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    • Emily47 at RF (post no 54) reports, "I mixed Afrin and CeraVe (suggested my dermatologist) and it worked! Immediately less redness!" According to Vitacost.com, oxymetazoline hydrochloride, 0.05 percent, the active ingredient in Afrin nasal spray, works by constricting, or shrinking, the blood vessels in the nose, and thereby reducing nasal blood flow. - livestrong.com
    • Fluorouracil (5-FU), aka, Adrucil, Carac, Efudex, Efudix, others, used to treat cancer has the side effect or risk of inflammation of the skin. There are reports that this treatment exacerbates rosacea. Caveat emptor. Thread at RF about this
    • Hello Brady! Greetings from The Black Sea! You are right. The sad true just received in a message from Renee Marie Stephano(president and co-founder of the Medical Tourism Association) yesterday: "During this process, I learned a life lesson that I now know is the dirty little secret of healthcare: the system is rigged. The industries of health are rigged. They are designed for profit, not for people." You said that rosacea sufferers are mostly centered on their own rosacea issues and that is true in case over the years they have not succeeded to control/ manage their rosacea like in your case. The last dermatologist I have seen in Bucharest told me that she has no miracle solutions for me as an example(the last cream that was prescribed to me Anthelios Ultra SPF50+ from Roche Posay was tolarated by my face only six days ending in terrible pains in the skin of the face). Still fighting everyday here. Life is not a fairy tale cause life is real. Going to a Ozone Center for other medical problems and seeing on the website of the best dermatologist in Romania dr Ioan Nedelcu uses laser, IPL and Ozone as terapies to control Rosacea (http://drnedelcuioan.ro/servicii-medicale/dermatologie-consultatii-tratamente/cuperoza-rozacee) I asked the owner and doctor of the Ozone Center if I can make cosmetic injections with ozone. She told me will not be a good ideea and the best thing to do is to try ozonated olive oil (a brevet that belongs to Nikolai Tesla from 1904. Here is the product recommended http://www.rheumapraxis-altstetten.com/en/oxaktiv-cosmetic-eng) and I am in the day forth(till now is more than all right but on my face no cream passed the test of more than 12 consecutive days. I am praying here that this time to be the lucky one) and counting, hoping for a solution. I tried to search on our website ozone therapy and ozonated oils and there is no article and no information about it (I wish I was the one writting it). There is an article here https://www.amaskincare.com/how-to-get-rid-of-rosacea-top-treatments saying that: "#4 WAY OF HOW TO GET RID OF ROSACEA – THE MAGIC OF OZONE One natural remedy stands alone among the myriad of other natural therapies, both in its therapeutic effectiveness and the enormous amount of scientific study dedicated to its clinical use. Ozone. Ozone is a completely natural element readily found in nature and that can be generated in a pure form for medical use. It is a form of oxygen (O3) that has tremendous capacity to stimulate healthy physiological activity in every organ system of our bodies, all the way down to the level of individual cells. There is so much therapeutic value to its clinical use, that I will dedicate a series of articles about Ozone Therapy. For now, know this. Infused into natural oils such as olive oil and sunflower oil, topical use of these “ozonated” oils is safe, easy, and extremely effective to use as a rosacea treatment. In our experience, clinical protocols that combine the use of ozonated oil with laser treatments is the single most effective way of how to get rid of rosacea." From whom can we know for sure that ozonated olive oil and sunflower oil are good for Rosacea??? The guys from PureO3(http://shop.puro3.com) told me that ozonated jojoba and coconut oils are also good for Rosacea. Also I wish I could try and afford to buy the LaFlore Probiotic Concentrated Serum recommended by dr.  Whitney Bowe  here https://www.allure.com/gallery/probiotics-skin-care-products but the prices are beyond my current financial possibilities(https://laflore.com/shop-retail). Take care.  PS: I will have a look at your diet as in my case no salt, no sugar products, no dairy products, no cereals, nothing made and difference. So the only diet remained to try is a diet without food.   
    • Elucidating the role of Demodex folliculorum in the pathogenesis of rosacea: exciting first steps…. Br J Dermatol. 2018 Jul 19;: Authors: Forton FMN PMID: 30024649 [PubMed - as supplied by publisher] {url} = URL to article
    • How do you know if you are reading fake rosacea news?  Or what if you read about a certain rosacea treatment whether topical or oral? Can you trust the reviews from the web site? Who would you trust to substantiate a news item about rosacea? Maybe your physician? A social media site?  How about a non profit organization for rosacea patient advocacy? How do you produce a watchdog (a rosacea Snopes) who can substantiate a rosacea news item or weed out a fake reviewer and expose the bum is lying about a rosacea treatment? The RRDi is one of best sources of rosacea data to compare rosacea news items with fake or with what's really a trusted source on any news item about rosacea and is the only non profit organization for rosacea patient advocacy. The other non profit organizations for rosacea are not founded by rosacea sufferers and have a different rosacea agenda. Just follow the money how any non profit organization for rosacea spend the donations and you will see what the agenda is all about. Is the spending 60% of the donations on private contractors owned by the director of the non profit the main agenda? Is most of the spending of more than 75% of the donations on 'annual and mid-year meetings' for the professional members of the non profit the main agenda?  Follow the money.  Read an interesting tech article related to fake news at wired, SHADOW POLITICS: MEET THE DIGITAL SLEUTH EXPOSING FAKE NEWS by BY ISSIE LAPOWSKY, about how media scholar Jonathan Albright discovered through endless hours of research how the the world's biggest internet platforms were riddled with fake news. This inspired me to comment on all the data I have collected (basically just about everything at this web site has been collected by me, there may be a small percentage of posts adding some new information from RRDi members, and it would take me a number of hours to give you the math on this, which really isn't important at all at this point, you will simply have to trust me on this until proven otherwise) on rosacea trying to put them into logical categories in the forum and the affiliate store. I have tried unsuccessfully so far to attract some kindred spirits to help me in this endeavor but alas, what I have found is most rosacea sufferers are mostly centered on their own rosacea issues, whether it is rosacea or some other rosacea mimic, and simply will not volunteer to help make the RRDi's mission come true. It is very sad. 14 years ago when the RRDi was founded, there were quite a number of impassioned volunteers who assisted me in this endeavor but they are now mostly faded away. Where have all the volunteer rosaceans volunteer gone? Where is a passionate rosacea volunteer with a spirit like Jonathan Albright to be found? Alas, such volunteer rosaceans are slim to none.  The reason I am writing this post is that after reading how Jonathan Albright's passionate hours and hours of researching to discover how fake news was being spread through all the internet platforms, making a detailed map, which without a doubt took more hours to make, it has inspired me to explain that I have spent endless hours putting the RRDi together and basically this web site and all the rosacea data collected is the Crown Jewels. The RRDi MAC is definitely a close second (you try to bring together some noted rosacea professionals into a group). Third, the Internal Revenue Service approval as a 501 c 3 approved non profit organization (along with the non profit approval from the State of Hawaii) is the last crowning achievement.  I am now sixty eight years old. I have my rosacea controlled and have updated my regimen here. So I am seeing the hand writing on the wall, since who is going to take over the RRDi if I croak?  Basically, if someone doesn't have the kind of passion I have had for this mission and steps up the plate, the RRDi is going to fade away and all you have left is the NRS and the AARS. Is that what you really want to happen?  So think about what I am telling you and please comment in this thread what you think should be done about this? Just think if there is no RRDi, no real legal non profit organization for rosacea patient advocacy, and all you have left are the two non profit organizations mentioned above who are set up by NON ROSACEANS and whose donations are from primarily pharmaceutical corporations who have a vested interest in promoting skin products and who spend little (compared to how much money is donated) on rosacea research?  So if the RRDi fades out of existence and you do nothing about this, is that the way you want it to go?   What rosacea news is the NRS and AARS spreading?  Both non profits clearly state on their websites that pharmaceutical companies are sponsors. What is the agenda when posting information about rosacea? What is the agenda of spending the donations mainly on what?  Dr. Kligman mentions the 'indifference of the National Institutes of Health, which with an annual budget of nearly 30 billion dollars, has not seen fit to fund a single grant for the investigation of rosacea.' Dr. Kligman also says that most research done on rosacea is by the skin industry which is 'voluminous literature, mainly focused on treatments sponsored by commercial interests; perhaps not the most credible source of unbiased research.' ” A Personal Critique on the State of Knowledge of Rosacea, Albert M. Kligman, M.D., Ph.D.
      Department of Dermatology, University of Pennsylvania, Philadelphia, PA, U.S.A.
      publikation_kligman.pdf  Why not join the RRDi, volunteer, help find the cure and expose rosacea fake news?
    • If others don't volunteer and work together for rosacea patient advocacy then rosaceans deserve what they get with the NRS and the AARS which are the only non profits doing any rosacea research. And what kind of research do these organizations do? Who donated primarily to the these organizations? Pharmaceutical companies. And what kind of research do they engage in? You guessed it. Here is a quote from my book I wrote in 2007 on page 82: 

      "Dr. Kligman mentions the 'indifference of the National Institutes of Health, which with an annual budget of nearly 30 billion dollars, has not seen fit to fund a single grant for the investigation of rosacea.' Dr. Kligman also says that most research done on rosacea is by the skin industry which is 'voluminous literature, mainly focused on treatments sponsored by commercial interests; perhaps not the most credible source of unbiased research.' ” A Personal Critique on the State of Knowledge of Rosacea, Albert M. Kligman, M.D., Ph.D.
      Department of Dermatology, University of Pennsylvania, Philadelphia, PA, U.S.A.
    • In this study, significant cardiovascular disease risk factors such as a family history of premature cardiovascular disease, obesity, prediabetes and high C-reactive protein levels were found to be higher in rosacea patients than controls. Although the underlying mechanism is not clear, it is thought that chronic inflammation and disregulation of innate immune system increase risk of cardiovascular disease in rosacea patients. The American Journal of Cardiology
      Volume 121, Issue 8, Supplement, 15 April 2018, Page e106
      OP-264 - Investigation of Cardiovascular Risk Factors in Rosacea Patients
      Muhammed Karadeniz
    • Highlights of Skin Disease Education Foundations 42nd Annual Hawaii Dermatology Seminar. Semin Cutan Med Surg. 2018 Jun;37(4S):S75-S84 Authors: Baldwin HE, Stein Gold LF, Gordon KB, Green JB, Leonardi CL, Sengelmann RD Abstract
      Updates on managing some of the most common dermatologic conditions for which patients seek care illuminated presentations at the Skin Disease Education Foundation's 42nd Annual Hawaii Dermatology Seminar®. This educational supplement summarizes the highlights of clinical sessions presented during this CME/CE conference. Treatment of psoriasis has continued to advance, with three interleukin (IL)-17 antagonists approved by the US Food and Drug Administration (FDA) and a fourth in phase 3 trials. An authority on the use of biologics in psoriasis presents current data on the safety and efficacy of these therapies. Tumor necrosis factor (TNF) inhibitors also retain a place in the management of psoriasis, with records of long-term safety. A fourth TNF inhibitor awaits FDA approval for use in psoriasis, offering data on transmission during pregnancy and lactation. An expert on the use of this drug class presents the evidence. Topical therapies remain the cornerstone of care for many patients with psoriasis as well as those with rosacea. Our faculty update readers about new and investigational topical therapies for moderate or severe psoriasis, as well as for acne and rosacea. The current literature on monitoring patients receiving isotretinoin also is summarized. Aesthetic and cosmetic dermatology services form a sizable portion of some practices. Our faculty review data on safety of topical and procedural therapies for cellulite as well as safe injection of facial fillers.
      PMID: 30016379 [PubMed - in process] {url} = URL to article
    • In order to really understand and put rosacea research in perspective it is important to understand where rosacea is in terms of total disease on this planet. Google Answers says, "According to the World Health Organization, there are still no effective treatments available for around three quarters of the 30,000
      diseases known today worldwide." [1] “For two thirds of all known sicknesses—about 20,000—there is so far no way of treating the cause.” [2] So rosacea is somewhere between three quarters and two thirds of what is termed idiopathic diseases. [3] Since the cause of rosacea isn't known, and the number of theories on the cause of rosacea has grown exponentially over the years, rosacea is an idiopathic disease.  According to Michael Detmar, M.D., in 2003, only one paper was published for every 144,000 rosacea patients in the United States, compared to a 1-to-11 ratio for melanoma and 1 to 4,900 for psoriasis. [4] This indicates how rosacea research is compared to other idiopathic skin diseases that have a more devastating impact on sufferers. If you had to choose one of these three diseases as a consequence which one would you choose?  Comparing rosacea to melanoma or psoriasis does put rosacea into perspective when it comes to suffering.   So any papers published about rosacea is indeed something to be grateful for. With the increase of spending on pharmaceutical treatments for rosacea comes more research spending. The NRS and AARS, being sponsored by pharmaceutical companies, have engaged in most of the rosacea research.  Dr. Kligman mentions the 'indifference of the National Institutes of Health, which with an annual budget of nearly 30 billion dollars, has not seen fit to fund a single grant for the investigation of rosacea.' Dr. Kligman also says that most research done on rosacea is by the skin industry which is 'voluminous literature, mainly focused on treatments sponsored by commercial interests; perhaps not the most credible source of unbiased research.' ” A Personal Critique on the State of Knowledge of Rosacea, Albert M. Kligman, M.D., Ph.D.
      Department of Dermatology, University of Pennsylvania, Philadelphia, PA, U.S.A.
      publikation_kligman.pdf If rosaceans want to sponsor their own novel rosacea research, they would need to be united, have a volunteer spirit, and use the RRDi to sponsor their own research. Put that into perspective.  End Notes [1] how many diseases are there? [2] The German pharmaceutical publication Statistics ’97 [3] Idiopathic Disease, Wikipedia [4] Rosacea: turning all stones for source of pathology Rebecca Bryant, Dermatology Times, Jun 1, 2004
    • Related Articles Advanced oxidation protein products and serum total oxidant/antioxidant status levels in rosacea. Postepy Dermatol Alergol. 2018 Jun;35(3):304-308 Authors: Erdogan HK, Bulur I, Kocaturk E, Saracoglu ZN, Alatas O, Bilgin M Abstract
      Introduction: Rosacea is a chronic, inflammatory dermatosis which develops due to the effect of genetic and environmental factors.
      Aim: To evaluate the oxidative stress in rosacea patients by measuring serum total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI) and advanced oxidation protein products (AOPP) levels in our study.
      Material and methods: Our study included rosacea patients and healthy volunteers aged between 18 and 65 years. Total antioxidant status, TOS and AOPP levels were measured and OSI was calculated.
      Results: The study included 70 rosacea patients and 30 healthy volunteers as a control group. When TAS, TOS, OSI and AOPP levels were compared between rosacea and control groups, there was no difference for OSI levels; while TAS, TOS and AOPP levels were significantly higher in the rosacea group (p = 0.151, p = 0.013, p = 0.034, p = 0.017, respectively). In the rosacea group, there was no correlation between TAS, TOS, OSI and AOPP levels and disease duration. Besides there was no difference between family history, rosacea type, symptom frequency and ocular involvement and TAS, TOS, OSI and AOPP levels in the rosacea group.
      Conclusions: We observed that serum TAS, TOS and AOPP levels were significantly higher in rosacea patients, but there was no significant difference among the disease activity parameters. These results can support the role of oxidative stress in the pathogenesis of rosacea.
      PMID: 30008650 [PubMed] {url} = URL to article
    • image courtesy of Espiritu Salon and Spa There are now spa treatments using cryotherapy. Will this work for rosacea? Cryotherapy has been used to treat phenotype 5. Will it improve any other phenotype? Time will tell since without a doubt we will be receiving reports whether any other phenotype is improved with cryotherapy.  There is a history of using cryotherapy for rosacea going back to an article published in 1948:  "Despite the fact that cold may be an aetiological factor in rosacea (Haxthausen, 1930, Lortat- Jacob and Solente, 1930, Sequeira, Ingram, and Brain, 1947), cryotherapy is the most valuable ancillary method of treatment......In U.S.A., Bluefarb (I945) and Hume (I948) recommended that powdered sulphur should be mixed with the slush. Solente (I925) pointed out that its value in rosacea was due to the ultimate diminution, in calibre of the local blood-vessels in the dermis. This is the accepted mechanism of its action but Lortat-Jacob and Solente (I930) claim that there is an additional reflex action via the sympathetic. Some workers, such as Vieira (1947) use the snow only to destroy the small, easily visible, dilated, superficial vessels. This is the only purpose for which a snow stick may be better than slush.... ...Shortly after treatment the skin becomes bright red and remains unsightly for a few hours. This is accompanied by a mild feeling of burning (the actual application of the slush is more painful), which may be relieved by fuller's earth, talcum, or face powder. By next day all sign of the immediate efects of treatment should have gone but there may be some blistering especially after the first treatment when the sensitivity of the skin - is not known. There is less likelihood of blistering after subsequent applications. The total length of treatment is variable and must be judged separately for each patient; four to eight sessions are usual. The treatment nearly always leads gradually to much improvement. Each week the skin can be seen to be paler with fewer obvious dilated vessels and less thickening. Complete cure is less common. It is essential to remember that cryotherapy is only a part of the treatment." CRYOTHERAPY FOR ROSACEA
      By E. LIPMAN COHEN, M.A., M.B., B.CHIR.(Cantab.) London
      Postgraduate Medical Journal, December 1948 p 656-659
      image courtesy of Cryo.com.au The Cryo.com.au website uses LED with cryotherapy and states, "CRYO LED uses two wavelengths of light that are Food & Drug Administration (FDA) approved to promote collagen and elastin production, helping to reduce wrinkles and tighten skin. This process feeds cells with wavelengths of light that they convert to the fuel source ATP that promotes cell reproduction and renewal. An increase in local blood circulation helps to flush toxins from the dermal layers of the skin. CRYOTHERAPY AND CRYO LED not only improves your appearance but the experience will make you feel fantastic." So if you try cryotherapy for your rosacea, please post your results in this thread. There are a number of reviews you can read concerning cryotherapy at cryo.com.au. 
    • Take the $500 Microablation and Triphasic Combination Facial at Cornelia Day Spa in New York City. Aestheticians wave an electromagnetic wand over the skin to stimulate collagen, minimize lines, reduce acne and ease chronic irritation (like eczema or rosacea). They then use a triphasic resonator that relies on heat, vibration and therapeutic electrical force to contour and sculpt the face.  World's Most Expensive Spa Treatments
      By Lauren Sherman, Forbes  
    • Related Articles Drugs and Lactation Database (LactMed) Book. 2006 Authors: Abstract
      Limited information indicates that maternal use of brimonidine 0.2% ophthalmic drops do not adversely affect their nursing infants. To substantially diminish the amount of drug that reaches the breastmilk after using eye drops, place pressure over the tear duct by the corner of the eye for 1 minute or more, then remove the excess solution with an absorbent tissue. Topical brimonidine gel used to treat rosacea has not been studied during breastfeeding. It is unlikely that the topical gel would affect the breastfed infant, but the manufacturer states that it should not be used during nursing. Until more data are available, an alternative topical agent might be preferred

      PMID: 30000738 {url} = URL to article
    • Related Articles Relationship between Helicobacter pylori and Rosacea: review and discussion. BMC Infect Dis. 2018 Jul 11;18(1):318 Authors: Yang X Abstract
      BACKGROUND: Rosacea is an inflammatory disease affecting the central part of face characterized by persistent or recurrent episodes of erythema, papules, pustules and telangiectasias of unknown etiology. Helicobacter pylori (H. pylori) is a gram-negative bacillus, which is one of the main causes of chronic gastritis, gastric cancer and gastrointestinal ulcers. Recent evidences have suggested that H. pylori infection is closely related to the occurrence of diseases. In recent years, studies have found that Helicobacter pylori infection is associated with the occurrence of acne rosacea. So the treatment of Helicobacter pylori infection may be a therapeutic method of acne rosacea. But it continues to be controversial. In other studies, the treatment of Helicobacter pylori did not significantly reduce the severity of acne rosacea. To further explore the association between acne rosacea and Helicobacter pylori infection, a summarize method was used to study the relationship between acne rosacea and Helicobacter pylori, providing reference for clinical acne rosacea therapy.
      METHODS: Systematic searches were conducted on Wanfang Data, CQVIP, Springer, Public Health Management Corporation (PHMC), CNKI, and Pubmed, from January 1,2008 to Mar. 1, 2018, using Helicobacter pylori and rosacea to retrieve the literature. Depending on the inclusion and exclusion criteria, 27 articles considered or confirmed the correlation between H. pylori and rosacea.
      RESULTS: Epidemiological investigations and experiments have confirmed that H. pylori infection is associated with the development of rosacea. The effect of anti-H. pylori therapy is better than the routine therapy for rosacea. H. pylori can stimulate the immune system to produce a large number of inflammatory mediators, leading to the occurrence and aggravation of rosacea inflammation.
      CONCLUSIONS: It is confirmed that H. pylori infection is involved in the development of rosacea. It is suggested that rosacea patients should be tested for H. pylori infection, the H. pylori-positive rosacea patients should be treated with eradication of H. pylori, so as to enhance the therapeutic effect of rosacea. This study adds that H. pylori infection is involved in the development of rosacea. Epidemiological investigations and experiments have confirmed the rationality. The effect of anti-H. pylori therapy is better than the routine therapy for rosacea. H. pylori-positive rosacea patients should be treated with the therapeutic method of eradication of H. pylori.
      PMID: 29996790 [PubMed - in process] {url} = URL to article
    • AARS 2017 Form 990 Review 2017-Form-990.pdf Total Contributions from public support (99.33%) in the amount of $309,032.
      Total Expenses were $440,381.
      At the end of the 2017 the AARS has 'unrestricted net assets' totaling $374,176. The AARS spent most of its expenses on 'ANNUAL AND MID-YEAR MEETINGS' for its members in the amount of $261,451. The second highest expense was for 'MENTORSHIP AND CLINICAL RESEARCH GRANTS' in the amount of $109,840. Of these grants three were for ACNE and one was for "bioinformatics analysis of acne and rosacea transcriptomes" by Rivka C. Stone, MD, PhD. One quarter of the research grant money ($26,460) was spent on 'acne and rosacea' so half of that would be $13,730*. So technically of the total donations received that was spent on rosacea research was 4.4%. That means for every dollar donated to the AARS 4 cents was spent on rosacea research, 31 cents spent on acne, 84 cents spent on 'annual and mid-year meetings, and the AARS spent more money than was received drawing on their net assets to accomplish this. The AARS still has a lot of money left in their net assets at the end of the year to draw on for 2018 expenses.  You can view the published papers of the grant recipients on its web site to confirm that three grants were for acne and only one grant mentions rosacea.  The board of directors received no money and there are no private contractor expenses. So while the AARS did spend more money on acne research (and little for rosacea) than last year which more than doubled 2016's research grants, the same pattern of spending the vast majority on meetings for the AARS professional members seems to be what the priority is when spending the donations of this non profit.  *Of the four research grants, three were for acne research and only one was for 'acne and rosacea.' So half of $26,460 is $13,730 which is technically what was spent on 'rosacea' research. It only figures that acne would get primary attention since the name of the organization is 'Acne and Rosacea' and what comes first? Obviously by the way the AARS spends its money on research grants rosacea is considered second. Of course, we have no way of knowing how the total amount ($109,840) was distributed to the recipients of the grant money since the AARS isn't saying how much each one received, so all we can do is divide by four ($26,460).
    • I began using the Lutein/Zeazanthin treatment for about three months and recommend you try it. I really do think it helps rosacea. I take 40 mg/Lutein, this one. 
    • "They hope their findings will eventually lead to the development of a potent, broad-spectrum anti-inflammatory therapeutic." Natural Lipid Acts as Potent Anti-Inflammatory
      NIH Scientists See Therapeutic Potential Against Bacteria, Viruses
      July 6, 2018
      National Institutes of Health
    • This long-term study demonstrated sustained safety, tolerability, and efficacy of oxymetazoline for moderate-to-severe persistent erythema of rosacea. J Am Acad Dermatol. 2018 Jun;78(6):1156-1163. doi: 10.1016/j.jaad.2018.01.027. Epub 2018 Jan 31.
      Efficacy and safety of oxymetazoline cream 1.0% for treatment of persistent facial erythema associated with rosacea: Findings from the 52-week open label REVEAL trial.
      Draelos ZD, Gold MH, Weiss RA, Baumann L, Grekin SK, Robinson DM, Kempers SE, Alvandi N, Weng E, Berk DR, Ahluwalia G. David Pascoe has some comments about the above trial results at this post. 
    • "RHOFADE should be used with caution in patients with severe or unstable or uncontrolled cardiovascular disease, orthostatic hypotension, and/or uncontrolled hypertension/hypotension." [1] "As the 5-HT2B receptor is potentially involved in drug-induced valvulopathy, the benefit/risk ratio should be carefully considered, especially in patients with cardiovascular disease or other comorbidities." [2] "Alpha-adrenergic agonists as a class may impact blood pressure. Advise patients with cardiovascular disease, orthostatic hypotension, and/or uncontrolled hypertension or hypotension to seek medical care if their condition worsens. (5.1)
       Usewithcautioninpatientswithcerebralorcoronary insufficiency, Raynaud’s phenomenon, thromboangiitis obliterans, scleroderma, or Sjögren’s syndrome and advise patients to seek medical care if signs and symptoms of potentiation of vascular insufficiency develop. (5.2)
       Advisepatientstoseekimmediatemedicalcareifsignsand symptoms of acute narrow-angle glaucoma develop. (5.3)" [3] End Notes
      [1] Once-Daily Treatment Reduces Persistent Facial Erythema (Redness) Associated With Rosacea Through 12 Hours, Allergan, 01.19.2017 | Investors [2] Drugs in R&D, March 2018, Volume 18, Issue 1, pp 87–90 
      In Vitro Safety Pharmacology Profiling of Topical α-Adrenergic Agonist Treatments for Erythema of Rosacea
      David Piwnica, Atul Pathak, Gregor Schäfer. James R. Docherty [3] Allergan Prescribing Information for Rhofade
    • Posted this to in inquiry by mickwayne on July 2018 at RF posts no 5 and 7 which I thought would be interesting for any RRDi members who may not be reading posts at RF and might read it here:   Originally Posted by mickwayne  ...goes to "irosaceaa.org/register" URL instead of "irosacea.org" URL.
      I also have a question, Brady. Do we ever do any cold calling or events to raise money for rosacea, or specifically for the RRDi or the NRS?
      Maybe we could even post DONATE buttons on our articles about rosacea so that people could donate.  
      I would love to help with this as it would be a great way to essentially volunteer for what might help be close to a cure one day...or at least more improvement 😛 MY REPLY:  There are rosaceans who donate to the NRS, such as the owner of this forum, David Pascoe, who was instrumental in donating $16K to the NRS. Without a doubt rosaceans prefer the NRS. The NRS is founded and run by non rosacea sufferers. What does the NRS spend most of its donations on? I have been following for a long time. Since 1998 through 2016 the NRS has received in donations $13,898,646. The majority (60%) of the donations are spent on two private contractors (two corporations) that are owned by the founder and director of the NRS, Sam Huff. About 10% of the donations are spent on rosacea research which amounts to $1,403,031 (which is significant since the NRS spends more on rosacea research than any other organization). However, to put this in terms you can understand, for every dollar donated to the NRS 60 cents is spent on two private corporations owned by Sam Huff. Ten cents is spent on rosacea research. The remaining 30 cents is spent on everything else. Here is the data; you can do the math yourself if you prefer. 

      However, the RRDi was formed completely separately from the NRS and is founded and run by rosacea sufferers. The RRDi has tried to get corporate sponsors like the NRS has done but all the pharmaceutical companies, i.e., Galderma, Allergan, Bayer, Cutanea, Beiersdorf, colorscience, prefer to donate to the NRS. Rosaceans rarely donate to the RRDi. If you want to change this volunteer. Volunteering is not something most rosaceans want to do. They prefer how the NRS is spending the money. I have tried to gather together rosaceans into a non profit organization but the members don't post, they don't volunteer, nor do they donate. If you want to help, join the RRDi and volunteer. Sure could use the help. You can donate by clicking here. By the way, it is gracious on David Pascoe's part to let me post these words in his forum. Mucho Mahalo to David Pascoe. RF happens to be the most active rosacea forum. I have posted more posts in RF than in the RRDi because very few if any RRDi members post in the RRDi member forum. Weird, isn't it?
    • In inquiry on the status of Perrigo's generic ivermectin cream provided a response from Bradley Joseph, VP, Global Investor Relations and Corporate Communications, Perrigo Company, who wrote, "No change in the status of this product.  We will announce via press release the launch of this product.  Thanks." 
    • DemoDerm is the the cosmetic version of the Zhongzhou ointment rebranded as DEMODERM and is available in Germany with more European countries as The Netherlands, Austria and Slovenia will follow soon. Here is a translation of the ingredients from the website:  Ingredients:
      Aqua, Stearyl alcohol, Propylene glycol, Glycerol, Stearic acid, Zinc oxide, Sulfur, Isopropyl myristate, Petrolatum, Glyceryl stearate, Dimethicone, Menthol, Sorbitan stearate, Polysorbate 80, Wheat germ oil, Azone, Salicylic acid, Sodium lauryl sulfate , Active ingredients: zinc and sulfur DemoDerm is manufactured in China and tested in Germany. The cream contains no additives such as antibiotics or hormones.

      DemoDerm is available in pharmacies and can be ordered either with the PZN 10974861 or with the PPN 111097486112. Non-binding selling price: 44.95 €  For those who may want to order there are web sites to choose from:  Demoderm Official Website You can buy DemoDerm online at the general importer Agenki GmbH with attractive price scale from 36.95 € *. Please click the following link to order the cream: www.agenki.de Also on Amazon you can buy the cream. The price is € 46.95 * with free delivery. Please click the following link to buy DemoDerm on Amazon: www.amazon.de Here is a comparison of the Zhongzhou ingredient list with the DemoDerm ingredient list:  Zhongzhou DemoDerm Zinc oxide 7.1% Zinc oxide Sulfur Sublimate 7.1% Sulfur Mint (Herba menthae) 2% Menthol Boric acid 2%   Salicylic Acid 0.5% Salicylic acid Dimethiconum Composite Dimethicone Java Brucea     Azone   Glycerol   Glyceryl stearate   Isopropyl myristate   Petrolatum       Propylene glycol   Polysorbate 80   Sodium lauryl Sulfate   Sorbitan stearate   Stearyl alcohol   Stearic acid   Wheat germ oil The RRDi has no affiliate relationship with any of the links above and has graciously provided these links to help those in Europe to be able to order DemoDerm in the spirit of helping anyone find a way to control their rosacea. Please post in this thread if you have success in using DemoDerm. Mahalo. 
    • Related Articles Energy-Based Devices in Male Skin Rejuvenation. Dermatol Clin. 2018 Jan;36(1):21-28 Authors: Juhász M, Marmur E Abstract
      Men seek cosmetic procedures for vastly different reasons than women. Men often seek discrete cosmetic services with little downtime. Male skin structure generally differs from female skin structure. Dermatologists should consider subtle differences in the psyche of the male cosmetic patient.
      PMID: 29108542 [PubMed - indexed for MEDLINE] {url} = URL to article
    • Epsolay, aka, VERED, S5G4T-1 and DER 45 EV, has reached Phase III clinical trial status according to Drug Development Technology. Epsolay is developed and promoted by Sol-Gel Technologies as "an innovative topical encapsulated benzoyl peroxide cream with a 5% concentration for the treatment of papulopustular rosacea."  Epsolay is designed for those who suffer from Phenotype 4.  Usually benzoyl peroxide exacerbates rosacea, but Epsolay is a "silica-based microencapsulation delivery system creates a silica barrier between benzoyl peroxide crystals and the skin, and as a result is expected to reduce irritation typically associated with topical application of benzoyl peroxide, thereby making the drug tolerable to rosacea-affected skin." [1] In a press release, June 18, 2018, Dr. Alon Seri-Levy, Chief Executive Officer of Sol-Gel, states, “Epsolay is aimed to address the need for more effective treatments for inflammatory papules and pustules of rosacea, a chronic condition for which patients often have low adherence to current drugs.”
      Sol-Gel Technologies Ltd., Israel  As more information is released it will be posted in this thread. If you are a member you can use the 'Notify me of replies' button near the bottom of this post and turn it on for any updates.  End Notes [1] Sol-Gel > Pipeline > VERED 
    • Hi Alexander,  Welcome to the RRDi. Practitioners are welcome as is evident from our list of MAC members. If members are interested in your service, they now are aware of it.  "Belief in such divine intervention is based on religious belief rather than empirical evidence that faith healing achieves an evidence-based outcome." Faith Healing, Wikipedia Do you suffer from rosacea and have a diagnosis of rosacea from a physician?  See rules no 4 and 5.  Admin 
    • Healing Erysipelas It’s well-known that since the beginning of time the most effective remedy for erysipelas has been faith healing by village women healers (we call them babka or elderly ladies). My personal experience fully proves the fact above as for fifty years of faith healing my own hands have cured dozens of erysipelas, and each case was a visual demonstration of quick and successful healing. I have always told my pupils that curing primary erysipelas is a healer skills assessment test. I have mostly healed villagers who perfectly know what to do in case of first attacks of erysipelas. Due to some reasons there are more cases of erysipelas in the villages than in the cities, and villagers know well that they should immediately ask a village woman healer (or babka) for help. Since I have been the principal woman healer in the village for over dozens of years, they have usually addressed me and I have never disappointed them. If timely treated, primary erysipelas is easily cured for one or two sessions of faith healing. The third session can be done as a confirming one. To mention, I have never seen any recurrence of erysipelas in patients who were treated with faith healing method. The situation is completely different in case of recurrent erysipelas. The easy and quick victory over the disease is not to be expected in that case. Pain relief, reducing redness and swelling occur even after the first session of faith healing. However, the signs above are not the recovery itself. The disease is likely to recur unless faith healing together with preparing healing water is continued for quite a prolonged period of time. In contrast to wide application of antibiotics, faith healing has neither contraindications nor side-effects. I have encountered four cases of erysipelas for this half a year. Two of them were primary ones, one of them was bullous and the other one was inveterate, recurring for over five years. There were no difficulties in healing the primary erysipelas while it took more than a month to cure the bullous one. I did faith healing once a week and later I did three sessions more, once a month each. Those sessions were a kind of preventive measure as the area which used to be affected with erysipelas was absolutely clean. As for the recurrent erysipelas, I had to spend more time on it, and even now it is still under my care. I occasionally do faith healing sessions and their results are quite good. City inhabitants start realizing the real danger of the disease only when it becomes serious and recurrent. Failing to follow doctor’s orders and switching to experiments with, to put it mildly, a wide range of incorrect home remedies including but not limited to red cloth or pounded brick can significantly aggravate the disease. Only then does the patient realize that erysipelas is a very serious disease. Improperly treated, it can result into patient’s disability, especially in case if he or she suffers from thrombophlebitis, diabetes, and many others. Erysipelas is extremely dangerous for newborns and infants. So, I would like pediatricians and children’s relatives to take this article seriously. In case of any skin problems, first, you should address a very good doctor to diagnose erysipelas. You cannot make an accurate diagnosis by yourself as primary manifestations of erysipelas are very similar to those of other skin diseases while methods of their treatment are different. After erysipelas has been diagnosed, you must follow all doctor’s orders. If you have done everything that way but the result of treatment is not satisfactory enough, which can happen very often, it’s up to you to choose whether or not to experiment with different kinds of home remedies. I wouldn’t criticize any methods of treating erysipelas. However, the most reliable one is to find a powerful woman healer or an intercessor who practices the method of Slavic village faith healing. The latter is, without doubt, the most effective in healing erysipelas. If you have not found a good village woman healer or an intercessor, I am ready to give you the contacts of my pupils working in Odessa, Kiev, Dnieper, Sumy, Poltava, Kherson, Simferopol and other cities who are highly likely to cope with this unpleasant disease. However, I would like to emphasize that healing erysipelas of any degree of complexity should be done only under the care of a highly experienced doctor. It is particularly the case when edema and lymphedema occur, and if erysipelas results from all kinds of disorders of blood vessels. Treating erysipelas requires both healer’s efforts and application of medicines and medical procedures. In case you did not manage to find a healer or an intercessor within your reach or due to some circumstances including your poor health you cannot travel at long distances to address a healer, you can still get the help you need. You can master the faith healing method after reading a book My Job is a Healer. There you can find a detailed description of this great method which is a real historical heritage of our Slavic nation. Using this method, you will be able not only to win the disease by yourself or, what is better, with the assistance of your nearest and dearest person but also you will feel God’s help in all His Majesty. I wish you good health and success in your fighting the disease!   By Alexander Novikov, the healer.   For more information, please visit: http://iscelenie-molitvoj.com/eng/mindexe.html If you have any further questions, feel free to contact Alexander Novikov e-mail: healerprayer@gmail.com
    • Related Articles Prescription to Over-the-Counter Switch of Metronidazole and Azelaic Acid for Treatment of Rosacea. JAMA Dermatol. 2018 Jul 03;: Authors: McGee JS, Wilkin JK PMID: 29971432 [PubMed - as supplied by publisher] {url} = URL to article
    • Effects of Initiation Time of Glycemic Control on Skin Collagen Recovery in Streptozotocin-Induced Diabetic Rats. Dermatology. 2018 Jul 04;:1-9 Authors: Suh Y, Moon J, Yoon JY, Kim SW, Choi YS Abstract
      BACKGROUND: Diabetes damages the collagen in the skin. No study has investigated the relationship between the treatment initiation time and the degree of collagen recovery. This study aimed to evaluate the effects of the initiation time of glycemic control on collagen recovery and to determine the basic molecules mediating the process.
      METHODS: Streptozotocin-induced diabetic rats were divided into five groups: normal controls (C), those with untreated diabetes (DM), and those with diabetes treated with daily insulin injections from 7 weeks (7W), 10 weeks (10W), and 13 weeks (13W) after diabetes induction. The levels of collagen and several molecules were compared among skin tissues collected at 14 weeks.
      RESULTS: The amounts of total collagen, collagen 1, and collagen 3 were significantly lower in DM than in C. Among the treated groups, recovery reaching normal levels was only observed in 7W and 10W. The earlier the treatment began, the greater was the collagen recovery. Similar to that of collagen, the expression of transforming growth factor-β1 (TGF-β1), vascular endothelial growth factor (VEGF), and insulin-like growth factor 1 receptor (IGF-1R) significantly decreased in DM compared with that in C. Higher recovery of TGF-β1 and VEGF was detected in groups with earlier treatment, whereas the IGF-1R level was identically elevated in all treated groups. The results suggest that these molecules affect collagen recovery at different time points during glycemic control.
      CONCLUSION: The initiation time of glycemic control is expected to have a considerable effect on collagen recovery in the diabetic skin through modulation of TGF-β1, VEGF, and IGF-1R.
      PMID: 29972827 [PubMed - as supplied by publisher] {url} = URL to article
    • STING crystal structure created by PDB protein workshop rendering PDB: 4EMU
      Wikipedia There is a theory that rosacea is a disorder of the innate immune system. In a recent article published In Nature, Targeting STING with covalent small-molecule inhibitors, [1] scientists at the Ecole Polytechnique Fédérale de Lausanne [EPFL] have discovered two small-molecule compound series that can effectively block a central pathway of the innate immune system. "STING plays an important role in innate immunity." [2] "To find out the compounds' mechanism of action, the researchers painstakingly mutated several of the amino acids that make up STING in order to find out which ones are targeted by the compounds. Doing so, the scientists identified a conserved transmembrane cysteine, which binds to the compounds irreversibly. As a consequence of this interaction, this particular cysteine residue can no longer undergo palmitoylation - a post-translational modification that attaches a fatty acid (palmitic acid) to STING." [3] Andrea Ablasser, Assistant Professor at EPFL, explains, "“Our work uncovered an unexpected mechanism to target STING and provided the first proof-of-concept that anti-STING therapies are efficacious in autoinflammatory disease. Beyond specific monogenic autoinflammatory syndromes, the innate immune system is implicated in even broader ‘inflammatory’ conditions, so we are excited to learn more about the role of STING in human diseases.” [4] The Nature article concludes, "In summary, our work uncovers a mechanism by which STING can be inhibited pharmacologically and demonstrates the potential of therapies that target STING for the treatment of autoinflammatory disease." [1] This may hold some hope for an 'Anti-STING Therapy for Rosacea."  End Notes [1] Nature, Letter, Published: 04 July 2018
      Targeting STING with covalent small-molecule inhibitors
      Simone M. Haag, Muhammet F. Gulen, Luc Reymond, Antoine Gibelin, Laurence Abrami, Alexiane Decout, Michael Heymann, F. Gisou van der Goot, Gerardo Turcatti, Rayk Behrendt & Andrea Ablasser  [2] Stimulator of interferon genes (STING), Wikipedia [3] New small molecules offer promising new way to treat autoinflammatory diseases, News Medical, Life Sciences, July 4, 2018 [4] New small molecules for the treatment of autoinflammatory diseases, EPFL News, July 4. 2018
    • "Rifaximin, sold under the trade name Xifaxan among others, is an antibiotic used to treat traveler's diarrhea, irritable bowel syndrome, and hepatic encephalopathy." Wikipedia  "Of the patients with SIBO, 28 were treated with rifaximin: 46% reported cleared or markedly improved rosacea, 25% reported moderately improved rosacea, and 11% reported mildly improved rosacea. All 4 patients with ocular rosacea and SIBO reported marked improvement. Rosacea was unchanged in 18% of patients.." [1]  For more information.  End Notes [1] Journal of the American Academy of Dermatology
      Volume 68, Issue 5, Pages 875–876, May 2013
      Rosacea and small intestinal bacterial overgrowth: Prevalence and response to rifaximin
      Leonard B. Weinstock, MD, Martin Steinhoff, MD, PhD
    • Abstract
      Rosacea affects many individuals and is commonly treated with long-term antibiotics, which are associated with the emergence of antibiotic-resistant organisms. Recently, subantimicrobial dose doxycycline 20 mg twice a day (SDD) has been used to treat rosacea because of its anti-inflammatory properties. Results of clinical studies support the benefits of SDD, its efficacy in rosacea and acne vulgaris, and even its potential use to prevent atherosclerosis. Cutis. 2005 Apr;75(4 Suppl):19-24.
      Subantimicrobial dose doxycycline: a unique treatment for rosacea.
      Berman B, Zell D.
    • "A 50-patient, open-label experience trial with SD doxycycline in the treatment of rosacea also provided evidence of the utility of the drug. The use of SD doxycycline can potentially avoid the adverse events of standard-dose, long-term therapy with tetracyclines for acne and thereby enhance patient compliance. In addition, widespread adoption of this dosage as part of a maintenance therapy for acne and rosacea will limit exposure of patients and their microflora to doxycycline and may slow the steadily increasing rate of resistance of P. acnes and other organisms to the tetracyclines." Subantimicrobial Dose Doxycycline for Acne and Rosacea
      Joseph B. Bikowski, MD
      Skinmed. 2003;2(4), Medscape
    • In an article, 100mg a day of Doxycycline is no better than Oracea, by David Pascoe, Rosacea Support, it points out, "If Oracea is too costly to be a part of your rosacea regime, you should consider 50mg a day of generic doxycycline. This is likely to be a much cheaper alternative but also offer the same benefits as oracea. [sic]" This point is valid. It may be possible that taking 50 mg/day of doxycycline is just as effective as Oracea. Another article by David Pascoe asks this question, "Is Oracea different to 50mg a day of Doxycycline?" Basically the only difference is that Oracea is 40 mg and has some timed release doxycycline and generic doxycycline doesn't have any time release properties.  Any further validation of this point will be placed in this thread. 
    • "Minocycline 100 mg is noninferior to doxycycline 40 mg in efficacy over a 16- week treatment period." Br J Dermatol. 2017 Jun;176(6):1465-1474. doi: 10.1111/bjd.15155. Epub 2017 May 8.
      DOMINO, doxycycline 40 mg vs. minocycline 100 mg in the treatment of rosacea: a randomized, single-blinded, noninferiority trial, comparing efficacy and safety.
      van der Linden MMD, van Ratingen AR, van Rappard DC, Nieuwenburg SA, Spuls PI.
    • Related Articles Rosacea-like demodicosis and papulopustular rosacea may be two phenotypes of the same disease, and pityriasis folliculorum may be their precursor. Response to the comment of Tatu. J Eur Acad Dermatol Venereol. 2018 Jul 01;: Authors: Forton F, De Maertelaer V Abstract
      We thank Tatu et al for their comment1 on our recent article2 in which they agree with the idea that rosacea-like demodicosis (RLD) and papulopustular rosacea (PPR) may be two phenotypes of the same disease. Tatu et al raise the question of the potential role of some of the numerous species of bacteria3 inadvertently ingested by Demodex that could potentially influence its behaviour.1 We did not explore this interesting hypothesis in our study but agree that this and other types of interactions, such as those of Staphylococcus epidermidis,4 are important areas for future study. This article is protected by copyright. All rights reserved.
      PMID: 29961950 [PubMed - as supplied by publisher] {url} = URL to article
    • The controversy of obtaining nutrients from supplements rather than from healthy food is widely discussed. The overall consensus is that eating natural, organic, healthy food to obtain nutrients is preferred over supplemental nutrition. However, even all the experts say there are exceptions.  For example, in an article published by the Harvard Health Letter, discussing this controversy says, "The evidence about the benefits of multivitamins is mixed." [1] The consensus is that eating a healthy diet is the best way to obtain nutrients. The counter argument is that if one is suffering from a disease, whether age related or not, is it possible that nutrient supplements may improve or at the very least assist in improving the disease? The overall consensus to this question is yes. For example, what if an individual is on a long trip and has no access to fruit with vitamin C? Yes, eating limes or lemons is preferred, but obviously taking Ascorbic Acid at the very least would help prevent scurvy from developing.  Consumer Lab answers the controversy with nutrients from supplements by stating, "It is generally best to get your vitamins (as well as minerals) naturally from foods or, in the case of vitamin D, controlled sun exposure.," but qualifies this with some examples of how nutrient supplements actually do help, i.e., "two B vitamins," then discusses the controversy of synthetic vs natural supplements concluding, "Sometimes synthetic forms of vitamins offer advantages over natural forms." The Mayo Clinic in an article under 'Nutrition and healthy eating' writes, "Supplements aren't for everyone, but older adults and others may benefit from specific supplements." [2] This underscores the point that since rosacea often develops in older individuals that possibly something in the diet is either contributing to the development of rosacea or something, i.e., a nutrient, is lacking in the diet?  The article continues that nutrients may be recommended in certain women and in individuals 50 years and older. [2] Time magazine wrote on this subject and concluded, "Most experts say that if you’re eating a healthy diet and don’t have an underlying health conditions that interferes with your body’s ability to absorb nutrients from your food, you generally shouldn’t need to take supplements. The same vitamins and minerals are often available in food." [3] Again, if you "don’t have an underlying health conditions" so if you have rosacea, is there a supplement that can improve your rosacea? The NY Times article on this subject had some insightful thoughts, such as, "Crops and animals will not grow properly if soil or feed is missing critical nutrients. Some nutrients are lost in shipment and storage and even more in processing, but generally not to the point that the food becomes nutritionally worthless. Far greater nutrient losses generally occur in kitchens than in food processing plants.....Considering the symptoms of marginal nutrient deficiencies - malaise, reduced appetite, sleepiness, insomnia, irritability and reduced attention span, among others - it's easy to see why so many people turn to supplements as a cure-all." [4] Scientific American has an article [5] discussing the difference between pill nutritional supplements vs nutrients in food stating, "Foods contain substances other than vitamins and minerals for good health. Fruits, vegetables and whole grains contain phytochemicals, or plant chemicals, that can help to fight the development and progression of many chronic diseases, including cancer." The article discusses the absorption value of pills vs food and states, "With only a few exceptions, the vitamins in pills are utilized and handled by the body just as efficiently, or more so, than the vitamin forms found in foods. Indeed, some of the vitamin forms (called vitamers) found in foods are less active and less easily converted into activated forms than the vitamers used in pills." [5] The Journal of Nutrition concluded, "Without enrichment and/or fortification and supplementation, many Americans did not achieve the recommended micronutrient intake levels set forth in the Dietary Reference Intake." [6] This is a strong indicator that supplemental nutrition is worthy of consideration. The article concludes, "Health professionals must be aware of the contribution that enrichment and/or fortification and dietary supplements make to the nutritional status of Americans." [6] Nutrition.gov has four Questions To Ask Before Taking Vitamin and Mineral Supplements.   Tanya Zuckerbrot, MS, RD, Fox News, points out, "Nutritional supplements can be helpful if: you don’t eat a balanced diet; you are a vegetarian or vegan; you are a woman who is pregnant or may become pregnant; or you are an adult over the age of 50. It is recommended that adults over the age of 50 take a supplement of B-12, either separately or in a multivitamin. Women who are pregnant should take iron supplements either separately or in a prenatal vitamin, and women who may become pregnant are advised to take 400 micrograms per day of folic acid." [7] The general consensus of health and nutritional experts agree with Ms Zuckerbrot's statement above. However, is the above the only times nutritional supplements are helpful?  Are there nutrients that rosacea sufferers are deficient in?  The answer to that question is the subject of another post.  End Notes [1] Should you get your nutrients from food or from supplements?, Harvard Health Letter, May 2015 [2] Supplements: Nutrition in a pill?, By Mayo Clinic Staff [3] Foods You Should Eat Instead of Taking Vitamins, By ALEXANDRA SIFFERLIN March 30, 2015, Time [4] FOR GOOD NUTRITION: BALANCED DIET VS. VITAMIN PILLS, By JANE E. BRODY, The New York Times, 1982 [5] Do vitamins in pills differ from those in food?, Scientific American, Christine Rosenbloom, Health [6] J Nutr. 2011 Oct;141(10):1847-54. doi: 10.3945/jn.111.142257. Epub 2011 Aug 24.
      Foods, fortificants, and supplements: Where do Americans get their nutrients?
      Fulgoni VL, Keast DR, Bailey RL, Dwyer J. [7] The Truth About Vitamin Supplements, Tanya Zuckerbrot, MS, RD, Fox News, FITNESS + WELL-BEING, 
    • Long-term effects of intense pulsed light treatment on the ocular surface in patients with rosacea-associated meibomian gland dysfunction. Cont Lens Anterior Eye. 2018 Jun 26;: Authors: Seo KY, Kang SM, Ha DY, Chin HS, Jung JW Abstract
      PURPOSE: We aimed to determine the long-term effects of intense pulsed light (IPL) treatment in rosacea-associated meibomian gland dysfunction (MGD).
      METHODS: We enrolled 17 rosacea subjects with moderate and severe MGD who underwent four IPL sessions at 3-week intervals and were followed up for 12 months. The subjects underwent clinical examinations at baseline (first IPL) and at 3 (second), 6 (third), 9 (fourth), and 12 weeks, as well as 6 and 12 months, after baseline. Ocular surface parameters, including the Ocular Surface Disease Index (OSDI), tear break-up time (TBUT), staining score, and noninvasive Keratograph tear break-up time (NIKBUT), as well as meibomian gland parameters, including the lid margin vascularity and meibum expressibility and quality, were evaluated.
      RESULTS: All ocular surface and meibomian gland parameters for all subjects exhibited significant changes from baseline to the final examination (Friedman, P < 0.050 for all). In particular, improvements in the lower lid margin vascularity, meibum expressibility and quality, and ocular symptoms persisted up to the final examination (Wilcoxon, P < 0.050 for all). However, the improvements of TBUT, staining score, and NIKBUT after IPL were not maintained at 6 and 12 months after baseline.
      CONCLUSIONS: In rosacea-associated MGD, four IPL treatments at 3-week intervals can improve long-term lid parameters and ocular symptoms without adverse effects.
      PMID: 29958778 [PubMed - as supplied by publisher] {url} = URL to article
    • Rosacea-like demodicosis (but not primary demodicosis) and papulo pustular rosacea may be two phenotypes of the same disease-a microbioma,therapeutic and diagnostic tools perspective. J Eur Acad Dermatol Venereol. 2018 Jun 29;: Authors: Tatu AL, Clatici VG, Nwabudike LC Abstract
      The scope of their research appears to be limited to the effects of Demodex spp in rosacea and thus does not consider possible confounding factors such as the effects of Bacillus oleronius, which has been isolated from Demodex folliculorum and been identified as a trigger of inflammation in rosacea(2). Other endosymbionts described as related to Demodex are:I.Bacillus simplex, which was isolated from Demodex folliculorum in a patient with primary demodicosis(3) II. Bacillus pumilus positive culture and mass spectrometry were found in a patient with rosacea and D. Folliculorum(4)III.Bacillus cereus, instead of B. oleronius was identified in a patient with secondary demodicosis associated with steroid-induced rosacea-like facial dermatitis in one positive culture.(5) Would they care to comment on this? This article is protected by copyright. All rights reserved.
      PMID: 29959784 [PubMed - as supplied by publisher] {url} = URL to article