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    • rss
      PubMed RSS Feed - -Dermoscopy of granulomatous and autoimmune skin diseases

      By rss · Posted

      Dermatologie (Heidelb). 2023 Mar 7. doi: 10.1007/s00105-023-05123-8. Online ahead of print. ABSTRACT Dermoscopy is an easily accessible, noninvasive diagnostic tool, originally used in the differentiation of benign and malignant skin tumors. Other structures beside pigment content observed by dermoscopy, e.g., scaling, follicles, or vessels, may present in a specific pattern in different dermatoses. Recognition of these patterns may aid the diagnosis of inflammatory and infectious dermatological conditions. The aim of this article is to review the distinct dermoscopic features of granulomatous and autoimmune skin diseases. Diagnosis of granulomatous skin disorders is based on the histopathological examination. The dermoscopic picture of these diseases (cutaneous sarcoidosis, granuloma annulare, necrobiosis lipoidica, and granulomatous rosacea) show many similarities; however, there are some differences to note between the dermatoses, mainly in granuloma annulare. The cornerstones of the diagnostic process of autoimmune skin diseases (morphea, systemic sclerosis, dermatomyositis, cutaneous lupus erythematosus) include the clinical picture, immunoserology, and histology; however, dermoscopy may aid the diagnostic process and follow-up of the patients. For those diseases, where vascular abnormalities play an important role in the pathogenesis, videocapillaroscopy is used for examination of the microcirculation at the nailfold capillaries. Dermoscopy can be an easy-to-use everyday diagnostic tool in clinical practice regarding granulomatous and autoimmune skin diseases. Although punch biopsy is inevitable in many cases, the distinct dermoscopic structures can aid the diagnostic process. PMID:36881125 | DOI:10.1007/s00105-023-05123-8 {url} = URL to article
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      PubMed RSS Feed - -TRPV1: A promising therapeutic target for skin aging and inflammatory skin diseases

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      Front Pharmacol. 2023 Feb 15;14:1037925. doi: 10.3389/fphar.2023.1037925. eCollection 2023. ABSTRACT TRPV1 is a non-selective channel receptor widely expressed in skin tissues, including keratinocytes, peripheral sensory nerve fibers and immune cells. It is activated by a variety of exogenous or endogenous inflammatory mediators, triggering neuropeptide release and neurogenic inflammatory response. Previous studies have shown that TRPV1 is closely related to the occurrence and/or development of skin aging and various chronic inflammatory skin diseases, such as psoriasis, atopic dermatitis, rosacea, herpes zoster, allergic contact dermatitis and prurigo nodularis. This review summarizes the structure of the TRPV1 channel and discusses the expression of TRPV1 in the skin as well as its role of TRPV1 in skin aging and inflammatory skin diseases. PMID:36874007 | PMC:PMC9975512 | DOI:10.3389/fphar.2023.1037925 {url} = URL to article
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      PubMed RSS Feed - -Assessment of the Efficacy and Safety of 30% Supramolecular Salicylic Acid Peeling for Papulopustular Rosacea Treatment

      By rss · Posted

      Indian J Dermatol. 2022 Sep-Oct;67(5):625. doi: 10.4103/ijd.ijd_353_21. ABSTRACT BACKGROUND: Thirty per cent supramolecular salicylic acid (SSA) is a water-soluble, sustained release salicylic acid (SA) modality, which is well tolerated by sensitive skin. Anti-inflammatory therapy plays an important role in papulopustular rosacea (PPR) treatment. SSA at a 30% concentration has a natural antiinflammatory property. AIMS: This study aims to investigate the efficacy and safety of 30% SSA peeling for PPR treatment. METHODS: Sixty PPR patients were randomly divided into two groups: SSA group (30 cases) and control group (30 cases). Patients of the SSA group were treated with 30% SSA peeling three times every 3 weeks. Patients in both groups were instructed to topically apply 0.75% metronidazole gel twice daily. Transdermal water loss (TEWL), skin hydration and erythema index were assessed after 9 weeks. RESULTS: Fifty-eight patients completed the study. The improvement of erythema index in the SSA group was significantly better than that in the control group. No significant difference was found in terms of TEWL between the two groups. The content of skin hydration in both the groups increased, but there was no statistical significance. No severe adverse events were observed in both the groups. CONCLUSION: SSA can significantly improve the erythema index and overall appearance of skin in rosacea patients. It has a good therapeutic effect, good tolerance and high safety. PMID:36865859 | PMC:PMC9971792 | DOI:10.4103/ijd.ijd_353_21 {url} = URL to article
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      PubMed RSS Feed - -Elucidating the potential pharmaceutical mechanism of Gyejibokryeong-hwan on rosacea using network analysis

      By rss · Posted

      Medicine (Baltimore). 2023 Mar 3;102(9):e33023. doi: 10.1097/MD.0000000000033023. ABSTRACT Rosacea is a chronic erythematous disease with telangiectasia that affects the central area of the face. However, because of the ambiguity in the pathophysiology of rosacea, its treatment has not been clearly elucidated; therefore, new therapeutic options need to be developed. Gyejibokryeong-hwan (GBH) is widely used in clinical practice for various blood circulation disorders, including hot flushes. Therefore, we explored the potential pharmaceutical mechanism of GBH on rosacea and investigated the therapeutic points exclusive to GBH through comparative analysis with chemical drugs recommended in 4 guidelines for rosacea based on network analysis. The active compounds in GBH were identified, and the proteins targeted by these compounds and the genes related to rosacea were searched. Additionally, the proteins targeted by the guideline drugs were also searched to compare their effects. And the pathway/term analysis of common genes was conducted. Ten active compounds were obtained for rosacea. There were 14 rosacea-related genes targeted by GBH, with VEGFA, TNF, and IL-4, which were suggested as core genes. The pathway/term analysis of the 14 common genes revealed that GBH could potentially act on rosacea via 2 pathways: the "interleukin 17 signaling pathway" and the "neuroinflammatory response." Comparison and analysis of the protein targets between GBH and guideline drugs revealed that only GBH separately acts on the "vascular wound healing pathway." GBH has the potential to act on IL-17 signaling pathway, neuroinflammatory response and vascular wound healing pathway. Further studies are needed to determine the potential mechanism of GBH in rosacea. PMID:36862896 | PMC:PMC9981404 | DOI:10.1097/MD.0000000000033023 {url} = URL to article
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      PubMed RSS Feed - -Contact hypersensitivity and Demodex mite infestation in patients with rosacea: a retrospective cohort analysis

      By rss · Posted

      Eur J Dermatol. 2022 Nov 1;32(6):716-723. doi: 10.1684/ejd.2022.4358. ABSTRACT BACKGROUND: Contact hypersensitivity or Demodex mite infestation is commonly reported in patients with rosacea. However, the associations and clinical implications of these two phenomena are poorly described in the literature. OBJECTIVES: This study aimed to investigate the association between clinical characteristics, contact sensitization profiles, and Demodex mite infestation in patients with rosacea. MATERIALS & METHODS: We retrospectively reviewed 189 patients diagnosed with rosacea, and categorized the patients into a rosacea-contact hypersensitivity or rosacea-non-contact hypersensitivity group. RESULTS: The rosaceacontact hypersensitivity group had older age (median: 45.5 vs. 37.0 years; p = 0.006), a higher frequency of itching (63.0% vs. 45.1%; p = 0.040), and a higher Demodex mite density (15.0/cm2 vs. 7.0/cm2; p = 0.002) than the rosacea-non-contact hypersensitivity group. Nickel sensitization was correlated with a higher Demodex mite density, female sex, and papulopustular subtype of rosacea. Based on the multivariate regression model, a favourable clinical outcome was correlated with nickel sensitization alone (odds ratio: 2.20, 95% confidence interval: 1.01-4.81). CONCLUSION: Patients with rosacea and contact hypersensitivity showed distinctive clinical features and a higher Demodex mite density. The association between nickel sensitization, Demodex mite infestation, and treatment response may reflect the role of allergen-specific TH polarization in the pathogenesis of rosacea. PMID:36856381 | DOI:10.1684/ejd.2022.4358 {url} = URL to article
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      PubMed RSS Feed - -Microtoxin for Improving Pore Size, Skin Laxity, Sebum Control, and Scars: A Roundtable on Integrating Intradermal Botulinum Toxin Type A Microdoses into Clinical Practice

      By rss · Posted

      Aesthet Surg J. 2023 Mar 1:sjad044. doi: 10.1093/asj/sjad044. Online ahead of print. ABSTRACT BACKGROUND: In the aesthetic clinical practice, botulinum toxin type A (BoNT-A) is best known for its use as a neuromodulator for the treatment of dynamic facial lines; however, when injected intradermally as microdroplets, BoNT-A can improve skin quality and overall skin appearance. OBJECTIVES: To discuss key aspects of microtoxin use in clinical practice and provide expert guidance on use. METHODS: As part of a Continuing Medical Education (CME) lecture series and roundtable, the authors discussed key aspects of microtoxin patient selection, injection technique, and safety. RESULTS: The experiences of expert faculty are shared here. Clinical experience is consistent with reported data. Microtoxin can be used to reduce pore size, sebum production, rosacea, acne, and fine lines, and to improve jawline and neck definition. Intradermal injection can also be used for the improvement of transverse neck lines as well as for the safe prevention and management of scars and keloids. CONCLUSIONS: Expanding the use of BoNT-A, a predictable, minimally invasive, and affordable treatment to address commonly encountered complaints, is appealing. The authors have found that making patients aware of microtoxin as a treatment option results in increased interest, increased use of BoNT-A, and high satisfaction among appropriately selected patients. PMID:36857534 | DOI:10.1093/asj/sjad044 {url} = URL to article
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      PubMed RSS Feed - -Role of the skin microbiota and intestinal microbiome in rosacea

      By rss · Posted

      Front Microbiol. 2023 Feb 10;14:1108661. doi: 10.3389/fmicb.2023.1108661. eCollection 2023. ABSTRACT Rosacea is a chronic inflammatory cutaneous disorder of uncertain etiology that mainly affects the centrofacial region, including cheeks, nose, chin, forehead, and eyes. The pathogenesis of rosacea remains unclear because it involves several complex factors. Additionally, the potential treatment methods need to be explored. We reviewed the common bacterial species in the skin microbiota and gut microbiota of rosacea patients such as Demodex folliculorum, Staphylococcus epidermidis, Bacillus oleronius, Cutibacterium acnes, and Helicobacter pylori and identified their role in the pathogenesis. Besides, we summarized the influence factors such as temperature and age on rosacea patients. We also systematically reviewed the commonly used clinical treatment methods, including antibiotics, probiotics. as well as their treatment mechanism and application precautions. PMID:36846769 | PMC:PMC9950749 | DOI:10.3389/fmicb.2023.1108661 {url} = URL to article
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      PubMed RSS Feed - -Effect Of Lead On The Skin And Health Of Female Dermatitis Patients Through Cosmetics

      By rss · Posted

      J Ayub Med Coll Abbottabad. 2023 Feb-Mar;35(1):88-94. doi: 10.55519/JAMC-01-11442. ABSTRACT BACKGROUND: Cosmetics have been a part of routine body care not only for the upper classes but also for the middle and lower classes since the dawn of civilization. Cosmetic formulations are in more demand as the public's interest in skin whitening grows. The contamination of cosmetics with heavy metals is a major concern as they containing heavy metals and pose a major risk to human health. This study looks in to the effects of Lead on human skin. METHODS: In this cross sectional study different products were examined. The matrices (scalp hair, blood, serum and nails) of reference and dermatitis cosmetic female patients (seborrhoeic dermatitis, rosacea, allergic contact dermatitis, and irritant contact dermatitis) and cosmetic samples were used in a 2:1 mixture of HNO3 (65%) and H2O2 (30%), and oxidation was performed using a microwave. The oxidized beauty and biological specimen underwent electrothermal atomic emission spectrophotometry after microwave-assisted acid digestion. The validity and precision of the methodology were verified using certified reference materials. Cosmetic products (lipstick, face powder, Eye Liner and Eye shadow) of different brands contain Pb concentrations in the ranges of 50.5-120 μg/g, 14.6-30.7 μg/g, 2.87-4.25 μg/g and 15.3-21.6 μg/g, respectively. RESULTS: In the present study, cosmetic products (lipstick (N=15), face powder (N=13), eye liner (N=11), eye shadow (N=15) and female patients with dermatitis (N=252) residing in Hyderabad city, Sindh, Pakistan, was investigated. The outcome of this investigation showed significantly higher levels of Pb in biological samples (blood and scalp hair) of different types of female dermatitis patients than in reference subjects (p<0.001). CONCLUSIONS: The cosmetic products, especially with regard to heavy metals adulteration, are in use by the female population. PMID:36849384 | DOI:10.55519/JAMC-01-11442 {url} = URL to article
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      PubMed RSS Feed - -Melatonin in Dermatologic Allergic Diseases and Other Skin Conditions: Current Trends and Reports

      By rss · Posted

      Int J Mol Sci. 2023 Feb 17;24(4):4039. doi: 10.3390/ijms24044039. ABSTRACT Melatonin is the main hormone that regulates the sleep cycle, and it is mostly produced by the pineal gland from the amino acid tryptophan. It has cytoprotective, immunomodulatory, and anti-apoptotic effects. Melatonin is also one of the most powerful natural antioxidants, directly acting on free radicals and the intracellular antioxidant enzyme system. Furthermore, it participates in antitumor activity, hypopigmentation processes in hyperpigmentary disorders, anti-inflammatory, and immunomodulating activity in inflammatory dermatoses, maintaining the integrity of the epidermal barrier and thermoregulation of the body. Due predominantly to its positive influence on sleep, melatonin can be used in the treatment of sleep disturbances for those with chronic allergic diseases accompanied by intensive itching (such as atopic dermatitis and chronic spontaneous urticaria). According to the literature data, there are also many proven uses for melatonin in photoprotection and skin aging (due to melatonin's antioxidant effects and role in preventing damage due to DNA repair mechanisms), hyperpigmentary disorders (e.g., melasma) and scalp diseases (such as androgenic alopecia and telogen effluvium). PMID:36835450 | PMC:PMC9967801 | DOI:10.3390/ijms24044039 {url} = URL to article
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      PubMed RSS Feed - -CREB Is Activated by the SCF/KIT Axis in a Partially ERK-Dependent Manner and Orchestrates Survival and the Induction of Immediate Early Genes in Human Skin Mast Cells

      By rss · Posted

      Int J Mol Sci. 2023 Feb 18;24(4):4135. doi: 10.3390/ijms24044135. ABSTRACT cAMP response element binding protein (CREB) functions as a prototypical stimulus-inducible transcription factor (TF) that initiates multiple cellular changes in response to activation. Despite pronounced expression in mast cells (MCs), CREB function is surprisingly ill-defined in the lineage. Skin MCs (skMCs) are critical effector cells in acute allergic and pseudo-allergic settings, and they contribute to various chronic dermatoses such as urticaria, atopic dermatitis, allergic contact dermatitis, psoriasis, prurigo, rosacea and others. Using MCs of skin origin, we demonstrate herein that CREB is rapidly phosphorylated on serine-133 upon SCF-mediated KIT dimerization. Phosphorylation initiated by the SCF/KIT axis required intrinsic KIT kinase activity and partially depended on ERK1/2, but not on other kinases such as p38, JNK, PI3K or PKA. CREB was constitutively nuclear, where phosphorylation occurred. Interestingly, ERK did not translocate to the nucleus upon SCF activation of skMCs, but a fraction was present in the nucleus at baseline, and phosphorylation was prompted in the cytoplasm and nucleus in situ. CREB was required for SCF-facilitated survival, as demonstrated with the CREB-selective inhibitor 666-15. Knock-down of CREB by RNA interference duplicated CREB's anti-apoptotic function. On comparison with other modules (PI3K, p38 and MEK/ERK), CREB was equal or more potent at survival promotion. SCF efficiently induces immediate early genes (IEGs) in skMCs (FOS, JUNB and NR4A2). We now demonstrate that CREB is an essential partaker in this induction. Collectively, the ancient TF CREB is a crucial component of skMCs, where it operates as an effector of the SCF/KIT axis, orchestrating IEG induction and lifespan. PMID:36835547 | PMC:PMC9966046 | DOI:10.3390/ijms24044135 {url} = URL to article
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      PubMed RSS Feed - -Demodicosis in Different Age Groups and Alternative Treatment Options-A Review

      By rss · Posted

      J Clin Med. 2023 Feb 19;12(4):1649. doi: 10.3390/jcm12041649. ABSTRACT Infestation with Demodex mites is a common occurrence, especially in adults and the elderly. More recent attention has been paid to the presence of Demodex spp. mites in children, even ones without comorbidities. It causes both dermatological and ophthalmological problems. The presence of Demodex spp. is often asymptomatic, thus it is suggested to include parasitological investigation tests in dermatological diagnostics, in addition to bacteriological analysis. Literature reports show that Demodex spp. are related to the pathogenesis of numerous dermatoses, including rosacea or demodicosis gravis, and common eye pathologies reported by patients such as dry eye syndrome or ocular surface inflammatory conditions, such as blepharitis, chalazia, Meibomian gland dysfunction, and keratitis. Treatment of patients is a challenge and is usually prolonged, therefore it is important to carefully diagnose and properly select the therapy regimen for the treatment to be successful, and with minimal side effects, especially for young patients. Apart from the use of essential oils, research is ongoing for new alternative preparations active against Demodex sp. Our review was focused on the analysis of the current literature data on the available agents in the treatment of demodicosis in adults and children. PMID:36836184 | PMC:PMC9961532 | DOI:10.3390/jcm12041649 {url} = URL to article
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      PubMed RSS Feed - -Efficacy and Tolerance of Oral Minocycline Combined with Photobiomodulation Therapy for Rosacea: An Evaluator-blinded Randomized, Controlled Clinical Trial

      By rss · Posted

      Photodermatol Photoimmunol Photomed. 2023 Feb 24. doi: 10.1111/phpp.12869. Online ahead of print. NO ABSTRACT PMID:36825933 | DOI:10.1111/phpp.12869 {url} = URL to article
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      PubMed RSS Feed - -Associations of adherence to Mediterranean-like diet pattern with incident rosacea: A prospective cohort study of government employees in China

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      Front Nutr. 2023 Feb 2;10:1092781. doi: 10.3389/fnut.2023.1092781. eCollection 2023. ABSTRACT BACKGROUND: Despite of growing evidence on gastrointestinal comorbidities of rosacea, there was a lack of literatures regarding the role of diet on rosacea. OBJECTIVES: To investigate the relationship between adherence to a Mediterranean-like diet pattern and the risk of incident rosacea. METHODS: This was a prospective cohort study of government employees aged >20 years conducted between January 2018 and December 2021 from five cities of Hunan province of China. At baseline, participants completed a food frequency questionnaire and participated in a skin examination. Presence of rosacea was determined by certified dermatologists. Subsequent skin examinations during follow-up were performed every one-year interval since the entry of the study. The Mediterranean diet score (MDS) was generated based on seven food groups (whole grains, red meats, fish, raw vegetables, legumes, fruits and nuts). Binary logistic regression models adjusted for potential confounders were used to estimate risks for incident rosacea. RESULTS: Of the 3,773 participants who completed at least two consecutive skin examinations, 3,496 were eligible for primary analyses. With a total follow-up of 8,668 person-years, we identified 83 incident rosacea cases. After full adjustments for covariates, the MDS was associated a decreased risk of incident rosacea (aOR: 0.84, 95% CI: 0.72, 0.99; P trend = 0.037 for 1-point increment of MDS). In subgroup analyses by body mass index (BMI), this inverse association was consistently observed in the lowest and medium tertiles of BMI (<24.5 kg/m2), but not in the highest tertile of BMI (≥24.5 kg/m2), with a significant interaction effect (P < 0.001). CONCLUSIONS: Our results suggested that adherence to a Mediterranean-like diet pattern might reduce the risk of incident rosacea among non-overweight individuals. PMID:36819686 | PMC:PMC9932686 | DOI:10.3389/fnut.2023.1092781 {url} = URL to article
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      PubMed RSS Feed - -Paroxetine is an effective treatment for refractory erythema of rosacea: primary results from the PRRERCT (Prospective Rosacea Refractory Erythema Randomized Clinical Trial)

      By rss · Posted

      J Am Acad Dermatol. 2023 Feb 15:S0190-9622(23)00197-4. doi: 10.1016/j.jaad.2023.01.044. Online ahead of print. ABSTRACT BACKGROUND: Patients with refractory erythema of rosacea have limited treatment options. OBJECTIVE: To evaluate the efficacy and safety of a 12-week course of paroxetine for moderate-to-severe erythema of rosacea. METHODS: In a multicenter, randomized, double-blinded, placebo-controlled trial, patients with refractory erythema of rosacea were randomly assigned (1:1) to receive paroxetine 25 mg daily or placebo for 12 weeks. RESULTS: Overall, 97 patients completed the study (paroxetine: 49; placebo: 48). The primary endpoint was the proportion of participants achieving Clinical Erythema Assessment (CEA) success (defined as CEA score of 0, 1 or ≥ 2-grade improvement from baseline) at week 12; this was significantly greater in the paroxetine group than in the placebo group (42.9% vs. 20.8%, P=0.02). Some secondary endpoints were met, such as flushing success with point reductions ≥2 (44.9% vs. 25.0%, p = 0.04) and improvement in overall flushing (2.49 ± 3.03 vs. 1.68 ± 2.27, P=0.047), burning sensation (46.9% vs. 18.8%, P=0.003), and depression (P=0.041). The most reported adverse events associated with paroxetine were dizziness, lethargy, nausea, dyspepsia, and muscle tremors. LIMITATIONS: Only a single-dosage regimen of paroxetine within a 12-week study was evaluated. CONCLUSION: Paroxetine is an effective and well-tolerated alternative treatment for moderate-to-severe erythema of rosacea. PMID:36806645 | DOI:10.1016/j.jaad.2023.01.044 {url} = URL to article
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      PubMed RSS Feed - -Dynamic Observation of Atypical Sporotrichosis Before and After Itraconazole Treatment by Dermoscopy

      By rss · Posted

      Clin Cosmet Investig Dermatol. 2023 Feb 3;16:339-343. doi: 10.2147/CCID.S400302. eCollection 2023. ABSTRACT Sporotrichosis is a deep fungus infection caused by the Sporothrix. In China, the most common species is Sporothrix globosa which is difficult to treat with most antifungal drugs. Atypical clinical forms of sporotrichosis can be a hinder to clinicians for an early diagnosis and treatment. We report a case of fixed cutaneous sporotrichosis of the face caused by S. globosa in a healthy adult that was initially misdiagnosed as rosacea due to its unusual clinical features. We made an effort to dermoscopically track changes in skin lesions both before and after treatment, confirming that itraconazole was effective in the treatment of sporotrichosis. PMID:36762257 | PMC:PMC9904292 | DOI:10.2147/CCID.S400302 {url} = URL to article
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      PubMed RSS Feed - -Prevalence of rosacea in transgender and gender-diverse populations: a retrospective cohort study

      By rss · Posted

      Br J Dermatol. 2023 Feb 10;188(2):304-306. doi: 10.1093/bjd/ljac041. NO ABSTRACT PMID:36763873 | DOI:10.1093/bjd/ljac041 {url} = URL to article
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      PubMed RSS Feed - -Epsolay - a benzoyl peroxide cream for rosacea

      By rss · Posted

      Med Lett Drugs Ther. 2023 Feb 6;65(1669):21-22. doi: 10.58347/tml.2023.1669c. NO ABSTRACT PMID:36757349 | DOI:10.58347/tml.2023.1669c {url} = URL to article
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      PubMed RSS Feed - -SH2 domain-containing protein tyrosine phosphatase-2 is enriched in eyelid specimens of rosacea

      By rss · Posted

      Skin Health Dis. 2022 Nov 17;3(1):e190. doi: 10.1002/ski2.190. eCollection 2023 Feb. ABSTRACT BACKGROUND: Rosacea is a cutaneous disease that may secondarily affect the ocular surface. Due to the vision threatening, cosmetic, psychological, and work productivity impact, the identification of cellular targets that govern rosacea would enhance our understanding of the biology of the disease and delineate targets for therapeutic manipulation. OBJECTIVE: To characterize the involvement of SH2 domain-containing protein tyrosine phosphatase-2 (SHP2) in the pathogenesis of rosacea. METHODS: Specimens from elective ectropion surgery (n = 20) were processed from patients with rosacea (n = 10) and control patients (n = 10). Immunohistochemistry (IHC) and quantitative western blotting (WB) were performed to identify and quantify the presence of SHP2 and 4G10 (a phosphotyrosine antibody) in rosacea compared to normal tissue. IHC samples were graded according to an intensity scale (0-4). Mann-Whitney statistical analyses were performed via a dedicated computerized software package. RESULTS: On WB, SHP2 was expressed in higher concentrations in rosacea specimens (p < 0.05). On IHC, SHP2 was enriched in the epidermis in rosacea (p < 0.05), although 4G10 levels were not statistically significantly different between the two groups (p > 0.05). CONCLUSIONS: SHP2 is enriched in cutaneous specimens of rosacea, suggesting a critical role for this protein in the disease and indicating a modifiable therapeutic moiety. PMID:36751313 | PMC:PMC9892417 | DOI:10.1002/ski2.190 {url} = URL to article
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      PubMed RSS Feed - -Correlation of rosacea with hot beverage intake

      By rss · Posted

      Skin Health Dis. 2022 Sep 8;3(1):e154. doi: 10.1002/ski2.154. eCollection 2023 Feb. ABSTRACT In this report, we correlated the incidence of rosacea with coffee (regular and decaffeinated) and tea consumption in a large cohort of middle-aged men and women living within the United Kingdom. Caffeinated coffee drinkers had lower odds for rosacea diagnosis compared to non-coffee drinkers. We hypothesize that the vasoconstrictive effects of caffeine in regular coffee overpower the vasodilatory effects associated with hot beverages and support it to be protective against rosacea. PMID:36751326 | PMC:PMC9892423 | DOI:10.1002/ski2.154 {url} = URL to article
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      PubMed RSS Feed - -A Rare Case of Demodicosis Following Treatment With Oral Fluconazole

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      Cureus. 2023 Jan 3;15(1):e33309. doi: 10.7759/cureus.33309. eCollection 2023 Jan. ABSTRACT Demodex folliculorum and Demodex brevis are commensal human ectoparasites that reside within or near hair follicles and have been highly associated with rosacea-like papulopustular skin eruptions. We present an interesting case of recurrent, iatrogenic demodicosis in a 56-year-old man. We suspect this to have been triggered by antifungal therapy given it occurred twice closely following azole treatment. We propose that oral antifungals in the setting of immunosuppression can alter the skin microbiome, facilitating Demodex proliferation. PMID:36741596 | PMC:PMC9894334 | DOI:10.7759/cureus.33309 {url} = URL to article
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      PubMed RSS Feed - -Interleukin-18 and IL-18BP in inflammatory dermatological diseases

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      Front Immunol. 2023 Jan 18;14:955369. doi: 10.3389/fimmu.2023.955369. eCollection 2023. ABSTRACT Interleukin (IL)-18, an interferon-γ inducer, belongs to the IL-1 family of pleiotropic pro-inflammatory factors, and IL-18 binding protein (IL-18BP) is a native antagonist of IL-18 in vivo, regulating its activity. Moreover, IL-18 exerts an influential function in host innate and adaptive immunity, and IL-18BP has elevated levels of interferon-γ in diverse cells, suggesting that IL-18BP is a negative feedback inhibitor of IL-18-mediated immunity. Similar to IL-1β, the IL-18 cytokine is produced as an indolent precursor that requires further processing into an active cytokine by caspase-1 and mediating downstream signaling pathways through MyD88. IL-18 has been implicated to play a role in psoriasis, atopic dermatitis, rosacea, and bullous pemphigoid in human inflammatory skin diseases. Currently, IL-18BP is less explored in treating inflammatory skin diseases, while IL-18BP is being tested in clinical trials for other diseases. Thereby, IL-18BP is a prospective therapeutic target. PMID:36742296 | PMC:PMC9889989 | DOI:10.3389/fimmu.2023.955369 {url} = URL to article
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      PubMed RSS Feed - -Quality of life measurement in rosacea. Position statement of the European Academy of Dermatology and Venereology Task Forces on Quality of Life and Patient Oriented Outcomes and Acne, Rosacea and Hidradenitis Suppurativa

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      J Eur Acad Dermatol Venereol. 2023 Feb 6. doi: 10.1111/jdv.18918. Online ahead of print. ABSTRACT The European Academy of Dermatology and Venereology (EADV) Task Forces (TFs) on Quality of Life (QoL) and Patient-Oriented Outcomes and Acne, Rosacea and Hidradenitis Suppurativa (ARHS) do not recommend the use of any generic instrument as a single method of Health Related (HR) QoL assessment in rosacea, except when comparing quimp (quality of life impairment) in rosacea patients with that in other non-dermatologic skin diseases and/or healthy controls. The EADV TFs on QoL and Patient-Oriented Outcomes and ARHS recommend the use of the dermatology-specific HRQoL instrument the Dermatology Life Quality Index (DLQI) and the rosacea-specific HRQoL instrument RosaQoL in rosacea patients. The DLQI minimal clinically important difference may be used as a marker of clinical efficacy of the treatment and DLQI score banding of 0 or 1 corresponding to no effect on patients' HRQoL could be an important treatment goal. This information may be added to consensuses and guidelines for rosacea. PMID:36744752 | DOI:10.1111/jdv.18918 {url} = URL to article
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      PubMed RSS Feed - -Supplement Individual Article: The Importance of a Healthy Skin Barrier From the Cradle to the Grave Using Ceramide-Containing Cleansers and Moisturizers: A Review and Consensus

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      J Drugs Dermatol. 2023 Feb 1;22(2):SF344607s3-SF344607s14. ABSTRACT INTRODUCTION: Inflammatory skin disorders compromise skin barrier health. Early and daily skincare use aims to maintain a life-long healthy skin barrier. Racial/ethnic and age variations in skin barrier properties, cultural differences, and clinical presentation of the inflammatory skin disorder influence the choice of treatment and skin care. Ceramide-containing skin care may play a role in restoring and maintaining a healthy skin barrier. METHODS: A panel of 6 dermatologists met to develop consensus statements based on their 8 previous publications on promoting skin barrier health throughout life using ceramide-containing skin care. The publications covered skin barrier integrity in the newborn and infant, and the role of the skin barrier in mitigating atopic dermatitis (AD); racial/ethnic variations in the skin barrier and implications for skin care; the role of the skin barrier in inflammatory skin conditions including acne, AD and psoriasis in skin of color (SOC) populations; skin barrier integrity in patients with rosacea; and xerosis in patients with diabetes mellitus. The panel synthesized the 8 publications, selected information from a literature review, and their expert opinions and experiences to create the statements. The consensus was reached through a modified Delphi method where the panel met face-to-face and followed up virtually. RESULTS: The panel adopted 6 consensus statements highlighting the importance of skin care in restoring/maintaining a healthy skin barrier in the populations mentioned above. Skin care suited to this role is gentle, has near-physiologic pH, is pleasant to use, and contains ceramides. This type of skin care can promote a healthy skin barrier and attenuate or delay inflammatory skin conditions. CONCLUSIONS: Adjunctive daily skin care throughout life promotes a healthy skin barrier and is beneficial in managing various inflammatory skin disorders in all populations. However, when choosing optimal treatment and skin care, physicians should consider variations in age, skin properties, presentation of the condition, and cultural differences. J Drugs Dermatol. 2023;22:2(Suppl 1):s3-14. PMID:36745380 {url} = URL to article
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      PubMed RSS Feed - -Trace element zinc and skin disorders

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      Front Med (Lausanne). 2023 Jan 17;9:1093868. doi: 10.3389/fmed.2022.1093868. eCollection 2022. ABSTRACT Zinc is a necessary trace element and an important constituent of proteins and other biological molecules. It has many biological functions, including antioxidant, skin and mucous membrane integrity maintenance, and the promotion of various enzymatic and transcriptional responses. The skin contains the third most zinc in the organism. Zinc deficiency can lead to a range of skin diseases. Except for acrodermatitis enteropathic, a rare genetic zinc deficiency, it has also been reported in other diseases. In recent years, zinc supplementation has been widely used for various skin conditions, including infectious diseases (viral warts, genital herpes, cutaneous leishmaniasis, leprosy), inflammatory diseases (hidradenitis suppurativa, acne vulgaris, rosacea, eczematous dermatitis, seborrheic dermatitis, psoriasis, Behcet's disease, oral lichen planus), pigmentary diseases (vitiligo, melasma), tumor-associated diseases (basal cell carcinoma), endocrine and metabolic diseases (necrolytic migratory erythema, necrolytic acral erythema), hair diseases (alopecia), and so on. We reviewed the literature on zinc application in dermatology to provide references for better use. PMID:36733937 | PMC:PMC9887131 | DOI:10.3389/fmed.2022.1093868 {url} = URL to article
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      PubMed RSS Feed - -Two Alternative Approaches to "Treating Severe Rhinophyma: A Stepwise Approach"

      By rss · Posted

      Dermatol Surg. 2023 Feb 1;49(2):208-209. doi: 10.1097/DSS.0000000000003686. Epub 2023 Jan 18. ABSTRACT Supplemental Digital Content is Available in the Text. PMID:36728072 | PMC:PMC9891264 | DOI:10.1097/DSS.0000000000003686 {url} = URL to article
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      PubMed RSS Feed - -Successful Treatment of Minocycline-Induced Facial Hyperpigmentation with a Combination of Chemical Peels and Intense Pulsed Light

      By rss · Posted

      Clin Cosmet Investig Dermatol. 2023 Jan 26;16:253-256. doi: 10.2147/CCID.S394754. eCollection 2023. ABSTRACT Minocycline is a tetracycline derivative antibiotic commonly used to treat acne, rosacea, and other inflammatory skin conditions. Taking minocycline risks inducing skin pigmentation. If minocycline-induced hyperpigmentation is not treated, it may take months to years for the symptoms to subside after discontinuation of the drug, or the hyperpigmentation may never disappear completely, which can lead to cosmetic anxiety and affect people's quality of life. Previous treatment options for hyperpigmentation were mainly q-switched nd: YAG, ruby, and alexandrite lasers. This article reports a case of facial hyperpigmentation caused by minocycline using a combination of chemical peel and intense pulsed light in a patient with eosinophilic cellulitis (Wells syndrome) who was taking oral minocycline. This case suggests combining chemical peel and intense pulsed light is an effective treatment option for minocycline-induced hyperpigmentation. PMID:36726812 | PMC:PMC9885878 | DOI:10.2147/CCID.S394754 {url} = URL to article
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      PubMed RSS Feed - -A Randomized, Controlled Clinical Trial of a Dermocosmetic Containing Vichy Volcanic Mineralizing Water and Probiotic Fractions in Subjects with Rosacea Associated with Erythema and Sensitive Skin and Wearing Protective Masks

      By rss · Posted

      Clin Cosmet Investig Dermatol. 2023 Jan 11;16:71-77. doi: 10.2147/CCID.S391893. eCollection 2023. ABSTRACT PURPOSE: Rosacea is a common facial dermatosis, with flares induced by exposome factors. M89PF containing Vichy mineralizing water, probiotic fractions, hyaluronic acid, niacinamide and tocopherol repairs the skin barrier and reinforces skin defences against exposome factors. This study assessed the benefit of M89PF in subjects with rosacea associated with erythema and sensitive skin during the Covid-19 pandemic using protective face masks. METHODS: M89PF was compared to usual skin care in a randomized, split-face study, for 30 days in subjects with rosacea associated with erythema and sensitive skin. Clinical evaluations included erythema, desquamation, skin tightness, dryness, burning sensation, itching, stinging, stinging test, and local tolerability. Instrument evaluations included erythema, skin hydration and TEWL. Subject satisfaction was also assessed. RESULTS: Erythema significantly improved with M89PF at both time points (p<0.01 at D15, and p<0.001 at D30). Skin sensitivity assessed by the skin stinging test improved significantly (p<0.01) with M89PF at D30, compared to baseline and usual skin care. Skin erythema, tightness, dryness, hydration and TEWL significantly improved (p≤0.05) with M89PF at D15 and D30, versus baseline and the untreated side. Subjects were highly satisfied with M89PF at D15 and D30. Tolerance was very good in all subjects. CONCLUSION: In subjects with rosacea, M89PF significantly reduces erythema, skin tightness, dryness and TEWL, and improves skin hydration and skin sensitivity, even when using protective masks. M89PF is well tolerated and received high satisfaction ratings. CLINICALTRIALSGOV NO: NCT05562661. PMID:36660190 | PMC:PMC9843703 | DOI:10.2147/CCID.S391893 {url} = URL to article
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      PubMed RSS Feed - -Perception of accountability decreases with age: observations from a clinical study of patients with rosacea

      By rss · Posted

      Arch Dermatol Res. 2023 Jan 18. doi: 10.1007/s00403-023-02531-7. Online ahead of print. ABSTRACT Patient adherence to medications usually increases with age, however, it can also be impacted by other factors. Accountability is a psychosocial construct that is defined as the expectation for an individual to account for their actions. Accountability may also influence patients' motivation to adhere to their treatments. We assessed the relationship between age and perception of accountability as well as efficacy of interventions to improve accountability in a clinical study of 30 rosacea patients. Accountability was assessed using the validated Accountability Measurement Tool. Interventions to improve accountability included a digital interaction group and a digital skin analysis group. All patients were given ivermectin cream 1% and informed to apply it daily for 3-months. There was a negative association between age and AMT scores in all intervention groups, including the control group. Younger patients have a baseline greater perception of accountability that responded more to our interventions. PMID:36652005 | DOI:10.1007/s00403-023-02531-7 {url} = URL to article

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