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    • Emily47 at RF (post no 54) reports, "I mixed Afrin and CeraVe (suggested my dermatologist) and it worked! Immediately less redness!" According to Vitacost.com, oxymetazoline hydrochloride, 0.05 percent, the active ingredient in Afrin nasal spray, works by constricting, or shrinking, the blood vessels in the nose, and thereby reducing nasal blood flow. - livestrong.com
    • Fluorouracil (5-FU), aka, Adrucil, Carac, Efudex, Efudix, others, used to treat cancer has the side effect or risk of inflammation of the skin. There are reports that this treatment exacerbates rosacea. Caveat emptor. Thread at RF about this
    • Hello Brady! Greetings from The Black Sea! You are right. The sad true just received in a message from Renee Marie Stephano(president and co-founder of the Medical Tourism Association) yesterday: "During this process, I learned a life lesson that I now know is the dirty little secret of healthcare: the system is rigged. The industries of health are rigged. They are designed for profit, not for people." You said that rosacea sufferers are mostly centered on their own rosacea issues and that is true in case over the years they have not succeeded to control/ manage their rosacea like in your case. The last dermatologist I have seen in Bucharest told me that she has no miracle solutions for me as an example(the last cream that was prescribed to me Anthelios Ultra SPF50+ from Roche Posay was tolarated by my face only six days ending in terrible pains in the skin of the face). Still fighting everyday here. Life is not a fairy tale cause life is real. Going to a Ozone Center for other medical problems and seeing on the website of the best dermatologist in Romania dr Ioan Nedelcu uses laser, IPL and Ozone as terapies to control Rosacea (http://drnedelcuioan.ro/servicii-medicale/dermatologie-consultatii-tratamente/cuperoza-rozacee) I asked the owner and doctor of the Ozone Center if I can make cosmetic injections with ozone. She told me will not be a good ideea and the best thing to do is to try ozonated olive oil (a brevet that belongs to Nikolai Tesla from 1904. Here is the product recommended http://www.rheumapraxis-altstetten.com/en/oxaktiv-cosmetic-eng) and I am in the day forth(till now is more than all right but on my face no cream passed the test of more than 12 consecutive days. I am praying here that this time to be the lucky one) and counting, hoping for a solution. I tried to search on our website ozone therapy and ozonated oils and there is no article and no information about it (I wish I was the one writting it). There is an article here https://www.amaskincare.com/how-to-get-rid-of-rosacea-top-treatments saying that: "#4 WAY OF HOW TO GET RID OF ROSACEA – THE MAGIC OF OZONE One natural remedy stands alone among the myriad of other natural therapies, both in its therapeutic effectiveness and the enormous amount of scientific study dedicated to its clinical use. Ozone. Ozone is a completely natural element readily found in nature and that can be generated in a pure form for medical use. It is a form of oxygen (O3) that has tremendous capacity to stimulate healthy physiological activity in every organ system of our bodies, all the way down to the level of individual cells. There is so much therapeutic value to its clinical use, that I will dedicate a series of articles about Ozone Therapy. For now, know this. Infused into natural oils such as olive oil and sunflower oil, topical use of these “ozonated” oils is safe, easy, and extremely effective to use as a rosacea treatment. In our experience, clinical protocols that combine the use of ozonated oil with laser treatments is the single most effective way of how to get rid of rosacea." From whom can we know for sure that ozonated olive oil and sunflower oil are good for Rosacea??? The guys from PureO3(http://shop.puro3.com) told me that ozonated jojoba and coconut oils are also good for Rosacea. Also I wish I could try and afford to buy the LaFlore Probiotic Concentrated Serum recommended by dr.  Whitney Bowe  here https://www.allure.com/gallery/probiotics-skin-care-products but the prices are beyond my current financial possibilities(https://laflore.com/shop-retail). Take care.  PS: I will have a look at your diet as in my case no salt, no sugar products, no dairy products, no cereals, nothing made and difference. So the only diet remained to try is a diet without food.   
    • Elucidating the role of Demodex folliculorum in the pathogenesis of rosacea: exciting first steps…. Br J Dermatol. 2018 Jul 19;: Authors: Forton FMN PMID: 30024649 [PubMed - as supplied by publisher] {url} = URL to article
    • How do you know if you are reading fake rosacea news?  Or what if you read about a certain rosacea treatment whether topical or oral? Can you trust the reviews from the web site? Who would you trust to substantiate a news item about rosacea? Maybe your physician? A social media site?  How about a non profit organization for rosacea patient advocacy? How do you produce a watchdog (a rosacea Snopes) who can substantiate a rosacea news item or weed out a fake reviewer and expose the bum is lying about a rosacea treatment? The RRDi is one of best sources of rosacea data to compare rosacea news items with fake or with what's really a trusted source on any news item about rosacea and is the only non profit organization for rosacea patient advocacy. The other non profit organizations for rosacea are not founded by rosacea sufferers and have a different rosacea agenda. Just follow the money how any non profit organization for rosacea spend the donations and you will see what the agenda is all about. Is the spending 60% of the donations on private contractors owned by the director of the non profit the main agenda? Is most of the spending of more than 75% of the donations on 'annual and mid-year meetings' for the professional members of the non profit the main agenda?  Follow the money.  Read an interesting tech article related to fake news at wired, SHADOW POLITICS: MEET THE DIGITAL SLEUTH EXPOSING FAKE NEWS by BY ISSIE LAPOWSKY, about how media scholar Jonathan Albright discovered through endless hours of research how the the world's biggest internet platforms were riddled with fake news. This inspired me to comment on all the data I have collected (basically just about everything at this web site has been collected by me, there may be a small percentage of posts adding some new information from RRDi members, and it would take me a number of hours to give you the math on this, which really isn't important at all at this point, you will simply have to trust me on this until proven otherwise) on rosacea trying to put them into logical categories in the forum and the affiliate store. I have tried unsuccessfully so far to attract some kindred spirits to help me in this endeavor but alas, what I have found is most rosacea sufferers are mostly centered on their own rosacea issues, whether it is rosacea or some other rosacea mimic, and simply will not volunteer to help make the RRDi's mission come true. It is very sad. 14 years ago when the RRDi was founded, there were quite a number of impassioned volunteers who assisted me in this endeavor but they are now mostly faded away. Where have all the volunteer rosaceans volunteer gone? Where is a passionate rosacea volunteer with a spirit like Jonathan Albright to be found? Alas, such volunteer rosaceans are slim to none.  The reason I am writing this post is that after reading how Jonathan Albright's passionate hours and hours of researching to discover how fake news was being spread through all the internet platforms, making a detailed map, which without a doubt took more hours to make, it has inspired me to explain that I have spent endless hours putting the RRDi together and basically this web site and all the rosacea data collected is the Crown Jewels. The RRDi MAC is definitely a close second (you try to bring together some noted rosacea professionals into a group). Third, the Internal Revenue Service approval as a 501 c 3 approved non profit organization (along with the non profit approval from the State of Hawaii) is the last crowning achievement.  I am now sixty eight years old. I have my rosacea controlled and have updated my regimen here. So I am seeing the hand writing on the wall, since who is going to take over the RRDi if I croak?  Basically, if someone doesn't have the kind of passion I have had for this mission and steps up the plate, the RRDi is going to fade away and all you have left is the NRS and the AARS. Is that what you really want to happen?  So think about what I am telling you and please comment in this thread what you think should be done about this? Just think if there is no RRDi, no real legal non profit organization for rosacea patient advocacy, and all you have left are the two non profit organizations mentioned above who are set up by NON ROSACEANS and whose donations are from primarily pharmaceutical corporations who have a vested interest in promoting skin products and who spend little (compared to how much money is donated) on rosacea research?  So if the RRDi fades out of existence and you do nothing about this, is that the way you want it to go?   What rosacea news is the NRS and AARS spreading?  Both non profits clearly state on their websites that pharmaceutical companies are sponsors. What is the agenda when posting information about rosacea? What is the agenda of spending the donations mainly on what?  Dr. Kligman mentions the 'indifference of the National Institutes of Health, which with an annual budget of nearly 30 billion dollars, has not seen fit to fund a single grant for the investigation of rosacea.' Dr. Kligman also says that most research done on rosacea is by the skin industry which is 'voluminous literature, mainly focused on treatments sponsored by commercial interests; perhaps not the most credible source of unbiased research.' ” A Personal Critique on the State of Knowledge of Rosacea, Albert M. Kligman, M.D., Ph.D.
      Department of Dermatology, University of Pennsylvania, Philadelphia, PA, U.S.A.
      publikation_kligman.pdf  Why not join the RRDi, volunteer, help find the cure and expose rosacea fake news?
    • If others don't volunteer and work together for rosacea patient advocacy then rosaceans deserve what they get with the NRS and the AARS which are the only non profits doing any rosacea research. And what kind of research do these organizations do? Who donated primarily to the these organizations? Pharmaceutical companies. And what kind of research do they engage in? You guessed it. Here is a quote from my book I wrote in 2007 on page 82: 

      "Dr. Kligman mentions the 'indifference of the National Institutes of Health, which with an annual budget of nearly 30 billion dollars, has not seen fit to fund a single grant for the investigation of rosacea.' Dr. Kligman also says that most research done on rosacea is by the skin industry which is 'voluminous literature, mainly focused on treatments sponsored by commercial interests; perhaps not the most credible source of unbiased research.' ” A Personal Critique on the State of Knowledge of Rosacea, Albert M. Kligman, M.D., Ph.D.
      Department of Dermatology, University of Pennsylvania, Philadelphia, PA, U.S.A.
      publikation_kligman.pdf
    • In this study, significant cardiovascular disease risk factors such as a family history of premature cardiovascular disease, obesity, prediabetes and high C-reactive protein levels were found to be higher in rosacea patients than controls. Although the underlying mechanism is not clear, it is thought that chronic inflammation and disregulation of innate immune system increase risk of cardiovascular disease in rosacea patients. The American Journal of Cardiology
      Volume 121, Issue 8, Supplement, 15 April 2018, Page e106
      OP-264 - Investigation of Cardiovascular Risk Factors in Rosacea Patients
      Muhammed Karadeniz
    • Highlights of Skin Disease Education Foundations 42nd Annual Hawaii Dermatology Seminar. Semin Cutan Med Surg. 2018 Jun;37(4S):S75-S84 Authors: Baldwin HE, Stein Gold LF, Gordon KB, Green JB, Leonardi CL, Sengelmann RD Abstract
      Updates on managing some of the most common dermatologic conditions for which patients seek care illuminated presentations at the Skin Disease Education Foundation's 42nd Annual Hawaii Dermatology Seminar®. This educational supplement summarizes the highlights of clinical sessions presented during this CME/CE conference. Treatment of psoriasis has continued to advance, with three interleukin (IL)-17 antagonists approved by the US Food and Drug Administration (FDA) and a fourth in phase 3 trials. An authority on the use of biologics in psoriasis presents current data on the safety and efficacy of these therapies. Tumor necrosis factor (TNF) inhibitors also retain a place in the management of psoriasis, with records of long-term safety. A fourth TNF inhibitor awaits FDA approval for use in psoriasis, offering data on transmission during pregnancy and lactation. An expert on the use of this drug class presents the evidence. Topical therapies remain the cornerstone of care for many patients with psoriasis as well as those with rosacea. Our faculty update readers about new and investigational topical therapies for moderate or severe psoriasis, as well as for acne and rosacea. The current literature on monitoring patients receiving isotretinoin also is summarized. Aesthetic and cosmetic dermatology services form a sizable portion of some practices. Our faculty review data on safety of topical and procedural therapies for cellulite as well as safe injection of facial fillers.
      PMID: 30016379 [PubMed - in process] {url} = URL to article
    • In order to really understand and put rosacea research in perspective it is important to understand where rosacea is in terms of total disease on this planet. Google Answers says, "According to the World Health Organization, there are still no effective treatments available for around three quarters of the 30,000
      diseases known today worldwide." [1] “For two thirds of all known sicknesses—about 20,000—there is so far no way of treating the cause.” [2] So rosacea is somewhere between three quarters and two thirds of what is termed idiopathic diseases. [3] Since the cause of rosacea isn't known, and the number of theories on the cause of rosacea has grown exponentially over the years, rosacea is an idiopathic disease.  According to Michael Detmar, M.D., in 2003, only one paper was published for every 144,000 rosacea patients in the United States, compared to a 1-to-11 ratio for melanoma and 1 to 4,900 for psoriasis. [4] This indicates how rosacea research is compared to other idiopathic skin diseases that have a more devastating impact on sufferers. If you had to choose one of these three diseases as a consequence which one would you choose?  Comparing rosacea to melanoma or psoriasis does put rosacea into perspective when it comes to suffering.   So any papers published about rosacea is indeed something to be grateful for. With the increase of spending on pharmaceutical treatments for rosacea comes more research spending. The NRS and AARS, being sponsored by pharmaceutical companies, have engaged in most of the rosacea research.  Dr. Kligman mentions the 'indifference of the National Institutes of Health, which with an annual budget of nearly 30 billion dollars, has not seen fit to fund a single grant for the investigation of rosacea.' Dr. Kligman also says that most research done on rosacea is by the skin industry which is 'voluminous literature, mainly focused on treatments sponsored by commercial interests; perhaps not the most credible source of unbiased research.' ” A Personal Critique on the State of Knowledge of Rosacea, Albert M. Kligman, M.D., Ph.D.
      Department of Dermatology, University of Pennsylvania, Philadelphia, PA, U.S.A.
      publikation_kligman.pdf If rosaceans want to sponsor their own novel rosacea research, they would need to be united, have a volunteer spirit, and use the RRDi to sponsor their own research. Put that into perspective.  End Notes [1] how many diseases are there? [2] The German pharmaceutical publication Statistics ’97 [3] Idiopathic Disease, Wikipedia [4] Rosacea: turning all stones for source of pathology Rebecca Bryant, Dermatology Times, Jun 1, 2004
    • Related Articles Advanced oxidation protein products and serum total oxidant/antioxidant status levels in rosacea. Postepy Dermatol Alergol. 2018 Jun;35(3):304-308 Authors: Erdogan HK, Bulur I, Kocaturk E, Saracoglu ZN, Alatas O, Bilgin M Abstract
      Introduction: Rosacea is a chronic, inflammatory dermatosis which develops due to the effect of genetic and environmental factors.
      Aim: To evaluate the oxidative stress in rosacea patients by measuring serum total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI) and advanced oxidation protein products (AOPP) levels in our study.
      Material and methods: Our study included rosacea patients and healthy volunteers aged between 18 and 65 years. Total antioxidant status, TOS and AOPP levels were measured and OSI was calculated.
      Results: The study included 70 rosacea patients and 30 healthy volunteers as a control group. When TAS, TOS, OSI and AOPP levels were compared between rosacea and control groups, there was no difference for OSI levels; while TAS, TOS and AOPP levels were significantly higher in the rosacea group (p = 0.151, p = 0.013, p = 0.034, p = 0.017, respectively). In the rosacea group, there was no correlation between TAS, TOS, OSI and AOPP levels and disease duration. Besides there was no difference between family history, rosacea type, symptom frequency and ocular involvement and TAS, TOS, OSI and AOPP levels in the rosacea group.
      Conclusions: We observed that serum TAS, TOS and AOPP levels were significantly higher in rosacea patients, but there was no significant difference among the disease activity parameters. These results can support the role of oxidative stress in the pathogenesis of rosacea.
      PMID: 30008650 [PubMed] {url} = URL to article
    • image courtesy of Espiritu Salon and Spa There are now spa treatments using cryotherapy. Will this work for rosacea? Cryotherapy has been used to treat phenotype 5. Will it improve any other phenotype? Time will tell since without a doubt we will be receiving reports whether any other phenotype is improved with cryotherapy.  There is a history of using cryotherapy for rosacea going back to an article published in 1948:  "Despite the fact that cold may be an aetiological factor in rosacea (Haxthausen, 1930, Lortat- Jacob and Solente, 1930, Sequeira, Ingram, and Brain, 1947), cryotherapy is the most valuable ancillary method of treatment......In U.S.A., Bluefarb (I945) and Hume (I948) recommended that powdered sulphur should be mixed with the slush. Solente (I925) pointed out that its value in rosacea was due to the ultimate diminution, in calibre of the local blood-vessels in the dermis. This is the accepted mechanism of its action but Lortat-Jacob and Solente (I930) claim that there is an additional reflex action via the sympathetic. Some workers, such as Vieira (1947) use the snow only to destroy the small, easily visible, dilated, superficial vessels. This is the only purpose for which a snow stick may be better than slush.... ...Shortly after treatment the skin becomes bright red and remains unsightly for a few hours. This is accompanied by a mild feeling of burning (the actual application of the slush is more painful), which may be relieved by fuller's earth, talcum, or face powder. By next day all sign of the immediate efects of treatment should have gone but there may be some blistering especially after the first treatment when the sensitivity of the skin - is not known. There is less likelihood of blistering after subsequent applications. The total length of treatment is variable and must be judged separately for each patient; four to eight sessions are usual. The treatment nearly always leads gradually to much improvement. Each week the skin can be seen to be paler with fewer obvious dilated vessels and less thickening. Complete cure is less common. It is essential to remember that cryotherapy is only a part of the treatment." CRYOTHERAPY FOR ROSACEA
      By E. LIPMAN COHEN, M.A., M.B., B.CHIR.(Cantab.) London
      Postgraduate Medical Journal, December 1948 p 656-659
      CRYOTHERAPY_FOR_ROSACEA.pdf
      image courtesy of Cryo.com.au The Cryo.com.au website uses LED with cryotherapy and states, "CRYO LED uses two wavelengths of light that are Food & Drug Administration (FDA) approved to promote collagen and elastin production, helping to reduce wrinkles and tighten skin. This process feeds cells with wavelengths of light that they convert to the fuel source ATP that promotes cell reproduction and renewal. An increase in local blood circulation helps to flush toxins from the dermal layers of the skin. CRYOTHERAPY AND CRYO LED not only improves your appearance but the experience will make you feel fantastic." So if you try cryotherapy for your rosacea, please post your results in this thread. There are a number of reviews you can read concerning cryotherapy at cryo.com.au. 
    • Take the $500 Microablation and Triphasic Combination Facial at Cornelia Day Spa in New York City. Aestheticians wave an electromagnetic wand over the skin to stimulate collagen, minimize lines, reduce acne and ease chronic irritation (like eczema or rosacea). They then use a triphasic resonator that relies on heat, vibration and therapeutic electrical force to contour and sculpt the face.  World's Most Expensive Spa Treatments
      By Lauren Sherman, Forbes  
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