Jump to content
  • rrdiLogo384x64.jpg.3cd1bd79f5d066075bdd9

    Legal Disclaimer

    All use of the Rosacea Research & Development Institute (RRDi or irosacea.org) Web site is subject to the terms and conditions set forth below. When referring to the Rosacea Research & Development Institute (RRDi or irosacea.org) in this legal discaimer includes the following domains:

    irosacea.org
    rosaceans.org
    rosaceans.com
    rrdinstitute.org
    rosacea-control.com
    rosacea-research-and-development-institute.org
    legal_disclaimer.png

    Any use of such Web pages constitutes the user's agreement to abide by the following terms and conditions.

    The Rosacea Research & Development Institute [RRDi] is a non profit corporation registered in the states of Alabama and Hawaii, USA as well as recognized June 7, 2004 by the USA Internal Revenue Service as a 501 (c) (3) non profit tax exempt organization.

    All medical information on this Web site has been reviewed for accuracy. However, the information posted here by the Rosacea Research & Development Institute or any third party should not be considered medical advice, nor is it intended to replace consultation with a qualified physician. The Institute does not evaluate, endorse or recommend any particular medications, products, equipment or treatments. Rosacea may vary substantially from one patient to another, and treatment must be tailored by a physician for each individual case.

    Links to other Web sites found on irosacea.org are provided as a service to our users. Such linkage does not constitute endorsement of the site by the Rosacea Research & Development Institute, and the Institute is not responsible for the content of external web sites. Links to commercial rosacea web sites are prohibited at this time.

    The Rosacea Research & Development Institute Web pages are designed for educational purposes only. This information is not intended to substitute for informed medical advice. You should not use this information to diagnose or treat a health problem or disease without consulting with a qualified health care provider. The Rosacea Research & Development Institute does not endorse or attest to the validity or accuracy of any treatments or medications discussed herein. Before acting on any information contained on the Web pages, you agree that you will consult your health care provider to determine whether the information you are relying on is appropriate for your medical condition.

    All information provided by the Rosacea Research & Development Institute is owned by or licensed to the Rosacea Research & Development Institute. The Rosacea Research & Development Institute retains all proprietary rights to the information contained on the pages. Except for making one hard copy print of the information or downloading the material for a one-time use, information on the pages may not be reproduced, transmitted, distributed, or displayed, without the express consent of the Rosacea Research & Development Institute.

    THIS WEB SITE IS PROVIDED "AS IS" WITHOUT WARRANTY OF ANY KIND, EITHER EXPRESS OR IMPLIED, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE, OR NON-INFRINGEMENT. THIS WEB SITE COULD INCLUDE TECHNICAL INACCURACIES OR TYPOGRAPHICAL ERRORS. CHANGES ARE PERIODICALLY ADDED TO THE INFORMATION HEREIN; THESE CHANGES WILL BE INCORPORATED IN NEW EDITIONS OF THE WEB SITE. THE ROSACEA RESEARCH & DEVELOPMENT INSTITUTE MAY MAKE IMPROVEMENTS AND/OR CHANGES TO THE PROGRAM(S) DESCRIBED IN THIS WEB SITE AT ANY TIME

    NOTICE AND TAKEDOWN PROCEDURES; COPYRIGHT AGENT

    The RRDi does not knowlingly use any material (images or text) that is copyrighted by others. If you believe any materials accessible on or from this web site infringe your copyright, you may request removal of those materials (or access thereto) from this web site by the RRDi copyright agent (identified below) and providing the following information:
    Identification of the copyrighted work that you believe to be infringed. Please describe the work, and where possible include a copy or the location (e.g., URL) of an authorized version of the work. Identification of the material that you believe to be infringing and its location. Please describe the material, and provide us with its URL or any other pertinent information that will allow us to locate the material. Your name, address, telephone number and (if available) e-mail address.
    A statement that you have a good faith belief that the complained of use of the materials is not authorized by the copyright owner, its agent, or the law.
    A statement that the information that you have supplied is accurate, and indicating that "under penalty of perjury," you are the copyright owner or are authorized to act on the copyright owners behalf.

    A signature or the electronic equivalent from the copyright holder or authorized representative.

    The irosacea.org agent for copyright issues relating to this web site is as follows:

    RRDi Copyright Agent
    PO Box 858
    Centre, Alabama, 35960

    Or use our contact form explaining your copyright issue with our website. We will handle such matters in an appropriate and timely manner. 

    In an effort to protect the rights of copyright owners, the irosacea.org maintains a policy for the termination, in appropriate circumstances, of subscribers and account holders of this web site who are repeat infringers.

    International Disclaimer

    This Web site can be accessed from other countries around the world and may contain references to rosacea products, services, treatments or programs that have not been announced in your country. These references do not imply that irosacea.org intends to announce such products, services or programs in your country.

    Governing Law and Jurisdiction

    This web site (excluding linked sites) is controlled by irosacea.org from its office within the state of Hawaii, United States of America. By accessing this Web site, you and irosacea.org agree that all matters relating to your access to, or use of, this Web site shall be governed by the statutes and laws of the state of Hawaii, without regard to the conflicts of laws principles thereof. You and irosacea.org also agree and hereby submit to the exclusive personal jurisdiction and venue of the Superior Court of the District of Honolulu, Honolulu County and the United States District Court for the District of Hawaii with respect to such matters. irosacea.org makes no representation that materials on this Web site are appropriate or available for use in other locations, and accessing them from territories where their contents are illegal is prohibited. Those who choose to access this site from other locations do so on their own initiative and are responsible for compliance with local laws.

    Privacy Policy

    Our Privacy Policy is the commitment to respect the privacy of the information entrusted to our institute with your personal information by not giving your personal information to others or using it inappropriately. If you have any questions or concerns regarding our privacy policy please direct them to privacy@irosacea.org

    You may also send a letter to:

    Rosacea Research & Development Institute, PO Box 858, Centre, Alabama 35960

    irosacea.org does not sell, exchange, or release your personal information (name, e-mail address, mailing address, credit card data, etc.) without your consent to any third parties.

    Information gathered through the use of cookies is not related to any personally identifiable details.

    What information does irosacea.org collect from our users and how do we collect it?

    irosacea.org only contacts individuals who specifically request that we do so. irosacea.org collects personally identifying information from our users during (1) online registration, (2) online public surveys, (3) online purchasing, and (4) messages posted to our public forum board and the private forum. Generally, this information includes name, e-mail address, postal address, and answers to public survey questions. This information is used for internal purposes and helps us determine how to continually improve our site and the institute. Names and email addresses may be posted in public forums and public databases by individual members who post such information on their own. The RRDi is not responsible if a member posts their own real name, address, phone number, or email address. If a member later regrets posting this information the member can report where the post is and have it removed upon request. If you do not want your name listed in any of the public surveys or databases you should use a bogus name or alias (nickname) since the institute is not responsible if you use your real name or email address in a public survey or database. However, the institute will not publicly display any of the members names, email addresses or postal addresses. Each member is responsible for his or her own privacy when using any of the institute's web site when posting. Non voting members can join the RRDi by providing an email address. 

    Members who donate to the RRDi are named in public financial records unless the donor specifically instructs us that the donation is anonymous.

    Corporate Members Forum Guidelines and Privacy Policy

    The corporate members only private forum is provided as a free service of the RRDi. The institute will not release any names, mailing addresses or email addresses of who is using the private (or public) forum to any third parties without your consent.

    Privacy is important to the RRDi and you can rest assured your contact information is safe with us and we will not disclose your contact info to anyone without your permission or only if we are required by law to disclose your contact info. The privacy policy also includes the Member Forum, Blog and Gallery areas of our site as well as the Tapatalk hosted private form. The Guidelines policy is enforced and binding on all members and guests.

    Blog, Clubs and Gallery

    The Blog, Clubs and Gallery, if available, are provided as a free service by the RRDi to its members only and you are responsible for your own privacy with regard to this service if you engage with another member and disclose your private information in the Blog, Clubs or post photos in the Gallery. The RRDi cannot be held responsible for your privacy if you use the Blog, Clubs or Gallery and our privacy policy, legal disclaimer, rules, and official documents are still binding if you violate this policy.  We warn you to not disclose your private information or post inappropriate content in the Blog, Clubs or Gallery.

    The institute will not release any names or email addresses of who is using the Blog, Clubs or Gallery service without your consent.

    Cookies

    What are cookies and how do we use them?

    Cookies help track a person''s session while online. They are used on our site to gather basic tracking information. Cookies are not related to any personally identifiable information and are not used to retrieve information from your computer that was not originally sent in a cookie.

    Many browsers are set to accept cookies. You may prefer to set your browser to refuse cookies. It is possible, however, that some areas of the site will not function properly if you do so. This is especially likely when trying to order a publication.

    Third-Party Advertising

    Advertisements are not currently allowed on this site. If advertisements are allowed then information about your visits to this site, such as the number of times you have viewed an ad (but not your name, address, or other personal information), is used to serve ads to you. In the course of serving advertisements to this site, third-party advertisers may place or recognize unique cookies on your browser. Links to third-party advertising, or commercial web sites are prohibited.

    Amazon Affiliate

    The RRDi has joined Amazon Affiliates and links to items at amazon.com may be placed throughout the site. The RRDi receives a small fee for each item that is purchased by users who click on an item featured on our site.

    Demodex Solutions Affiliate

    The RRDi has joined the Demodex Solutions affiliate program and links to this program are placed throughout the site. The RRDi receives a small fee for each item that is purchased by users who click on an item featured on our site.

    Disclaimer

    This policy may be changed at any time at Rosacea Research & Development Institute's discretion.

    Copyright

    © Rosacea Research & Development Institute. All rights reserved. Reproduction, re-transmission or reprinting of the contents of this Web site, in part or in its entirety, is expressly prohibited without prior written permission from the Rosacea Research & Development Institute.



  • Member Statistics

    • Total Members
      1,669
    • Most Online
      499

    Newest Member
    Dallas
    Joined
  • Posts

    • Expert Rev Clin Immunol. 2022 Sep 22. doi: 10.1080/1744666X.2022.2128334. Online ahead of print. ABSTRACT INTRODUCTION: : Recent advances in the understanding of the pathophysiology of rosacea have led to increased focus on the disease's immunologic etiology and to the development of immunologically based treatments. With many patients suffering from incomplete control, addressing the immune components of the disease process may provide a more effective treatment option for rosacea patients that may improve quality of life. AREAS COVERED: : This review will provide a brief overview of the pathophysiology or rosacea, as well as specific immunologic contributions to the disease state. Current standard-of-care treatments will be described, including anti-parasitic, anti-inflammatory agents, and antibiotics. Emphasis will be placed on treatments that target the immune components of the disease process. EXPERT OPINION: : Rosacea remains a difficult dermatologic disease to treat, partially due to an incomplete understanding of the disease pathophysiology. The immune pathophysiology of rosacea, particularly the key role of inflammation, has been clarified over the past decade. Identification of specific molecules, including cytokines and nuclear transcription factors, may allow for the development of targeted rosacea-specific biologic and topical treatments. However, medication nonadherence is a limiting factor to achieving symptomatic control among rosacea patients. Focusing on the development of oral or injectable forms of therapy may circumvent poor adherence. PMID:36137266 | DOI:10.1080/1744666X.2022.2128334 {url} = URL to article
    • J Cosmet Dermatol. 2022 Sep 20. doi: 10.1111/jocd.15271. Online ahead of print. NO ABSTRACT PMID:36126208 | DOI:10.1111/jocd.15271 {url} = URL to article
    • JAAD Case Rep. 2022 Jul 19;28:83-86. doi: 10.1016/j.jdcr.2022.07.014. eCollection 2022 Oct. NO ABSTRACT PMID:36105757 | PMC:PMC9467856 | DOI:10.1016/j.jdcr.2022.07.014 {url} = URL to article
    • Cureus. 2022 Sep 3;14(9):e28726. doi: 10.7759/cureus.28726. eCollection 2022 Sep. ABSTRACT Facial hypervascularity is a condition that manifests as erythema and edema caused by aberrant blood vessels. Often, the cause of these abnormal blood vessels can be attributed to previous trauma or vascular conditions such as rosacea, although sometimes the cause is unknown. Pulsed dye laser (PDL) can be an effective treatment even when the cause is unknown. We present a case of a 24-year-old male presenting with intermittent swelling, redness, and throbbing sensations of the nose and cheeks for the past five years. Physical examination was notable for prominent erythema and swelling of the nasal skin and mild erythema on the cheeks. He underwent treatment with PDL and achieved complete resolution of his symptoms. This case illustrates the effectiveness of PDL in the treatment of facial hypervascularity. PMID:36105901 | PMC:PMC9447474 | DOI:10.7759/cureus.28726 {url} = URL to article
    • J Dtsch Dermatol Ges. 2022 Sep 13. doi: 10.1111/ddg.14879. Online ahead of print. ABSTRACT This guideline aims to improve the efficiency and safety of lasers and optical radiation sources with similar effects (especially IPL). Laser therapy of skin lesions with an increased amount of melanocytes should be performed with caution. Laser treatment of pigmented melanocytic nevi is not recommended. The guideline contains recommendations regarding the treatment of lentigines and café-au-lait spots, non-pigmented dermal nevi, Becker nevus, nevus of Ota/Hori/Ito and melasma. Further recommendations focus on the treatment of skin lesions without an increased amount of melanocytes (ephelides, postinflammatory hyperpigmentation including berloque dermatitis, seborrheic keratoses, traumatic/decorative tattoos and metallic deposits), hypopigmentation (vitiligo), benign non-pigmented neoplasms (fibrous papule of the nose, nevus sebaceus, epidermal nevus, neurofibroma, sebaceous gland hyperplasia, syringoma, xanthelasma palpebrarum), inflammatory dermatoses (acne papulopustulosa/conglobata, acne inversa, granuloma faciale, lichen sclerosus, lupus erythematosus, psoriasis vulgaris, rosacea, rhinophyma), wrinkles/dermatochalasis/striae, hypertrichosis, scars (atrophic, hypertrophic; keloids, burn/scald scars), laser-assisted skin healing, onychomycosis, precancerous lesions and malignant tumors (actinic keratoses/field cancerization, cheilitis actinica, basal cell carcinoma), vascular skin lesions (angiokeratoma, angioma, hemangioma, malformation, spider veins, granuloma telangiectaticum (pyogenic granuloma), rubeosis (erythrosis interfollicularis colli, ulerythema ophryogenes), nevus flammeus, telangiectasias and Osler's disease (hereditary hemorrhagic telangiectasia) and viral skin lesions (condylomata acuminata, mollusca contagiosa, verrucae planae juveniles/vulgares/ verrucae palmares et plantares). PMID:36098675 | DOI:10.1111/ddg.14879 {url} = URL to article
    • Dermatol Ther (Heidelb). 2022 Sep 13. doi: 10.1007/s13555-022-00798-8. Online ahead of print. NO ABSTRACT PMID:36098878 | DOI:10.1007/s13555-022-00798-8 {url} = URL to article
    • J Cosmet Dermatol. 2022 Sep 13. doi: 10.1111/jocd.15384. Online ahead of print. ABSTRACT BACKGROUND: Rosacea is a chronic inflammatory skin disease affecting the face, and the current treatment effect is not satisfactory. Based on the photomodulation of optimal pulse technology (OPT), we developed a novel treatment mode, namely, advanced OPT with low energy, three pulses, and long pulse width (AOPT-LTL). AIMS: We aimed to explore the feasibility and underlying molecular mechanisms of AOPT-LTL treatment in a rosacea-like mouse model. Furthermore, we evaluated the safety and efficacy in patients with erythematotelangiectatic rosacea (ETR). MATERIALS AND METHODS: Morphological, histological, and immunohistochemical analyses were used to investigate the efficacy and mechanisms of AOPT-LTL treatment in the LL-37-induced rosacea-like mouse model. Moreover, twenty-three patients with ETR were included and received different times of treatment at intervals of two weeks depending on the severity of their condition. The treatment effect was assessed by comparing clinical photographs at baseline, one week and three months after treatment, combined with the red value, GFSS, and CEA scores. RESULTS: After the AOPT-LTL treatment of the mice, we observed that the rosacea-like phenotype, inflammatory cell infiltration, and vascular abnormalities were significantly ameliorated, and the expression of the core molecules of rosacea was significantly inhibited. In the clinical study, the AOPT-LTL treatment exerted satisfactory therapeutic effects on erythema and flushing of ETR patients. No serious adverse events were observed. CONCLUSIONS: AOPT-LTL is a safe and effective method for the treatment of ETR. PMID:36099436 | DOI:10.1111/jocd.15384 {url} = URL to article
    • Dermatol Ther. 2022 Sep 12:e15819. doi: 10.1111/dth.15819. Online ahead of print. ABSTRACT OBJECTIVE: Brimonidine is a vasoconstrictive agent used to treat several dermatologic disorders. Here, we review the uses of brimonidine in different aspects of dermatology. METHODS: We searched keywords including rosacea, erythema, topical brimonidine, dermatology, and skin disease in PubMed, Cochrane, and Google Scholar to collect the related published articles. RESULTS: In a review of 15 articles, we found topical brimonidine improved the facial erythema of rosacea. In addition, it reduced the erythema associated with alcohol flushing syndrome, intense pulsed light therapy, and photodynamic therapy. Furthermore, topical brimonidine was used as a hemostatic agent in dermatosurgery procedures such as Mohs surgery and nail surgery to reduce intra-operative and postoperative bleeding. Some side effects such as erythema, flushing, and burning were reported in a few patients. CONCLUSION: Based on our findings, brimonidine is a beneficial drug that can be used in various dermatologic disorders with negligible side effects. This article is protected by copyright. All rights reserved. PMID:36097378 | DOI:10.1111/dth.15819 {url} = URL to article
    • Front Immunol. 2022 Aug 24;13:985081. doi: 10.3389/fimmu.2022.985081. eCollection 2022. ABSTRACT BACKGROUND: In recent years, frontal fibrosing alopecia (FFA), a type of scarring alopecia, has attracted increasing attention. Several studies have reported the frequent occurrence of rosacea in FFA; however, the association between FFA and rosacea and the underlying pathogenesis have not been thoroughly clarified. Thus, this study aimed to quantify these relationships and investigate their shared molecular mechanisms. METHODS: We evaluated the association between FFA and rosacea by analyzing clinical data from nine observational studies. We then analyzed the gene expression profiles of FFA and rosacea. First, differential expression analysis and weighted gene co-expression network analysis were used to identify the common differentially expressed genes (DEGs). Later, we conducted a functional enrichment analysis and protein-protein interaction network and used seven algorithms to identify hub genes. Then, we performed a correlation analysis between the hub genes and the gene set variation analysis scores of common pathways in the gene set enrichment analysis (GSEA). The results were validated using different datasets. Finally, transcription factors were predicted and verified, and CIBERSORT and single-sample GSEA were used to estimate the infiltrating immune cells. RESULTS: Patients with FFA had significantly higher odds for rosacea (pooled odds ratio [OR], 2.46; 95% confidence interval [CI], 1.78-3.40), and the pooled prevalence of rosacea in patients with FFA was 23% (95% CI, 14-23%). Furthermore, we identified 115 co-DEGs and 13 hub genes (CCR5, CCL19, CD2, CD38, CD83, CXCL8, CXCL9, CXCL10, CXCL11, CXCR4, IRF1, IRF8, and PTPRC). Seven pathways showed a high correlation with these hub genes. In addition, one TF, STAT1, was highly expressed in both diseases, and the results of the immune infiltration analysis indicated the importance of M1 macrophages and effector memory CD8+ T cells. CONCLUSION: This study contributes to the understanding of the relationship between FFA and rosacea, and based on the hub genes, we reveal the potential pathologies shared by the two diseases. This finding provides new insights of underlying molecular mechanisms and it may inspire future research on this comorbidity. PMID:36091020 | PMC:PMC9448884 | DOI:10.3389/fimmu.2022.985081 {url} = URL to article
    • J Am Acad Dermatol. 2022 Sep 8:S0190-9622(22)02640-8. doi: 10.1016/j.jaad.2022.09.004. Online ahead of print. NO ABSTRACT PMID:36089188 | DOI:10.1016/j.jaad.2022.09.004 {url} = URL to article
    • Int J Mol Sci. 2022 Aug 30;23(17):9858. doi: 10.3390/ijms23179858. ABSTRACT Rosacea is a chronic inflammatory skin disease whose prevalence rates remain unknown in Chile. Laboratory benchmark testing for this disease is not useful, therefore, we aimed to evaluate the gingival crevicular fluid (GCF) levels of extracellular metalloproteinases (MMP)-2 and MMP-9 as novel rosacea biomarkers. We designed a cross-sectional study with a control group. Participants were systemically healthy adults (n = 20) and persons with rosacea (n = 18). We performed a periodontal evaluation and collected gingival crevicular fluid to measure MMP-2 and MMP-9 levels. Analysis showed mean and standard deviation of MMP-9 concentrations in the GCF for patients with rosacea was 764.52 ± 569.83 pg/mL; for healthy patients, it was 260.69 ± 170.43 pg/mL (p < 0.05). The diagnosis of rosacea was responsible for the levels of MMP-9 in the GCF (p < 0.05), as opposed to periodontitis, smoking, and age (p > 0.05). The Area under ROC for MMP-9 was 0.869 (95%, C.I: 0.719-0.956), with a sensitivity of 72.22% and specificity of 81.58% for the diagnosis of rosacea. We conclude that the quantification of MMP-9 in the GCF could be used as a biomarker of rosacea. Also, rosacea was responsible for increasing the levels of MMP-9 in the GCF independent of periodontal status. PMID:36077255 | PMC:PMC9455966 | DOI:10.3390/ijms23179858 {url} = URL to article
    • J Cosmet Dermatol. 2022 Sep 9. doi: 10.1111/jocd.15365. Online ahead of print. ABSTRACT BACKGROUND: Rosacea is a chronic inflammatory skin disease of unknown pathogenesis. TWEAK and TRAIL are two cytokines thought to have a role in the pathogenesis of some inflammatory and autoimmune diseases. AIMS: The purpose of this study was to examine TWEAK and TRAIL serum levels and oxidative stress markers in patients with rosacea. MATERIAL AND METHOD: Forty rosacea patients and 40 sex and age -matched healthy controls were involved in the study. Serum TWEAK and TRAIL levels were evaluated with ELISA kits. Serum total antioxidant status, total oxidant status, total thiol, native thiol, disulfide levels were evaluated and oxidative stress index was computed. RESULTS: Serum levels of TWEAK, TRAIL and oxidative stress markers did not differ statistically in the patients and controls. Both TWEAK and TRAIL levels in the patients were detected to be statistically higher in male than in female. CONCLUSION: TWEAK and TRAIL may not have a systemic effect in rosacea, unlike other inflammatory diseases. More studies are needed to investigate the role of TWEAK and TRAIL in rosacea. PMID:36083238 | DOI:10.1111/jocd.15365 {url} = URL to article
×
×
  • Create New...

Important Information

Terms of Use