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    • As a medical assistant for a dermatologist I worry about the added fragrance in the baby shampoo causing further irritation. 
    • I work as a medical assistant for a dermatologist. I definitely think it is a possibility for rosacea to through periods of remissions and flare-ups. This can be due to environmental factors as well as psychological factors. 
    • Related Articles Symptomatic vulvar demodicosis: A case report and review of the literature. J Cutan Pathol. 2020 Nov;47(11):1063-1066 Authors: Hedberg ML, Chibnall RJ, Compton LA Abstract Demodex folliculorum is a mite that commonly inhabits the pilosebaceous units of facial skin, particularly in a perioral and periorbital distribution. While typically an incidental and asymptomatic parasite, Demodex spp. are proposed to contribute to the pathogenesis of facial folliculitis, chronic blepharitis and papulopustular rosacea. Reports of demodicosis in anatomic locations other than the face are exceedingly rare. Here we report a 36-year-old woman with symptomatic Demodex spp. infestation of Fordyce spots of the labia minora. She was referred to dermatology after a 9-month history of tender red bumps on the vulva that would arise and drain over a 24 to 72 hours period, several times per week. Physical examination revealed erythema of the labia minora and introitus with a 4 mm, pink, dome-shaped soft papule on the left labium minus. Wet mount, microbiologic cultures and sexually transmitted infection (STI) screenings were unremarkable. Histopathologic examination revealed a well-circumscribed nodule of suppurative granulomatous inflammation arising in a background of mucosa with Fordyce spots, the majority of which were infiltrated by Demodex spp. Treatment with oral ivermectin and topical metronidazole cream resulted in a symptom-free period of 22 months. This case represents an unusual presentation of symptomatic Demodex infestation. PMID: 33448447 [PubMed - in process] {url} = URL to article More information on oral ivermectin
    • This question has come up at RF whether Finasteride or Minoxidil causes flushing or may be a rosacea trigger and you may be interested in knowing that apparently there isn't any consensus on this and these two drugs haven't been listed on any rosacea trigger list as far as we know. If you have anything to add to this or your experience using either of these treatments with your rosacea, please find the reply to topic button.  For more information 
    • Related ArticlesResolution of Refractory Corneal Neovascularization with Subconjunctival Bevacizumab. Case Rep Ophthalmol. 2020 Sep-Dec;11(3):652-657 Authors: Britton AK, Crayford BB Abstract Corneal neovascularization (CNV) has a variety of causes and threatens corneal clarity, thus optimal visual acuity. Conventional medical management includes topical steroids and matrix metalloproteinase inhibitors like doxycycline. Anti-vascular endothelial growth factor (anti-VEGF) agents have demonstrated promise but remain off-label for this indication. However, these agents hold value in cases refractory to first-line medical management. We report the case of a 63-year-old woman who presented with ocular rosacea and CNV affecting vision, on a background of acne rosacea. She was initially treated with fluorometholone and doxycycline, yet continued to deteriorate. Eventually she received two 1.5-mg subconjunctival injections of bevacizumab 2 months apart. CNV completely resolved and results were maintained at 4-year follow-up. This case demonstrates that refractory CNV can be effectively treated with subconjunctival injection of anti-VEGF bevacizumab. The resolution of CNV was also maintained years after injection with minimal adjunctive therapy during this period, and to our knowledge there are no other studies reporting a follow-up period of 4 years after treatment. This is a pertinent case for other clinicians treating patients in a similar situation. PMID: 33442379 [PubMed] {url} = URL to article
    • We have a new video, Welcome to the RRDi Official Website found on our WELCOME PAGE for rosacea newbies.  
    • Related ArticlesThe association of photo-induced collagen degeneration and the development of telangiectasias in rosacea. J Anat. 2021 Jan 11;: Authors: Thompson KG, Rainer BM, Leung S, Qi J, Kang S, Chien AL Abstract Rosacea is a chronic, often progressive disorder characterized by facial erythema, telangiectasias, papules, pustules, and/or rhinophyma. In this study, we investigated the tissue structure in rosacea compared to controls. We performed a case-control study between five patients with mild-to-moderate erythematotelangiectatic rosacea (ETR) and five matched controls. Facial biopsy samples from rosacea patients and controls were stained with picrosirius red for collagen and CD31 for microvessel identification. Mean collagen content was significantly greater in control samples (19.603% ±8.821%) compared to rosacea samples (16.812% ± 7.787%, p = 0.030). In contrast, mean microvessel density was significantly higher in rosacea patients (4.775 E-5 ± 1.493 E-5 µm-3 ) compared to controls (2.559 E-5 ± 8.732 E-6 µm-3 , p = 0.004). Mean microvessel lumen area was also significantly higher in rosacea patients (491.710 ± 610.188 µm2 ) compared to controls (347.879 ± 539.624 µm2 , p = 0.003). We identified a correlation between decreased collagen content and increased microvessel size and density in rosacea patients that was not observed in controls. These structural changes to the dermal matrix may contribute to the characteristic vessel growth and dilation in rosacea. PMID: 33432575 [PubMed - as supplied by publisher] {url} = URL to article
    • Gladskin makes a cream or gel for rosacea that is available in the UK on Amazon. The RRDi doesn't have an affiliate relationship with Amazon UK but in the the spirit of 'everything rosacea' we would hope rosaceans in the UK would let us know about this treatment and find the reply to topic button to report if they have success using this cream or gel. The USA Gladskin website doesn't mention this treatment. The Gladskin UK website has more information as well as the following video:  Ingredients Aqua, Propylene glycol, Hydroxypropyl methylcellulose, Glycerin, Arginine HCl, Sodium chloride, Trometamol, Staphefekt™ SA.100 C2.4, Calcium chloride. Reply to this Topic There is a reply to this topic button somewhere on the device you are reading this post. If you never heard about this topic and you learned about it here first, wouldn't it be a gracious act on your part to show your appreciation for this topic by registering with just your email address and show your appreciation with a post?  And if registering is too much to ask, could you post your appreciation for this topic by finding the START NEW TOPIC button in our guest forum where you don't have to register?  We know how many have viewed this topic because our forum software shows the number of views. However, most rosaceans don't engage or show their appreciation for our website and the RRDi would simply ask that you show your appreciation, please, simply by a post.  
    • Related ArticlesChildhood granulomatous periorificial dermatitis: case report and review of the literature. Dermatol Online J. 2020 Dec 15;26(12): Authors: Fakih A, Makhoul R, Grozdev I Abstract Childhood granulomatous periorificial dermatitis (CGPD), considered a clinical variant of perioral dermatitis, typically affects prepubertal children of African descent. It is a condition of unknown etiology characterized by the presence of a monomorphic yellow-brown papular eruption limited to the perioral, perinasal, and periocular regions that histopathologically shows a granulomatous pattern. This disorder should be differentiated from other conditions as granulomatous rosacea, sarcoidosis, and lupus miliaris disseminatus faciei. We report a case of a 9-year-old boy who presented with flesh-colored perorificial papules on the face, evolving for two months. Upon treatment with topical tacrolimus for follicular eczema, an aggravation of the condition was observed. A skin biopsy confirmed the diagnosis of CGPD. Our patient was successfully treated with a combination of topical metronidazole and topical erythromycin. PMID: 33423420 [PubMed - in process] {url} = URL to article
    • Related Articles Facial and neck erythema associated with dupilumab treatment: A systematic review. J Am Acad Dermatol. 2021 Jan 08;: Authors: Jo CE, Finstad A, Georgakopoulos JR, Piguet V, Yeung J, Drucker AM Abstract BACKGROUND: Dupilumab-associated facial and/or neck erythema was not reported in phase 3 clinical trials for the treatment of atopic dermatitis, but there have been a number of reports of patients developing this adverse event in clinical practice. OBJECTIVE: To outline all cases of reported dupilumab-associated facial and/or neck erythema to better characterize this adverse event, identify potential etiologies and management strategies. METHODS: A search was conducted on EMBASE and PubMed databases. Two independent reviewers identified relevant studies for inclusion and performed data extraction. RESULTS: A total of 101 patients from 16 studies were reported to have dupilumab-associated facial and/or neck erythema. 52/101 (52%) had baseline atopic dermatitis facial and/or neck involvement and 45/101 (45%) reported different cutaneous symptoms from pre-existing atopic dermatitis, possibly suggesting a different etiology. Suggested etiologies included rosacea, allergic contact dermatitis, and head and neck dermatitis. Most commonly used treatments included topical corticosteroids, topical calcineurin inhibitors, and antifungal agents. In the 57 patients with data on the course of the AE, improvement was seen in 29, clearance in 4, no response in 16, and worsening in 8 patients. 11/101 (11%) discontinued dupilumab due to this adverse event. LIMITATIONS: Limited diagnostic testing, non-standardized data collection and reporting across studies, and reliance on retrospective case reports and case series. CONCLUSION: Some patients on dupilumab develop facial and/or neck erythema which differs from their usual atopic dermatitis symptoms. Prompt identification and empiric treatment may minimize distress and potential discontinuation of dupilumab due to this adverse event. PMID: 33428978 [PubMed - as supplied by publisher] {url} = URL to article More information on dupilumab
    • Related Articles Minocycline foam (Zilxi) for rosacea. Med Lett Drugs Ther. 2020 Nov 16;62(1611):179-180 Authors: PMID: 33429414 [PubMed - as supplied by publisher] {url} = URL to article More information on Zilxi
    • There are many encouraging stories of people who've healed their rosacea by addressing the underlying causes. One of those is often NOT diet, nutrition, toxins, but emotions such as anger and resentment. In Chinese medicine, these emotions live in the liver and spleen, often the organs related to rosacea. I have teamed up with a holistic life coach who has had tremendous success helping people heal physical ailments by addressing the emotional component behind the ailment. Together we have created a 7-week coaching program for rosacea healing, where we discuss the underlying causes of rosacea. Our next session starts February 10th 2021. For more info, please see RECLAIM ROSACEA PROGRAM - Journey To Glow.
    • Demodex Solutions, one of our sponsors, has graciously allowed us to award a free jar of the ZZ Cream to the best poster on our website each month. If you are the best poster of the month, you will receive a free jar of the ZZ Cream shipped to your address. So start posting!!! You have till the end of the month and someone will be awarded as the best poster and will be announced who the monthly winner is by clicking here if you want to know who the best poster is for the month. 
    • Related ArticlesAntibiomania: A Rare Case of Metronidazole-Induced Mania. Cureus. 2021 Jan 01;13(1):e12414 Authors: Puri P, Parnami P, Chitkara A, Athwal PSS, Khetrapal S Abstract Metronidazole is a very commonly used drug for the treatment of ailments caused by bacteria and parasites. It can treat a vast array of conditions like rosacea, sexually transmitted diseases (STDs), liver abscess, bedsores, etc. Metronidazole comes with generic side-effects like nausea, vomiting, dizziness, metallic taste, and also rare side-effects like paresthesia, syncope, cerebellar symptoms, psychosis but mania is a rare side-effect. Here, we present a case of metronidazole induced mania in a 50-year-old male with no past medical history who initially presented with a complaint of mild fever, loss of appetite, and fatigue from the past 10-12 days. On further examination and investigations, diagnosis of the amebic liver abscess was made on the basis of USG, serum serology for amebiasis IgG, and a CT scan. Consequently, the patient was started on the drug of choice for amebic liver abscess; IV metronidazole 1.5g/day divided over the day into three doses. Other drugs that were administered were pantoprazole, paracetamol, and ondansetron. On the ninth day of admission, the patient's wife as well as the physician-daughter of the patient reported a change in the behavior of the patient which became a major concern for the family. The patient was restless, energetic, unable to sleep, had racing thoughts, elated mood, petulant, and kept singing loudly in the private patient room. There was no history of any psychiatric illness in the family. Mr. K´s manic symptoms were managed using haloperidol and lorazepam. Upon discontinuing metronidazole, there was a gradual improvement in the manic symptoms, and symptoms improved, haloperidol and lorazepam were able to be tapered down and eventually stopped. Mr. K did not require any use of any selective serotonin reuptake inhibitor (SSRIs), monoamine oxidase inhibitors (MAOIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), or any other atypical psychotropic drug. Manic-psychosis side-effect is a rare entity caused by antibiotics and the symptoms of which would disappear in a few days after stopping the antibiotic. It is also notable that this patient recovered without the use of any psychotropic drugs. Physicians should be aware of the possible neuropsychiatric side-effects of antibiotics which can lead to unnecessary workup. This side-effect did not require the use of any psychotropic drugs in this patient. PMID: 33409111 [PubMed] {url} = URL to article
    • Related Articles Rhinophyma in women: a case series. Lasers Med Sci. 2021 Jan 07;: Authors: Ismail D, Asfour L, Madan V Abstract Rosacea has an overall female predominance; however, rhinophyma, a feature attributed to advanced rosacea, is exceedingly rare in females. The impact of this condition on quality of life can be profound. Multiple treatment modalities have been described. However fully ablative carbon dioxide (CO2) laser for moderate-severe rhinophyma has been shown to be most effective with good cosmetic outcome and high patient satisfaction. We describe a series of 7 female patients presenting with rhinophyma to a tertiary NHS laser centre and a private dermatology clinic. A retrospective case review of rhinophyma management was performed, assessing presentation, treatments and outcomes. The mean age at presentation was 47 years (27-62 years). Three patients developed rhinophyma before the age of 30 years. One patient had severe, 2 patients had moderate and 4 patients had minor rhinophyma. Four patients underwent fractional CO2 laser treatment with a good cosmetic outcome. Two further patients developed scarring following fully ablative CO2 laser. Long-term low-dose oral isotretinoin was used in 3 patients following laser treatment, to prevent relapse. One patient solely received isotretinoin with a good outcome. In our experience, females suffering with rhinophyma presented for treatment at an early age and stage of severity. Fractional or fully ablative CO2 laser alone or in combination with oral isotretinoin is a very effective treatment modality. PMID: 33411129 [PubMed - as supplied by publisher] {url} = URL to article Reply to this TopicThere is a reply to this topic button somewhere on the device you are reading this post. If you never heard about this topic and you learned about it here first, wouldn't it be a gracious act on your part to show your appreciation for this topic by registering with just your email address and show your appreciation with a post?  And if registering is too much to ask, could you post your appreciation for this topic by finding the START NEW TOPIC button in our guest forum where you don't have to register?  We know how many have viewed this topic because our forum software shows the number of views. However, most rosaceans don't engage or show their appreciation for our website and the RRDi would simply ask that you show your appreciation, please, simply by a post.  
    • Thanks Apurva.  We have a little more than $300 left in the bank which may keep us going for a few months. I can't keep this non profit organization going by myself and have devoted a huge number of volunteer hours keeping this non profit organization legal to keep our IRS exempt status going which means donating to the RRDi is tax deductible. Keeping a non profit organization exempt, legal and active requires many volunteer hours. As you mentioned, we know that thousands visit our website each month and obviously take away huge amounts of rosacea treatment data which the amount on our website is significant since it reflects over seventeen years of rosacea research data to help rosaceans control their rosacea. It would be a simple gesture of appreciation if just half the members would donate ONE DOLLAR using the PayPal Giving Fund and that would keep us going probably for a year. That is less than the cost of a cup of coffee. 
    • Apurva,  Thanks for your post. Sure hope you are not having any Covid 19 repurcussions or other health issues. Thank God you are ok and got through your illness. Sorry your rosacea flamed up during your stressful period which without a doubt added to your illness. Keep us informed of any other issues you may experience and update us using this thread.  
    • Hii everyone, I want to share my experience with you. I was corona positive last month and what was interesting is I had mild symptoms of corona and I got perfectly fit after 3 to 4 days but then I realized that I have lost my sense of smell and taste and it lasted one month and then now I am regaining slowly and after all these chaos I found that my rosacea had become more aggressive and covered almost my entire face. Blood vessels became dilated and torn and big red blotches were visible and I could not understand why this corona had this big impact on my rosacea and this aggressive effect left my skin like a peel but then I cured it slowly with mild scrubbing and gut cleaning and with healthy food. So I experienced that corona has its impact on rosacea.
    • Hello Rosaceans, if you can donate some money to our non-profit organization it would propel us to post more matter on this topic. I know that many rosaceans view our site, read each and every material, gain knowledge from this site which you will never find anywhere on other rosacea website but you never appreciate us giving some donation money. We keep asking members for some donation but I think its all throwing stone in water and admin has already declared that if we don't get money he will close the organization and then where will you read such good material from? think on this.
    • Related ArticlesOcular manifestations of rosacea: A clinical review. Clin Exp Ophthalmol. 2021 Jan 06;: Authors: Tavassoli S, Wong N, Chan E Abstract Ocular rosacea is a chronic inflammatory condition that can occur in the absence of cutaneous features. The most common ocular features are chronic blepharoconjunctivitis with eyelid margin inflammation, and meibomian gland dysfunction. Corneal complications include corneal vascularisation, ulceration, scarring and, rarely, perforation. Diagnosis is largely based on clinical signs, although it is often delayed in the absence of cutaneous changes, particularly in children. It can also be associated with systemic disorders such as cardiovascular disease. Management ranges from local therapy to systemic treatment, depending on the severity of the disease. In this review, we describe the epidemiology, pathophysiology, clinical features and treatment of rosacea and ocular rosacea. PMID: 33403718 [PubMed - as supplied by publisher] {url} = URL to article
    • Pediatric Demodicosis Associated with Gain-of-Function Variant in STAT1 Presenting as Rosacea-Type Rash. J Clin Immunol. 2021 Jan 06;: Authors: Baghad B, El Fatoiki FZ, Benhsaien I, Bousfiha AA, Puel A, Migaud M, Chiheb S, Ailal F PMID: 33404972 [PubMed - as supplied by publisher] {url} = URL to article
    • Association between Rosacea and Smoking: A Systematic Review and Meta-Analysis. Dermatol Ther. 2021 Jan 06;:e14747 Authors: Yuan X, Yin D Abstract Rosacea is a chronic inflammatory disease of the centrofacial region. However, the association between rosacea and smoking remains controversial. To evaluate the association between rosacea and smoking, we performed a systematic review and meta-analysis. A comprehensive systematic search of literature published before October 15, 2020 on online databases (including Web of Science, PubMed, Cochrane Library, and Embase) was performed. The pooled odds ratios (ORs) were calculated. Twelve articles were included, covering 80 156 controls and 54 132 patients with rosacea. Tobacco consumption was not found to increase the risk of rosacea. However, using subtype analysis (involving five articles), we found there was a decreased risk of rosacea in current smokers but an increased risk in ex-smokers. In addition, smoking appears to increase the risk of papulopustular rosacea (PPR) and phymatous rosacea (PhR). Analysis of all included studies also showed that ex-smoking was associated with an increased risk, while current smoking was associated with a reduced risk of rosacea. In order to prevent many diseases, including rosacea, the public should be encouraged to avoid smoking. This article is protected by copyright. All rights reserved. PMID: 33406295 [PubMed - as supplied by publisher] {url} = URL to article Other Systemic Cormorbidities in Rosacea Image courtesy of Wikimedia Commons
    • Related ArticlesOcular manifestations of dermatological diseases part I: infectious and inflammatory disorders. Int J Dermatol. 2021 Jan;60(1):5-11 Authors: Al Akrash LS, Al Semari MA, Al Harithy R Abstract Skin and eyes share a common embryological origin from the embryonic surface ectoderm. Ocular manifestations are one of the most important and common associations of dermatological diseases. Currently, there are few comprehensive reviews of the ocular manifestations of dermatological diseases. We have reviewed more than 40 published articles related to the ocular manifestations of the most important dermatological diseases. The search included Pubmed, Google Scholar, and Cochrane databases from 2014 to 2019. This review was divided into three parts including infections, inflammatory, genetics, connective tissue, autoimmune, neoplasms, and drug-related disorders. We excluded metabolic, endocrine, and nutrition-related dermatological diseases. The relationship of ocular manifestations and dermatological diseases is important to recognize for appropriate management since many dermatological diseases can manifest initially with ocular findings. In this part, we summarized the most common and significant ocular findings in infectious and inflammatory dermatological disorders with appropriate referral recommendations to ophthalmology. PMID: 33232519 [PubMed - indexed for MEDLINE] {url} = URL to article
    • Related ArticlesSuccessful Treatment of Periorificial Dermatitis With Novel Narrow Spectrum Sarecycline. J Drugs Dermatol. 2021 Jan 01;20(1):98-100 Authors: Graber E, Kay CR Abstract Broad spectrum tetracyclines are a well-known, widely used, and often successful treatment for use in inflammatory skin pathologies such as acne and rosacea. However, the steady rise of antibiotic resistance and gut dysbiosis associated with broad spectrum tetracyclines emphasizes the importance and responsibility of antibiotic stewardship. Narrow spectrum antibiotics have become increasingly important therapies to slow the progression of resistance as well as decrease negative side effect profiles, particularly those associated with broad spectrum tetracyclines. This case shows the successful treatment of periorificial dermatitis with a novel, narrow spectrum tetracycline, sarecycline, in a patient with underlying Crohn’s. J Drugs Dermatol. 2021;20(1):98-100. doi:10.36849/JDD.2021.5678. PMID: 33400418 [PubMed - as supplied by publisher] {url} = URL to article
    • Related Articles Cinnamtannin B1 attenuates rosacea-like signs via inhibition of pro-inflammatory cytokine production and down-regulation of the MAPK pathway. PeerJ. 2020;8:e10548 Authors: Kan HL, Wang CC, Cheng YH, Yang CL, Chang HS, Chen IS, Lin YC Abstract Background: Rosacea is a common inflammatory disease of facial skin. Dysregulation of innate immunity with enhanced inflammation and increased abundance of LL-37 at the epidermal site is a characteristic feature of rosacea. Cinnamtannin B1 (CB1) is a condensed tannin with anti-inflammatory and anti-microbial activities. The aims of the study were to evaluate the potential of CB1 as a therapy for rosacea and to characterize the potential mechanisms of action. Methods: We intraperitoneally administered 20 mg/kg CB1 once daily for 2 days into the LL-37-induced mouse model of rosacea. The effects of CB1 in vivo were evaluated by the observations of lesions, histology, immunohistochemistry, and the transcription and translation of pro-inflammatory cytokines and chemokines. Human keratinocyte HaCaT and monocyte THP-1 were used to characterize the effects of CB1 on LL-37-induced inflammation in vitro. The changes in pro-inflammatory chemokine interleukin-8 (IL-8) were quantitated by enzyme-linked immunosorbent assay (ELISA), and the expressions of genes involved were determined by Western blotting. Results: CB1 attenuated local redness, inflammation, and neutrophil recruitment in the mouse model of rosacea in vivo. CB1 suppressed myeloperoxidase (MPO) and macrophage inflammatory protein 2 (MIP-2) production, a functional homolog of interleukin-8 (IL-8), at the lesions. In vitro experiments confirmed that CB1 reversed the LL-37-induced IL-8 production in human keratinocytes HaCaT and monocyte THP-1 cells. CB1 inhibited IL-8 production through downregulating the phosphorylation of extracellular signal-regulated kinase (ERK) in the mitogen-activated protein kinase (MAPK) pathway. Conclusion: CB1 attenuated LL-37-induced inflammation, specifically IL-8 production, through inhibiting the phosphorylation of ERK. CB1 has potential as a treatment for rosacea. PMID: 33391878 [PubMed] {url} = URL to article More information on Cathelicidin Peptide LL-37 and Vitamin D3
    • Related Articles The Effect of Volatile Oil from Chinese Mugwort Leaf on Human Demodecid Mites In Vitro. Acta Parasitol. 2021 Jan 04;: Authors: Du J, Gao R, Zhao J Abstract BACKGROUND: Human demodecid mites including Demodex folliculorum and Demodex brevis Akbulatova can cause acne, rosacea, epifolliculitis, blepharitis, seborrheic dermatitis, perioral dermatitis, acromastitis and such skin health problems. Artemisia (Composiate) are widely distributed in temperate regions in the northern hemisphere. It has been reported that 17 species of plants in Artemisia used to be mugwort in China. Mugwort volatile oil (MVO) has antibacterial and antiviral effects, can relieve cough and asthma, acts as an expectorant, choleretic and sedative, and promotes circulation and enhances immunity. PURPOSE: This research was to observe the effect of MVO on two types of human demodecid mites in vitro. METHODS: The MVO was obtained via the supercritical CO2 extraction method, and the human demodecid mites were acquired with cellophane tape. MVO had a distinct killing effect on two types of human demodecid mites, Demodex folliculorum and Demodex brevis. The body of the demodecid mites has a classical temporal process, which consists of excitement, contractions, death and transparency. The killing time was lengthened with decreasing concentration, thus showing an evident dependence on concentration. RESULTS: The experiment showed that 3.125% was the minimum effective concentration of MVO for killing D. brevis, and 6.25% was the minimum effective concentration for killing D. folliculorum; the killing effect of MVO on D. brevis was greater than on D. follilorum. CONCLUSION: This result suggests that mugwort, which acts as a traditional Chinese herbal medicine, has a noticeable killing effect on human demodecid mites. PMID: 33394383 [PubMed - as supplied by publisher] Image courtesy of Wikimedia Commons {url} = URL to article Reply to this Topic There is a reply to this topic button somewhere on the device you are reading this post. If you never heard about this topic and you learned about it here first, wouldn't it be a gracious act on your part to show your appreciation for this topic by registering with just your email address and show your appreciation with a post?  And if registering is too much to ask, could you post your appreciation for this topic by finding the START NEW TOPIC button in our guest forum where you don't have to register?  We know how many have viewed this topic because our forum software shows the number of views. However, most rosaceans don't engage or show their appreciation for our website and the RRDi would simply ask that you show your appreciation, please, simply by a post.  
    • “Many types of non-501(c)(3) tax-exempt organizations including social welfare organizations, business leagues and trade associations, social clubs, voluntary employees’ beneficiary associations, cemetery companies, and veterans’ organizations, among others, are prohibited, by statute, from allowing inurement of net earnings or assets of the organization to benefit any insider. An insider is a person who has a personal or private interest in the activities of the organization such as an officer, director, or a key employee. An example of prohibited inurement would include payment of unreasonable compensation to an insider.” Private Benefit and Inurement, Page 5, Compliance Guide for Tax-Exempt Organizations From 1998 thru 2019 the NRS has received in donations/revenue  $15.5 million and spent over $10 million (65%) on private contractors owned by Sam Huff who serves on the board of directors of the NRS.  During this same period the NRS spent less than 10% of the revenue on rosacea research. For details on the math for this period click here. What do you think?  Sam Huff has served on the board of directors of the NRS for over twenty years. The NRS has spent over 60% of the majority of the donations/revenue received during this period on two private contractors owned by Sam Huff, Glendale Communications Group, Inc and Park Mailing and Fulfillment, Inc (see for yourself). Could Sam Huff be an 'example of prohibited inurement' [that] 'would include payment of unreasonable compensation to an insider'? What You Can Do Can you do anything about it?  Here are two recommendations:  (1) Write the IRS that you want this non profit to be investigated:  Internal Revenue Service Exempt Organizations Determinations Room 4024 P.O. Box 2508 Cincinnati, OH 45201 RE: National Rosacea Society (EIN: 36-4120334) Here is a sample letter for your consideration:  01_05_21.pdf You may want to include in your letter that the IRS reconsider whether the NRS qualifies as a 501 c 3 since "A tax-exempt organization that does not restrict its participation in certain activities and does not absolutely refrain from others, risks failing the operational requirements for exemption from income tax and jeopardizing its tax-exempt status." [1] The NRS acts more like a 501 c 6 since the majority of its spending benefits businessmen and dermatologists qualifying it as a business league or professional association. For more information see the post about the difference between a non profit and a not for profit or how non profits work.  (2) Support the RRDi with your donations and stop donating to the NRS which is obviously spending the vast majority of its donations/revenue not on benefiting the public but instead benefits businessmen and dermatologists. You don't have to worry about the NRS going under since the pharmaceutical companies that donate to the NRS will continue to do so since these companies are happy with how the NRS spends it money and benefit since dermatologists benefit from the money these pharmaceutical companies are giving to the NRS and you can probably figure out why this arrangement will continue on. The NRS is embedded in this relationship and both are benefiting so the NRS won't miss your paltry donation since it receives most of its funding from pharmaceutical companies that have a vested interest in how the NRS supports 10% of its donations/revenues on rosacea research.  End Notes  [1] Compliance Guide for Tax Exempt Organizations, Publication 4221-NC (Rev. 9 -2014) Catalog Number 52447N, Department of the Treasury Internal Revenue Service p4221nc.pdf
    • "Recent publications certify that the disease appears to be universal and does not just affect Caucasians." An Bras Dermatol. 2020 Nov-Dec; 95(Suppl 1): 53–69.Consensus on the therapeutic management of rosacea – Brazilian Society of DermatologyClivia Maria Moraes de Oliveira, Luiz Mauricio Costa Almeida, Renan Rangel Bonamigo, Carla Wanderley Gayoso de Lima, Ediléia Bagatinf
    • In harmony with this thread, it is time to review the activities of the NRS for 2019 since the NRS doesn't post its Form 990 for 2019 until the END of 2020 which anyone can download and review on its financial page by clicking here (scroll to the bottom of the page to find the Form 990 download). The page paints a very pretty picture with a graph and a list of expenses which shows 'Research Grants' in the amount of $231,526. Here is a screen shot for your enjoyment:  The Form 990 for 2019 that the NRS reports to the Internal Revenue Service shows a very different picture than the math in the above screen shot for research grants. The actual amount shown on Form 990 for research grants is only $23,315 which is ten times less what is shown above. Here is a screen shot of Form 990, Schedule I, which shows the Regents of the University of California at Irvine received the grant: So you can choose to believe what the NRS publishes on its financial page, painting a pretty picture of how it spends ten times the amount shown on rosacea research on its website, or you can read for yourself Form 990 reported to the Internal Revenue Service and discover yourself, but the math on the Form 990 shows ten times less.  The Form 990 for 2019 shows that the NRS received in donations and revenue $303,013 and the total expenses were $419,490.  If you note below in the screenshot of the first page, you can see LINE 13, Grants and similar amounts paid (Part IX, column (A), lines 1-3) in the amount of $23,315. You will be hard pressed to find anywhere reported ten times that amount on research grants.  So the NRS spent 7% of its donations/revenue received in 2019 on rosacea research. To understand this better, for every dollar received by the NRS in 2019 seven cents was spent on rosacea research in 2019. What is enlightening in Form 990 for 2019 is how much the NRS spent on Glendale Communications Group in 2019 which is shown below in this screenshot reported as Section B. Independent Contractors with the same address as the NRS in the amount of $285,871:  That means that Glendale Communications group received 94% of the total amount received in donations/revenue for the 2019 year. Glendale Communications Group, Inc., is owned by Sam Huff. The Form 990 for this year also has an interesting report shown in the screenshot below on Schedule L regarding 'Business Transactions Involving Interested Persons.'  This is how the NRS operates.  nrs_990_2019.pdf
    • Related ArticlesLaser and light-based therapies in the management of rosacea: an updated systematic review. Lasers Med Sci. 2021 Jan 03;: Authors: Husein-ElAhmed H, Steinhoff M Abstract Unlike other rosacea therapies which need daily takings or applications over long periods, the edge of lasers and light-based therapies (LLBT) is the limited number of sessions to achieve improvement. The proper selection of the adequate physical device in accordance with the patients' skin features and rosacea-related signs and symptoms should be considered and the management with physical sources should be updated as new data become available. This article reviews and discusses the current use of lasers and light-based therapies in rosacea with reference to all the available literature.This systematic review demonstrates the quality of evidence to support any recommendation on LLBT in rosacea is low-to-moderate. Among all the available devices, PDL holds the most robust evidence. Treatments options should be tailored for each specific clinical scenario as it is unlike that single modality results in complete resolution. Platforms that include two or more devices and combined therapies with topical agents are suitable and they warrant further investigations. PMID: 33389310 [PubMed - as supplied by publisher] {url} = URL to article
    • Related Articles Carotid intima-media thickness and serum proinflammatory cytokine levels in rosacea patients without cardiovascular risk factors. Dermatol Ther. 2021 Jan 02;: Authors: Ertekin SS, Koku Aksu AE, Koçyiğit A, Güler EM, Baykara Ulusan M, Gürel MS Abstract BACKGROUND: There is a growing body of evidence linking rosacea to various systemic disorders, even though data regarding the association between rosacea and cardiovascular diseases are presently controversial. We sought to investigate the potential association of rosacea with subclinical atherosclerosis and serum proinflammatory/proatherogenic markers. METHODS: This study included 44 patients with rosacea and 44 age- and sex-matched healthy control subjects. Patients with traditional cardiovascular risk factors or a history of cardiovascular events were excluded. Demographic, clinical, and laboratory data, including serum interleukin-1 beta (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and high-sensitivity C-reactive protein (hs-CRP) levels were assessed. Carotid intima-media thickness (CIMT) and carotid plaques were measured by carotid ultrasonography. RESULTS: Serum IL-1β (p<.001), IL-6 (p<.001), TNF-α (p<.001), and hs-CRP (p<.001) levels were significantly higher in the patient group compared to the control group. Mean CIMT values did not differ significantly between the patient group and control group (p>.05). Patients with moderate to severe rosacea had a significantly greater CIMT than those with mild rosacea (p=.047). Rosacea patients with eye involvement had a significantly greater CIMT than those without eye involvement (p=.008). There was no significant correlation between CIMT values and inflammation parameters. CONCLUSIONS: Rosacea is associated with increased systemic inflammation parameters. In the absence of other traditional cardiovascular risk factors, rosacea does not seem to affect mean CIMT value. However, specific subgroups such as patients with moderate to severe disease or with eye involvement are associated with increased subclinical atherosclerosis and may require additional attention for cardiovascular disease prevention. This article is protected by copyright. All rights reserved. PMID: 33389789 [PubMed - as supplied by publisher] {url} = URL to article  More information on systemic cormorbidities in rosacea
    • "Ivermectin 1% cream QD had favorable incremental cost-effectiveness when compared with metronidazole 0.75% cream BID and dominated azelaic acid 15% gel BID in the treatment of papulopustular rosacea in the United States. Therefore, ivermectin 1% cream QD may be a good first-line treatment for papulopustular rosacea, providing additional clinical benefit at no or low additional cost."  Manag Care Spec Pharm. 2016 Jun;22(6):654-65.  doi: 10.18553/jmcp.2016.15210. Epub 2016 Apr 28. Cost-Effectiveness of Ivermectin 1% Cream in Adults with Papulopustular Rosacea in the United States Alain Taieb, Linda Stein Gold, Steven R Feldman, Viktor Dansk, Evelina Bertranou  
    • Related ArticlesDifferential expression of microRNAs in the skin tissue of patients with severe papulopustular rosacea. J Dermatol Sci. 2020 Dec 23;: Authors: Seo SM, Hong JY, Lee HJ, Yang NG, Chung EH, Lee SY, Park YL, Lee SH, Lee SH, Lee DW, Shin MJ, Ryu S, Kim JE PMID: 33386184 [PubMed - as supplied by publisher] {url} = URL to article
    • Related ArticlesAn unusual case of acquired facial pigmentation. BMJ. 2020 10 28;371:m3388 Authors: Bryan P, Lloyd-Lavery A PMID: 33115725 [PubMed - in process] {url} = URL to article
    • Volunteering is at the core of the RRDi non profit organization. Watch this short video about why you should volunteer to post at the RRDi forum or at the very least donate one dollar to keep the RRDi going. 
    • Related Articles Facial Erythema in an Elderly Man. JAMA Dermatol. 2020 05 01;156(5):587-588 Authors: Navarrete-Dechent C, Busam KJ, Markova A PMID: 32211818 [PubMed - in process] Abstract {url} = URL to article
    • This probiotic has come to my attention, although I haven't tried it.  It is supposedly better than the majority of probiotics that are found on shop shelves as it contains strains used in research, which have demonstrated benefits.  Personally, I don't tolerate probiotics and it has been suggested my adverse reactions may be due to  SIBO. However, I am not certain about that as my face is much calmer and  in general free of P&P's unless I take probiotics of any kind that I have tried thus far.  There is mention on the linked site that Daily Synbiotic may be suitable for  people who have SIBO as it bypasses the small intestine and resists digestion until it has reached the large colon. I am not convinced, however  it may be true. Has anyone tried this  Daily Synbiotic? If so, it would be  helpful if they shared their results.  https://my.seed.com/daily-synbiotic  
    • "The formula of hypochlorous acid is HOCl. A chemist discovered hypochlorous acid in 1834. It is a primary compound of innate immunity. This acid is effective to use against a wide range of microorganisms." [1]  "0.01% hypochlorous acid (HyClear™) was effective in disinfecting hybrid contact lenses and cases contaminated with bacteria, a yeast, and adenovirus." [2] Demodex "HOCl has potent antimicrobial properties. Laboratory studies show that it effectively kills the nymph form of the Demodex mites, as well as the Bacillus oleronius and Staphylococcus aureus bacteria that live on eyelids and that are found inside the Demodexgut. In addition, HOCl also neutralizes the inflammatory toxins released by both mites and bacteria." [3] Bacteria "In a recent study, a saline hygiene solution preserved with pure hypochlorous acid was shown to reduce the bacterial load significantly without altering the diversity of bacterial species on the eyelids. After 20 minutes of treatment, there was >99% reduction of the Staphylococci bacteria" [4] Fungus "In our study, hypochlorous acid, 0.01%, effectively eliminated all molds (including Fusarium and Aspergillus) and yeasts (Candida spp.) tested, with fungicidal activity observed in as little as 15 seconds. This rapid fungicidal and sporicidal activity is a significant advantage over traditional antifungal treatments that require hours or even days to show activity and may not be active against conidia (spores). Unlike some antifungal agents that are active against certain species but not others, hypochlorous acid showed rapid and potent activity against all species tested, including the genera Acremonium, Aspergillus, Fusarium, Mucor, and Candida. This broad spectrum of activity makes hypochlorous acid an attractive candidate for a global antifungal prophylaxis agent, especially in developing countries." [5] Virus HOCI is produced by our white blood cells, so our body recognizes it. At 200 ppm, HOCl is also listed by the FDA as Generally Recognized As Safe (GRAS), and is listed as being safe for use on food-contact surfaces by the USDA without the requirement of a rinse step. With HOCL there are no health risks with normal use, as evidenced by all zeros on safety data sheet. HOCL kills the Covid 19 virus. [6] Treatments Clinical Reset by CelleRx is a pure hypochlorous acid, .01% as a preservative in saline. Alevicyn is another treatment.  Amazon Hypochlorous Acid Treatments Active Skin Repair Spray Avenova Antimicrobial Eyelid and Lash Cleanser Briotech Topical Skin Spray BRIOTECH Topical Skin Spray 4 oz CleanSmart Antimicrobial Skin Cleanser Curativa Bay Hypochlorous Spray Mist Defense Antimicrobial Skin Cleanser Heyedrate Dry Eye Relief Kit Heyedrate Hypochlorous Lid and Lash Cleanser Ocusoft Hypochlor OCuSOFT HypoChlor 0.02% Hypochlorous Acid Eyelid and Eyelash Gel Puracyn Plus Wound and Skin Cleanser SkinSmart Antimicrobial Clear Spray Reply to this Topic There is a reply to this topic button somewhere on the device you are reading this post. If you never heard about this topic and you learned about it here first, wouldn't it be a gracious act on your part to show your appreciation for this topic by registering with just your email address and show your appreciation with a post?  And if registering is too much to ask, could you post your appreciation for this topic by finding the START NEW TOPIC button in our guest forum where you don't have to register?  We know how many have viewed this topic because our forum software shows the number of views. However, most rosaceans don't engage or show their appreciation for our website and the RRDi would simply ask that you show your appreciation, please, simply by a post.   End Notes HOCI image courtesy of Wikimedia Commons [1] Does Hypochlorous Acid Eliminate Fungus?, Holistic Density, USA, Joe Doctora [2] ARVO Annual Meeting Abstract  |   June 2020 The Disinfection of Bacterial, Fungal, and Viral Contaminated Contact Lenses and Cases with Hypochlorous Acid Eric G Romanowski; Kathleen A Yates; John E Romanowski; Alex Mammen; Deepinder K Dhaliwal; Vishal Jhanji; Robert M Q Shanks; Regis P Kowalski [3] New Approaches for Fighting Demodex Mites, Dr. Kathryn Najafi-Tagol, MD, Founder and Medical Director of the Eye Institute of Marin, New Medical Life Sciences [4] Stroman, D. W; Mintun, K; Epstein, A. B; Brimer, C. M; Patel, C. R; Branch, J. D; Najafi-Tagol, K (2017). "Reduction in bacterial load using hypochlorous acid hygiene solution on ocular skin". Clinical Ophthalmology. 11: 707–714. doi:10.2147/OPTH.S132851. PMC 5402722. PMID 28458509. [5] Cornea. 2015 Dec; 34(12): 1599–1605. Fungal Infections Following Boston Type 1 Keratoprosthesis Implantation: Literature Review and In Vitro Antifungal Activity of Hypochlorous Acid Silvia Odorcic, MD, FRCSC, Wolfgang Haas, PhD, Michael S. Gilmore, PhD, and Claes H. Dohlman, MD, PhD [6] New Study Proves That Hypochlorous Acid Kills Novel Coronavirus, The Maritime Executive Is hypochlorous acid key to reducing coronavirus risk?, Digital Journal  
    • Related ArticlesOVERVIEW OF TIKTOK'S MOST VIEWED DERMATOLOGIC CONTENT AND ASSESSMENT OF ITS RELIABILITY. J Am Acad Dermatol. 2020 Dec 21;: Authors: Villa-Ruiz C, Kassamali B, Mazori DR, Min M, Cobos G, LaChance A PMID: 33359080 [PubMed - as supplied by publisher] {url} = URL to article
    • Related ArticlesInvestigating the relationship between rosacea and use of vasodilatory medications in a hospital-wide population. J Am Acad Dermatol. 2020 Dec 23;: Authors: Abid R, Reid AT, Zafar F, Powers EM, Powers JG PMID: 33359782 [PubMed - as supplied by publisher] {url} = URL to article
    • Related ArticlesPediatric rosacea in a patient with a dark phototype: Clinical and dermoscopic features. Clin Case Rep. 2020 Dec;8(12):3257-3259 Authors: Chabchoub I, Litaiem N, Zeglaoui F Abstract Rosacea is rare in children and patients with dark phototype. Dermoscopy helps make the correct diagnosis. Positive family history of rosacea is reported in affected children, which suggests a strong familial inheritance of the disorder. PMID: 33363916 [PubMed] {url} = URL to article
    • Related ArticlesDoxycycline-Associated Dual Cutaneous Adverse Reaction to the Drug (CARD): Case Report of Concurrent Photosensitivity and Morbilliform Exanthem to Doxycycline. Cureus. 2020 Nov 18;12(11):e11546 Authors: Jacob JS, Cohen PR Abstract Antibiotics have been observed to cause drug-induced reactions. These can include a cutaneous adverse reaction to the drug (CARD) such as photosensitivity. A 51-year-old woman initiated doxycycline monohydrate for rosacea. Within nine days, she developed two different, simultaneous skin rashes: a phototoxic reaction and a morbilliform drug eruption. The medication was stopped; topical and oral corticosteroids were initiated. Within two weeks, her rashes resolved. Common cutaneous adverse reactions to doxycycline include photosensitivity and morbilliform exanthem. Less common skin side effects include bullous eruptions, lupus-like eruptions, pigmentary disorders, and vasculitis. Albeit uncommon, doxycycline-associated dual CARD - such as the photosensitivity and morbilliform exanthem - may occur. PMID: 33365215 [PubMed] {url} = URL to article
    • Related ArticlesSafety and Efficacy of an Augmented Intense Pulse Light Protocol for Dry Eye Syndrome and Blepharitis. Photobiomodul Photomed Laser Surg. 2020 Dec 28;: Authors: Zhang-Nunes S, Guo S, Lee D, Chang J, Nguyen A Abstract Objective: We evaluated the safety and efficacy of an augmented BroadBand Light (BBL™) protocol on the upper and lower eyelids in improving meibomian gland dysfunction (MGD) and/or dry eye disease (DED). Background: DED, often associated with MGD, can cause significant morbidity and accounts for 3.54 billion U.S. dollars of health care spending yearly. Intense pulsed light (IPL) has been used to treat MGD DED with some success. BBL therapy, a high-quality IPL machine, shows much promise for decreasing inflammation and redness in rosacea, as well as hyperpigmentation from sun damage. Methods: A retrospective medical chart review was performed for MGD DED and/or hyperpigmentation patients who received BBL therapy between January 1, 2015, and February 28, 2020. Inclusion criteria included patients who underwent at least one BBL treatment. Each treatment involved the upper and lower eyelids, as well as cheeks, nose, and face. Each MGD DED subject completed the Ocular Surface Disease Index (OSDI) and underwent pre- and post-treatment standard clinical examinations. Results: Forty-seven patients had treatment without significant adverse effects; all patients with MGD DED reported improvement in their dry eye or blepharitis. BBL was determined to be a safe and effective treatment. There were no changes in visual acuity (p = 0.555) and OSDI scores were improved (p = 0.016). There was one case each of mild corneal/conjunctival abrasion, temporary hyperpigmentation, and two of temporary eyelash thinning. Patients with MGD also showed significant improvement in blepharitis and reduced hordeolum frequency after BBL treatment. Conclusions: This novel IPL/BBL protocol appears safe and effective for treating dry eye and blepharitis. PMID: 33370543 [PubMed - as supplied by publisher] {url} = URL to article
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