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    • Most, if not all of the rosacea research being done is being funded by pharmaceutical companies or what is called the skin industry who have a vested interest in rosacea. The only non profit organizations for rosacea doing any rosacea research are the NRS and the AARS (possibly others) who clearly state that on their financial reports that they are heavily funded by pharmaceutical companies that offers rosacea drug treatments. These non profits as well any just about all rosacea research is funded by the skin industry.  The skin industry includes not only pharmaceutical companies that offer rosacea treatments but also the cosmetic companies that offer over the counter treatments for rosacea.  Science is assumed to be researched in integrity, after all it is science. "Science is a systematic endeavor that builds and organizes knowledge in the form of testable explanations and predictions about the universe." [1] Research is the "creative and systematic work undertaken to increase the stock of knowledge". [2] Integrity is "the practice of being honest and showing a consistent and uncompromising adherence to strong moral and ethical principles and values." [3] While most science research is without question done in integrity, there is a small unknown percentage of dark science worth investigating that results in retractable published research papers due to fraud or other data misinformation. [4]  The Rosacea Research & Development Institute [RRDi] was formed for the purpose of engaging in novel rosacea research that rosacea sufferers want done which is totally in contrast to the current rosacea research being done by the skin industry. For example, if 10K members of the RRDi each donated a dollar and decided what should be researched on rosacea, this non profit organization could actually engage in a different direction than how the skin industry does their research for their own agenda.  While we appreciate any rosacea research being done, it would be incredible if enough rosaceans got together and actually funded their own rosacea research. Are you in? Join the RRDi.  End Notes [1] Science, Wikipedia [2] Research, Wikipedia [3] Integrity, Wikipedia [4] The Truth Police, BBC
    • JAAD Case Rep. 2023 Apr 11;36:32-33. doi: 10.1016/j.jdcr.2023.03.022. eCollection 2023 Jun. NO ABSTRACT PMID:37215297 | PMC:PMC10195851 | DOI:10.1016/j.jdcr.2023.03.022 {url} = URL to article
    • Int J Dermatol. 2023 May 22. doi: 10.1111/ijd.16717. Online ahead of print. ABSTRACT BACKGROUND: Facial erythema in rosacea is a troublesome embarrassing presentation with limited options of treatment. Daily brimonidine gel was shown to be an effective modality of treatment. Being unavailable in Egypt and the scarcity of objective evaluation of its therapeutic effect motivated the search for other alternatives. OBJECTIVE: To evaluate the use and effectiveness of topical brimonidine eye drops for the management of facial erythema in rosacea with the aid of objective assessment. METHODS: The study was conducted on 10 rosacea patients presented with facial erythema. Brimonidine tartrate eye drops 0.2% were applied twice daily for 3 months on areas of red facial skin. Punch biopsies were obtained before and after 3 months of treatment. Routine hematoxylin and eosin (H&E) staining as well as CD34 immunohistochemical staining were performed for all biopsies. Sections were examined to detect the changes in the count and the surface area of blood vessels. RESULTS: Evaluation of clinical results showed good improvement of facial redness at the end of treatment (55-75%). Only 10% of subjects expressed rebound erythema. H&E and CD34 stained sections showed an increased count of dilated dermal blood vessels, which decreased significantly after treatment in count and surface area (P = 0.005, and P = 0.004, respectively). CONCLUSION: Topical brimonidine eye drops proved to be effective in managing facial erythema in rosacea, providing an available and cheaper alternative to brimonidine gel. The study improved the subjective evaluation in the context of objective assessment of treatment efficacy. PMID:37212604 | DOI:10.1111/ijd.16717 {url} = URL to article
    • Front Public Health. 2023 May 3;11:1096687. doi: 10.3389/fpubh.2023.1096687. eCollection 2023. ABSTRACT BACKGROUND: The associations between single risk factors and incident rosacea have been reported, but the effects of social risk factors from multiple domains coupled remain less studied. OBJECTIVES: To quantify the influence of social determinants on rosacea comprehensively and investigate associations between the polysocial risk score (PsRS) with the risks of incident rosacea. METHODS: This was a prospective cohort study of government employees undertaken from January 2018 to December 2021 among participants aged >20 from five cities in Hunan province of China. At baseline, information was collected by a questionnaire and participants were involved in an examination of the skin. Dermatologists with certification confirmed the diagnosis of rosacea. The skin health status of participants was reassessed every year since the enrolment of study during the follow-up period. The PsRS was determined using the nine social determinants of health from three social risk domains (namely socioeconomic status, psychosocial factors, and living environment). Incident rosacea was estimated using binary logistic regression models adjusted for possible confounding variables. RESULTS: Among the 3,773 participants who completed at least two consecutive skin examinations, there were 2,993 participants included in the primary analyses. With 7,457 person-years of total follow-up, we detected 69 incident rosacea cases. After adjustment for major confounders, participants in the group with high social risk had significantly raised risks of incident rosacea with the adjusted odds ratio (aOR) being 2.42 (95% CI 1.06, 5.55), compared to those in low social risk group. CONCLUSION: Our findings suggest that a higher PsRS was associated with an elevated risk of incident rosacea in our study population. PMID:37206873 | PMC:PMC10191232 | DOI:10.3389/fpubh.2023.1096687 {url} = URL to article
    • Adv Biomed Res. 2023 Mar 28;12:72. doi: 10.4103/abr.abr_233_21. eCollection 2023. ABSTRACT BACKGROUND: Rosacea is a skin chronic inflammation with an unknown cause and cure. Environmental and genetic factors could not entirely explain the disease pathogenesis. Recently, infections like Chlamydia pneumoniae are of more attention in the rosacea progression. This study investigated the relationship between the C. pneumoniae seropositivity and the rosacea disorder. MATERIALS AND METHODS: We aimed at a cohort of 100 patients with the rosacea disorder (60 active and 40 inactive) and from 100 sex- and age-matched healthy controls in Isfahan and determined the immunoglobulin M (IgM)/IgG antibodies titers to C. pneumoniae in the serum using the enzyme-linked immunosorbent assay method. The groups were compared using the analysis of variance procedure at the significant level of P < 0.05, statistically. RESULTS: The mean of IgG in the controls was significantly higher than the levels in both the active and the inactive rosacea patients (p < 0.022). Also, the titer of serum IgM to C. pneumoniae in the controls was different, compared with the active (p < 0.019) and the inactive (p < 0.02) rosacea patients. In addition, the median titer of serum IgG (not IgM) to C. pneumoniae in the females with the inactive rosacea disorder was lower than the active rosacea disorder (p < 0.019) and controls women (p < 0.008). Furthermore, the serum level of IgG or IgM to C. pneumoniae in the controls males was higher than the males with the rosacea disorder (p < 0.05) and (p < 0.02), alternatively. CONCLUSION: C. pneumoniae seropositivity in the rosacea patients and controls was insignificant. PMID:37200759 | PMC:PMC10186054 | DOI:10.4103/abr.abr_233_21 {url} = URL to article
    • Most Viewed FAQs List Guide  • Please note: If you click and receive a message that 'you do not have permission to view" that means you need to Join the RRDi to View ($2 minimum subscription). Maybe you have some of the same questions and want to do some research. That is what the RRDi is all about.  Below are the FAQs in the order of the most views as of February 2021:  Is this rosacea?  By far the most frequently asked question on the internet and on the RRDi website.  Are there any Oracea Anecdotal Reports? (New FAQ) Answer shows 81.6K views What about Mirvaso for rosacea? (New FAQ) Answer shows 23.6K views What is demodectic rosacea? (New FAQ) Answer shows 23.2K views What is the most viewed rosacea regimen on the RRDi website? (New FAQ) Answer shows 19.7K views What about Isotretinoin for Rosacea? (New FAQ) Answer shows 18.2K views Is Carbohydrate Essential For Human Survival? (New FAQ) Answer shows 16.4K views What about sugar and rosacea? (New FAQ) Answer shows 14.8K views What is Horse Paste for Rosacea? (New FAQ) Answer shows 13.5K views What about researching diet/lifestyle and rosacea? (New FAQ) Answer shows 13.4K views What does a dietician nutritionist have to say about rosacea? (New FAQ) Answer shows 13.1K views What is Steroid Rosacea? (New FAQ) Answer shows 12.1K views Why Form Another Non Profit Organization For Rosacea? (New FAQ) Answer shows 11.4K views Do Rosaceans Suffer from Nutritional Deficiencies? 959 views in FAQs (The answer shows 10.8K views) What is Seborrheic Dermatitis? (New FAQ) Answer shows 10.3K views What should a newbie rosacean learn about rosacea? (New FAQ) Answer shows 9.6K views What Prescription and Non Prescription Flushing Avoidance Treatments are there? (New FAQ) Answer shows 9.2K views What are the latest theories on the cause of rosacea? (New FAQ) Answer shows 9.1K views What about Antibiotic Resistance, Bacterial Overgrowth, Side Effects? (New FAQ) Answer shows 8.6K views Can Rosacea Go Into Remission? 7.5K views What rosacea trigger factors are there? (New FAQ) Answer shows 7.5K views What about NSAIDs For Rosacea? (New FAQ) Answer shows 7.4K views What is Oracea for rosacea? (New FAQ) Answer shows 7.2K views Does Yogurt Or Liver Trigger Rosacea? 3.1K views in FAQs (The article with the answer shows 7.2K views) Are there any Doxycycline Anecdotal Reports? (New FAQ) Answer shows 7.1K views Is the Subtype Classification Of Rosacea Controversial? (New FAQ) Answer shows 6.8K views What is Keratosis Pilaris Rubra Faceii (KPRF)? (New FAQ) Answer shows 6.6K views Do You Have A Gut Feeling About Your Rosacea? (New FAQ) Answer shows 6.5K views What full coverage make up foundation is for rosacea? (New FAQ) Answer shows 6.5K views) How do you make a home made ivermectin cream? (New FAQ) Answer shows 6.5K views) What about aspirin for rosacea? (New FAQ) Answer shows 6.4K views) Is Carbohydrate A Rosacea Trigger? (new FAQ) Answer shows 6.1K views What is Periorol Dermatitis? (New FAQ) Answer shows 6K views What cosmetics are there for rosacea? (New FAQ) Answers show 5.9K views What is the Innate Immune Response Disorder theory on rosacea? (New FAQ) Answers show 5.7K views Are there any Anecdotal Reports of Carbohydrate and Sugar Rosacea Trigger Avoidance? (New FAQ) Answers show 5.7K views Is Coffee A Rosacea Trigger? 5.6K views How is a Differential Diagnosis Of Rosacea Obtained? (New FAQ) Answer shows 5.6K views What is Keratosis Pilaris Rubra Faceii? (New FAQ) Answer shows 5.6K views Is Rosacea A ‘Complicated Diagnosis Path’ And Mysterious Disorder? (New FAQ) Answer shows 5.4K views What Sugars Should I Avoid to Control My Rosacea? (New FAQ) Answer shows 5.4K views What is the Ketamine 0.5% and Amitriptyline 1% Treatment for Rosacea? (New FAQ) Answer shows 5.4K views What about IBS and Rosacea? (New FAQ) Answer shows 5.4K views What is Gram-Negative Folliculitis? (New FAQ) Answer shows 5.3K views What is Neurogenic Rosacea? (New FAQ) Answer shows 5.3K views What about researching Gene therapy & Isolation of Rosacea Genes? (New FAQ) Answer shows 5.3K views What Should I Ask My Physician? 5K views What about Soolantra for rosacea? (New FAQ) Answer shows 5K views Does Vitamin B Complex Trigger Rosacea? 4.9K views What is Rosacea LTD-IV? (New FAQ) Answer shows 4.9K views What diet triggers rosacea? (New FAQ) Answer shows 4.9K views Is Lamb's Quarters A Rosacea Trigger? (New FAWQ) Answer shows 4.8K views What Is The World Wide Number Of Cases Of Rosacea? 4.6K views What is Telangiectasias (Phenotype 3)? (New FAWQ) Answer shows 4.6K views What is Granulomatous Rosacea? (New FAWQ) Answer shows 4.5K views What are some Treatments for Demodex Skin Mites? (New FAQ) Answer shows 4.4 views What is ZOSSO (aka ZZ Cream)? (New FAQ) Answer shows 4.4 views What is Rosacea Fulminans? (New FAQ) Answer shows 4.3 views  What is the Helicobacter Pylori Theory in Rosacea? (New FAQ) Answer shows 4.3 views  What about Zeloglin for rosacea? (New FAQ) Answer shows 4.3 views Rosacea or Demodex, Which Came First? (New FAQ) Answer shows 4.1 views What two rosacea mimics are called PF? (New FAQ) Answer shows 4.1 views Can You Get A Diagnosis For Rosacea On The Internet? 4K views What about SIBO and Rosacea? (New FAQ) Answer shows 4K views What are some Natural Treatments For Rosacea? (New FAQ) Answer shows 3.9K views Does IPL Kills Demodex Mites? (New FAQ) Answer shows 3.9K views What anti-flushing drugs for rosacea are there?  (New FAQ) Answer shows 3.9K views What about oral ivermectin for Rosacea? (New FAQ) Answer shows 3.7K views What about red clover for rosacea flushing? (New FAQ) Answer shows 3.7K views What is the GPSkin® Barrier Device for Rosacea? (New FAQ) Answer shows 3.6K views Does Aspirin Help for Rosacea Flushing? (New FAQ) Answer shows 3.6K views What about Psychology and Rosacea? (New FAQ) Answer shows 3.6K views What about low gastric acid and rosacea? (New FAQ) Answer shows 3.6K views What is an elimination diet? (New FAQ) Answer shows 3.5K views Is there more information on sugar and rosacea? (New FAQ) Answer shows 3.5K views How can I avoid blushing? (New FAQ) Answer shows 3.5K views What Is The Rosacea Butterfly Or T Zone? 3.4K views If My Rosacea Is Severe What Treatments Are Available? 3.4K views What is the difference between a Papule, Pustule, Pimple, Comedo, Lesion, Cyst? (New FAQ) Answers shows 3.4K views What is Pyoderma Faciale? (New FAQ) Answers shows 3.4K views What is Dr. Dray Anti-Redness Regimen? (New FAQ) Answers shows 3.4K views Is rosacea caused by bacteria? (New FAQ) Answers shows 3.4K views Is Rosacea Triggered By A Vitamin B Complex Supplement? (New FAQ) Answers shows 3.4K views What Causes Rosacea? 3.3K views (New FAQ) Answer shows 3.3K views What is Argan Organics anti redness + rosacea cream? (New FAQ) Answer shows 3.3K views Is Rosacea Caused by Genetics? (New FAQ) Answer shows 3.3K views What about Sodium Sulfacetamide - Sulfur for rosacea? (New FAQ) Answer shows 3.2K views What are some rosacea rare flareups? (New FAQ) Answer shows 3.2K views Is Sugar A Rosacea Trigger? 3.1 views What is the Gold Standard for Rosacea Treatment? (New FAQ) Answer shows 3.1K views What about Lutein with Zeaxanthin for Rosacea? (New FAQ) Answer shows 3.1K views What about metronidazole and rosacea? (New FAQ) Answer shows 3.1K views What about flushing and rosacea? (New FAQ) Answer shows 3.1K views Is Flushing Rosacea? 3K views Does Rosacea Progress In Stages? 3K views Do Acne Treatments Irritate Rosacea? 3K views What is Erysipelas? (New FAQ) Answer shows 2.9K views What about Immunosuppressants for rosacea? New FAQ) Answer shows 2.9K views What Is A Rosacea Trigger? 2.8K views What is the difference between a Variant, a Subtype and a Phenotype? New FAQ) Answer shows 2.8K views What is Gastrointestinal Rosacea [GR] (aka, Gut Rosacea)? (New FAQ) Answer shows 2.8K views Does a honey mask improve rosacea? (New FAQ) Answer shows 2.8K views What about Cathelicidin Peptide LL-37 and Vitamin D3 in rosacea? (New FAQ) Answer shows 2.8K views Is Rosacea Misdiagnosed? (New FAQ) Answer shows 2.7K views What is Erythromelalgia? (New FAQ) Answer shows 2.7K views What is the history of ivermectin? (New FAQ) Answer shows 2.7K views What is Lupoid Rosacea? (New FAQ) Answer shows 2.6K views Are Migraine Headaches Related To Rosacea? 2.5K views Can a doctor diagnose rosacea in five minutes or less? (New FAQ) Answer shows 2.5K views What is Eczema (Atopic Dermatitis)? (New FAQ) Answer shows 2.5K views What is Rosacea Conglobata? (New FAQ) Answer shows 2.5K views What is the Angiogenesis & VEGF theory on rosacea? (New FAQ) Answer shows 2.5K views How can I volunteer for the RRDi? (New FAQ) Answer shows 2.5K views Do any of the royal family in the UK have rosacea? (New FAQ) Answer shows 2.5K views Is Lupus a rosacea mimic? (New FAQ) Answer shows 2.4K views What is ProSkin Rosacea Natural Skin Cream by Mama Nature? (New FAQ) Answer shows 2.4K views What is Azelaic Acid for rosacea? (New FAQ) Answer shows 2.4K views Is Sugar Addictive? (New FAQ) Answer shows 2.4K views Has anyone committed suicide because of blushing? (New FAQ) Answer shows 2.4K views Is Flushing Rosacea? 2.4K views When posting on the RRDi website how can I balance Anonymity and Transparency? (New FAQ) Answer shows 2.4K views What rosacea panel recommended the phenotype classification? (New FAQ) Answer shows 2.4K views Can You Self Diagnose Rosacea? 2.3K views What is the X Factor in Rosacea? 2.3K views What is Glandular Rosacea? (New FAQ) Answer shows 2.3K views What is Low Dose Naltrexone for rosacea? (New FAQ) Answer shows 2.3K views Is Perioral Dermatitis a rosacea variant? (New FAQ) Answer shows 2.3K views What is Dermatomyositis? (New FAQ) Answer shows 2.3K views What does Cathelicidin have to do with rosacea? (New FAQ) Answer shows 2.2K views Does a vacation to the South Pacific which includes snorkeling improve rosacea? 2.1K views What If I Don't Want To Lose Weight Or I Need Carbohydrate For Athletics? 2.1K views What about LED for rosacea? (New FAQ) Answer shows 2.1K views What about Antibiotics For Rosacea? (New FAQ) Answer shows 2.1K views What about Rhofade for rosacea? (New FAQ) Answer shows 2.1K views How do you use the RRDi FAQs? 2.1K views What is the Autoimmune Protocol Diet? (New FAQ) Answer shows 2.1K views Will a Humidifier Help Rosacea? 2K views Are there any Demodex Mite Videos? (New FAQ) Answer shows 2K vews What is the difference between a rosacea flare up and flushing? 2K views What is the History of Demodectic Rosacea? (New FAQ) Answer shows 2K views What about ETS and rosacea? (New FAQ) Answer 2K views Is The Lymphatic System Involved With Rosacea? 1.9K views What is an Alternative to Soolantra's (Ivermectin) High Cost? (New FAQ) Answer shows 1.9K views What is Tranexamic Acid Solution for rosacea? (New FAQ) Answer shows 1.9K views What about MSM and Grapefruit Seed Extract for Rosacea? (New FAQ) Answer shows 1.9K views What is the Hanacure Face Mask? (New FAQ) Answer shows 1.9K views What brand of laser for rosacea? (New FAQ) Answer shows 1.8K views Are there any IPL Anecdotal Negative Reports? (New FAQ) Answer shows 1.8K views What do alarmins have to do with rosacea? (New FAQ) Answer shows 1.8K views What is the Rosacea Diet? (New FAQ) Answer shows 1.8K views Spicy Food A Rosacea Trigger? (New FAQ) Answer 1.8K views What Is An Elimination Diet? 1.7K views Does Lifestyle Effect Rosacea? 1.7K views What Non Prescription Treatments Are Available? 1.7K views Is Obesity A Factor In Rosacea? 1.7K views Does Coconut Oil Improve Rosacea? (New FAQ) Answer shows 1.7K views Are there any Laser Anecdotal Negative Reports? (New FAQ) Answer shows 1.7K views Is there a generic ivermectin cream?  (New FAQ) Answer shows 1.7K views Does Lifestyle Effect Rosacea? 1.7K views What are 7 Things Girls With Rosacea Are Tired Of Hearing? (New FAQ) Answer shows 1.7K views Will I Get Rhinophyma? 1.6K views What is sulfur butter for rosacea? (New FAQ) Answer shows 1.6K views What About Steroid Induced Rosacea? 1.6K views If you take Soolantra continuously does it get worse before it gets better? (New FAQ) Answer shows 1.6K views What about Fluorescent Lights (and other artificial lights) and rosacea? (New FAQ) Answer shows 1.6K views Does Sai Pallavi suffer from rosacea? (New FAQ) Answer shows 1.6K views Does Lex Gillies, Beauty Blogger Have Rosacea? (New FAQ) Answer shows 1.6K views Does Amy Schumer suffer from rosacea? (New FAQ) Answer shows 1.6K views Is Sofia Vergara “prone to rosacea”? (New FAQ) Answer shows 1.6K views What is the Antioxidant System Defect Hypothesis Theory in rosacea? (New FAQ) Answer shows 1.6K views What Prescription Treatments Are Prescribed For Rosacea? 1.5K view Is Rosacea A Genetic Disease Or Caused By The Environment? 1.5K views What are the Jennifer Brown Soolantra Videos? (New FAQ) Answer shows 1.5K views What about amberin for hot flashes? (New FAQ) Answer shows 1.5K views How can I post a review of an item in the RRDi affiliate store? (New FAQ) Answer shows 1.5K views Do Renee Zellweger and Cameron Diaz Both have Rosacea? (New FAQ) Answer shows 1.5K views What is radio frequency for rosacea? (New FAQ) Answer shows 1.4K views What is the difference between demodex, dust mites, bed bugs and scabies? (New FAQ) Answer shows 1.4K views What treatments are there for Phymatous (Rhinophyma) Phenotype 5? (New FAQ) Answer shows 1.4K views What is a rosacea mimic (video)? (New FAQ) Answer shows 1.4K views What is Kwellada-P Lotion for rosacea? (New FAQ) Answer shows 1.4K views What is IPL for rosacea? (New FAQ) Answer shows 1.4K views Are there other light devices for rosacea besides laser, LED and IPL? (New FAQ) Answer shows 1.4K views What about Oral Ivermectin Compared with Ivermectin–Metronidazole Combined Therapy? (New FAQ) Answer shows 1.4K views What about Melanotan (Afamelanotide) for rosacea? (New FAQ) Answer shows 1.4K views What does Chlamydophila Pneumoniae have to do with rosacea? (New FAQ) Answer shows 1.4K views How does the AARS spend its donations? (New FAQ) Answer shows 1.4K views (New FAQ) Answer shows 1.4K views Is there any treatment for rosacea that works on everyone? (New FAQ) Answer shows 1.4K views What about Rossoseq for Rosacea? (New FAQ) Answer shows 1.4K views Which Alcohol is Your Rosacea Trigger? 1.3K views What Natural Treatments Are There For Rosacea? 1.3K views What are some free or inexpensive treatments for rosacea? 1.3K views Is The Nervous System Involved With Rosacea? 1.3K views Is Rosacea Confusing, A Bewilderment And A Mystery? 1.3K views Do Children Get Rosacea? 1.3K views What About The Immune System Theory On Rosacea? 1.3K views What Is The Vascular Theory On Rosacea? 1.3K views What Bacteria Is Associated With Rosacea? 1.3K views What is Persistent Erythema ( Phenotype 2)? (New FAQ) Answer 1.3K views What is Avenova? (New FAQ) Answer 1.3K views Does Going to the Beach Improve Rosacea? (New FAQ) Answer 1.3K views What about Botox for Rosacea? (New FAQ) Answer 1.3K views What about Praziquantel for rosacea? (New FAQ) Answer 1.3K views How does the NRS spend its donations? (New FAQ) Answer 1.3K views What are the steps to receive a free RRDi G Suite account?  (New FAQ) Answer 1.3K views What is Medscape Clinical Advances in Rosacea? (New FAQ) Answer 1.3K views Does William Shatner suffer from rosacea? (New FAQ) Answer 1.3K views Did Rembrandt suffer from rosacea? (New FAQ) Answer 1.3K views What about Multistat® For Treatment Of Rosacea? (New FAQ) Answer 1.3K views What about Multistat® For Treatment Of Rosacea? (New FAQ) Answer 1.3K views Can Rosacea be Cured? 1.2K views What is Nu-Stock? (New FAQ) Answer shows 1.2K views Demodex Density Count - What are the Numbers? (New FAQ) Answer shows 1.2K views What is Arquebusade Herbal Water for Rosacea? (New FAQ) Answer shows 1.2K views Is Carbohydrate a Rosacea Trigger? 1.2K views Do You Have A Gut Feeling? 1.2K views What does Tom Busby have to say about ocular rosacea (phenotype 6)? (New FAQ) Answer shows 1.2K views What is broad band light for rosacea?  (New FAQ) Answer shows 1.2K views What about Brimonidine for rosacea? (New FAQ) Answer shows 1.2K views What about Taurine Bromamine for rosacea? (New FAQ) Answer shows 1.2K views What does Propionibacterium Acnes have to do with rosacea? (New FAQ) Answer shows 1.2K views Name Five Five Celebrities with Rosacea? (New FAQ) Answer shows 1.2K views Does William Clinton suffer from rosacea? (New FAQ) Answer shows 1.2K views Who is the rosacea poster boy? (New FAQ) Answer shows 1.2K views Does Infrared Sauna Hurt or Help Rosacea? (New FAQ) Answer shows 1.2K views Does Kristin Chenoweth Have Rosacea? (New FAQ) Answer shows 1.2K views What About Candida Albicans And Rosacea? 1.1K views What Is The Inflammatory Theory On Rosacea? 1.1K views What is Halogen rosacea? (New FAQ) Answer 1.1K views  What is the Ivermectin for Rosacea Horse Paste Poll? (New FAQ) Answer 1.1K views What is Cat's Claw for Rosacea? (New FAQ) Answer 1.1K views What Is PDT? 1.1K views What are some treatments for Phenotype 2? (New FAQ) Answer 1.1K views What is the Thoemmes Demodex DNA Test? (New FAQ) Answer 1.1K views What is Endothelyol for Erythematotelangiectatic Rosacea? (New FAQ) Answer 1.1K views What Light Devices are available for rosacea? (New FAQ) Answer 1.1K views How do you wash off Soolantra? (New FAQ) Answer 1.1K views Do Anti-Anxiety Prescriptions Improve Rosacea? (New FAQ) Answer 1.1K views What is Nonpathogenic E. coli strain Nissle 1917 in Probiotics? (New FAQ) Answer 1.1K views What is Rosacea Beyond the Visible? (New FAQ) Answer 1.1K views Is the painting in the Lourve, The Old Man and His Grandson Phenotype 5? (New FAQ) Answer 1.1K views Can I join the RRDi with just an email address? (New FAQ) Answer 1.1K views How is rosacea research compared with other skin conditions? (New FAQ) Answer 1.1K views Is this rosacea? 1K views Is there a steroid rosacea video? (New FAQ) Answer shows 1K views Does Salvia hispanica kills mites in 7 minutes? (New FAQ) Answer shows 1K views What About H Pylori And Rosacea? 1K views What about alcohol and rosacea? 1K views What about Plaquenil (Hydroxychloroquine) for Rosacea? (New FAQ) Answer shows 1K views Does Levothyroxine ( L-thyroxine) Exacerbates Rosacea? (New FAQ) Answer shows 1K views What about Caper Extract Cream for Rosacea? (New FAQ) Answer shows 1K views Who do Male Patients With Telangiectasia, Rosacea Tend To Wait To Seek Treatment? (New FAQ) Answer shows 1K views What are the benefits of volunteering for the RRDi? (New FAQ) Answer shows 1K views What is the difference between acne and rosacea? 943 views What about florescent lights and rosacea? 943 views What is the Rosacea Rescue Web Site? (New FAQ) Answer shows 935 views What do demodex mites have to do with rosacea? 927 views What Rosacea Treatment And Skin Care Tips Are Available? 911 views What Microorganisms Have Been Associated With Rosacea? 878 views What Oxidative Stress, Ferritin and Rosacea? (New FAQ) Answer shows 844 views What About Accutane For Rosacea? 839 views Does treatment for rosacea usually gets worse before it gets better? (New FAQ) Answer shows 837 views Can Rosacea Be Misdiagnosed? 826 views What About Demodex Mites And Rosacea? 821 views Who is Amelia Fais Harnas and her Art, Wine, & Rosacea? (New FAQ) Answer shows 817 views What is Rosacea? - Talk with Neal Schultz, MD 812 views Can Rosacea Co-Exist With Other Skin Conditions? 800 views What is Bionect Cream for rosacea? (New FAQ) Answer shows 780 views Is Rosacea Contagious? 773 views What's The Difference Between A Subtype And A Variant Of Rosacea? 772 views How Do I Deal With Rosacea Emotionally? 760 views What About Steroids For Rosacea? 744 views Can You Use the Skin Microbiome to Clear Rosacea? (New FAQ) Answer shows 721 views What is a Grassroots Rosacea Non Profit? (New FAQ) Answer shows 719 views What Is Neurogenic Rosacea? 717 views Any tips for reducing or preventing flushing or flare ups caused by exercise? 716 views What is a grassroots non profit organization for rosacea? (New FAQ) Answer shows 711 views What Anti-Flushing Drugs Are Available? 707 views What about 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    • Curr Issues Mol Biol. 2023 Mar 24;45(4):2703-2716. doi: 10.3390/cimb45040177. ABSTRACT Rosacea is a chronic inflammatory skin disease whose late manifestations have not yet been clearly reported in animal models. The objective of this study is to describe the skin lesions and major histopathological changes in a rosacea-like phenotype in mice induced by prolonged LL-37 administration and furthermore, to assess the potential of long-term LL-37 administration in inducing irreversible rosacea-like skin lesion models. Balb/c mice were continuously injected intradermally with LL-37 every 12 h to induce a rosacea-like phenotype. After LL-37 injections were administered for 20 consecutive days, the area of rosacea-like lesions gradually expanded in the first 13 days, then entered a stable phase. Haematoxylin and eosin (H&E) and Van Gieson's staining showed a high degree of inflammatory cell aggregation, thickening of the epidermis and dermis, and collagen deposition in large quantities. The results of immunofluorescence staining and Western blotting showed that the expression of α-SMA, TNF-α, vimentin, and COL1 in the skin of mice was significantly upregulated. Short-term LL-37 administration induced rosacea-like lesions that only featured the aggregation of inflammatory factors and thickening of the epidermis, whereas no collagen hyperplasia was observed, and a full recovery was noticed. However, rosacea-like skin lesions induced by long-term LL-37 administration did not completely recover. Our study compares rosacea-like lesions induced by short-term versus long-term LL-37 administration, and the results suggest that irreversible rosacea-like lesions can be induced by long-term LL-37 administration. PMID:37185701 | PMC:PMC10136735 | DOI:10.3390/cimb45040177 {url} = URL to article
    • Georgian Med News. 2023 Mar;(336):66-72. ABSTRACT Rosacea is a chronic, inflammatory skin disorder that adversely affects patients' life quality. The aim of the study was to evaluate the quality of life (QoL) and to find the connection between QoL and coping strategies in the patients suffering from rosacea. A total of 138 patients, aged from 22 to 80, took part in this research with the first-time confirmed diagnosis of rosacea. All patients completed the Dermatology Life Quality Index (DLQI) questionnaire in order to evaluate the patients' attitudes to the impact of rosacea on QoL and Coping Strategies Questionnaires (COPE). The study has determined that Average DLQI in the case of rosacea equals 14.09+3.18. Mean Rosacea-Specific DLQI is symptoms and feelings - 3.75+1.92, daily activities - 3.12+1.77; leisure - 2.52+1.81, work and/or school - 1.52+1.50, personal relationships - 2.42+1.90, treatment - 1.59+1.04. The usage of instrumental social support - 3.39 has the highest score factor in the COPE questionnaire. Rosacea has a strong impact on human life. QoL in rosacea patients is connected to such factors as age, gender, employment status, self-esteem, and subtype of the disease. Correlation analysis shows the connection between the quality of life and coping strategy. Based on the recession analysis formula, the large and extremely large effect of DLQI can be calculated according to the existing risk consequently, the results obtained in our study may be a kind of starting point for the elaboration of complex support for patients with rosacea. PMID:37166883 {url} = URL to article
    • Curr Med Chem. 2023 May 8. doi: 10.2174/0929867330666230508141434. Online ahead of print. ABSTRACT Statins are HMG-CoA reductase inhibitors and decrease plasma low-density lipoprotein cholesterol (LDL-C) levels. They are well tolerated, and because of their LDL-C-lowering effect, they are utilized to decrease the risk of atherosclerosis and cardiovascular disease. However, statins have pleiotropic effects, including immunomodulatory, anti-inflammatory, antioxidant, and anticancer. Currently, oral administration is the only Food and Drug Administration (FDA)-approved route of administration for statins. However, other administration routes have demonstrated promising results in different pre-clinical and clinical studies. For instance, statins also seem beneficial in dermatitis, psoriasis, vitiligo, hirsutism, uremic pruritus, and graft-versus-host disease. Topically applied statins have been studied to treat seborrhea, acne, rhinophyma, and rosacea. They also have beneficial effects in contact dermatitis and wound healing in animal studies, (HIV) infection, osseointegration, porokeratosis, and some ophthalmologic diseases. Topical and transdermal application of statins is a non-invasive drug administration method that has shown significant results in bypassing the first-pass metabolism in the liver, thereby reducing possible adverse effects. This study reviews the multifaceted molecular and cellular impacts of statins, their topical and transdermal application, novel delivery systems, such as nanosystems for topical and transdermal administration and the challenges concerning this approach. PMID:37157198 | DOI:10.2174/0929867330666230508141434 {url} = URL to article
    • Skinmed. 2023 May 9;21(2):110-111. eCollection 2023. ABSTRACT EpsolayTM cream is a novel topical treatment that utilizes microencapsulated benzoyl peroxide to treat moderate to severe papulopustular rosacea. It is effective at decreasing, and for some patients clearing, the papules, pustules, and telangiectasias associated with rosacea. It is well-tolerated with minimal adverse effects and has demonstrated efficacy comparable to other topical agents that are used for the condition. PMID:37158351 {url} = URL to article
    • Am J Clin Dermatol. 2023 May 9. doi: 10.1007/s40257-023-00777-5. Online ahead of print. ABSTRACT BACKGROUND: Although lesion counting is an evaluation method that effectively analyzes facial acne severity, its usage is limited because of difficult implementation. OBJECTIVES: We aimed to develop and validate an automated algorithm that detects and counts acne lesions by type, and to evaluate its clinical applicability as an assistance tool through a reader test. METHODS: A total of 20,699 lesions (closed and open comedones, papules, nodules/cysts, and pustules) were manually labeled on 1213 facial images of 398 facial acne photography sets (frontal and both lateral views) acquired from 258 patients and used for training and validating algorithms based on a convolutional neural network for classifying five classes of acne lesions or for binary classification into noninflammatory and inflammatory lesions. RESULTS: In the validation dataset, the highest mean average precision was 28.48 for the binary classification algorithm. Pearson's correlation of lesion counts between algorithm and ground-truth was 0.72 (noninflammatory) and 0.90 (inflammatory), respectively. In the reader test, eight readers (100.0%) detected and counted lesions more accurately using the algorithm compared with the reader-alone evaluation. CONCLUSIONS: Overall, our algorithm demonstrated clinically applicable performance in detecting and counting facial acne lesions by type and its utility as an assistance tool for evaluating acne severity. PMID:37160644 | DOI:10.1007/s40257-023-00777-5 {url} = URL to article
    • Ital J Dermatol Venerol. 2023 Apr;158(2):110-116. doi: 10.23736/S2784-8671.23.07484-4. ABSTRACT While rosacea is a common dermatologic condition, ocular rosacea is sometimes evident either with cutaneous rosacea or occasionally by itself. Manifesting with such varied symptoms as dry eye, Meibomian gland dysfunction, and corneal erosion, ocular rosacea can be confused with a multitude of other diseases. While ocular rosacea is commonly mild and rarely severe, physicians should still expand their examination to include ocular manifestations of rosacea. In addition, we propose diagnostic criteria for ocular rosacea, stressing the importance of early recognition and treatment. PMID:37153945 | DOI:10.23736/S2784-8671.23.07484-4 {url} = URL to article
    • Eur J Dermatol. 2023 Feb 1;33(1):6-11. doi: 10.1684/ejd.2023.4405. ABSTRACT BACKGROUND: Rosacea prevalence varies worldwide and there is a lack of information in Brazil. OBJECTIVES: To describe the epidemiological profile of rosacea in subjects who consulted in dermatological outpatient clinics in Brazil. MATERIALS & METHODS: A cross-sectional study was conducted in 13 dermatological outpatient clinics across the country. Patients with rosacea diagnosis were eligible for the study according to the investigator's clinical assessment. Clinical, social and demographic data were collected. The overall and regional rosacea prevalence was calculated, and association with baseline characteristics was analysed. RESULTS: A total of 3,184 subjects were enrolled, and rosacea prevalence was 12.7%. The southern region of Brazil presented a higher prevalence, followed by the southeast. The subjects in the rosacea group were older than those without rosacea (52.5 ±14.9 vs. 47.5 ±17.5; p<0.001). Moreover, the rosacea group was associated with Fitzpatrick's phototypes I and II, Caucasian ethnicity, a family history of rosacea, and facial erythema, however, no association with gender was found. The most prevalent clinical sign and clinical subtype in rosacea patients were erythema and erythematotelangiectatic, respectively. CONCLUSION: Rosacea is highly prevalent in Brazil, mostly in the southern region, associated with phototypes I and II and a family history. PMID:37154809 | DOI:10.1684/ejd.2023.4405 {url} = URL to article
    • Int Immunopharmacol. 2023 May 5:110233. doi: 10.1016/j.intimp.2023.110233. Online ahead of print. NO ABSTRACT PMID:37150709 | DOI:10.1016/j.intimp.2023.110233 {url} = URL to article
    • Zh Nevrol Psikhiatr Im S S Korsakova. 2023;123(4. Vyp. 2):36-43. doi: 10.17116/jnevro202312304236. ABSTRACT OBJECTIVE: Development of a clinical typology of nosogenic psychosomatic disorders in patients with skin diseases. MATERIAL AND METHODS: The study was carried out in the interclinical psychosomatic department of the Clinical Center and the Clinic of Skin and Venereal Diseases named after. V.A. Rakhmanov Sechenov University in 2007 to 2022. Nine hundred and forty-two patients (253 males, 689 females, average age 37.3±12.4 years) with nosogenic psychosomatic disorders in chronic dermatoses, including ichen planus (n=143), psoriasis (n=137), atopic dermatitis (n=132), acne (n=118), rosacea (n=115), eczema n=10), seborrheic dermatitis (n=88), vitiligo (n=52), pemphigus (n=48), were studied. Index of clinical symptoms (ICS); the Dermatology Quality of Life Index (DQLI); itching severity questionnaire - Behavioral rating scores (BRS); the Hospital Anxiety and Depression Scale (HADS) and statistical methods were used. RESULTS: In patients with chronic dermatoses, nosogenic psychosomatic disorders were diagnosed according to ICD-10 criteria within adaptation disorders [F43.8] (n=465; 49.3%); hypochondriacal disorder [F45.2] (n=235; 24.9%); constitutionally determined and acquired (hypochondriac development) personality disorders [F60] (n=118; 12.5%); schizotypal disorder [F21] (n=65; 6.9%); recurrent depressive disorder [F33] (n=59; 6.2%). A typological model of nosogenic disorders in dermatology has been developed: hypochondriacal nosogenies in severe clinical forms of dermatosis (pemphigus, psoriasis, lichen planus, atopic dermatitis, eczema) and dysmorphic nosogenies in objectively mild, but cosmetically significant forms of dermatosis (acne, rosacea, seborrheic dermatitis, vitiligo). When analyzing socio-demographic and psychometric indicators, significant differences were revealed between the selected groups (p<0.001). In turn, the selected groups of nosogenic disorders demonstrate significant clinical heterogeneity and include various types of nosogenies that form a unique palette of the nosogenic spectrum in the structure of an extensive psychodermatological continuum. Along with the severity of the skin process, the dominant role in the formation of the clinical picture of nosogeny, including cases of paradoxical dissociation of the quality of life with the severity of dermatosis, amplification and somatization of itching, has a premorbid personality structure and somatoperceptive accentuation of the patient, as well as the presence of a comorbid mental disorder. CONCLUSION: The typology of nosogenic psychosomatic disorders in patients with skin diseases requires consideration of both the psychopathological structure of the disorders under discussion and the severity/clinical features of the skin process. PMID:37141127 | DOI:10.17116/jnevro202312304236 {url} = URL to article
    • Br J Dermatol. 2023 May 4:ljad148. doi: 10.1093/bjd/ljad148. Online ahead of print. ABSTRACT BACKGROUND: Vitiligo is an autoimmune skin disorder characterized by loss of melanocytes. Protease-mediated disruption of junctions between keratinocytes and/or keratinocyte intrinsic dysfunction may directly contribute to melanocyte loss. House dust mite (HDM), an environmental allergen with potent protease activity, contributes to respiratory and gut disease but also to atopic dermatitis and rosacea. OBJECTIVE: To verify if HDM can contribute to melanocyte detachment in vitiligo and if so, by which mechanism(s). METHODS: Using primary human keratinocytes, human skin biopsies from healthy and vitiligo patients, and 3D reconstructed human epidermis, we studied the effect of HDM on cutaneous immunity, tight and adherent junction expression and melanocyte detachment. RESULTS: HDM increased keratinocyte production of vitiligo-associated cytokines and chemokines and increased expression of TLR-4. This was associated with increased in situ MMP-9 activity, reduced cutaneous expression of adherent protein E-cadherin, increased soluble E-cadherin in culture supernatant and significantly increased number of supra-basal melanocytes in the skin. This effect was dose-dependent and driven by cysteine protease Der p1 and MMP-9. Selective MMP-9 inhibitor, Ab142180 restored E-cadherin expression and inhibited HDM-induced melanocyte detachment. Keratinocytes from vitiligo patients were more sensitive to HDM-induced changes than healthy keratinocytes. All results were confirmed in 3D model of healthy skin and in human skin biopsies. CONCLUSIONS: Our results highlight that environmental mite may act as an external source of PAMPs in vitiligo and topical MMP-9 inhibitors may be useful therapeutic targets. Whether HDM contributes to onset of flares in vitiligo remains to be tested in carefully controlled trials. PMID:37140010 | DOI:10.1093/bjd/ljad148 {url} = URL to article
    • Exp Dermatol. 2023 May 4. doi: 10.1111/exd.14830. Online ahead of print. ABSTRACT Common skin disorders such as acne vulgaris, rosacea and folliculitis are bothersome prevalent inflammatory diseases of hair follicles that can easily be investigated bedside using optical coherence tomography (OCT) and reflectance confocal microscopy (RCM) with micrometre resolution, opening a novel era for high-resolution hair follicle diagnostics and quantitative treatment evaluation. EMBASE, PubMed and Web of Science were searched until 5 January 2023 to identify all studies imaging hair follicle characteristics by RCM and OCT for diagnosis and monitoring of treatment in hair follicle-based skin disorders. This study followed PRISMA guidelines. After inclusion of articles, methodological quality was assessed using the QUADAS-2 critical appraisal checklist. Thirty-nine in vivo studies (33 RCM and 12 OCT studies) were included. The studies focused on acne vulgaris, rosacea, alopecia areata, hidradenitis suppurativa, folliculitis, folliculitis decalvans, lichen planopilaris, discoid lupus erythemasus, frontal fibrosing alopecia and keratosis pilaris. Inter- and perifollicular morphology including number of demodex mites, hyperkeratinization, inflammation and vascular morphology could be assessed by RCM and OCT in all included skin disorders. Methodological study quality was low, and interstudy outcome variability was high. Quality assessment showed high or unclear risk of bias in 36 studies. Both RCM and OCT visualize quantitative features as size, shape, content and abnormalities of hair follicles, and have potential to support clinical diagnosis and evaluate treatment effects. However, larger studies with better methodological quality are needed to implement RCM and OCT directly into clinical practice. PMID:37140216 | DOI:10.1111/exd.14830 {url} = URL to article
    • J Cosmet Dermatol. 2023 May 2. doi: 10.1111/jocd.15747. Online ahead of print. ABSTRACT BACKGROUND: Since there is currently no conclusion on the efficacy and adverse effects of oxymetazoline, this meta-analysis attempts to explore its efficacy and adverse events, so as to provide guidance for clinical medication. METHODS: We searched PubMed, Embase, and Cochrane Library from the establishment of the database to May 2021. We included studies that patients were randomly assigned to receive oxymetazoline or vehicle, and we excluded duplicate publications, research without full text, incomplete information or inability to conduct data extraction, animal experiments, reviews, and systematic reviews. STATA 15.1 was used to analyze the data. RESULTS: The pooled results show that the 3 (RR = 1.76, 95% CI: 1.53-2.03), 6 (RR = 1.71, 95% CI: 1.47-2.00), 9 (RR = 1.63, 95% CI: 1.40-1.90), 12 (RR = 1.41, 95% CI: 1.18-1.67) -hours CEA success rate and the 3 (RR = 1.65, 95% CI: 1.34-2.03), 6 (RR = 1.75, 95% CI: 1.43-2.14), 9 (RR = 1.63, 95% CI: 1.33-2.00), 12 (RR = 1.78, 95% CI: 1.45-2.18) -hours SSA success rate after oxymetazoline treatment for rosacea is significantly higher than that of vehicle. Additionally, the pooled results show that the incidence of TEAEs after treatment with oxymetazoline is significantly higher than that of vehicle (RR = 1.34, 95% CI: 1.10-1.2). However, our analysis of specific adverse events found that the oxymetazoline group was only significantly higher than the vehicle group in the incidence of application-site dermatitis (RR = 8.91, 95% CI: 1.76-45.23), and there was no statistical significance in the difference in the incidence of other adverse events. CONCLUSION: Oxymetazoline is effective and can be selected for the treatment of persistent facial erythema of rosacea. Additionally, application-site dermatitis was the most important one. PMID:37128814 | DOI:10.1111/jocd.15747 {url} = URL to article
    • Int J Mol Sci. 2023 Apr 10;24(8):7021. doi: 10.3390/ijms24087021. ABSTRACT Under physiological conditions, skin mast cells play an important role as guardians that quickly react to stimuli that disturb homeostasis. These cells efficiently support, fight infection, and heal the injured tissue. The substances secreted by mast cells allow for communication inside the body, including the immune, nervous, and blood systems. Pathologically non-cancerous mast cells participate in allergic processes but also may promote the development of autoinflammatory or neoplastic disease. In this article, we review the current literature regarding the role of mast cells in autoinflammatory, allergic, neoplastic skin disease, as well as the importance of these cells in systemic diseases with a pronounced course with skin symptoms. PMID:37108184 | DOI:10.3390/ijms24087021 {url} = URL to article
    • Int J Mol Sci. 2023 Apr 11;24(8):7053. doi: 10.3390/ijms24087053. ABSTRACT Lipidomics is a term used to define the field that analyzes the structure, functions, and interactions of lipids. Inflammatory dermatoses and lipid disturbances are interrelated, especially due to chronic inflammatory conditions. This review discusses lipidomics in selected inflammatory skin diseases: psoriasis, lichen planus, and atopic dermatitis, as well as the less commonly mentioned hidradenitis suppurativa, rosacea, and acne vulgaris. Lipid homeostasis disorders are common; they are especially well-documented in psoriasis, lichen planus, and atopic dermatitis. Future studies are required for better insight into this issue, particularly on the skin lipidome. Understanding lipidomics, in particular skin diseases, increases our knowledge about their pathogenesis, and may become useful in adjusting tailored management for each patient as well establishing prognosis. Noteworthily, it seems advisable to alert doctors to the need to analyze lipid parameters and the complications of abnormal lipid metabolism in dermatological patients, which could decrease their comorbidities and improve the life quality and health condition of dermatological patients. PMID:37108216 | DOI:10.3390/ijms24087053 {url} = URL to article
    • Exp Dermatol. 2023 Apr 28. doi: 10.1111/exd.14823. Online ahead of print. ABSTRACT The translatability of research is highly dependent on models that recapitulate human tissues and organs. Here, we describe a procedure for the generation of human epidermis organotypic cultures (HEOCs) from primary keratinocytes isolated from foreskin and adult skin as well as from an immortalized keratinocyte cell line (KerTr). We tested several media conditions to develop a defined HEOC growing and expansion media. We characterized the HEOCs and show that in optimal culture conditions they express the proliferation marker Ki67, the basement membrane protein collagen 17 (col17) and the epidermal differentiation markers keratin 15 (K15), keratin 14 (K14), keratin 5 (K5), keratin 10 (K10), keratin 1 (K1), transglutaminase 1 (TGM1), transglutaminase 3 (TGM3) and filaggrin (FLG). Thus, they recapitulate the human epidermis and are stratified from the basal layer to the stratum corneum. These HEOC can be generated reproducibly on a large scale, making it an invaluable model for screening therapeutic compounds and also for the study of pathologies affecting the epidermis. PMID:37114406 | DOI:10.1111/exd.14823 {url} = URL to article
    • Ophthalmologie. 2023 Apr 27. doi: 10.1007/s00347-023-01863-z. Online ahead of print. ABSTRACT Overall, conjunctival scarring is rare and often overlooked during routine examination. However, the differential diagnostic distinction of cicatricial mucous membrane pemphigoid from other causes is crucial for further treatment planning. Other entities that lead to conjunctival scarring, are ocular rosacea, ocular graft-versus-host disease, atopic keratoconjunctivitis, infections, trauma and further sometimes very rare diseases. Most of these differential diagnoses have in common that conjunctival scarring does not progress indefinitely if untreated, in contrast to mucous membrane pemphigoid. PMID:37106092 | DOI:10.1007/s00347-023-01863-z {url} = URL to article
    • You are spot on with your comment. Just need someone like you to post some more and engage as a volunteer to implement your insight into all this. Change your membership status from inactive to active, which would be helpful. 
    • Just an update on your financial situation. We were able to continue with Invision Community for our website, but this has depleted our  donations to just $152.86 at the end of March. Not sure if we can continue unless we get 100 active subscribers which would keep us going. Donations in 2022 including subscriptions totaled $357.94. Expenses in 2022 amounted to $415.82.   We also need some active subscribers who post as well as any volunteers who would like to serve on the board of directors. Could you  post in this thread your thoughts on whether you think the RRDi should keep going or not?  In order to post in this thread you will need to join the RRDi. If you want to volunteer to serve on the board of directors please post why and what you would do to make the RRDi an active non profit organization for rosacea sufferers.  This final appeal has been going on now since June 2021 and we scrapped by with just barely covering our expenses to keep this non profit organization going. It is estimated that in 2023 we will need at least $1K in donations to keep going. Subscriptions help but we simply don't have enough subscribers to meet our expenses. Here is a list of the major expenses:  Invision Community website forum  Registering our domains  Apple Developer account (to be able to use Sign in with Apple  If you want all the details of our financial situation, click here. 
    • Exp Dermatol. 2023 Apr 23. doi: 10.1111/exd.14820. Online ahead of print. ABSTRACT Recent data indicate that distinct skin areas show different microbial/chemical milieu. Keratinocytes (KC) respond to these stimuli by producing cytokine mediators. Therefore, we aimed to determine KC-derived cytokine expression in distinct healthy skin regions (gland-poor [GP], sebaceous gland-rich [SGR] and apocrine gland-rich [AGR]), and their changes in skin diseases of the given regions (atopic dermatitis [AD], papulopustular rosacea [PPR] and psoriasis). Cytokines were analysed at the mRNA and protein levels, and literature analysis was performed for functional categorization. The three regions showed characteristically different cytokine patterns. GP was featured by an IL-25/IL-33/IL-36RA/IL-38/IL-18 cytokine milieu, SGR was characterized by IL-23/IL-17C/IL-18, and AGR skin exhibited a mixed IL-25/IL-33/IL-23/IL-18 profile. Literature analyses revealed different homeostatic and proinflammatory roles of these cytokine patterns (Th2 related in GP, Th17 related in SGR and mixed Th2/Th17 in AGR). In skin diseases which are primarily epidermal cytokine-driven (AD, PPR), the level of the regionally characteristic cytokines were further elevated, in contrast to the autoantigen-driven psoriasis, where the cytokine pattern was independent from the localization. Healthy skin regions are equipped with different KC-derived cytokine profiles, which may influence each region's capability of mediator production in certain types of dermatoses. PMID:37088961 | DOI:10.1111/exd.14820 {url} = URL to article
    • Can J Ophthalmol. 2023 Apr 20:S0008-4182(23)00108-4. doi: 10.1016/j.jcjo.2023.03.020. Online ahead of print. ABSTRACT PURPOSE: To describe clinical features and management of toxic keratoconjunctivitis associated with punctal and (or) canaliculus stenosis (toxic soup syndrome). DESIGN: Retrospective observational case series. METHODS: Electronic medical record database search for the keywords "toxic soup syndrome" and retrospective chart review were performed. Thirty-five eyes of 25 patients were seen at a tertiary cornea clinic between January 2017 and December 2021. Sex, age, distance-corrected visual acuity, topical medications, symptoms, clinical signs, and outcomes after medical and surgical interventions were analyzed. The main outcome measured was improvement in ocular surface signs and symptoms after interventions. RESULTS: Overall, 35 eyes of 25 patients with a mean age of 66.8 ± 12.8 years, of which 72% were female, were included. The primary complaint was hyperemia and epiphora in all patients. Rosacea or meibomian gland disease were present in all patients, 7 (28%) had glaucoma, and 7 (28%) developed limbal stem cell deficiency. Twenty-two patients (88%) were using topical medications on presentation. All eyes had either punctal plugs, cauterized puncta, or punctal and (or) canaliculus stenosis. Management of all patients consisted of suspension of all preserved topical medications and institution of some type of anti-inflammatory therapy. Nineteen patients (76%) improved after improvement of lacrimal drainage. One patient with severe resistance in the canaliculus required ongoing preservative-free topical steroids. CONCLUSIONS: Chronic drug-induced or pooled inflammatory mediators causing toxic conjunctivitis may be aggravated by punctal and (or) canaliculus stenosis, leading to toxic soup syndrome. Clearance of punctal obstruction leads to improvement in most patients. PMID:37088101 | DOI:10.1016/j.jcjo.2023.03.020 {url} = URL to article
    • Exp Dermatol. 2023 Apr 22. doi: 10.1111/exd.14812. Online ahead of print. ABSTRACT Rosacea is a complex chronic inflammatory skin disorder with high morbidity. Pyroptosis is known as a regulated inflammatory cell death. While its association with immune response to various inflammatory disorders is well established, little is known about its functional relevance of rosacea. So, we aimed to explore and enrich the pathogenesis involved in pyroptosis-related rosacea aggravations. In this study, we evaluated the pyroptosis-related patterns of rosacea by consensus clustering analysis of 45 ferroptosis-related genes (FRGs), with multiple immune cell infiltration analysis to identify the pyroptosis-mediated immune response in rosacea using GSE65914 dataset. The co-co-work between PRGs and WGCNA-revealed hub genes has established using PPI network. FRG signature was highlighted in rosacea using multi-transcriptomic and experiment analysis. Based on this, three distinct pyroptosis-related rosacea patterns (non/moderate/high) were identified, and the notably enriched pathways have revealed through GO, KEGG and GSEA analysis, especially immune-related pathways. Also, the XCell/MCPcount/ssGSEA/Cibersort underlined the immune-related signalling (NK cells, Monocyte, Neutrophil, Th2 cells, Macrophage), whose hub genes were identified through WGCNA (NOD2, MYD88, STAT1, HSPA4, CXCL8). Finally, we established a pyroptosis-immune co-work during the rosacea aggravations. FRGs may affect the progression of rosacea by regulating the immune cell infiltrations. In all, pyroptosis with its mediated immune cell infiltration is a critical factor during the development of rosacea. PMID:37086043 | DOI:10.1111/exd.14812 {url} = URL to article
    • J Cosmet Dermatol. 2023 Apr 18. doi: 10.1111/jocd.15758. Online ahead of print. NO ABSTRACT PMID:37073424 | DOI:10.1111/jocd.15758 {url} = URL to article
    • Dermatol Reports. 2022 Jul 7;15(1):9526. doi: 10.4081/dr.2022.9526. eCollection 2023 Mar 7. ABSTRACT Coronavirus disease 2019 is a severe acute respiratory syndrome, and wearing a mask is an important preventive measure. However, long-term use can cause maskne, or mask-induced acne. This study evaluated the prevalence, clinical characteristics, and severity of mask-induced acne and its effect on pre-existing dermatosis using an online questionnaire. The questionnaire comprised 15 questions on 6 primary topics: demographic data, type of face mask, dermatological symptoms after using a mask, preexisting dermatological conditions, the duration of use, and the effects of mask use on existing dermatological conditions. We included 1,025 participants; 48.6% had dermatological symptoms after using masks. The most common symptoms were red papules (33.8%) and itching (27.2%). Individuals who wore masks for more than 4 hours daily experienced more dermatological symptoms, for example, healthcare providers, who had a higher risk of maskrelated dermatosis than participants with other occupations. Moreover, masks significantly increased the severity of rosacea, contact dermatitis, and seborrheic dermatitis. These results suggest that board-certified dermatologists should assess patients in larger-scale studies to determine adequate management strategies. PMID:37063397 | PMC:PMC10099290 | DOI:10.4081/dr.2022.9526 {url} = URL to article
    • Dermatol Reports. 2022 Jul 6;15(1):9511. doi: 10.4081/dr.2022.9511. eCollection 2023 Mar 7. ABSTRACT Irregularities of vitamin levels are being increasingly identified associated with skin conditions, and systemic and topical therapies have shown promising improvements. There have been some remarkable improvements achieved, but large variations in outcomes suggest that these conditions are not simply related to a single deficiency or solved by providing a single supplement. Cyanocobalamin, pyridoxine (B6) and riboflavin (B2) supplementation were linked with exacerbating existing acne. There were also reports of allergic reactions to parenteral cobalamin including acne, rosacea, allergic site reactions or anaphylaxis with cobalamin injections. This was also reported in patients who had allergic contact dermatitis to cobalt, where cobalamin therapy resulted in cutaneous manifestations such as chronic vesicular hand dermatitis, cheilitis and stomatitis. The use of niacinamide in acne vulgaris as an alternative to clindamycin or adjunct is also notable, as well as its application for hyperpigmentation. Vitamin B3 also has promise in chemoprevention in particular nonmelanoma skin cancer prophylaxis. Folic acid has a developing role in psoriasis. The data for vitiligo remains inconclusive. Assessment for potential vitamin deficiency, particularly B vitamins, should form part of the normal work-up for a wide range of skin conditions. PMID:37063401 | PMC:PMC10099312 | DOI:10.4081/dr.2022.9511 {url} = URL to article
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