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    We're searching for volunteers. Volunteering has been shown to improve not only your health but also your hope.

    Read more about the benefits of volunteering 

    An Active Member is one who has posted within the last thirty days and has full access to the RRDi website. An Inactive Member is one who has not posted in the last thirty days and is therefore restricted to guest privlieges of access to the site until such time as the member becomes active again and full access to the site is restored. Any SUBSCRIBED member is not restricted to post within thirty days. Volunteer Active Members may waive the subscription fee. If you want to have your membership as a volunteer active member and have the subscription fee waived use the fill out this form. If you are an inactive member mention when filling out the form to volunteer that you are already registered with the RRDi but have become inactive so we can activate your membership. 

    Some rosaceans tend to center themselves on their own skin issues resulting in a spiral into reciprocal deep depression with a tendency to isolate themselves. Volunteering breaks this cycle. It forces a rosacean into seeing that there are others out there with even more severe cases of rosacea than what they are experiencing. Helping a fellow rosacea suffer is worth every effort you can muster. The satisfaction of volunteering as a rosacean for other rosaceans is only experienced if you take the step to offer yourself willingly as a RRDi volunteer rosacean. 

    Could you seriously consider volunteering for the RRDi? We are appealing to millennials to think about helping others with rosacea through our non profit organization so we can keep this web site on the internet with its wealth of information on rosacea. If some don't step up to the plate and volunteer the RRDi may eventually close up shop. Seriously, do you want to see this organization cease?  The statistics globally show that volunteering is dropping (read this post). Then read below why you are needed. 

    An Active Member is one who has posted within the last thirty days and has full access to the RRDi website. An Inactive Member is one who has not posted in the last thirty days and is therefore restricted to guest privlieges of access to the site until such time as the member becomes active again and full access to the site is restored. Any SUBSCRIBED member is not restricted to post within thirty days. Volunteer Active Members may waive the subscription fee. 

    If you would like to volunteer by simply joining our cause adding you name to our list and do nothing more that is the easiest way to volunteer. At the very least join the RRDi to increase our membership and if that is all you can do we understand and appreciate whatever you can do. Your email address is all we require to join. Our goal is to reach 10,000 members. And we are a grassroots, non profit organization. 

    If all you can do to volunteer is post on our website, that is probably the best thing you can do. Just post and show you care about other rosacea sufferers. Your experience with rosacea may inspire others to join our cause. Two Steps to Volunteer.

    Social Media
    Where have all the rosaceans gone? Social media. So, if you prefer Facebook, Instagram, Twitter, Reddit or any other social media rosacea PRIVATE group, why not join the RRDi and be a moderator for the RRDi Facebook, Instagram, Twitter or Reddit groups?  That way you can still be in your favorite platform and be a volunteer for the RRDi. We need moderators for our RRDi social media rosacea groups as volunteers. Watch this 3 minute video below for more information:

    Volunteers are needed to recruit more members, for fund raising, public relations, writers to write posts on our member forum, editors for the newsletter, accounting/book keeping, webmasters, forum moderators, board members, researchers, Google AdWords expert, and grant writers. If you have a skill not mentioned, let us know. Why not suggest what you might volunteer to do when you join the RRDi, and in the application to become a corporate member there is a place to add a comment what your volunteer skills are. If you have questions, contact us. If you want to know what will volunteering do for you (?), skip down to the subheading, 'What's in it for me below.' 

    We would like to offer each author reimbursement if we publish the article in the next Journal of the RRDi.  If you want to volunteer to be on the publication team as an editor, author, proofreader, or any other job please join our cause and state in the comment box you want to join the Journal Publication Team.

    Volunteers are needed for the public relations committee or to write requests for donations to major corporations in our Funding Committee. Please join and mention you would like to help on the Funding Committee or for Public Relations. Or you can personally write a fund raiser letter using this sample letter.

    To Volunteer as a Writer please join. Check our announcements for special needs. Writers, editors, graphic artists and proof readers are needed! We have the ability to turn your post into an article. Why not post your article?

    Volunteer to write letters for donations by clicking here.

    Grant Writers are needed.

    What's In It For Me?
    There is scientific evidence that volunteering improves health and well being. For more information read this post

    Volunteers may receive a special Gmail account associated with the RRDi domain email which is a Google Workspace (formerly G Suite, Google Apps) account associated with our domain, irosacea.org.

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    To know more about the Google Workspace click here.

    You may receive the RRDi Newsletter by joining as a corporate member and requesting the newsletter by checking the box when you fill out the application.

    You may receive on request a job referral with our letterhead if you volunteer for at least year to add to your resume or need a recommendation letter showing that you have regularly volunteered for our non profit organization. 

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    Volunteers to POST comments in our member forum. 

    Volunteers to Write Donation Letters

    Google AdWords Technician

    Google Analytics Technician

    Grant Writers

    Social Media Moderators

    Webmaster

    Forum Moderator

    Steps to Volunteer

    (1) Join the RRDi

    Mention which job you are volunteering for or create your own volunteer job and mention this in the appropriate box when applying.

    Another way to support is by purchasing our RRDi Tee Shirt, the Journal of the RRDi from Amazon or iUniverse which will help us continue its publication and may lead to some novel rosacea research. If you use Amazon why not check out our Amazon Affiliate Store using our shopping cart is another way to support our non profit. If you care to donate that would be appreciated. Two Steps to Volunteer



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  • Posts

    • Front Pharmacol. 2023 Mar 1;14:1092473. doi: 10.3389/fphar.2023.1092473. eCollection 2023. ABSTRACT Background: Rosacea is a common facial skin inflammatory disease featured by hyperactivation of mTORC1 signaling in the epidermis. Due to unclear pathogenesis, the effective treatment options for rosacea remain limited. Methods: Weighted gene co-expression network analysis (WGCNA) analyzed the relationship between epidermis autophagy and mTOR pathways in rosacea, and further demonstrated it through immunofluorescence and qPCR analysis. A potential therapeutic agent for rosacea was predicted based on the key genes of the WGCNA module. In vivo and in vitro experiments were conducted to verify its therapeutic role. Drug-target prediction (TargetNet, Swiss, and Tcmsp) and molecular docking offered potential pharmacological targets. Results: WGCNA showed that epidermis autophagy was related to the activation of mTOR pathways in rosacea. Next, autophagy was downregulated in the epidermis of rosacea, which was regulated by mTOR. In addition, the in vivo experiment demonstrated that autophagy induction could be an effective treatment strategy for rosacea. Subsequently, based on the key genes of the WGCNA module, epigallocatechin-3-gallate (EGCG) was predicted as a potential therapeutic agent for rosacea. Furthermore, the therapeutic role of EGCG on rosacea was confirmed in vivo and in vitro. Finally, drug-target prediction and molecular docking revealed that AKT1/MAPK1/MMP9 could be the pharmacological targets of EGCG in rosacea. Conclusion: Collectively, our findings revealed the vital role of autophagy in rosacea and identified that EGCG, as a therapeutic agent for rosacea, attenuated rosacea-like inflammation via inducing autophagy in keratinocytes. PMID:36937834 | PMC:PMC10014537 | DOI:10.3389/fphar.2023.1092473 {url} = URL to article
    • Cureus. 2023 Feb 15;15(2):e35011. doi: 10.7759/cureus.35011. eCollection 2023 Feb. ABSTRACT The most common cutaneous manifestations of alcoholism include urticarial reaction, flushing, porphyria cutanea tarda, psoriasis, rosacea, seborrheic dermatitis, and pruritus. Here, we present a case of a young male with a history of alcohol abuse who presented with non-blanching, petechial, and perifollicular macular rash secondary to vitamin C deficiency in view of poor oral intake. The rash improved significantly with vitamin C supplementation. Although rare in developed countries, clinicians should keep vitamin C deficiency as a differential diagnosis for skin rash in alcohol consumers. PMID:36938293 | PMC:PMC10021349 | DOI:10.7759/cureus.35011 {url} = URL to article
    • J Dermatol. 2023 Mar 20. doi: 10.1111/1346-8138.16779. Online ahead of print. ABSTRACT Symptomatic dermographism (SD) is the most common form of chronic inducible urticarias. The etiology of this disease has rarely been reported in the literature. Minocycline is widely used in the treatment of acne, rosacea, and other inflammatory skin diseases. Herein we report four cases of SD onset during minocycline administration. These were young women in their 20s to 30s who were taking minocycline orally for acne vulgaris or rosacea. They all experienced the onset of SD 2-3 weeks after taking the drug, and then the complete disappearance of SD 1 month after stopping the drug. Minocycline was thought to be the culprit drug in these cases as other drugs were ruled out on clinical grounds. Our small series suggests that oral minocycline may induce SD, thus raising the awareness of this association in clinical practice. More research is needed to further confirm this association and reveal the underlying mechanism(s). PMID:36938687 | DOI:10.1111/1346-8138.16779 {url} = URL to article
    • Arch Dermatol Res. 2023 Mar 20. doi: 10.1007/s00403-023-02602-9. Online ahead of print. ABSTRACT Individuals with rosacea have different facial erythema distribution patterns; however, whether they are related to the skin type is unclear. This study enrolled 201 Chinese patients, including 195 females and six males, diagnosed with rosacea. Facial images were taken using the VISIA® Complexion Analysis System, and red-area images were further analyzed. The erythema distribution pattern of rosacea was divided into peace signs, wing shapes, and neither of the two patterns, according to the distribution location. Skin types were divided according to the Fitzpatrick skin type, and oily-dry skin subtypes were determined according to the Baumann skin-type scale. There were 130 and 44 cases of typical peace signs and typical wing shapes, respectively. The remaining 27 cases were of neither type. Among the 76 patients with peace-sign patterns, the majority (58.5%) had oily combination skin. Among the patients with a typical wing shape, 43 (97.7%) had dry combination skin. Among the 27 patients with no peace-sign or wing-shape pattern, 17 (63.0%) had dry combination skin (p < 0.05). The peace sign pattern was more common in individuals with darker skin tones (p < 0.05). The differences in the immune microenvironment, Demodex habitation, and altered lipid content may explain the presence of the peace-sign pattern in the oily combination skin population. Wing-type patterns are associated with the lateral parts of the cheeks and could be caused by abnormal vessel dilations of the anatomic branches of the zygomatic-facial and facial arteries, which indicates that the main pathogenesis for this type of rosacea may be neurovascular. Our study is the first to report that facial erythema distribution characteristics of rosacea are associated with skin types. PMID:36939880 | DOI:10.1007/s00403-023-02602-9 {url} = URL to article
    • Photobiomodul Photomed Laser Surg. 2023 Mar;41(3):104-119. doi: 10.1089/photob.2022.0120. ABSTRACT Objective: To evaluate relevant clinical outcomes and conclude possible mechanisms of intense pulsed light (IPL) in eyelid inflammation. Background: IPL devices were primarily applied in cutaneous vascular malformations and have been used in ocular diseases for about 20 years, mostly including meibomian gland dysfunction (MGD), blepharitis, and ocular rosacea. Recent findings: Seventy-two original clinical researches were included, 57 for MGD, 4 for blepharitis or blepharitis-related keratoconjunctivitis, and 11 for rosacea. Dry eye symptoms, (tear) break-up time (BUT), and meibomian structure and/or functions were improved in most patients, but production of reactive oxygen species is an important link in the photobiomodulation mediated by IPL, which can influence numerous signal pathways to achieve anti-inflammatory, anti-infective, and prodifferentiation effects. Conclusions: The evidence suggests that IPL is an effective therapeutic tool for most patients with MGD, but more clinical evidence is needed for other indications. PMID:36927050 | DOI:10.1089/photob.2022.0120 {url} = URL to article
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