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"Rosacea is a common inflammatory skin disorder mediated by the dysregulation of both keratinocytes and T cells. Here, we report that aquaporin 3 (AQP3), a channel protein that mediates the transport of water/glycerol, was highly expressed in the epidermis and CD4+ T cells of both rosacea patients and experimental mice....Our findings reveal that AQP3-mediated activation of NF-κB in keratinocytes and activation of STAT3 in CD4+ T cells acted synergistically and contributed to the inflammation in rosacea." 
"Aquaporin 3 (AQP-3) is the protein product of the human AQP3 gene." 
"Aquaporins (AQPs) are water channels that facilitate transepithelial water transport across plasma membranes following an osmotic gradient . AQPs are glycosylated integral membrane proteins and widely expressed in bacteria (for review ), yeast , plants  (for review ), and mammals..." 
Obviously we need more rosacea research on this subject. Do you want to support such targeted research? Join the RRDi and post in this thread. A Graphical abstract of AQP3 
 PubMed RSS Feed - -Targeting Aquaporin-3 Attenuates Skin Inflammation in Rosacea
 Aquaporin-3, Wikipedia
 Aquaporin-3 in Cancer
Saw Marlar, Helene H. Jensen, Frédéric H. Login, and Lene N. Nejsum
Int J Mol Sci. 2017 Oct; 18(10): 2106.
Published online 2017 Oct 7. doi: 10.3390/ijms18102106
 Biochimica et Biophysica Acta (BBA) - Biomembranes
Volume 1861, Issue 4, 1 April 2019, Pages 768-775
Single-channel permeability and glycerol affinity of human aquaglyceroporin AQP3
Roberto A. Rodriguez, Huiyun Liang, Liao Y. Chen, Germán Plascencia-Villa, George Perry