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  1. Related Articles Giant rhinophyma in low-resource setting: a case report. Int J Dermatol. 2017 Aug;56(8):875-877 Authors: Antunes M, Frasson G, Ottaviano G, Schiavone M, Pizzol D PMID: 28650103 [PubMed - indexed for MEDLINE] {url} = URL to article
  2. Dietary supplementation with turmeric polyherbal formulation decreases facial redness: a randomized double-blind controlled pilot study. J Integr Med. 2018 Nov 22;: Authors: Vaughn AR, Pourang A, Clark AK, Burney W, Sivamani RK Abstract BACKGROUND: Facial redness is multifactorial in nature and may be a sign of many different conditions, including rosacea, photo damage and flushing. Herbal medicines have been used for thousands of years to treat a variety of dermatological conditions. Turmeric (Curcuma longa) and its constituents have been shown to mediate dilation and constriction of peripheral arterioles and have demonstrated anti-oxidant, anti-inflammatory and wound-healing properties. OBJECTIVE: To investigate the effects of turmeric and turmeric-containing polyherbal combination tablets versus placebo on facial redness. DESIGN, SETTING, PARTICIPANTS, AND INTERVENTIONS: This was a prospective, double-blind, randomized pilot study. Thirty-three healthy participants were recruited from the dermatology clinic at the University of California, Davis and nearby community from 2016 to 2017. Thirty participants were enrolled, and 28 participants completed the study. The enrolled participants were randomized to receive one of three interventions (placebo, turmeric or polyherbal combination tablets) and were told to take the intervention tablets by mouth twice daily for 4 weeks. Facial redness was assessed at baseline and 4 weeks after intervention by clinical grading and by image-based analysis. MAIN OUTCOME MEASURES: The primary outcome measure was image-based facial quantification of redness using a research camera and software analysis system. The investigators performed an intention-to-treat analysis by including all subjects who were enrolled in the trial and received any study intervention. Differences were considered statistically significant after accounting for multiple comparisons. Effect sizes for clinical grading were calculated with a Hedges' g where indicated. RESULTS: Twenty-eight participants completed the study and there were no reported adverse events. Based on clinical grading, facial redness intensity and distribution down trended in the polyherbal combination group after 4 weeks (P = 0.1). Under photographic image analysis, the polyherbal combination group had a significant decrease in redness of 40% compared to baseline (P = 0.03). The placebo and turmeric groups had no statistically significant changes in image analysis-based facial redness. CONCLUSION: Polyherbal combination tablet supplementation improved facial redness compared to the turmeric or placebo. Overall, our findings suggested further investigations into the effects of turmeric and polyherbal formulations in skin conditions associated with facial redness would be warranted. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT03065504. PMID: 30527287 [PubMed - as supplied by publisher] {url} = URL to article
  3. Nested Polymerase Chain Reaction and Cutaneous Tuberculosis. Am J Dermatopathol. 2018 Nov 27;: Authors: Maldonado-Bernal C, Ramos-Garibay A, Rios-Sarabia N, Serrano H, Carrera M, Navarrete-Franco G, Jurado-Santacruz F, Isibasi A Abstract The role of Mycobacterium tuberculosis in the etiology and pathogenesis of cutaneous tuberculosis is controversial because of the difficulties associated with demonstrating the presence of these mycobacteria in tuberculid cutaneous lesions by routinely available microbiological and histological techniques. In this study, we aimed to demonstrate the presence of M. tuberculosis in cutaneous tuberculosis. Multiple polymerase chain reaction (PCR) followed by nested PCR was used to amplify genomic fragments from 3 different mycobacteria species. DNA was isolated from 30 paraffin-embedded skin biopsies. Samples were selected randomly from patients with a clinical and histopathological diagnosis of the most frequent groups of cutaneous tuberculosis in Mexico as follows: 5 cases of scrofuloderma tuberculosis; 2 cases of lupus vulgaris tuberculosis; and 5 cases of tuberculosis verrucosa cutis. The other cases denominated tuberculids in some countries such as Mexico and included the following: 7 cases of rosacea-like tuberculosis; one case of papulonecrotic tuberculosis; and 10 cases of erythema induratum of Bazin. Four normal skin biopsies were included as controls. M. tuberculosis DNA was amplified successfully by nested PCR in 80% of the samples (24 of the 30 samples) assayed. Mycobacterial DNA was not detected in the normal skin biopsies used as controls. Detection of M. tuberculosis DNA in 80% of cutaneous tuberculosis analyzed implicates this mycobacterium in the pathogenesis of multiple clinical forms of cutaneous tuberculosis. PMID: 30531542 [PubMed - as supplied by publisher] {url} = URL to article
  4. Related Articles [Not Available]. Prensa Med. 1946;6(2):10-2 Authors: VEINTEMILLA F, DEL CASTILLO H PMID: 20991596 [PubMed - indexed for MEDLINE] {url} = URL to article
  5. Related Articles [Not Available]. Arch Derm Syphilol. 1946 Jan;53:67 Authors: LENTZ JW PMID: 21065801 [PubMed - indexed for MEDLINE] {url} = URL to article
  6. Use of an Alternative Method to Evaluate Erythema Severity in a Clinical Trial: Difference in Vehicle Response With Evaluation of Baseline and Postdose Photographs for Effect of Oxymetazoline Cream 1.0% for Persistent Erythema of Rosacea in a Phase 4 Study. Br J Dermatol. 2018 Nov 30;: Authors: Eichenfield LF, Del Rosso JQ, Tan JKL, Hebert AA, Webster GF, Harper J, Baldwin HE, Kircik LH, Stein-Gold L, Kaoukhov A, Alvandi N Abstract BACKGROUND: Once-daily topical oxymetazoline cream 1.0% significantly reduced persistent facial erythema of rosacea in trials requiring live, static patient assessments. OBJECTIVE: To critically evaluate the methodology of clinical trials that require live, static patient assessments by determining whether assessment of erythema is different when reference to the baseline photograph is allowed. METHODS: In two identically designed, randomised, phase 3 trials, adults with persistent facial erythema of rosacea applied oxymetazoline or vehicle once daily. This phase 4 study evaluated standardised digital facial photographs from the phase 3 trials to record ≥1-grade Clinician Erythema Assessment (CEA) improvement at 1, 3, 6, 9, and 12 hours postdose. RESULTS: Among 835 patients (oxymetazoline n=415, vehicle n=420), significantly greater proportions of patients treated with oxymetazoline versus vehicle (P<0.0001) achieved ≥1-grade CEA improvement (up to 85.3% vs 29.8%). When reference to baseline photographs was allowed while evaluating posttreatment photographs, the results for oxymetazoline were similar to results of the phase 3 trials, but a significantly lower proportion of vehicle recipients achieved ≥1-grade CEA improvement (up to 52.3% vs 29.7%; P<0.001). Up to 80.2% of oxymetazoline patients achieved at least moderate erythema improvement, versus up to 22.9% of vehicle patients. The association between patients' satisfaction with facial skin redness and percentage of erythema improvement was statistically significant (Spearman rank correlation, 0.1824; P<0.0001 [oxymetazoline]; 0.0623; P=0.01 [vehicle]). CONCLUSIONS: Assessment of study photographs, with comparison to baseline, confirmed significant erythema reduction with oxymetazoline on the first day of application. Compared to the phase 3 trials results, significantly fewer vehicle recipients attained ≥1-grade CEA improvement, inferring a mitigated vehicle effect. This methodology may improve the accuracy of clinical trials evaluating erythema severity. This article is protected by copyright. All rights reserved. PMID: 30500065 [PubMed - as supplied by publisher] {url} = URL to article
  7. Topical Oxymetazoline Cream 1.0% for Persistent Facial Erythema Associated With Rosacea: Pooled Analysis of the Two Phase 3, 29-Day, Randomized, Controlled REVEAL Trials J Drugs Dermatol. 2018 Nov 01;17(11):1201-1208 Authors: Stein-Gold L, Kircik L, Draelos ZD, Werschler P, DuBois J, Lain E, Baumann L, Goldberg D, Kaufman J, Tanghetti E, Ahluwalia G, Alvandi N, Weng E, Berk D Abstract Background: Rosacea is a chronic dermatologic condition with limited treatment options. Methods: Data were pooled from two identically designed phase 3 trials. Patients with moderate to severe persistent erythema of rosacea were randomized to receive oxymetazoline cream 1.0% or vehicle once daily for 29 days and were followed for 28 days posttreatment. The primary efficacy outcome was the proportion of patients with ≥2-grade improvement from baseline on both Clinician Erythema Assessment (CEA) and Subject Self-Assessment (SSA) at 3, 6, 9, and 12 hours postdose, day 29. Results: The pooled population included 885 patients (78.8% female); 85.8% and 91.2% had moderate erythema based on CEA and SSA, respectively. The primary outcome was achieved by significantly more patients in the oxymetazoline than vehicle group (P<0.001). Individual CEA and SSA scores and reduction in facial erythema (digital image analysis) favored oxymetazoline over vehicle (P<0.001). The incidence of treatment-emergent adverse events was low (oxymetazoline, 16.4%; vehicle, 11.8%). No clinically relevant erythema worsening (based on CEA and SSA) was observed during the 28-day posttreatment follow-up period (oxymetazoline, 1.7%; vehicle, 0.6%). Conclusion: Oxymetazoline effectively reduced moderate to severe persistent facial erythema of rosacea and was well tolerated. J Drugs Dermatol. 2018;17(11):1201-1208. PMID: 30500142 [PubMed - as supplied by publisher] {url} = URL to article
  8. Related Articles Rosacea-specific quality of life questionnaire: translation, cultural adaptation and validation for Brazilian Portuguese. An Bras Dermatol. 2018 Nov/Dec;93(6):836-842 Authors: Tannus FC, Picosse FR, Soares JM, Bagatin E Abstract BACKGROUND: Brazil does not have a rosacea-specific quality of life questionnaire. OBJECTIVES: translation into Brazilian Portuguese, development of cultural adaptation, and validation of the RosaQoL disease-specific questionnaire for rosacea of any subtype. METHODS: the recommended procedures for translation, cultural adaptation, and validation of an instrument were followed, and three interviews were conducted: baseline; seven to fourteen days after baseline; and at four to six months. The questionnaire was analyzed (with 95% confidence interval) for reliability by internal consistency (Cronbach's alpha); testretest reproducibility (intraclass correlation coefficient); responsiveness and validity. RESULTS: terms of the original questionnaire were replaced to guarantee cultural and semantic equivalence. Validity was demonstrated by expressive correlations between the RosaQoL domains and by significance in the Jonckheere-Terpstra test (p≤0.05) between the scores of the RosaQoL domains and the participants' self-perception in relation to the disease. Reliability was acceptable; alpha coefficient ranged from 0.923 to 0.916 in the first and second applications of the RosaQoL, respectively, and the Intraclass Correlation Coefficient (ICC) ranged from 0.671 to 0.863 in the seven- to fourteen-day period. Responsiveness, measured by grouping participants into three categories based on self-perception of rosacea (better, worse or unchanged), was found for the "better" response group (p≤0.05). STUDY LIMITATIONS: small sample; limited variety of screening sources. CONCLUSIONS: RosaQoL-BR (Brazil) was demonstrated as a reliable, valid and responsive questionnaire, with limitations, for individuals with any subtype of rosacea. PMID: 30484528 [PubMed - in process] {url} = URL to article
  9. Risk of psychiatric disorders in rosacea: A nationwide, population-based, cohort study in Taiwan. J Dermatol. 2018 Nov 22;: Authors: Hung CT, Chiang CP, Chung CH, Tsao CH, Chien WC, Wang WM Abstract Rosacea has been reported to be associated with psychiatric disorders. Nevertheless, a nationwide study of the relationship between rosacea and comorbid psychiatric diseases in an Asian population has not been conducted. The aim of this study was to clarify the role of rosacea in the various psychiatric disorders by using a nationwide database in Taiwan. Data were obtained from the National Health Insurance Research Database of Taiwan from 2000 to 2013. In total, 7881 patients with rosacea and 31 524 age- and sex-matched controls were enrolled. Patients with rosacea tended to have more coexisting psychiatric disorders. After adjusting for age, sex, comorbidity and residence/regions, the adjusted hazard ratio (HR) of psychiatric disorders for patients with rosacea was 2.761 (95% CI = 2.650-2.877, P < 0.001). Among them, the highest adjusted HR are phobic disorder and obsessive-compulsive disorder of 7.841 (95% CI = 7.526-8.170, P < 0.001) and 6.389 (95% CI = 6.132-6.657, P < 0.001), respectively. The National Health Insurance Research Database of Taiwan does not include the information about rosacea subtypes, severity and laboratory parameters. In conclusion, rosacea is related to various psychiatric disorders. In addition to anxiety and depression, patients are also at increased risk of phobic disorder and obsessive-compulsive disorder. PMID: 30466187 [PubMed - as supplied by publisher] {url} = URL to article
  10. Potassium Iodide for Cutaneous Inflammatory Disorders: A Monocentric, Retrospective Study. Dermatology. 2018 Nov 21;:1-7 Authors: Anzengruber F, Mergenthaler C, Murer C, Dummer R Abstract OBJECTIVES: Potassium iodide (KI) is a medication that has been used for decades in dermatology and it is mentioned as a treatment option in all major dermatology textbooks. Yet, there is little recent information on its efficacy. In our study, we wanted to retrospectively evaluate the therapy response to KI in our patients. METHODS: The hospital information system was searched for patients treated with KI at the Department of Dermatology (University Hospital Zurich) in the last 20 years (January 1, 1998 to December 31, 2017). A total of 52 patients were found and, subsequently, 35 patients were included in our study. RESULTS: KI was prescribed for the following skin conditions: erythema nodosum, disseminated granuloma anulare, necrobiosis lipoidica, nodular vasculitis, cutaneous sarcoidosis, and granulomatous perioral dermatitis/ rosacea. The median duration of KI intake was 5 ± 7.7 weeks (range 1-26). The global assessment of efficacy by the treating physician showed an improvement of disease in about a third of all patients. No response was seen in 14 patients and 9 even had a progression of disease. An adverse event was documented in 16 cases. CONCLUSIONS: Our findings show that an improvement was reached in only about a third of all cases. High response rates with only mild side effects (in 16 out of 35 patients) were observed. PMID: 30463069 [PubMed - as supplied by publisher] {url} = URL to article
  11. Related Articles The Spectrum and Sequelae of Acne in Black South Africans Seen in Tertiary Institutions. Skin Appendage Disord. 2018 Oct;4(4):301-303 Authors: Dlova NC, Mosam A, Tsoka-Gwegweni J Abstract Introduction: Acne is a chronic disorder of the pilosebaceous unit affecting all ethnic groups. It remains in the top 5 skin conditions seen worldwide. The paucity of data characterizing acne in South African Blacks led us to the documentation of types and sequelae of acne. Methods: This is a cross- sectional study describing the spectrum and variants of acne in 5 tertiary hospitals in the second most populous province in South Africa over 3 months (January 1 - March 31, 2015). Results: Out of 3,814 patients seen in tertiary dermatology clinics, 382 (10%) had a primary diagnosis of acne or rosacea, forming the fourth most common condition seen. Acne accounted for 361 (94.5%); acne vulgaris was the commonest subtype at 273 (75.6%), followed by steroid-induced acne 46 (12.7%), middle-age acne 6 (1.7%), acne excoriée 2 (0.6%), and "undefined" 34 (9.4%). Conclusion: The observation of steroid-induced acne as the second most common variant in Black patients underlines the need to enquire about steroid use and education about the complications of using steroid-containing skin-lightening creams. Treatment of postinflammatory hyperpigmentation should be part of the armamentarium for holistic acne treatment in Blacks, as it remains a major concern even after active acne has resolved. PMID: 30410901 [PubMed] {url} = URL to article
  12. Related Articles Comprehensive Diagnosis and Planning for the Difficult Rhinoplasty Patient: Applications in Ultrasonography and Treatment of the Soft-Tissue Envelope. Facial Plast Surg. 2017 Oct;33(5):509-518 Authors: Kosins AM PMID: 28962057 [PubMed - indexed for MEDLINE] {url} = URL to article
  13. Body Piercing: A National Survey in France. Dermatology. 2018 Nov 07;:1-8 Authors: Kluger N, Misery L, Seité S, Taieb C Abstract BACKGROUND: There are no recent data available in France regarding body piercing (BP). OBJECTIVE: We examined the demographics, motivations, quality of life, cutaneous conditions, and cutaneous side effects after BP within the French population. METHODS: A representative sample of 5,000 individuals (aged 15 and over) from the general population responded to a survey online between April and August 2017. Data regarding demographics, BP characteristics (location, age at first piercing, hesitation, regrets, motivations, cutaneous side effects), tobacco, skin conditions (acne, contact eczema, atopic eczema, rosacea, psoriasis, vitiligo), and tattoos were collected. Respondents also filled an SF-12 quality of life questionnaire. RESULTS: Overall, 12% of the respondents reported at least one BP (women: 19.4%, men: 8.4%, p < 0.01). The prevalence was highest among those aged between 25 and 34 years (25.8%). Individuals with BP were more likely to smoke (p < 0.01). The most common body parts for piercings were the external part of the ear (42%), the navel (24%), the tongue (15%), and the nose (11%). Gender differences included localization (belly button and nose for women, eyebrows for men) and motivations (embellishment of the body for women, individuality and sexuality for men). A total of 33.6% of the study participants reported having skin problems after BP, primarily infection (44%). Individuals with BPs were more likely to report having contact eczema, atopic dermatitis, and acne. BP was associated with a lower mental quality of life score. CONCLUSION: This is the largest epidemiological study on BP in France to date. It allows us to draw a precise current snapshot of French indi viduals with BP. PMID: 30404090 [PubMed - as supplied by publisher] {url} = URL to article
  14. Related Articles [Not Available]. Ugeskr Laeger. 2016 Jan 25;178(4):V66927 Authors: Carlsen BC, Larsen HK, Hædersdal M PMID: 26815717 [PubMed - indexed for MEDLINE] {url} = URL to article
  15. Related Articles The microbiome in dermatology. Clin Dermatol. 2018 May - Jun;36(3):390-398 Authors: Musthaq S, Mazuy A, Jakus J Abstract The skin supports a delicate ecosystem of microbial elements. Although the skin typically acts as a barrier, these microbes interact with the internal body environment and imbalances from the "healthy" state that have been linked to several dermatologic diseases. Understanding the changes in microbial flora in disease states allows for the potential to treat by restoring equilibrium. With the rising popularity of holistic and natural consumerism, prebiotics, probiotics, symbiotic, and other therapies are under study to find alternative treatments to these skin disorders through manipulation or supplementation of the microbiome. PMID: 29908581 [PubMed - indexed for MEDLINE] {url} = URL to article