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  1. Related ArticlesErythematous Papules Involving the Eyebrows in a Patient with a History of Rosacea and Hair Loss. Skin Appendage Disord. 2020 Jun;6(3):190-193 Authors: Kłosowicz A, Thompson C, Tosti A PMID: 32656245 [PubMed] {url} = URL to article
  2. Related ArticlesFacial dermatoses in general population due to personal protective masks: first observations after lockdown. Clin Exp Dermatol. 2020 Jul 13;: Authors: Giacalone S, Minuti A, Spigariolo CB, Passoni E, Nazzaro G Abstract Since SARS-COV-2 pandemic began, frontline healthcare workers demonstrated to develop facial dermatoses, such as acne, rosacea and seborrheic dermatitis, secondary to prolonged use of personal protective equipment (PPE). PMID: 32658350 [PubMed - as supplied by publisher] {url} = URL to article
  3. StatPearls Book. 2020 01 Authors: Abstract Lupus miliaris disseminatus faciei (LMDF) is an idiopathic granulomatous disease affecting facial skin primarily. Nosologically, it is on a spectrum of facial granulomatous dermatoses and shares overlapping features with rosacea and sarcoidosis. In most cases, this disorder resolves spontaneously within several years but can leave potentially disfiguring scarring. The name derives from a historic putative association with tuberculosis, as discussed below. More recent authors have proposed adopting the term facial idiopathic granulomas with regressive evolution (FIGURE) instead of the entrenched LMDF. However, it does not appear that a name change has been widely accepted.[1] Older terms for a similar facial granulomatous dermatosis include micropapular tuberculid, Lewandowsky’s eruption, and lupoid rosacea.[2] Acne agminata has been used to refer to similar lesions in the axilla. PMID: 32644491 {url} = URL to article
  4. Related ArticlesPulsed dye laser followed by intradermal botulinum toxin type-A in the treatment of rosacea-associated erythema and flushing. Dermatol Ther. 2020 Jul 07;: Authors: Al-Niaimi F, Glagoleva E, Araviiskaia E Abstract Rosacea is a common inflammatory skin disease characterized by erythema, episodes of flushing and inflammatory lesions. It typically affects the face and is more prevalent among fair skin individuals affecting women more than men. Various treatments are available for rosacea with light-based therapies commonly used in the management of erythema. The use of intradermal botulinum toxin type-A has been reported to be beneficial in the treatment of rosacea-associated erythema and flushing with good results and a low side-effect profile. In this article we present our experience on the successful combination of both pulsed dye laser and intradermal botulinum toxin type-A in erythema and flushing in 20 rosacea patients. In addition to subjective improvement we measured the degree of erythema using a 3D Antera™ camera in order to quantify our results. We demonstrated high efficacy and satisfaction rate with this combined approach and a low side-effect profile. To our knowledge the combination of laser and intradermal botulinum toxin in the management of rosacea has not been previously reported. This article is protected by copyright. All rights reserved. PMID: 32633449 [PubMed - as supplied by publisher] {url} = URL to article
  5. Related ArticlesRosacea and the cardiovascular system. J Cosmet Dermatol. 2020 Jul 03;: Authors: Searle T, Al-Niaimi F, Ali FR Abstract Rosacea and the cardiometabolic syndrome are both associated with chronic inflammation and a pro-inflammatory phenotype. Emerging clinical evidence supports the relationship between rosacea and cardiometabolic syndrome hypertension and obesity. This article reviews our current findings and understanding in the skin and cardiovascular relationship in rosacea. Rosacea appears to be associated with hypertension, dyslipidaemia and obesity. The role of smoking in rosacea is currently less clear. It remains uncertain whether treatment of these risk factors will aid improvement of rosacea. Greater understanding of rosacea and its association with the cardiovascular system and underlying risk factors could allow for a greater understanding of the body's inflammatory response as well as the formulation of new guidelines for attending clinicians. Dermatologists treating rosacea patients might need to consider enquiring and evaluate their patients' underlying cardiovascular risk factors. PMID: 32621366 [PubMed - as supplied by publisher] {url} = URL to article
  6. A rare case of lupoid leishmaniasis defying diagnosis for a decade. J Cutan Pathol. 2020 Jul 04;: Authors: Gehlhausen J, Sibindi C, Ko CJ, Grant M, Zubek A Abstract Cutaneous leishmaniasis is a common disease affecting millions in endemic areas worldwide. We present a case of lupoid leishmaniasis, a rare variant of cutaneous leishmaniasis, which clinically mimicked sarcoidosis and/or granulomatous rosacea for ten years until ultimate diagnosis. An 82-year-old U.S. citizen with an extensive travel history presented with a ten-year history of facial plaques on the cheeks and was previously diagnosed and treated as sarcoidosis. Multiple biopsies (previously and at presentation) revealed tuberculoid granulomas with negative special stains for microrganisms and negative sterile tissue cultures for AFB, bacteria, and fungal organisms. A diagnosis of granulomatous rosacea was rendered and multiple medical therapies were attempted, none with sustained improvement. Repeat biopsy of a new lesion revealed intracellular organisms consistent with leishmaniasis, which was confirmed by PCR. Lupoid leishmaniasis is a rare presentation of cutaneous leishmaniasis including facial plaques that can mimic granulomatous diseases affecting the face including sarcoidosis and granulomatous rosacea. Cutaneous leishmaniasis can sometimes be challenging to diagnose through standard histopathologic examination; IHC for CD1a can be used to augment tissue-based examination and PCR should be sent early in cases with sufficient concern. This article is protected by copyright. All rights reserved. PMID: 32623733 [PubMed - as supplied by publisher] {url} = URL to article
  7. Efficacy and Safety Results of Micellar Water, Cream and Serum for Rosacea in comparison to a control group. J Cosmet Dermatol. 2020 Jul 05;: Authors: Guertler A, Jøntvedt NM, Clanner-Engelshofen BM, Cappello C, Sager A, Reinholz M Abstract BACKGROUND: Rosacea is a common inflammatory skin disorder with centrofacial erythema, flushing, telangiectasia, papules/pustules and possible ocular or phymatous manifestation. Patients' skin is particularly sensitive to chemical and physical stimuli leading to burning, stinging, dryness and skin tightness. OBJECTIVE: Dermatological evaluation of the efficacy and safety of skin care products designed for centrofacial erythema in rosacea patients, in comparison to a control group using objective measurements. Rosacea symptoms (itching, tension, warmth, burning, dryness) and quality of life were examined. METHODS: Sixty Caucasians with centrofacial erythema were enrolled in an eight-week prospective study, fifty of them exclusively using the study products (micellar water, cream and serum) with ten participants randomly assigned to a control group. Patients were evaluated at baseline (V0), at four weeks (V1) and at eight weeks (V2). Three-dimensional objective measurements (VECTRA® ) as well as standardized questionnaires were used. RESULTS: Results were compared with the control group. A significant reduction of 16% in skin redness as indicated by VECTRA® analysis was seen in the intervention group comparing V0 to V2. Furthermore, rosacea associated symptoms diminished by 57.1%, while life quality of affected patients within the intervention group improved by 54.5% comparing V0 to V2 respectively. CONCLUSIONS: A skin care regime suitable for sensitive and redness prone skin led to an enhanced clinical appearance, to a decrease of associated symptoms in rosacea patients and to an improved life quality. PMID: 32623833 [PubMed - as supplied by publisher] {url} = URL to article
  8. Related ArticlesRosacea induced by selexipag in a patient with pulmonary arterial hypertension. Dermatol Ther. 2020 Jul 02;:e13947 Authors: Dominguez-Santas M, Diaz-Guimaraens B, Burgos-Blasco P, Ortega-Quijano D, Suarez-Valle A, Saceda-Corralo D PMID: 32618056 [PubMed - as supplied by publisher] {url} = URL to article
  9. Related ArticlesUse of proton pump inhibitors and risk of rosacea: A nationwide population-based study. J Dermatol. 2020 Jul 01;: Authors: Dai YX, Tai YH, Chen CC, Chang YT, Chen TJ, Chen MH Abstract Proton pump inhibitors (PPI) are commonly used drugs. However, little is known about the association between PPI use and rosacea. This study aimed to investigate the association between PPI use and rosacea risk. Patients with prior PPI therapy, including 1067 rosacea cases and 4268 matched controls, were identified from the National Health Insurance Research Database in Taiwan. The cumulative defined daily dose (cDDD) was used to quantify the PPI use. Logistic regression was used for the analyses. After adjustment for potential confounders, PPI use with cDDD of more than 365 was significantly associated with an increased risk of rosacea (odds ratio [OR], 1.54; 95% confidence interval [CI], 1.10-2.15). Rosacea risk was significantly associated with PPI use of cDDD of more than 365 in women (OR, 1.62; 95% CI, 1.08-2.46) but not in men. Stratified by PPI indications, risk of rosacea was significantly associated with PPI use of cDDD of more than 365 for peptic ulcer (OR, 1.58; 95% CI, 1.12-2.21). In conclusion, prolonged PPI use was associated with an increased risk of rosacea, particularly in women and patients with peptic ulcers. PMID: 32613686 [PubMed - as supplied by publisher] {url} = URL to article
  10. Related ArticlesExcessive cleansing: an underestimating risk factor of rosacea in Chinese population. Arch Dermatol Res. 2020 Jun 27;: Authors: Li G, Wang B, Zhao Z, Shi W, Jian D, Xie H, Huang Y, Li J Abstract Appropriate skincare is essential in the prevention and management of rosacea. We sought to investigate whether cleansing habits, the initial step of skin care, would influence the onset and progression of rosacea and their associations with clinical features of rosacea in the Chinese population. We analyzed the daily cleansing habits data collected from 999 rosacea cases and 1010 skin-healthy controls from China. Overall, the high frequency of cleansing (more than once daily) (OR = 1.450) and the large amount of cleansers (> 5 pieces/year) (OR = 1.612) presented a positive correlation with rosacea occurring. The cleansing duration and types of cleansers appeared not to be correlated with the onset of rosacea in this study. Significant risk factors also included the deep cleansing habits, such as the overuse of cleansing tool (more than four times/week) (OR 2.179) and oil control and exfoliating behaviors via daily used products (OR 2.435), facial mask (OR 1.459) or projects in beauty salons (OR 2.688). The analysis of the clinical features of rosacea showed that patients who prefer deep cleansing were more prone to present an initial symptom of papule and pustule (OR 1.63-3.15). What is more, using daily exfoliating products presented a positive correlation with the progression of the symptoms from flushing to erythema (OR = 2.01), papule and pustule (OR = 2.28) and telangiectasis (OR = 2.14), and the affected areas from a single area to pan facial (OR = 1.650). In conclusion, excessive cleansing habits were substantial risk factors for the incidence and progression of rosacea in the Chinese population. PMID: 32594335 [PubMed - as supplied by publisher] {url} = URL to article
  11. Related ArticlesUpdate on the pathogenesis and management of ocular rosacea: an interdisciplinary review. Eur J Ophthalmol. 2020 Jun 25;:1120672120937252 Authors: Jabbehdari S, Memar OM, Caughlin B, Djalilian AR Abstract PURPOSE: Rosacea is one of the most common conditions affecting the ocular surface. The purpose of this review is to provide an update on the pathogenesis and treatment of rosacea based on the dermatology and ophthalmology literatures. METHODS: Literature searches were conducted for rosacea and ocular rosacea. Preference was given to systematic reviews, meta-analysis, case-controlled studies, and documented case reports while excluding poorly documented case studies and commentaries. The data were examined and independently analyzed by more than two of the authors. RESULTS: Rosacea is a complex inflammatory condition involving the pilosebaceous unit. Its underlying mechanism involves an interplay of the microbiome, innate immunity, adaptive immunity, environmental triggers, and neurovascular sensitivity. The latest classification of rosacea includes three dermatologic subgroups and a fourth subgroup, ocular rosacea. Ocular rosacea clinically displays many features that are analogous to the cutaneous disease, such as lid margin telangiectasia and phlyctenulosis. The role of environmental triggers in the exacerbation of ocular rosacea appears to be understudied. While lid hygiene and systemic treatment with tetracycline drugs remain the mainstay of treatment for ocular rosacea, newer dermatologic targets and therapies may have potential application for the eye disease. CONCLUSIONS: Ocular rosacea appears to embody many of the manifestation of the dermatologic disease. Hence, the basic pathophysiologic mechanisms of the ocular and cutaneous disease are likely to be shared. Better understanding of the ocular surface microbiome and the immunologic mechanisms, may lead to novel approaches in the management of ocular rosacea. PMID: 32586107 [PubMed - as supplied by publisher] {url} = URL to article
  12. Related ArticlesColor Doppler Ultrasound Evaluation of Management of Papulopustular Rosacea. J Am Acad Dermatol. 2020 Jun 23;: Authors: Bustos R, Cortes A, McNab ME, Fuentes E, Castro A, Wortsman X PMID: 32590034 [PubMed - as supplied by publisher] {url} = URL to article
  13. Related Articles[Treatmentof rhinophyma with laser and surgery]. Ugeskr Laeger. 2020 Jun 15;182(25): Authors: Borhani-Khomani K, Møller MP, Thomsen MV, Karmisholt K, Hædersdal M, Bonde CT Abstract Rhinophyma is a disfiguring skin condition characterised by progressive hyperplasia of the nasal sebaceous glands and proliferation of blood vessels and connective tissue. It is considered the end stage of rosacea and affects primarily older males of Northern European descent. Several surgical and laser treatment options are available. None of these has been compared in randomised, controlled prospective trials. In this review, we provide an overview of the different treatment modalities and account for their respective strengths and limitations. PMID: 32584764 [PubMed - as supplied by publisher] {url} = URL to article
  14. Related ArticlesRosacea Patients Are at Higher Risk for Obstructive Sleep Apnea: Automated Retrospective Research. Stud Health Technol Inform. 2020 Jun 16;270:1381-1382 Authors: Elkin PL, Mullin S, Sakilay S Abstract Using big data science we employ NLP and a novel interface the BMI Investigator to answer clinically meaninful questions. The use case presented is the association between Rosacea and Obstructive Sleep Apnea. PMID: 32570669 [PubMed - in process] {url} = URL to article
  15. Related Articles Value of GPSkin for the measurement of skin barrier impairment and for monitoring of rosacea treatment in daily practice. Skin Res Technol. 2020 Jun 23;: Authors: Logger JGM, Driessen RJB, de Jong EMGJ, van Erp PEJ Abstract BACKGROUND: Stratum corneum hydration (SCH) and transepidermal water loss (TEWL) provide useful information about skin barrier function. This study aimed to determine the value of GPSkin Pro, a new handheld device determining both SCH and TEWL, to measure skin barrier impairment and to monitor barrier function in rosacea in daily practice. MATERIALS AND METHODS: Two pilots were performed. Pilot 1: in 27 healthy participants, GPSkin SCH and TEWL were compared to Aquaflux® and Epsilon® values at the forearm before and after skin barrier perturbation via tapestripping. Moreover, GPSkin values were measured at both cheeks without intervention. Pilot 2: in 16 rosacea patients, GPSkin measurements were performed at the forearm, and at both cheeks before and during anti-inflammatory treatment. They were compared to clinical symptoms and to GPSkin values from pilot 1. RESULTS: Pilot 1: after merging data from before and after tapestripping, a strong correlation was observed between GPSkin TEWL and Aquaflux® (Rs = 0.9256), and GPSkin SCH and Epsilon® (Rs = 0.8798). Pilot 2: SCH was significantly lower at the cheeks of rosacea patients compared to controls, with a normalizing trend during successful treatment. TEWL was comparable among patients and controls and did not change during treatment at all locations. CONCLUSION: The GPSkin determines TEWL and SCH accurately in healthy and impaired skin barrier state and can monitor skin barrier function in rosacea during treatment. The GPSkin device is much more practical compared to previous skin barrier tools when used in clinical practice. Its further validation in other inflammatory skin diseases is recommended. PMID: 32573826 [PubMed - as supplied by publisher] {url} = URL to article More information on the GPSkin device
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