Botox for Rosacea

[Guide]

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Botox is sometimes used to treat rosacea. David Pascoe has been following Botox treatment for sometime now and I defer to him on this. Here is the link to his reports.

How much does Botox Cost?, USA Today

Botox is listed as one of the Biologic Treatments for Rosacea. 

Botox Reduces LL-37-Induced Erythema

Please post your experience with botox for rosacea in this thread by finding the reply button.

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[Guide]

"Botulinum toxin has been used to treat persistent erythema and flushing in rosacea for several years."
Botulinum Toxin: An Effective Treatment for Flushing and Persistent Erythema in Rosacea

Botulinum Toxin for the Treatment of Refractory Erythema and Flushing of Rosacea
Park K.Y.a · Hyun M.Y.a · Jeong S.Y.b · Kim B.J.a · Kim M.N.a · Hong C.K.a 
Department of Dermatology, Chung-Ang University College of Medicine, and GoodDay Skin and Laser Clinic, Seoul, South Korea

Botulin Toxin Use in Rosacea and Facial Flushing Treatment.
Open Access Maced J Med Sci. 2019 Sep 30;7(18):2985-2987
Scala J, Vojvodic A, Vojvodic P, Vlaskovic-Jovicevic T, Peric-Hajzler Z, Matovic D, Dimitrijevic S, Vojvodic J, Sijan G, Stepic N, Wollina U, Tirant M, Thuong NV, Fioranelli M, Lotti T

[Guide]

"The possible therapeutic action of botulinum toxin type A for facial erythema and redness has been discussed in several recent reports including both some interesting case reports and equally discouraging results...Botulinum toxin appears to be an effective therapy not only for primary or postmenopausal flushing but also in refractory erythema and flushing in patients with rosacea, as demonstrated in a report of two cases by Park et al. [65] and in a literature review conducted by Abokwidir et al. [66] Some studies have recently been published demonstrating the effectiveness of combining laser and botulinum toxin injections to improve erythema and flushing in patients with rosacea....The available data on the use of BoNT-A in these diseases is still questionable and published studies have revealed conflicting results in terms of efficacy. Furthermore, it is difficult to objectively assess transient and subjective signs such as erythema and flushing. Not least, the studies conducted up to date have a very short follow-up with minimal long-term data on efficacy and safety "

Toxins (Basel). 2021 Feb; 13(2): 120.
Therapeutic Use of Botulinum Neurotoxins in Dermatology: Systematic Review
Emanuela Martina, Federico Diotallevi, Giulia Radi, Anna Campanati, Annamaria Offidani

[Guide]

"Botulinum toxin could have overall satisfying efficacy and safety in the treatment of rosacea, though limited by small sample size, imperfect study design, and short follow-up visits." [1]

This is because as the above statement explains, due to 'limited by small sample size.' There simply are not enough clinical studies on this treatment. 

End Notes

[1] Use of Botulinum Toxin in Treating Rosacea: A Systematic Review

[Guide]

"The average costs of BTX treatment were USD410.09." [in China]

Willingness-to-Pay and Benefit-Cost Analysis of Botulinum Toxin for the Treatment of Rosacea in China: Findings from a Web-Based Survey

[Guide]

"A thorough understanding of the anatomy of the facial muscles is therefore essential when treating the perioral area with botulinum toxin to ensure the safe delivery of this medication."

J Clin Aesthet Dermatol. 2022 Apr; 15(4): 12.
Anatomical Exhortations of Botulinum Toxin Injections for Rosacea
Tamara Searle, BSc, Faisal R. Ali, PhD, MRCP, and Firas Al-Niaimi, MRCP