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  1. Related ArticlesAdipokines in the Skin and in Dermatological Diseases. Int J Mol Sci. 2020 Nov 28;21(23): Authors: Kovács D, Fazekas F, Oláh A, Törőcsik D Abstract Adipokines are the primary mediators of adipose tissue-induced and regulated systemic inflammatory diseases; however, recent findings revealed that serum levels of various adipokines correlate also with the onset and the severity of dermatological diseases. Importantly, further data confirmed that the skin serves not only as a target for adipokine signaling, but may serve as a source to
  2. Related Articl Coptis chinensis Franch Directly Inhibits Proteolytic Activation of Kallikrein 5 and Cathelicidin Associated with Rosacea in Epidermal Keratinocytes. Molecules. 2020 Nov 26;25(23): Authors: Roh KB, Ryu DH, Cho E, Weon JB, Park D, Kweon DH, Jung E Abstract Rosacea is a common and chronic inflammatory skin disease that is characterized by dysfunction of the immune and vascular system. The excessive production and activation of kallikerin 5 (KLK5) and cathelicidin have been implicated in the pathogenesis of rosacea. Coptis chinensis Franch (CC) has been use
  3. Related ArticlesParkinson's disease and skin. Parkinsonism Relat Disord. 2020 Nov 20;82:61-76 Authors: Niemann N, Billnitzer A, Jankovic J Abstract Parkinson's disease is associated with a variety of dermatologic disorders and the study of skin may provide insights into pathophysiological mechanisms underlying this common neurodegenerative disorder. Skin disorders in patients with Parkinson's disease can be divided into two major groups: 1) non-iatrogenic disorders, including melanoma, seborrheic dermatitis, sweating disorders, bullous pemphigoid,
  4. Related ArticlesEosinophilic pustular folliculitis (EPF) in a patient with HIV infection. Infection. 2020 Nov 25;: Authors: Kanaki T, Hadaschik E, Esser S, Sammet S Abstract Eosinophilic pustular folliculitis is a chronic, recurrent dermatosis, of unknown etiology, which is histologically characterized by folliculotropic inflammatory infiltrates with admixed eosinophils in the dermis. It has often presented with immunosuppression and especially with HIV-Infection. In the HAART-era, eosinophilic pustular folliculitis has become a rarity. It is ofte
  5. Related ArticlesChildhood rosacea and related disorders. Clin Exp Dermatol. 2020 Nov 20;: Authors: Noguera-Morel L, Hernández-Martín A, Torrelo A Abstract Rosacea is a chronic inflammatory condition that affects the skin and the eyes. The pathogenesis of rosacea is complex and includes the interaction between genetic and environmental factors, dysregulation of the innate immune system, neurovascular modifications and the interaction with skin commensals. Clinical manifestations in children include the telangiectatic form, papulopustular rosacea, o
  6. Related Articles Neurogenic rosacea in Korea. J Dermatol. 2020 Nov 19;: Authors: Kim HO, Kang SY, Kim KE, Cho SY, Kim KH, Kim IH Abstract Rosacea with severe neurological symptoms such as burning and stinging is often not treated effectively by conventional therapies. The aim of this study was to investigate the clinical characteristics of Korean rosacea patients with prominent neurological symptoms. The demographic features, medical history, clinical manifestations and treatment modalities of 17 neurogenic rosacea patients who had prominent neurological symptoms and 1
  7. Related Articles Updates on the Risk of Neuropsychiatric and Gastrointestinal Comorbidities in Rosacea and Its Possible Relationship with the Gut-Brain-Skin Axis. Int J Mol Sci. 2020 Nov 10;21(22): Authors: Woo YR, Han YJ, Kim HS, Cho SH, Lee JD Abstract Rosacea is a common chronic cutaneous inflammatory disorder. Recently, patients with rosacea were identified as having a higher risk of developing various comorbidities such as cardiovascular disease, psychiatric disorders, neurologic disorders, and gastrointestinal disorders. However, the risks of some comorbidities i
  8. Related ArticlesAnalysis of trends and status of physician-based evaluation methods in acne vulgaris from 2000 to 2019. J Dermatol. 2020 Nov 12;: Authors: Cho SI, Yang JH, Suh DH Abstract Various evaluation methods for acne severity have been used without standardization, and the diversity of acne outcome measures is an obstacle to the integrated analysis of various acne studies. In this study, we sought to investigate physician-based evaluation methods used in clinical studies of acne vulgaris and to determine differences according to time, regio
  9. Related ArticlesErythematotelangiectatic rosacea: the combination of 0.5% brimonidine tartrate gel and broadband pulse light therapy to reverse its effects. J Cosmet Dermatol. 2020 Nov 11;: Authors: Rusina T, Snarskaya E Abstract Rosacea is a common skin disease that is troublesome for both the patients and the dermatologists. Erythema, telengiectasia, papulopustular changes and phymatous changes are the main problems faced by the patients and dermatologists in everyday practice. Due to the chronic and relapsing nature of the disease, patients are
  10. Related Articles Facial Flushing and Erythema of Rosacea Improved by Carvedilol. Dermatol Ther. 2020 Nov 11;:e14520 Authors: Seo BH, Kim DH, Suh HS, Choi YS Abstract BACKGROUND: Flushing and erythema are the most common symptoms of rosacea; however, management of these symptoms remains challenging. Recent case studies suggest that treatment with carvedilol may reduce facial flushing and persistent erythema in the pathogenesis of rosacea. OBJECTIVE: To find the effect of carvedilol in the treatment of facial flushing and erythema in rosacea. METHODS: Twenty-four ros
  11. Related ArticlesDermatological Manifestations of Parkinson's Disease: Clues for Diagnosis. Cureus. 2020 Oct 07;12(10):e10836 Authors: Shahid W, Satyjeet F, Kumari R, Raj K, Kumar V, Afroz MN, Memon MK Abstract Background and objective Parkinson's disease (PD) is a common neurodegenerative disorder. There are various manifestations of PD. Among them, motor dysfunction has been studied in many research studies; however, few studies are available related to the dermatological manifestations of PD. This study was conducted with the aim to shed light o
  12. Related ArticlesConsensus on the therapeutic management of rosacea - Brazilian Society of Dermatology. An Bras Dermatol. 2020 Oct 10;: Authors: Oliveira CMM, Almeida LMC, Bonamigo RR, Lima CWG, Bagatin E Abstract BACKGROUND: Rosacea is a chronic inflammatory disease of the skin, relatively more frequent in women over 30 with a low phototype and proven genetic predisposition. Although its etiology is unknown and possibly multifactorial, the immunological abnormality, associated with neurovascular dysregulation and triggering factors, are important
  13. Related Articles Diversity and Composition of the Skin, Blood and Gut Microbiome in Rosacea-A Systematic Review of the Literature. Microorganisms. 2020 Nov 08;8(11): Authors: Tutka K, Żychowska M, Reich A Abstract Rosacea is a chronic inflammatory skin disorder of a not fully understood pathophysiology. Microbial factors, although not precisely characterized, are speculated to contribute to the development of the condition. The aim of the current review was to summarize the rosacea-associated alterations in the skin, blood, and gut microbiome, investigated using cultur
  14. Related Articles Rosacea and the Microbiome: A Systematic Review. Dermatol Ther (Heidelb). 2020 Nov 10;: Authors: Daou H, Paradiso M, Hennessy K, Seminario-Vidal L Abstract Rosacea, a chronic inflammatory skin disease characterized by recurrent episodes of facial flushing, erythema, pustules, and telangiectasia, largely affects fair-skinned women over 30 years of age. Although a long-recognized entity, the exact pathophysiology of this disease is still debated. Current theories highlight the role of the cutaneous microbiome and its associated inflammatory effects in ro
  15. Related ArticlesRosacea Treatment: Review and Update. Dermatol Ther (Heidelb). 2020 Nov 10;: Authors: Zhang H, Tang K, Wang Y, Fang R, Sun Q Abstract Rosacea is a chronic and inflammatory skin disease characterized by flushing, nontransient erythema, papules/pustules, telangiectasia, and phymatous changes. Secondary manifestations, such as itching, burning, or stinging, are often observed in patients with rosacea. In 2017, a phenotype-based approach for diagnosis and classification was recommended. With the update of the diagnosis and classificati
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