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    We need volunteers. Volunteering has been shown to improve not only your health but also your hope. Some rosaceans tend to center themselves on their own skin issues resulting in a spiral into reciprocal deep depression with a tendency to isolate themselves. Volunteering breaks this cycle. It forces a rosacean into seeing that there are others out there with even more severe cases of rosacea than what they are experiencing. Helping a fellow rosacea suffer is worth every effort you can muster. The satisfaction of volunteering as a rosacean for other rosaceans is only experienced if you take the step to offer yourself willingly as a RRDi volunteer rosacean. 

    Could you seriously consider volunteering for the RRDi? The founder/director is appealing to millennials to think about helping others with rosacea through our non profit organization so we can keep this web site on the internet with its wealth of information on rosacea. If some don't step up to the plate and volunteer the RRDi may eventually close up shop. Seriously, do you want to see this organization cease?  The statistics globally show that volunteering is dropping (read this post). Then read below why you are needed. 

    If you would like to volunteer by simply joining our cause adding you name to our list and do nothing more that is the easiest way to volunteer. At the very least join the RRDi to increase our membership and if that is all you can do we understand and appreciate whatever you can do. Your email address is all we require to join. Our goal is to reach 10,000 members. 

    Volunteers are needed to recruit more members, for fund raising, public relations, writers to write posts on our member forum, editors for the newsletter, accounting/book keeping, webmasters, forum moderators, board members, researchers, Google AdWords expert, and grant writers. If you have a skill not mentioned, let us know. Why not suggest what you might volunteer to do when you join the RRDi, and in the application to become a corporate member there is a place to add a comment what your volunteer skills are. If you have questions, contact us. If you want to know what will volunteering do for you (?), skip down to the subheading, What's in it for me below

    We would like to offer each author reimbursement if we publish the article in the next Journal of the RRDi.  If you want to volunteer to be on the publication team as an editor, author, proofreader, or any other job please join our cause and state in the comment box you want to join the Journal Publication Team.

    Volunteers are needed for the public relations committee or to write requests for donations to major corporations in our Funding Committee. Please join and mention you would like to help on the Funding Committee or for Public Relations. Or you can personally write a fund raiser letter using this sample letter.

    To Volunteer as a Writer please join. Check our announcements for special needs. Writers, editors, graphic artists and proof readers are needed! We have the ability to turn your post into an article. Why not post your article?

    Volunteer to write letters for donations by clicking here.

    Grant Writers are needed.

    What's In It For Me?

    There is scientific evidence that volunteering improves health and well being. For more information read this post

    Volunteers may receive a special Gmail account associated with the RRDi domain email which is a G Suite (formerly Google Apps) account associated with our domain, irosacea.org.

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    Google Apps Gmail

    You may receive the RRDi Newsletter by joining as a corporate member and requesting the newsletter by checking the box when you fill out the application. To know more about the Google apps account click here.

    You may receive on request a job referral with our letterhead if you volunteer for at least year to add to your resume or need a recommendation letter showing that you have regularly volunteered for our non profit organization. 

    Volunteers to POST comments in our member forum. 

    Volunteers Needed for the Following Jobs Immediately:

    Google AdWords Technician

    Google Analytics Technician

    Webmaster

    Forum Moderator

    Join the RRDi

    Mention which job you are volunteering for or create your own volunteer job and mention this in the appropriate box when applying.

    Another way help is by purchasing our Journal of the RRDi from Amazon or iUniverse which will help us continue its publication and may lead to some novel rosacea research. If you care to donate that would be appreciated.

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  • Posts

    • Impact of nanostructured lipid carriers on dapsone delivery to the skin; in vitro and in vivo studies. Int J Pharm. 2019 Nov 09;:118781 Authors: Elmowafy M, Shalaby K, Ali HM, Alruwaili NK, Salama A, Ibrahim MF, Akl MA, Ahmed TA Abstract The main objective of this study was to develop, characterize and evaluate the potential use of dapsone-loaded nanostructured lipid carriers (NLCs) as a topical treatment for acne. Differently charged NLC formulations were successfully prepared using an emulsification/sonication method. The particle sizes ranged from 106.2±5.6 nm to 151.3±7.4 nm, and the NLCs possessed the predicted surface charges, depending on the emulsifier used (Tween 80, Transcutol P, or cetyltrimethylammonium bromide). The entrapment efficiencies ranged from 76.5±3.8 % to 91.1±3.9 %. Selected formulations were assessed for possible interactions, in vitro release, ex vivo skin permeation, pharmacological efficacy and safety compared with a hydroalcoholic solution. Dapsone was embedded in the lipid matrix of NLCs and behaved as controlled release system with a good occlusive effect. Dapsone-loaded cationic NLC formulation enhanced the skin permeation of dapsone, increase the amount of dapsone retained in the skin in controlled manner, and improved the anti-rosacea activity. Based on these encouraging results, cationic NLC represents a promising carrier for the safe topical delivery of dapsone. PMID: 31715347 [PubMed - as supplied by publisher] {url} = URL to article
    • Related Articles Treatment of Erythematotelangiectatic Rosacea With Pulsed-Dye Laser and Oxymetazoline 1.0% Cream: A Retrospective Study. Lasers Surg Med. 2019 Nov 10;: Authors: Suggs AK, Macri A, Richmond H, Munavalli G, Friedman PM Abstract BACKGROUND AND OBJECTIVES: Pulsed-dye laser (PDL) and oxymetazoline 1.0% cream are each used for the treatment of erythematotelangiectatic (ET) rosacea. PDL targets oxyhemoglobin and can reduce facial erythema and telangiectasias. Oxymetazoline 1.0% cream is an α adrenergic agonist, which has shown to reduce facial erythema. The aim of this study was to determine the degree of erythema improvement and telangiectasia clearance after combination treatment with PDL plus oxymetazoline 1.0% cream. STUDY DESIGN/MATERIALS AND METHODS: This retrospective study was conducted at two sites. Pre- and post-treatment cross-polarized images from subjects on combination treatment with PDL and oxymetazoline 1.0% cream were graded by a board-certified dermatologist at each practice. Blinded images were analyzed using the Clinical Erythema Assessment (CEA) Scale (0 = clear and 4 = severe). Unblinded images were analyzed using the five-point Telangiectasia Scale to determine the degree of improvement post-treatment compared with baseline (1 = <5% clearance and 5 = 75-100% clearance). RESULTS: Thirty-one subjects (20 females, 11 males) of age 51 ± 13 years (mean ± standard deviation) were included in the study after an average of 4 months (range: 1-13) of daily oxymetazoline 1.0% cream and two (range: 1-4) PDL treatments. At baseline, 87% of subjects had CEA Grade 2 (mild erythema) or higher. For erythema, 55% of subjects improved by at least one CEA grade and 13% achieved two grades of improvement post-treatment. For telangiectasias, 90% of subjects achieved at least a two-point clearance (5-25%), 62% at least a three-point clearance (25-50%), and 41% at least a four-point clearance (50-75%) post-treatment. Compared with subjects with baseline CEA Grade 1-2 (almost clear to mild erythema), significantly more subjects with baseline CEA Grade 3-4 (moderate to severe erythema) achieved at least one CEA grade of improvement (P = 0.021) and two grades of CEA improvement (P = 0.041). A higher percentage of baseline CEA Grade 3-4 subjects achieved at least a two-point clearance in telangiectasias (P = 0.055). CONCLUSIONS: Combination treatment with PDL and daily oxymetazoline 1.0% cream can safely and effectively reduce erythema and telangiectasias. Limitations include the retrospective design of the study, small sample size, and lack of a control group. Lasers Surg. Med. © 2019 Wiley Periodicals, Inc. PMID: 31709571 [PubMed - as supplied by publisher] {url} = URL to article
    • Related Articles Sebaceous Glands participate in the inflammation of Rosacea. J Eur Acad Dermatol Venereol. 2019 Nov 11;: Authors: Lee SH, Lee SB, Heo JH, Yoon HS, Byun JW, Choi GS, Shin J Abstract Rosacea is a chronic inflammatory dermatosis that can present with a variety of cutaneous manifestations.1 Recently, mast cells are known to be importantly related to the pathogenesis of rosacea.2 The disease characteristically presents a centrofacial distribution1,3 , an area rich in sebaceous glands. PMID: 31709649 [PubMed - as supplied by publisher] {url} = URL to article
    • Related Articles Alterations of Immune and Keratinization Gene Expression in Papulopustular Rosacea by Whole Transcriptome Analysis. J Invest Dermatol. 2019 Nov 06;: Authors: Shih YH, Xu J, Kumar A, Li R, Chang ALS PMID: 31705873 [PubMed - as supplied by publisher] {url} = URL to article
    • Related Articles [Mushroom keratoplasty in rosacea keratitis complicated by corneal perforation (a clinical case)]. Vestn Oftalmol. 2019;135(5. Vyp. 2):215-219 Authors: Trufanov SV, Krakhmaleva DA, Zaitsev AV, Salovarova EP, Tekeeva LY, Budnikova EA Abstract Rosacea is a polyethiologic chronic inflammatory disease with varying clinical manifestations. It is primarily a dermatologic disease, which often manifests in the eyes affecting eyelids, cornea and conjunctiva. The leading role in the pathological process belongs to disruption of regulatory mechanisms in the vascular, immune and nervous systems. It is accompanied by increased levels of metalloproteinases and vascular endothelial growth factor (VEGF). Treatment depends on the severity of the disease and may vary from hygiene of the eyelid margins and use of artificial tears for dry eye disease management, to antibiotics and anti-inflammatory agents in moderate cases, and surgical treatment in severe or neglected state. A clinical case of severe rosacea shows that keratoplasty with mushroom-shaped profile of the surgical incision helps achieve good functional results and reduce the post-operative rehabilitation time, while significantly reducing the risk of postsurgical complications. Anti-VEGF therapy significantly reduces the risk of histoincompatibility reaction typical for rosacea keratitis. PMID: 31691663 [PubMed - in process] {url} = URL to article
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