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    • Comparative effectiveness of purpuragenic 595 nm pulsed dye laser versus sequential emission of 595 nm pulsed dye laser and 1,064 nm Nd:YAG laser: a double-blind randomized controlled study. Acta Dermatovenerol Alp Pannonica Adriat. 2019 Mar;28(1):1-5 Authors: Campos MA, Sousa AC, Varela P, Baptista A, Menezes N Abstract INTRODUCTION: Erythematotelangiectatic rosacea is a common condition in Caucasians. The most frequently used lasers to treat this condition are pulsed dye laser (PDL) and neodymium:yttrium-aluminum-garnet laser (Nd:YAG). This study compares the treatment efficacy of purpuragenic PDL with that of sequential emission of 595 nm PDL and 1,064 nm Nd:YAG (multiplexed PDL/Nd:YAG). METHODS: We performed a prospective, randomized, and controlled split-face study. Both cheeks were treated, with side randomization to receive treatment with PDL or multiplexed PDL/Nd:YAG. Efficacy was evaluated by spectrophotometric measurement, visual photograph evaluation, the Dermatology Quality of Life Index questionnaire, and a post-treatment questionnaire. RESULTS: Twenty-seven patients completed the study. Treatment was associated with a statistically significant improvement in quality of life (p < 0.001). PDL and multiplexed PDL/Nd:YAG modalities significantly reduced the erythema index (EI; p < 0.05). When comparing the degree of EI reduction, no differences were observed between the two treatment modalities. PDL was associated with a higher degree of pain and a higher percentage of purpura. Multiplexed PDL/Nd:YAG modality was associated with fewer side effects and greater global satisfaction, and 96.3% of the patients would recommend this treatment to a friend. CONCLUSIONS: Both laser modalities are efficacious in the treatment of erythematotelangiectatic rosacea. The multiplexed PDL/Nd:YAG modality was preferred by the patients. PMID: 30901061 [PubMed - in process] {url} = URL to article
    • Logo of the Human Microbiome Project, a program of the NIH Common Fund, National Institutes of Health, image courtesy of Wikimedia Commons This subject of microbiome-based therapeutic strategies for rosacea is one of my favorite subjects which I have done a great deal of research on. You may want to read the latest article I have written on this subject of the human microbiome. 
    • Related Articles Skin diseases are more common than we think: screening results of an unreferred population at the Munich Oktoberfest. J Eur Acad Dermatol Venereol. 2019 Mar 19;: Authors: Tizek L, Schielein MC, Seifert F, Biedermann T, Böhner A, Zink A Abstract BACKGROUND: Skin diseases are ranked as the fourth most common cause of human illness, resulting in an enormous non-fatal burden. Despite this, many affected people do not consult a physician. Accordingly, the actual skin disease burden might be even higher since reported prevalence rates are typically based on secondary data that exclude individuals who do not seek medical care. OBJECTIVE: The aim of the study was to investigate the prevalence of skin diseases in an unreferred population in a real-life setting. METHODS: A cross-sectional study of 9 days duration was performed in 2016 at the 'Bavarian Central Agricultural Festival', which is part of the Munich Oktoberfest. As part of a public health check-up, screening examinations were performed randomly on participating visitors. All participants were 18 years or older and provided written informed consent. RESULTS: A total of 2701 individuals (53.5% women, 46.2% men; mean age 51.9 ± 15.3 years) participated in the study. At least one skin abnormality was observed in 1662 of the participants (64.5%). The most common diagnoses were actinic keratosis (26.6%), rosacea (25.5%) and eczema (11.7%). Skin diseases increased with age and were more frequent in men (72.3%) than in women (58.0%). Clinical examinations showed that nearly two-thirds of the affected participants were unaware of their abnormal skin findings. CONCLUSION: Skin diseases might be more common than previously estimated based on the secondary data of some sub-populations. Further information and awareness campaigns are needed to improve people's knowledge and reduce the global burden associated with skin diseases. PMID: 30891839 [PubMed - as supplied by publisher] {url} = URL to article
    • Fractionated Carbon Dioxide Laser Resurfacing as an Ideal Treatment Option for Severe Rhinophyma: A Case Report and Discussion. J Clin Aesthet Dermatol. 2019 Jan;12(1):24-27 Authors: Comeau V, Goodman M, Kober MM, Buckley C Abstract Rhinophyma is a progressive, disfiguring condition that affects the nose and is caused by the hypertrophy of sebaceous glands and connective tissue. Although its exact pathogenesis remains unclear, it is generally thought to be a subtype of the chronic, inflammatory condition rosacea. To date, oral and topical treatments have been largely ineffective at treating rhinophyma. Laser resurfacing is an emerging treatment modality that offers hope for patients with severe rhinophyma. We present a case of rhinophyma treated via fractionated carbon dioxide laser resurfacing with impressive results, excellent tolerability, and minimal downtime. PMID: 30881573 [PubMed] {url} = URL to article
    • Effective Treatment of Morbihan's Disease with Long-term Isotretinoin: A Report of Three Cases. J Clin Aesthet Dermatol. 2019 Jan;12(1):32-34 Authors: Olvera-Cortés V, Pulido-Díaz N Abstract Morbihan's disease is characterized by the presence of chronic and persistent edema of the periorbital tissue, forehead, glabella, nose, and cheeks. In some cases, it is related to acne and rosacea, but its exact etiology remains unknown. A defined therapeutic approach has yet to be established for the treatment of Morbihan's disease. To date, the systemic and surgical options attempted have not been very successful and/or do not yield sustained results. Isotretinoin is a key systemic treatment used for the treatment of various skin conditions. However, there are few reports of isotretinoin being used to treat Morbihan's disease. Here, we present the details of three patients with Morbihan's disease who were successfully treated long-term with isotretinoin. PMID: 30881575 [PubMed] {url} = URL to article
    • They have now discovered that humans might be divided into three types of gut bacteria: Bacteroides, Prevotella and Ruminococcus, which may lead to personalizing medical treatment based upon which type gut microbes you predominantly have. "The three gut types can explain why the uptake of medicines and nutrients varies from person to person," [1] and may develop into a new ‘biological fingerprint’ on the same level as blood types and tissue types, akin to the 'blood type' diet and treatments. That is why probiotic treatment for rosacea is as valid, if not much better, as antibiotic treatment.  Bacteroides Bacteroides is a genus of Gram-negative, obligate anaerobic bacteria. Bacteroides species are non endospore-forming bacilli, and may be either motile or nonmotile, depending on the species. The DNA base composition is 40–48% GC. Unusual in bacterial organisms, Bacteroides membranes contain sphingolipids. They also contain meso-diaminopimelic acid in their peptidoglycan layer. Bacteroides species are normally mutualistic, making up the most substantial portion of the mammalian gastrointestinal microbiota, where they play a fundamental role in processing of complex molecules to simpler ones in the host intestine. As many as 1010–1011 cells per gram of human feces have been reported. They can use simple sugars when available; however, the main sources of energy for Bacteroides species in the gut are complex host-derived and plant glycans.[8] Studies indicate that long-term diet is strongly associated with the gut microbiome composition—those who eat plenty of protein and animal fats have predominantly Bacteroides bacteria, while for those who consume more carbohydrates the Prevotella species dominate.[2] Prevotella Prevotella is a genus of Gram-negative bacteria. Prevotella spp. are members of the oral, vaginal, and gut microbiota and are often recovered from anaerobic infections of the respiratory tract. These infections include aspiration pneumonia, lung abscess, pulmonary empyema, and chronic otitis media and sinusitis. They have been isolated from abscesses and burns in the vicinity of the mouth, bites, paronychia, urinary tract infection, brain abscesses, osteomyelitis, and bacteremia associated with upper respiratory tract infections. Prevotella spp. predominate in periodontal disease and periodontal abscesses. Research of human microbiota show that human gut is mainly inhabited by two phyla of bacteria – Firmicutes and Bacteroidetes, the latter mostly dominated by Bacteroides and Prevotella genera. Prevotella and Bacteroides are thought to have had a common ancestor. Formally, the two genera were differentiated in 1990. [3] Ruminococcus Ruminococcus is a genus of bacteria in the class Clostridia. They are anaerobic, Gram-positive gut microbes. One or more species in this genus are found in significant numbers in the intestines of humans. The type species is R. flavefaciens. As usual, bacteria taxonomy is in flux, with Clostridia being paraphyletic, and some erroneous members of Ruminococcus being reassigned to a new genus Blautia on the basis of 16S rRNA gene sequences. [4] End Notes [1] What’s in your gut? Microbiota categories might help simplify personalized medicineBy Katherine Harmon | April 20, 2011Scientific American [2] Bacteroides, Wikipedia [3] Prevotella, Wikipedia [4] Ruminococcus, Wikipedia
    • Caroline Jones, Rosacea Tips and Support Group, Facebook, reports, "I've been using egg white morning and night and my rosecea has completely gone after using for a month. I've suffered for over three years of red nose and cheeks with spots etc....Saw a programme about how they are looking at egg whites in medicine. It is full of collagen and helps get rid of wrinkles. So I tried it as anti wrinkle treatment.. Side effect was my rosecea started to get better....I just separate the white from the yolk and just smooth it as is over my skin. Leave for 10 mins ( your face will look like your young again whilst it tightens 😂) then just rinse with cold water. Pat dry. no whipping involved." If you try this treatment, please post in this thread your results.  
    • Dirk Bruere has a website where he has tried various formulas using DMSO with green tea, aspirin, alternating with a mixture of Copper Salicylate, Methyl Salicylate and Caffeine. He has tried other drugs/substances with DMSO which he lists that didn't work, and says he has totally cleared his rosacea for a good length of time. If you try this, please post your results in this thread. 
    • [Acne, rosacea, seborrheic dermatitis]. Rev Prat. 2018 Oct;68(8):e303-e309 Authors: Badaoui A, Mahé E Abstract PMID: 30869466 [PubMed - in process] {url} = URL to article
    • [Ocular and cutaneous rosacea in a child]. Arch Argent Pediatr. 2019 Apr 01;117(2):e170-e172 Authors: Di Matteo MC, Stefano PC, Cirio A, López B, Centeno M, Bocian M, Cervini AB Abstract Rosacea is a chronic skin disease characterized by erythema, telangiectasia, papules and pustules in the central facial region. It most often affects adults and is rare in children. Rosacea can also present ocular involvement. Symptoms can precede cutaneous findings, appear simultaneously or after them, with a higher risk of ocular complications in children. Because of low prevalence of rosacea in childhood, the diagnosis is frequently delayed. We report a 1-year-old boy with ocular and cutaneous rosacea who developed corneal opacities and visual impairment. Early diagnosis and treatment is considerable to avoid sequels. PMID: 30869500 [PubMed - in process] {url} = URL to article
    • violentred26 at Reddit (scroll down to find her post) reports, "All I did was buy a big thing of 99% pure aloe Vera gel from Whole Foods (their brand) and a bottle of Jarrow Formulas Curcumin 95. I then opened one capsule of curcumin and dumped it into like two tablespoons of aloe (approximate, I didn’t measure). Then I spread the mixture all over my face and left on for 15 minutes. Oh, I also keep the aloe refrigerated so it’s nice and cold when I put it on. I did this mask once per day starting last Saturday through Tuesday, and I **** you not, it completely killed the rosacea flare up."
    • Mastic Gum Tears - image Wikimedia Commons What is Mastic Gum? costcogoldmember at Reddit reports, "Took Mastic Gum for four weeks and HCL supplement (still to this day). This was the best my skin has ever looked in four years and it cleared up within a couple weeks. It's now March 2019 and I have clear skin." If you try this, please post in this thread your results.  Jarrow Mastic Gum.   Amazing Formulas     Betaine HCL.       Nutricost Betaine HCL                                        Mastic Gum
    • Related Articles New indications for topical ivermectin 1% cream: a case series study. Postepy Dermatol Alergol. 2019 Feb;36(1):58-62 Authors: Barańska-Rybak W, Kowalska-Olędzka E Abstract Introduction: Topical ivermectin is an effective treatment for inflammatory papulopustular rosacea in adults. Positive therapeutic effects of ivermectin due to its potential anti-inflammatory properties could be achieved in the other facial dermatoses. Aim: To assess the efficacy of topical ivermectin 1% cream therapy in mild and moderate perioral dermatitis (PD), seborrheic dermatitis (SD) and acne vulgaris (AV). Material and methods: The study comprising 20 patients diagnosed with PD (8), SD (8) and AV (4) was conducted between November 2016 and July 2017. Two scales were applied to establish efficacy of the treatment: Investigator Global Assessment score (IGA) and Patient Global Assessment of Treatment (PGA). Results: All patients responded to the treatment with topical ivermectin very well with a gradual reduction in inflammatory skin lesions. Complete or almost complete clearance (IGA score 0-1) was achieved in 20 cases. Four patients with PD achieved IGA 0-1 after 4 weeks of treatment, 1 patient after 5 weeks, 2 patients after 6 weeks and 1 patient after 12 weeks. In the total group of 8 patients with SD, 4 presented IGA 0 after 4 weeks of therapy, while 4 patients demonstrated IGA 1 after 6 weeks. Patients with AV required 8 and 10 weeks to obtain IGA 1. Nineteen patients of the studied group reported "very good" or "excellent" response to the therapy, only one patient with AV assessed therapy with topical ivermectin as "good". The adverse events were transient and manifested as mild-moderate desquamation, stinging and burning in 2 patients with PD. Conclusions: Topical ivermectin was well tolerated and beneficial for treatment of mild and moderate PD, SD and AV. PMID: 30858780 [PubMed] {url} = URL to article
    • Wish I could help but don't really know. You may want to know about Jamie Kern Lima, IT Cosmetics, who a rosacea sufferer. Our affiliate store carries some of her line of products. 
    • Related Articles Treatment of granulomatous rosacea with chromophore gel-assisted phototherapy. Photodermatol Photoimmunol Photomed. 2019 Mar 10;: Authors: Liu RC, Makhija M, Wong XL, Sebaratnam DF Abstract Granulomatous rosacea is a variant of rosacea characterized by discrete erythematous papules most commonly affecting the central face. It is a rare condition reported primarily in middle-aged women, and tends to have a chronic course often recalcitrant to therapy. We report a case of granulomatous rosacea treated with chromophore gel-assisted phototherapy (CGAP). This article is protected by copyright. All rights reserved. PMID: 30854732 [PubMed - as supplied by publisher] {url} = URL to article
    • Rebound according to Medicine.net is "The production of increased negative symptoms when the effect of a drug has passed or the patient no longer responds to the drug. If a drug produces a rebound effect, the condition it was used to treat may come back even stronger when the drug is discontinued or loses effectiveness."  This can happen with any drug, but with rosacea the reports of rebound most often are with Mirvaso (Brimonidine) and to a lesser extent with Rhofade (Oxymetazoline Hydrochloride). The RRDi began collecting anecdotal reports of Mirvaso Rebound and stopped at 242.  Both of these drugs are vasoconstrictors. You should be aware of this side effect or risk associated with these two drugs. 
    • sorry i don't try this recently i found the list of some best concealers in 2019 can you tell me what's your opinion ?? https://thefashionupdates.com/best-concealers/
    • The Daily Mail reports of an ex-model, Rebecca Morrison, who was able to stop her antibiotic treatment she was using for her rosacea and successfully used Kalme Day Defence SPF 25. Rebecca is reported to say, "I've now been using Kalme for a year and have been more or less free from all the symptoms for the majority of that time. Since using product I've seen almost 100 per cent improvement in my skin. I still get a few pimples now and then when I'm especially stressed and get a little flush if I'm out in the sun but zero flaking skin, painful irritation or furious redness! It has truly changed my life!" Kalme Day Defence SPF 25 is sold in the United Kingdom and you can review the ingredients.  Mother whose rosacea left her skin a 'furious' mess during pregnancy reveals she improved her skin in just four weeks WITHOUT medication - and it was all thanks to a £19.95 cream, By Chloe Morgan for MailOnline, Daily Mail  
    • Keep us posted on your progress. Taking probiotics (there is a lot of discussion on what brand to buy, but I think the main thing is your taking some kind of probiotic) along with Efracea can only help your gut and skin. I personally take bunch of vitamins and minerals. If you are interested in this subject, read this article on this FAQ: Do Rosacea Sufferers have Nutritional Deficiencies?
    • Thanks for your reply and it really helps me a lot!  I am so glad to meet RRDi and it just gave me so many information and solutions to tackle my skin problems (and not only rosacea).  I read some articles about probiotics from the forum and I am now taking a probiotic capsule which claimed to have 4 million friendly bateria. Do you have any suggestions on the brand/ type of bacteria?  Also I am now taking so many supplements. Evening Primrose oil, vitamin B, zinc picolinate and probiotics. I hope they work for me when I stop my Efracea ... i will start my soolantra treatment on Tue and hope it works for me and without making my skin worse.    Thanks a a lot again! 
    • Hi Jesse, Thanks for joining the RRDi and posting. The Efracea (European version of Oracea) and Soolantra are the gold standard for rosacea treatment currently, the state of the art. It has been reported that using Soolantra it does get worse before it gets better, but some report no worsening of the skin, only improvement. The Efracea should improve your skin since you responded so well with doxycycline before. You may want to look into probiotic treatment since this is now a medically acceptable treatment for rosacea. After you skin improves, you may want to consider the long term effects of antibiotic treatment and opt out for probiotics. There are many who report successful treatment of the gut, which the RRDi recognizes as GUT Rosacea when rosacea responds to intestinal treatment. Not all rosacea is demodectic rosacea and the RRDi is the only non profit for rosacea that recognizes thirteen variants of rosacea. Since you have dry skin you may want to consider the new cosmetic ZZ cream which will be released in April 2019 and is designed for dry skin manufactured in China by the Zhongzhou Pharmaceutical Company, the company that manufactures the original famous ZZ Cream. The Cosmetic ZZ cream has already been released in Europe as Demoderm. You may respond well to it so it may be worth your effort to try it since you are so close to the source. You will know in thirty days whether the ZZ cream works for you. Since you live in Hong Kong you may find is easy to drop by Demodex Solutions, a sponsor of the RRDi, at this address:  Demodex Solutions limited 1450 Chun Shing Factory Estate 85-89 Kwai Fuk Road Kwai Chung NT Hong Kong Tel: (852) 81916262 Mobile: (852) 85267369688 Fax: (852) 67369688 Email: info@demodex.com Skype name: demodexsolutions
    • Increased Risk of Cardiovascular Diseases in Female Rosacea Patients: A Nested Case-control Study. Acta Derm Venereol. 2019 Mar 08;: Authors: Sinikumpu SP, Jokelainen J, Auvinen J, Puukka K, Kaikkonen K, Tasanen K, Huilaja L PMID: 30848290 [PubMed - as supplied by publisher] {url} = URL to article
    • Hello.  I am Jesse and I am from Hong Kong. I am suffering from rosacea for more then three years and I found that there are little support in Hong Kong and China.  Three years ago, one day, I found there are so many papales and pustules on my cheeks and it was flushing. In my first year of rosacea, I was misdiagnosed by three doctors and they just prescribed steroid for me. I didn’t use that as I know it’s not good for me. Until the fourth doctor, who is a dermatologist, he diagnosed me with a rosacea. He prescribed me doxycycline and azelaic acid. The azelaic acid made my skin burn and I stopped to use it after applied it once. The doxycycline works well and I took it for two weeks. It seems it has been cured and I was so happy with this. However after the doxy treatment and until now the papales and pustules still appeared on my face and they were extremely itchy. As there are no flushing on my face, I didn’t think that it’s the rebound of the rocasea. Until there few months, my face become flushing and there are hundreds of pustules on my face. I found that my rocasea comes back occasionally ( I still can’t find what exactly trigger it in my case). I am so annoyed because it makes me so embarrassed and don’t want to go out.  I kept reading on the rocasea forums and the studies. I just want to ask if my rosacea comes out occasionally (twice a month), is it still possible to be caused by the  Demodex mites ? I have recently purchased Soolantra but afraid to use it as so many people said it will get worse before it get better.  I am now taking the Efracea (40mg modified release doxycycline). Would this be useful to calm the inflammation caused in the Soolantra treatment?  So many people gave good comments on the ZZ cream but some said that it dries out the skin. I have got a very sensitive dry skin, should I try Soolantra first or ZZ cream?  I have attached some photos in this post. Thanks a lot! 
    • Characterization of the Blood Microbiota in Korean Females with Rosacea. Dermatology. 2019 Mar 07;:1-5 Authors: Yun Y, Kim HN, Chang Y, Lee Y, Ryu S, Shin H, Kim WS, Kim HL, Nam JH PMID: 30844814 [PubMed - as supplied by publisher] {url} = URL to article
    • Related Articles Spanish Consensus Document on the Treatment Algorithm for Rosacea. Actas Dermosifiliogr. 2019 Mar 02;: Authors: Salleras M, Alegre M, Alonso-Usero V, Boixeda P, Domínguez-Silva J, Fernández-Herrera J, García-Navarro X, Jiménez N, Llamas M, Nadal C, Del Pozo-Losada J, Querol I, Salgüero I, Schaller M, Soto de Delás J Abstract Recent scientific evidence and the incorporation of new drugs into the therapeutic arsenal against rosacea have made it necessary to review and update treatment criteria and strategies. To this end, a panel of 15 dermatologists, all experts in rosacea, was formed to share experiences and discuss treatment options, response criteria, and changes to treatment. Based on a critical review of the literature and a discussion of the routine practices of Spanish dermatologists, the panel proposed and debated different options, with consideration of the experience of professionals and the preferences of patients or equality criteria. Following validation of the proposals, the final recommendations were formulated and, together with the evidence from the main international guidelines and studies, used to produce this consensus document. The goal of this consensus document is to provide dermatologists with practical recommendations for the management of rosacea. PMID: 30837074 [PubMed - as supplied by publisher] {url} = URL to article
    • Related Articles Rare diseases that mimic Systemic Lupus Erythematosus (Lupus mimickers). Joint Bone Spine. 2019 Mar;86(2):165-171 Authors: Chasset F, Richez C, Martin T, Belot A, Korganow AS, Arnaud L Abstract Several conditions have clinical and laboratory features that can mimic those present in Systemic Lupus Erythematosus (SLE). Some of these "SLE mimickers" are very common, such as rosacea which can be mistaken for the butterfly rash, while others such as Kikuchi disease, type-1 interferonopathies, Castleman's disease, prolidase deficiency, angioimmunoblastic T-cell lymphoma, Evans' syndrome in the context of primary immune deficiencies and the autoimmune lymphoproliferative syndrome are exceptionally uncommon. A proper diagnosis of SLE must therefore be based upon a complete medical history as well as on the adequate constellation of clinical or laboratory findings. While there is no single test that determines whether a patient has lupus or not, the search for auto-antibodies towards nuclear antigens is a key step in the diagnosis strategy, keeping in mind that ANAs are not specific for SLE. In case of persistent doubt, patients should be referred to reference centers with experience in the management of the disease. PMID: 30837156 [PubMed - in process] {url} = URL to article
    • image courtesy of Wikipedia Over the years it has amazed me how the public has so little knowledge of the three basic food groups, i.e., protein, fat and carbohydrate. Yes, a significant number of the public can name the three basic food groups, but that is as far as it goes and where the confusion begins. The public receives a lot of nutrition recommendations by not only their teachers, physicians, and the government, but also the incredible amount of data on the internet which appears to further confuse everyone. For example, the USDA Center for Nutrition Policy and Promotion lists five food groups in the MyPlate program, while the National Institute of Health proposes the Dietary Approaches to Stop Hypertension (DASH) diet lists eight food groups, and Pass My Exams lists seven nutrition food groups. If you google this subject, you will get so many different recommendations on what constitutes the food groups and how many there should be.  Nutrition Facts Label However, in most countries in the world, there is now mandated a Nutrition Facts Label that is prominently displayed on food and drink products that can really clear up all this confusion. In the USA, the "label was mandated for most food products under the provisions of the 1990 Nutrition Labeling and Education Act (NLEA), per the recommendations of the U.S. Food and Drug Administration." [1] Technically, the Pass My Exams that lists the seven nutrition food groups is closer to what is required for proper nutrition [2], and is true to survive and live healthy one needs all seven food groups listed but technically, carbohydrate is not an essential nutrient since you can obtain glucose, which is an essential carbohydrate nutrient required to survive that can be obtained from protein or fat. [3] Nevertheless, most humans obtain glucose from consuming carbohydrate and you do need the other six food groups and the Nutrition Facts Label can help sort through the confusion. For example, in the image at the top of this post is an example of the Nutrition Facts Label on a package of macaroni and cheese. The three basic food groups are in bold letters, Fat, Carbohydrate and Protein. Depending on the food or drink item the label may also include other nutrients such as Vitamins or minerals. However, if you note, water is never mentioned as a nutrition since everyone usually knows that water is essential for human survival and to maintain a healthy status, even though most food and drink contains some water. In this example, macaroni and cheese contains mostly carbohydrate (31 gram), fat (12 grams) and protein (5 grams) making a total of 48 grams. If you look at the total serving in this example it is 228 grams. If you subtract the basic three food groups from the total serving size you have 180 grams. So how do you account for the 180 grams? The Nutrition Facts Label acknowledges some of the essential nutrients such as sodium which amounts to 470 mg (less than half a gram). The other essential nutrients listed such as Vitamin A, Vitamin C, Calcium and Iron only take up such a trace amount of milligrams that it is not even listed. Water takes up most of the 180 grams unaccounted for. The label gives you information at the bottom concerning 'daily values' that is supposed to be helpful but can also be very confusing to the average reader, which if you want to clear up this confusion, you will have to do some more research.  What is the most helpful information about the Nutrition Facts Label is that it lists the three basic food groups, protein, fat and carbohydrate. You can determine the amount or the percentage of each of these food groups. To determine the percentage is simple math. Take our example of macaroni and cheese which contains a total of 48 grams. To determine the percentage of carbohydrate contained in this food serving you simply divide 31 grams into 48 grams and the result is 64.5% which is the total percentage of carbohydrate in a 228 gram serving of this item. This is why the label is so helpful, you can determine what the primary amount or percentage of a food or drink in terms of the three basic food groups. This helps you know how to see what you are consuming each day in terms of these basic three food groups.  Food Groups, Body Mass and Rosacea For rosaceans who are concerned about diet triggers, particularly sugar and carbohydrate diet triggers, understanding that the human body is mostly made up of water, protein and fat and how little is comprised of carbohydrate (about 1%) [4], should clear up some of the confusion on how over consuming carbohydrate can be an issue for rosacea sufferers. Using the Nutrition Facts Label to gain proper data on what you are consuming will help you see how your high carbohydrate diet is a factor in triggering your rosacea. [5] You can then decide what you want to do about this using the information you just read.  End Notes  [1] Nutrition facts label, Wikipedia [2] The seven essential nutrients are the following:  Carbohydrate Protein Fat Fibre Vitamins Mineral Water Source: Why We Need Food, Pass My Exams [3] Carbohydrate Not Essential For Human Survival [4] Carbohydrate Body Mass Percentage [5] Sugar and Rosacea
    • Many rosaceans complain of dry skin issues and want to find the perfect moisturizer. Those with oily skin usually don't complain about this issue. However, if you are treating your rosacea with sulphur based treatments, finding a perfect moisturizer can really be hard to find. You may want to ask your dermatologist for sample to try either the original formula emollient cream or the low sulphur emollient. This may be what the doctor ordered for your dry skin issues.  AVAR-e® Emollient Cream Prescribing Information AVAR-e® LS Emollient Cream Prescribing Information
    • My dermatologist gave me some samples of Avar-e Green and I noticed that it does indeed help my rosacea and SD. You may want to ask your dermatologist for some samples to try out and see if it works for you. Please post in this thread your results. AVAR-e Green® Cream Prescribing Information
    • Related Articles Idiopathic Facial Aseptic Granuloma: Updated Review of Diagnostic and Therapeutic Difficulties. Actas Dermosifiliogr. 2019 Feb 25;: Authors: Hasbún Z C, Ogueta C I, Dossi C T, Wortsman X Abstract Idiopathic facial aseptic granuloma is a pediatric skin condition involving asymptomatic reddish nodules. The etiology and pathogenesis is still under discussion, although the literature tends to place this condition within the spectrum of childhood rosaceas. The clinical course is chronic but benign, and cases have been reported to resolve spontaneously in less than a year. Even though no well-defined treatment has emerged, a conservative approach that avoids aggressive therapies is preferred. PMID: 30819406 [PubMed - as supplied by publisher] {url} = URL to article
    • Atrophic acne scar: A process from altered metabolism of elastic fibers and collagen fibers based on TGF-β1 signaling. Br J Dermatol. 2019 Mar 01;: Authors: Moon J, Yoon JY, Yang JH, Kwon HH, Min S, Suh DH Abstract BACKGROUND: Atrophic acne scar, a persistent sequela from acne, is undesirably troubling many patients in cosmetic and psychosocial aspects. Although there have been some reports to emphasize the role of early inflammatory responses in atrophic acne scarring, evolving perspectives on the detailed pathogenic process are promptly needed. OBJECTIVES: Examining the histological, immunological and molecular changes in early acne lesions susceptible to atrophic scarring can provide new insights to understand the pathophysiology of atrophic acne scar. METHODS: We experimentally validated several early fundamental hallmarks accounting for the transition of early acne lesions to atrophic scars by comparing molecular profiles of skin and acne lesions between patients who were prone to scar (APS) and not (ANS). RESULTS: In APS, compared to ANS, devastating degradation of elastic fibers and collagen fibers occurred in the dermis, followed by their incomplete recovery. Abnormally excessive inflammation mediated by innate immunity with Th17/Th1 cells was observed. Epidermal proliferation was significantly diminished. TGF-β1 was drastically elevated in APS, suggesting that the aberrant TGF-β1 signaling is an underlying modulator of all these pathological processes. CONCLUSIONS: These results may provide a basis for understanding the pathogenesis of atrophic acne scarring. Reduction of excessive inflammation and TGF-β1 signaling in early acne lesions is expected to facilitate the protection of normal extracellular matrix metabolism and the prevention of atrophic scar formation ultimately. This article is protected by copyright. All rights reserved. PMID: 30822364 [PubMed - as supplied by publisher] {url} = URL to article
    • image courtesy of Wikimedia Commons “The body of a healthy lean man is composed of roughly 62 percent water, 16 percent fat, 16 percent protein, 6 percent minerals, and less than 1 percent carbohydrate, along with very small amounts of vitamins and other miscellaneous substances. Females usually carry more fat (about 22 percent in a healthy lean woman) and slightly less of the other components than do males of comparable weight.” Human Nutrition, Kenneth Carpenter A. Stewart Truswell Douglas W. Kent-Jones Jean Weininger, Encyclopedia Britannica So depending on the weight and sex, you can see that the majority of the human body is water (62%), and protein and fat make up about a 50/50 ratio comprising of about a third of the body mass, while carbohydrate only amounts to a tiny 1% of the body mass. Since there is so little carbohydrate making up your body mass, why is it that today's modern diet consists of more carbohydrate than protein and fat? Yet, for most humans living in the modern world, the diet consists of a majority of carbohydrate. In times past, say a couple of hundred years ago, humans ate more protein and fat, or at the very least equal amounts of all three food groups. The increase of carbohydrate in the human diet, particularly sugar, whether as high fructose corn syrup or sucrose (or any other sugar) has only happened in the last couple of hundred years, particularly in the last one hundred years. What has the increased sugar intake in human consumption along with other carbohydrate done to health? The increased knowledge data of over consumption of sugar/carbohydrate continues to show the detrimental effect to human health and you are without a doubt aware you should limit your sugar/carbohydrate intake to improve your health. You know you are consuming too much sugar/carbohydrate in your diet and this is triggering your rosacea. If you are not convinced, why not try reducing sugar/carbohydrate for thirty days and see if your rosacea improves? This will probably be the hardest fast you have ever done since sugar/carbohydrate is embedded into the typical modern industrial diet and it is so difficult to avoid sugar/carbohydrate, mainly because you are addicted to sugar. But a clear face is worth it, isn’t it?        
    • image courtesy of Wikimedia Commons You without a doubt have heard about body mass so let me ask you a question: Question What percentage of body mass is your protein, fat and carbohydrate? You think about this for a while and then after you have your answer ready click below for the facts.
    • Related Articles Global rosacea treatment guidelines and expert consensus points: The differences. J Cosmet Dermatol. 2019 Feb 26;: Authors: Juliandri J, Wang X, Liu Z, Zhang J, Xu Y, Yuan C Abstract BACKGROUND: Rosacea is a highly prevalent, chronic inflammatory disease. The treatment of rosacea remains a challenge to dermatologists. Therapies include skin care, medications, lasers, and various combinations of these modalities. The appropriate treatment depends on clinical types and patient's various clinical symptoms. PURPOSE: The purpose of this study was to review and compare current therapies for rosacea of all severities from four different guidelines. METHODOLOGY: We searched PubMed using the keywords "rosacea," "treatment" AND ["erythema rosacea" OR "papulopustular rosacea" OR "ocular rosacea" OR "phymatous rosacea"]. We selected randomized controlled trials, observational studies, controlled clinical trials, and clinical trials. We indentified further studies (including the guidelines) by hand-searching relevant publications and included those that met the inclusion criteria. RESULTS: The total number of records identified was 421. We limited our search to the specific abovementioned study types. Twenty-five of these studies met with our inclusion criteria. An additional five manuscripts were selected using the abovementioned method, and four guidelines were included in this review. CONCLUSION: Diagnosing and choosing the appropriate treatment options of rosacea according to guidelines is the basis of scientific criteria. More large-scale randomized controlled clinical trials on new treatment methods, new drugs, or new dosage forms provide a new guideline for future rosacea treatment. Although there are some differences in the treatment of rosacea, it is generally based on anti-demodex, anti-inflammatory, and anti-angiogenesis. PMID: 30809947 [PubMed - as supplied by publisher] {url} = URL to article
    • Cutera has announced "a significant leap forward in the Company’s current excel V laser platform' introducing the excel V+ with the following features:  Fully-integrated 532/+ 1064 nm wavelengths, with the addition of ‘Green Genesis’ a micro-pulsed 532 nm procedure 50% more power with the 532 nm wavelength Large spot sizes up to 16 mm for 2X faster treatments New ‘Dermastat’ tracing handpiece to quickly treat small vascular and pigmented lesions on the face and body Cutera Announces Global Commercial Launch Of the excel V+® the Next Generation Laser Platform, Global Newswire
    • Update  "In the assessment of facial dermal tolerability at Week 52, more than 95% of patients had either no signs or symptoms, or signs/symptoms that were classified “mild” (burning/stinging, flushing/blushing, dryness, itching, peeling and hyperpigmentation). The severity of key clinical manifestations of rosacea - erythema and telangiectasia - had both significantly improved when compared to Baseline of the preceding double-blind studies. Patient satisfaction with FMX103 treatment remained high when re-assessed at Week 52 which was consistent with scores obtained at Week 12 (end of double-blind studies)." Foamix Announces Positive Results from Phase 3 Open-Label Safety Study Evaluating FMX103 Topical Minocycline Foam for Treatment up to 1 Year Long Term Data on FMX103 Demonstrated a Generally Favorable Safety Profile; 81.6% of Patients Achieved Clear or Almost Clear Skin at 52 Weeks Global Newswire
    • Update “Sol-Gel anticipates that building a portfolio of generic product candidates with favorable commercial agreements can supplement its branded pipeline and potentially have a meaningful contribution to the Company’s operating income,” stated Alon Seri-Levy, Chief Executive Officer of Sol-Gel. “This strategy first came to fruition last January when Perrigo received tentative approval from the FDA for ivermectin cream, 1%, developed in collaboration with Sol-Gel.  Perrigo was second to file and, as of today, has the only reported tentative approval for ivermectin cream, 1%, and there is no public disclosure of a third filer to the FDA," added Dr. Seri-Levy." Sol-Gel Technologies Announces Sixth Agreement for a Generic Product Candidate with Perrigo, Globe Newswire
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