skin, this complicates the dry skin issue further. Women's Health has an article on treating dry skin using The Inkey List treatments and has this to say about the subject:  "Dry skin needs – you guessed it – serious hydration."   The following four treatments are recommended:  (1) Polyglutamic Acid {2} Squalane Oil (contained in this package below} (3) Rosehip Oil  {4] Lactic Acid Etcetera There are a number of other moisturizers to consider in our affiliate store. 
    • "Allergic reactions in the skin can be caused by many different chemical compounds found in creams, cosmetics, and other topical consumer products, but how they trigger the reaction has remained somewhat mysterious." Study may explain how chemicals in skincare products trigger allergic contact dermatitis, New Medical 
    • Related Articles Morbihan Syndrome Successfully Treated with Omalizumab. Acta Derm Venereol. 2019 Jun 01;99(7):677-678 Authors: Kafi P, Edén I, Swartling C PMID: 30848286 [PubMed - indexed for MEDLINE] {url} = URL to article
    • Related Articles Bardolph's rosacea: skin disorders that define personality in Shakespeare's plays. Clin Dermatol. 2019 Sep - Oct;37(5):600-603 Authors: Hassan S, Mohammed TO, Hoenig LJ Abstract Several popular Shakespearean characters are dramatically portrayed on stage with striking physical appearances caused by medical and dermatologic disorders. Shakespeare's colorful portrayal of their maladies not only helps to entertain audiences but also serves to define the characters' personalities and behavior. Shakespeare himself emphasizes this point in his play Richard III, in which the notorious English king states that his evil nature is a direct result of his hideous spinal deformity. This contribution discusses four other famous Shakespearean characters: Bardolph, who appears to be suffering from rosacea; the Witches of Macbeth, who have beards; Juliet, who has green sickness (chlorosis); and Falstaff, who is morbidly obese. In all of these cases, their skin disorders and medical maladies serve to highlight their underlying nature. PMID: 31896414 [PubMed - in process] {url} = URL to article
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