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  • The Rosacea Research & Development Institute [RRDi] is the first 501 (c) (3) non profit organization approved by the IRS established June 7, 2004 in the State of Hawaii, USA for the purpose of finding a cure for rosacea, researching rosacea, and to form a rosacea patient advocacy organization established by volunteer rosaceans for rosacea sufferers. In December 2019 we have moved the corporate office to the State of Alabama and have registered as a non profit corporation.

    Our non profit organization for rosacea patient advocacy web site is a digital data repository of rosacea information that can serve you personally as an armamentarium of rosacea treatment options. We have tools to help you in your search for a cure to rosacea, or at least a way to control it.

    We have chosen the Invision Community as the chief digital platform tool (with beta versions for Android and iOS mobile apps) to use, a public platform for guests and inactive members. Our member forum is the most private forum for rosacea on the internet. We also have a private platform using Tapatalk using our rosacea-control.com domain. 

    We are rosacea sufferers [rosaceans] and all are volunteers. We rely on donations. No one is receiving a salary or getting paid. We don't spend donated funds on private contractors that are owned by any member of the board of directors. We do not spend donated funds so our members can attend dermatology conventions. All donations are spent on keeping this non profit organization for rosacea sufferers a viable patient advocacy organization and our rules state that 'members may not profit from the institute' (rule number 3). Read our mission statement

    No one has a paid salary, we pay NO private contractors nor do we use donations so our members can attend dermatology conventions. 

    All the other rosacea non profits are not run by rosacea sufferers (see Other Non Profit Rosacea Organizations on this page). Check out the other non profit organizations for rosacea, discover for yourself and you will find out who serve on the board of directors (non rosaceans - dermatologists/businessmen) and then simply follow the money (what does the organization spend most of the donated money on?) and discover for yourself that the other non profit organizations for rosacea spend most of the donations on (1) private contractors, (2) dermatologist member conventions or (3) salaries. We have no special interest other than finding the cure for rosacea and forming a rosacea patient advocacy organization. Our non profit has no salaries, no spending on private contractors, no expenses for member conventions. Follow the money (this is where we spend our money). Notice where most of the money is spent with another rosacea non profit, who has spent millions of dollars on private contractors owned by the president of the non profit and only 10% on rosacea research. 

    Read our Misson Statement and see if you agree? If you suffer from rosacea, this is the rosacea non profit to join. Your membership increases our impact on the medical community. Our goal is to reach 10,000 members. Please join and help us reach our goal. What if 10,000 members got together and each donated one dollar and all the members agreed we should sponsor a certain rosacea research study. Is this possible? Only with your help. 

    You may want to read our post about Anonymity, Transparency and Posting before joining. We have now switched to a subscription member service

    The logo of the RRDi includes a butterfly because rosacea typically manifests itself in a facial butterfly formation, however the irony of the butterfly effect is apropros. Learn More.

    You may want to learn about the history of this non profit or why it was formed

    If you are a rosacean, volunteer by joining our private member forum and posting or in our public guest forum (registration required) becoming a part of 'finding the cure' for rosacea if you join. Our goal is 10,000 members. Membership is free. You can help us reach our goal by joining with just your email address.  if privacy is of paramount importance to you use Sign in with Apple and join our private member forum. Or you can simply browse our web site and guest forum for free. Our non profit affiliate store is another source of rosacea treatment options. 

    If you want to post about your rosacea, we certainly allow you to post feedback in our GUEST forum or register an account in our member forum, i.e,, in our public community support, and, if you want to learn about and treat your rosacea, this is the best non profit organization for rosacea sufferers. At the social networks like Facebook, Instagram or Reddit can you find the incredible digital tools the RRDi provides free to its members or the ability to find what you are searching for in rosacea research? Are you able through such social media groups to influence the medical community how you feel about rosacea? Read our mission statement and compare with your private rosacea social media group, i.e., like Facebook, Instagram or Reddit.  

    The RRDi is registered at GuideStar and Trustpilot • Write a Review of Our Non Profit

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  • Registered with the USA Internal Revenue Service

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    EIN 20-1259275

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    • Most, if not all of the rosacea research being done is being funded by pharmaceutical companies or what is called the skin industry who have a vested interest in rosacea. The only non profit organizations for rosacea doing any rosacea research are the NRS and the AARS (possibly others) who clearly state that on their financial reports that they are heavily funded by pharmaceutical companies that offers rosacea drug treatments. These non profits as well any just about all rosacea research is funded by the skin industry.  The skin industry includes not only pharmaceutical companies that offer rosacea treatments but also the cosmetic companies that offer over the counter treatments for rosacea.  Science is assumed to be researched in integrity, after all it is science. "Science is a systematic endeavor that builds and organizes knowledge in the form of testable explanations and predictions about the universe." [1] Research is the "creative and systematic work undertaken to increase the stock of knowledge". [2] Integrity is "the practice of being honest and showing a consistent and uncompromising adherence to strong moral and ethical principles and values." [3] While most science research is without question done in integrity, there is a small unknown percentage of dark science worth investigating that results in retractable published research papers due to fraud or other data misinformation. [4]  The Rosacea Research & Development Institute [RRDi] was formed for the purpose of engaging in novel rosacea research that rosacea sufferers want done which is totally in contrast to the current rosacea research being done by the skin industry. For example, if 10K members of the RRDi each donated a dollar and decided what should be researched on rosacea, this non profit organization could actually engage in a different direction than how the skin industry does their research for their own agenda.  While we appreciate any rosacea research being done, it would be incredible if enough rosaceans got together and actually funded their own rosacea research. Are you in? Join the RRDi.  End Notes [1] Science, Wikipedia [2] Research, Wikipedia [3] Integrity, Wikipedia [4] The Truth Police, BBC
    • JAAD Case Rep. 2023 Apr 11;36:32-33. doi: 10.1016/j.jdcr.2023.03.022. eCollection 2023 Jun. NO ABSTRACT PMID:37215297 | PMC:PMC10195851 | DOI:10.1016/j.jdcr.2023.03.022 {url} = URL to article
    • Int J Dermatol. 2023 May 22. doi: 10.1111/ijd.16717. Online ahead of print. ABSTRACT BACKGROUND: Facial erythema in rosacea is a troublesome embarrassing presentation with limited options of treatment. Daily brimonidine gel was shown to be an effective modality of treatment. Being unavailable in Egypt and the scarcity of objective evaluation of its therapeutic effect motivated the search for other alternatives. OBJECTIVE: To evaluate the use and effectiveness of topical brimonidine eye drops for the management of facial erythema in rosacea with the aid of objective assessment. METHODS: The study was conducted on 10 rosacea patients presented with facial erythema. Brimonidine tartrate eye drops 0.2% were applied twice daily for 3 months on areas of red facial skin. Punch biopsies were obtained before and after 3 months of treatment. Routine hematoxylin and eosin (H&E) staining as well as CD34 immunohistochemical staining were performed for all biopsies. Sections were examined to detect the changes in the count and the surface area of blood vessels. RESULTS: Evaluation of clinical results showed good improvement of facial redness at the end of treatment (55-75%). Only 10% of subjects expressed rebound erythema. H&E and CD34 stained sections showed an increased count of dilated dermal blood vessels, which decreased significantly after treatment in count and surface area (P = 0.005, and P = 0.004, respectively). CONCLUSION: Topical brimonidine eye drops proved to be effective in managing facial erythema in rosacea, providing an available and cheaper alternative to brimonidine gel. The study improved the subjective evaluation in the context of objective assessment of treatment efficacy. PMID:37212604 | DOI:10.1111/ijd.16717 {url} = URL to article
    • Front Public Health. 2023 May 3;11:1096687. doi: 10.3389/fpubh.2023.1096687. eCollection 2023. ABSTRACT BACKGROUND: The associations between single risk factors and incident rosacea have been reported, but the effects of social risk factors from multiple domains coupled remain less studied. OBJECTIVES: To quantify the influence of social determinants on rosacea comprehensively and investigate associations between the polysocial risk score (PsRS) with the risks of incident rosacea. METHODS: This was a prospective cohort study of government employees undertaken from January 2018 to December 2021 among participants aged >20 from five cities in Hunan province of China. At baseline, information was collected by a questionnaire and participants were involved in an examination of the skin. Dermatologists with certification confirmed the diagnosis of rosacea. The skin health status of participants was reassessed every year since the enrolment of study during the follow-up period. The PsRS was determined using the nine social determinants of health from three social risk domains (namely socioeconomic status, psychosocial factors, and living environment). Incident rosacea was estimated using binary logistic regression models adjusted for possible confounding variables. RESULTS: Among the 3,773 participants who completed at least two consecutive skin examinations, there were 2,993 participants included in the primary analyses. With 7,457 person-years of total follow-up, we detected 69 incident rosacea cases. After adjustment for major confounders, participants in the group with high social risk had significantly raised risks of incident rosacea with the adjusted odds ratio (aOR) being 2.42 (95% CI 1.06, 5.55), compared to those in low social risk group. CONCLUSION: Our findings suggest that a higher PsRS was associated with an elevated risk of incident rosacea in our study population. PMID:37206873 | PMC:PMC10191232 | DOI:10.3389/fpubh.2023.1096687 {url} = URL to article
    • Adv Biomed Res. 2023 Mar 28;12:72. doi: 10.4103/abr.abr_233_21. eCollection 2023. ABSTRACT BACKGROUND: Rosacea is a skin chronic inflammation with an unknown cause and cure. Environmental and genetic factors could not entirely explain the disease pathogenesis. Recently, infections like Chlamydia pneumoniae are of more attention in the rosacea progression. This study investigated the relationship between the C. pneumoniae seropositivity and the rosacea disorder. MATERIALS AND METHODS: We aimed at a cohort of 100 patients with the rosacea disorder (60 active and 40 inactive) and from 100 sex- and age-matched healthy controls in Isfahan and determined the immunoglobulin M (IgM)/IgG antibodies titers to C. pneumoniae in the serum using the enzyme-linked immunosorbent assay method. The groups were compared using the analysis of variance procedure at the significant level of P < 0.05, statistically. RESULTS: The mean of IgG in the controls was significantly higher than the levels in both the active and the inactive rosacea patients (p < 0.022). Also, the titer of serum IgM to C. pneumoniae in the controls was different, compared with the active (p < 0.019) and the inactive (p < 0.02) rosacea patients. In addition, the median titer of serum IgG (not IgM) to C. pneumoniae in the females with the inactive rosacea disorder was lower than the active rosacea disorder (p < 0.019) and controls women (p < 0.008). Furthermore, the serum level of IgG or IgM to C. pneumoniae in the controls males was higher than the males with the rosacea disorder (p < 0.05) and (p < 0.02), alternatively. CONCLUSION: C. pneumoniae seropositivity in the rosacea patients and controls was insignificant. PMID:37200759 | PMC:PMC10186054 | DOI:10.4103/abr.abr_233_21 {url} = URL to article
    • Most Viewed FAQs List Guide  • Please note: If you click and receive a message that 'you do not have permission to view" that means you need to Join the RRDi to View ($2 minimum subscription). Maybe you have some of the same questions and want to do some research. That is what the RRDi is all about.  Below are the FAQs in the order of the most views as of February 2021:  Is this rosacea?  By far the most frequently asked question on the internet and on the RRDi website.  Are there any Oracea Anecdotal Reports? (New FAQ) Answer shows 81.6K views What about Mirvaso for rosacea? (New FAQ) Answer shows 23.6K views What is demodectic rosacea? (New FAQ) Answer shows 23.2K views What is the most viewed rosacea regimen on the RRDi website? (New FAQ) Answer shows 19.7K views What about Isotretinoin for Rosacea? (New FAQ) Answer shows 18.2K views Is Carbohydrate Essential For Human Survival? (New FAQ) Answer shows 16.4K views What about sugar and rosacea? (New FAQ) Answer shows 14.8K views What is Horse Paste for Rosacea? (New FAQ) Answer shows 13.5K views What about researching diet/lifestyle and rosacea? (New FAQ) Answer shows 13.4K views What does a dietician nutritionist have to say about rosacea? (New FAQ) Answer shows 13.1K views What is Steroid Rosacea? (New FAQ) Answer shows 12.1K views Why Form Another Non Profit Organization For Rosacea? (New FAQ) Answer shows 11.4K views Do Rosaceans Suffer from Nutritional Deficiencies? 959 views in FAQs (The answer shows 10.8K views) What is Seborrheic Dermatitis? (New FAQ) Answer shows 10.3K views What should a newbie rosacean learn about rosacea? (New FAQ) Answer shows 9.6K views What Prescription and Non Prescription Flushing Avoidance Treatments are there? (New FAQ) Answer shows 9.2K views What are the latest theories on the cause of rosacea? (New FAQ) Answer shows 9.1K views What about Antibiotic Resistance, Bacterial Overgrowth, Side Effects? (New FAQ) Answer shows 8.6K views Can Rosacea Go Into Remission? 7.5K views What rosacea trigger factors are there? (New FAQ) Answer shows 7.5K views What about NSAIDs For Rosacea? (New FAQ) Answer shows 7.4K views What is Oracea for rosacea? (New FAQ) Answer shows 7.2K views Does Yogurt Or Liver Trigger Rosacea? 3.1K views in FAQs (The article with the answer shows 7.2K views) Are there any Doxycycline Anecdotal Reports? (New FAQ) Answer shows 7.1K views Is the Subtype Classification Of Rosacea Controversial? (New FAQ) Answer shows 6.8K views What is Keratosis Pilaris Rubra Faceii (KPRF)? (New FAQ) Answer shows 6.6K views Do You Have A Gut Feeling About Your Rosacea? (New FAQ) Answer shows 6.5K views What full coverage make up foundation is for rosacea? (New FAQ) Answer shows 6.5K views) How do you make a home made ivermectin cream? (New FAQ) Answer shows 6.5K views) What about aspirin for rosacea? (New FAQ) Answer shows 6.4K views) Is Carbohydrate A Rosacea Trigger? (new FAQ) Answer shows 6.1K views What is Periorol Dermatitis? (New FAQ) Answer shows 6K views What cosmetics are there for rosacea? (New FAQ) Answers show 5.9K views What is the Innate Immune Response Disorder theory on rosacea? (New FAQ) Answers show 5.7K views Are there any Anecdotal Reports of Carbohydrate and Sugar Rosacea Trigger Avoidance? (New FAQ) Answers show 5.7K views Is Coffee A Rosacea Trigger? 5.6K views How is a Differential Diagnosis Of Rosacea Obtained? (New FAQ) Answer shows 5.6K views What is Keratosis Pilaris Rubra Faceii? (New FAQ) Answer shows 5.6K views Is Rosacea A ‘Complicated Diagnosis Path’ And Mysterious Disorder? (New FAQ) Answer shows 5.4K views What Sugars Should I Avoid to Control My Rosacea? (New FAQ) Answer shows 5.4K views What is the Ketamine 0.5% and Amitriptyline 1% Treatment for Rosacea? (New FAQ) Answer shows 5.4K views What about IBS and Rosacea? (New FAQ) Answer shows 5.4K views What is Gram-Negative Folliculitis? (New FAQ) Answer shows 5.3K views What is Neurogenic Rosacea? (New FAQ) Answer shows 5.3K views What about researching Gene therapy & Isolation of Rosacea Genes? (New FAQ) Answer shows 5.3K views What Should I Ask My Physician? 5K views What about Soolantra for rosacea? (New FAQ) Answer shows 5K views Does Vitamin B Complex Trigger Rosacea? 4.9K views What is Rosacea LTD-IV? (New FAQ) Answer shows 4.9K views What diet triggers rosacea? (New FAQ) Answer shows 4.9K views Is Lamb's Quarters A Rosacea Trigger? (New FAWQ) Answer shows 4.8K views What Is The World Wide Number Of Cases Of Rosacea? 4.6K views What is Telangiectasias (Phenotype 3)? (New FAWQ) Answer shows 4.6K views What is Granulomatous Rosacea? (New FAWQ) Answer shows 4.5K views What are some Treatments for Demodex Skin Mites? (New FAQ) Answer shows 4.4 views What is ZOSSO (aka ZZ Cream)? (New FAQ) Answer shows 4.4 views What is Rosacea Fulminans? (New FAQ) Answer shows 4.3 views  What is the Helicobacter Pylori Theory in Rosacea? (New FAQ) Answer shows 4.3 views  What about Zeloglin for rosacea? (New FAQ) Answer shows 4.3 views Rosacea or Demodex, Which Came First? (New FAQ) Answer shows 4.1 views What two rosacea mimics are called PF? (New FAQ) Answer shows 4.1 views Can You Get A Diagnosis For Rosacea On The Internet? 4K views What about SIBO and Rosacea? (New FAQ) Answer shows 4K views What are some Natural Treatments For Rosacea? (New FAQ) Answer shows 3.9K views Does IPL Kills Demodex Mites? (New FAQ) Answer shows 3.9K views What anti-flushing drugs for rosacea are there?  (New FAQ) Answer shows 3.9K views What about oral ivermectin for Rosacea? (New FAQ) Answer shows 3.7K views What about red clover for rosacea flushing? (New FAQ) Answer shows 3.7K views What is the GPSkin® Barrier Device for Rosacea? (New FAQ) Answer shows 3.6K views Does Aspirin Help for Rosacea Flushing? (New FAQ) Answer shows 3.6K views What about Psychology and Rosacea? (New FAQ) Answer shows 3.6K views What about low gastric acid and rosacea? (New FAQ) Answer shows 3.6K views What is an elimination diet? (New FAQ) Answer shows 3.5K views Is there more information on sugar and rosacea? (New FAQ) Answer shows 3.5K views How can I avoid blushing? (New FAQ) Answer shows 3.5K views What Is The Rosacea Butterfly Or T Zone? 3.4K views If My Rosacea Is Severe What Treatments Are Available? 3.4K views What is the difference between a Papule, Pustule, Pimple, Comedo, Lesion, Cyst? (New FAQ) Answers shows 3.4K views What is Pyoderma Faciale? (New FAQ) Answers shows 3.4K views What is Dr. Dray Anti-Redness Regimen? (New FAQ) Answers shows 3.4K views Is rosacea caused by bacteria? (New FAQ) Answers shows 3.4K views Is Rosacea Triggered By A Vitamin B Complex Supplement? (New FAQ) Answers shows 3.4K views What Causes Rosacea? 3.3K views (New FAQ) Answer shows 3.3K views What is Argan Organics anti redness + rosacea cream? (New FAQ) Answer shows 3.3K views Is Rosacea Caused by Genetics? (New FAQ) Answer shows 3.3K views What about Sodium Sulfacetamide - Sulfur for rosacea? (New FAQ) Answer shows 3.2K views What are some rosacea rare flareups? (New FAQ) Answer shows 3.2K views Is Sugar A Rosacea Trigger? 3.1 views What is the Gold Standard for Rosacea Treatment? (New FAQ) Answer shows 3.1K views What about Lutein with Zeaxanthin for Rosacea? (New FAQ) Answer shows 3.1K views What about metronidazole and rosacea? (New FAQ) Answer shows 3.1K views What about flushing and rosacea? (New FAQ) Answer shows 3.1K views Is Flushing Rosacea? 3K views Does Rosacea Progress In Stages? 3K views Do Acne Treatments Irritate Rosacea? 3K views What is Erysipelas? (New FAQ) Answer shows 2.9K views What about Immunosuppressants for rosacea? New FAQ) Answer shows 2.9K views What Is A Rosacea Trigger? 2.8K views What is the difference between a Variant, a Subtype and a Phenotype? New FAQ) Answer shows 2.8K views What is Gastrointestinal Rosacea [GR] (aka, Gut Rosacea)? (New FAQ) Answer shows 2.8K views Does a honey mask improve rosacea? (New FAQ) Answer shows 2.8K views What about Cathelicidin Peptide LL-37 and Vitamin D3 in rosacea? (New FAQ) Answer shows 2.8K views Is Rosacea Misdiagnosed? (New FAQ) Answer shows 2.7K views What is Erythromelalgia? (New FAQ) Answer shows 2.7K views What is the history of ivermectin? (New FAQ) Answer shows 2.7K views What is Lupoid Rosacea? (New FAQ) Answer shows 2.6K views Are Migraine Headaches Related To Rosacea? 2.5K views Can a doctor diagnose rosacea in five minutes or less? (New FAQ) Answer shows 2.5K views What is Eczema (Atopic Dermatitis)? (New FAQ) Answer shows 2.5K views What is Rosacea Conglobata? (New FAQ) Answer shows 2.5K views What is the Angiogenesis & VEGF theory on rosacea? (New FAQ) Answer shows 2.5K views How can I volunteer for the RRDi? (New FAQ) Answer shows 2.5K views Do any of the royal family in the UK have rosacea? (New FAQ) Answer shows 2.5K views Is Lupus a rosacea mimic? (New FAQ) Answer shows 2.4K views What is ProSkin Rosacea Natural Skin Cream by Mama Nature? (New FAQ) Answer shows 2.4K views What is Azelaic Acid for rosacea? (New FAQ) Answer shows 2.4K views Is Sugar Addictive? (New FAQ) Answer shows 2.4K views Has anyone committed suicide because of blushing? (New FAQ) Answer shows 2.4K views Is Flushing Rosacea? 2.4K views When posting on the RRDi website how can I balance Anonymity and Transparency? (New FAQ) Answer shows 2.4K views What rosacea panel recommended the phenotype classification? (New FAQ) Answer shows 2.4K views Can You Self Diagnose Rosacea? 2.3K views What is the X Factor in Rosacea? 2.3K views What is Glandular Rosacea? (New FAQ) Answer shows 2.3K views What is Low Dose Naltrexone for rosacea? (New FAQ) Answer shows 2.3K views Is Perioral Dermatitis a rosacea variant? (New FAQ) Answer shows 2.3K views What is Dermatomyositis? (New FAQ) Answer shows 2.3K views What does Cathelicidin have to do with rosacea? (New FAQ) Answer shows 2.2K views Does a vacation to the South Pacific which includes snorkeling improve rosacea? 2.1K views What If I Don't Want To Lose Weight Or I Need Carbohydrate For Athletics? 2.1K views What about LED for rosacea? (New FAQ) Answer shows 2.1K views What about Antibiotics For Rosacea? (New FAQ) Answer shows 2.1K views What about Rhofade for rosacea? (New FAQ) Answer shows 2.1K views How do you use the RRDi FAQs? 2.1K views What is the Autoimmune Protocol Diet? (New FAQ) Answer shows 2.1K views Will a Humidifier Help Rosacea? 2K views Are there any Demodex Mite Videos? (New FAQ) Answer shows 2K vews What is the difference between a rosacea flare up and flushing? 2K views What is the History of Demodectic Rosacea? (New FAQ) Answer shows 2K views What about ETS and rosacea? (New FAQ) Answer 2K views Is The Lymphatic System Involved With Rosacea? 1.9K views What is an Alternative to Soolantra's (Ivermectin) High Cost? (New FAQ) Answer shows 1.9K views What is Tranexamic Acid Solution for rosacea? (New FAQ) Answer shows 1.9K views What about MSM and Grapefruit Seed Extract for Rosacea? (New FAQ) Answer shows 1.9K views What is the Hanacure Face Mask? (New FAQ) Answer shows 1.9K views What brand of laser for rosacea? (New FAQ) Answer shows 1.8K views Are there any IPL Anecdotal Negative Reports? (New FAQ) Answer shows 1.8K views What do alarmins have to do with rosacea? (New FAQ) Answer shows 1.8K views What is the Rosacea Diet? (New FAQ) Answer shows 1.8K views Spicy Food A Rosacea Trigger? (New FAQ) Answer 1.8K views What Is An Elimination Diet? 1.7K views Does Lifestyle Effect Rosacea? 1.7K views What Non Prescription Treatments Are Available? 1.7K views Is Obesity A Factor In Rosacea? 1.7K views Does Coconut Oil Improve Rosacea? (New FAQ) Answer shows 1.7K views Are there any Laser Anecdotal Negative Reports? (New FAQ) Answer shows 1.7K views Is there a generic ivermectin cream?  (New FAQ) Answer shows 1.7K views Does Lifestyle Effect Rosacea? 1.7K views What are 7 Things Girls With Rosacea Are Tired Of Hearing? (New FAQ) Answer shows 1.7K views Will I Get Rhinophyma? 1.6K views What is sulfur butter for rosacea? (New FAQ) Answer shows 1.6K views What About Steroid Induced Rosacea? 1.6K views If you take Soolantra continuously does it get worse before it gets better? (New FAQ) Answer shows 1.6K views What about Fluorescent Lights (and other artificial lights) and rosacea? (New FAQ) Answer shows 1.6K views Does Sai Pallavi suffer from rosacea? (New FAQ) Answer shows 1.6K views Does Lex Gillies, Beauty Blogger Have Rosacea? (New FAQ) Answer shows 1.6K views Does Amy Schumer suffer from rosacea? (New FAQ) Answer shows 1.6K views Is Sofia Vergara “prone to rosacea”? (New FAQ) Answer shows 1.6K views What is the Antioxidant System Defect Hypothesis Theory in rosacea? (New FAQ) Answer shows 1.6K views What Prescription Treatments Are Prescribed For Rosacea? 1.5K view Is Rosacea A Genetic Disease Or Caused By The Environment? 1.5K views What are the Jennifer Brown Soolantra Videos? (New FAQ) Answer shows 1.5K views What about amberin for hot flashes? (New FAQ) Answer shows 1.5K views How can I post a review of an item in the RRDi affiliate store? (New FAQ) Answer shows 1.5K views Do Renee Zellweger and Cameron Diaz Both have Rosacea? (New FAQ) Answer shows 1.5K views What is radio frequency for rosacea? (New FAQ) Answer shows 1.4K views What is the 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    • Curr Issues Mol Biol. 2023 Mar 24;45(4):2703-2716. doi: 10.3390/cimb45040177. ABSTRACT Rosacea is a chronic inflammatory skin disease whose late manifestations have not yet been clearly reported in animal models. The objective of this study is to describe the skin lesions and major histopathological changes in a rosacea-like phenotype in mice induced by prolonged LL-37 administration and furthermore, to assess the potential of long-term LL-37 administration in inducing irreversible rosacea-like skin lesion models. Balb/c mice were continuously injected intradermally with LL-37 every 12 h to induce a rosacea-like phenotype. After LL-37 injections were administered for 20 consecutive days, the area of rosacea-like lesions gradually expanded in the first 13 days, then entered a stable phase. Haematoxylin and eosin (H&E) and Van Gieson's staining showed a high degree of inflammatory cell aggregation, thickening of the epidermis and dermis, and collagen deposition in large quantities. The results of immunofluorescence staining and Western blotting showed that the expression of α-SMA, TNF-α, vimentin, and COL1 in the skin of mice was significantly upregulated. Short-term LL-37 administration induced rosacea-like lesions that only featured the aggregation of inflammatory factors and thickening of the epidermis, whereas no collagen hyperplasia was observed, and a full recovery was noticed. However, rosacea-like skin lesions induced by long-term LL-37 administration did not completely recover. Our study compares rosacea-like lesions induced by short-term versus long-term LL-37 administration, and the results suggest that irreversible rosacea-like lesions can be induced by long-term LL-37 administration. PMID:37185701 | PMC:PMC10136735 | DOI:10.3390/cimb45040177 {url} = URL to article
    • Georgian Med News. 2023 Mar;(336):66-72. ABSTRACT Rosacea is a chronic, inflammatory skin disorder that adversely affects patients' life quality. The aim of the study was to evaluate the quality of life (QoL) and to find the connection between QoL and coping strategies in the patients suffering from rosacea. A total of 138 patients, aged from 22 to 80, took part in this research with the first-time confirmed diagnosis of rosacea. All patients completed the Dermatology Life Quality Index (DLQI) questionnaire in order to evaluate the patients' attitudes to the impact of rosacea on QoL and Coping Strategies Questionnaires (COPE). The study has determined that Average DLQI in the case of rosacea equals 14.09+3.18. Mean Rosacea-Specific DLQI is symptoms and feelings - 3.75+1.92, daily activities - 3.12+1.77; leisure - 2.52+1.81, work and/or school - 1.52+1.50, personal relationships - 2.42+1.90, treatment - 1.59+1.04. The usage of instrumental social support - 3.39 has the highest score factor in the COPE questionnaire. Rosacea has a strong impact on human life. QoL in rosacea patients is connected to such factors as age, gender, employment status, self-esteem, and subtype of the disease. Correlation analysis shows the connection between the quality of life and coping strategy. Based on the recession analysis formula, the large and extremely large effect of DLQI can be calculated according to the existing risk consequently, the results obtained in our study may be a kind of starting point for the elaboration of complex support for patients with rosacea. PMID:37166883 {url} = URL to article
    • Curr Med Chem. 2023 May 8. doi: 10.2174/0929867330666230508141434. Online ahead of print. ABSTRACT Statins are HMG-CoA reductase inhibitors and decrease plasma low-density lipoprotein cholesterol (LDL-C) levels. They are well tolerated, and because of their LDL-C-lowering effect, they are utilized to decrease the risk of atherosclerosis and cardiovascular disease. However, statins have pleiotropic effects, including immunomodulatory, anti-inflammatory, antioxidant, and anticancer. Currently, oral administration is the only Food and Drug Administration (FDA)-approved route of administration for statins. However, other administration routes have demonstrated promising results in different pre-clinical and clinical studies. For instance, statins also seem beneficial in dermatitis, psoriasis, vitiligo, hirsutism, uremic pruritus, and graft-versus-host disease. Topically applied statins have been studied to treat seborrhea, acne, rhinophyma, and rosacea. They also have beneficial effects in contact dermatitis and wound healing in animal studies, (HIV) infection, osseointegration, porokeratosis, and some ophthalmologic diseases. Topical and transdermal application of statins is a non-invasive drug administration method that has shown significant results in bypassing the first-pass metabolism in the liver, thereby reducing possible adverse effects. This study reviews the multifaceted molecular and cellular impacts of statins, their topical and transdermal application, novel delivery systems, such as nanosystems for topical and transdermal administration and the challenges concerning this approach. PMID:37157198 | DOI:10.2174/0929867330666230508141434 {url} = URL to article
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